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1. 发明申请

US20050164365A1 Genetically modified ecarin and process for producing the same 审中-公开
标题翻译：转基因茄子及其生产方法
公开(公告)号：US20050164365A1
公开(公告)日：2005-07-28
申请号：US10482925
申请日：2002-07-04
申请人： Hiroshi Yonemura , Takayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
发明人： Hiroshi Yonemura , Takayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
IPC分类号： C12N9/64 , C12N15/12 , C07H21/04 , C12N1/21 , C12N5/06 , C12N15/74
CPC分类号： C12N9/6418
摘要： A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.
摘要翻译：一种特异性激活凝血酶原的重组ecarin蛋白，所述蛋白通过遗传工程技术有效地制备，包括以下步骤：（1）培养用表达载体转化的转化体微生物或动物细胞，其中将编码ecarin的基因并入到促进剂，以在培养上清液或所述转化体内产生和积累ecarin并回收所产生的ecarin; 和（2）纯化含有回收的ecarin的溶液以获得纯化的ecarin。本发明允许以工业规模生产重组ecarin。

2. 发明授权

US08679783B2 Recombinant factor X with no glycosylation and method for preparing the same 有权
标题翻译：无糖基化的重组因子X及其制备方法
公开(公告)号：US08679783B2
公开(公告)日：2014-03-25
申请号：US13404747
申请日：2012-02-24
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C12P21/06 , C07H21/02 , C12N1/20 , C12N15/00
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，重组通过所述方法获得的没有糖基化的FX。

3. 发明授权

US08173777B2 Recombinant Factor X with no glycosylation and method for preparing the same 有权
标题翻译：没有糖基化的重组因子X及其制备方法
公开(公告)号：US08173777B2
公开(公告)日：2012-05-08
申请号：US12682445
申请日：2008-10-08
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C07K16/00 , C12P21/06
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，重组通过所述方法获得的没有糖基化的FX。

4. 发明授权

US08293874B2 Recombinant factor X with no glycosylation and method for preparing the same 有权
标题翻译：无糖基化的重组因子X及其制备方法
公开(公告)号：US08293874B2
公开(公告)日：2012-10-23
申请号：US13235076
申请日：2011-09-16
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C07K16/00 , C12P21/06
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为FX）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，重组通过所述方法获得的没有糖基化的FX。

5. 发明申请

US20100285568A1 RECOMBINANT FACTOR X WITH NO GLYCOSYLATION AND METHOD FOR PREPARING THE SAME 有权
标题翻译：没有糖苷化的重组因子X及其制备方法
公开(公告)号：US20100285568A1
公开(公告)日：2010-11-11
申请号：US12682445
申请日：2008-10-08
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C12N9/48 , C12N15/57 , C12N15/63 , C12N5/07
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，通过所述方法获得的没有糖基化的FX。

6. 发明申请

US20120231523A1 RECOMBINANT FACTOR X WITH NO GLYCOSYLATION AND METHOD FOR PREPARING THE SAME 有权
公开(公告)号：US20120231523A1
公开(公告)日：2012-09-13
申请号：US13404747
申请日：2012-02-24
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C12N9/64 , C12N15/85 , C12N5/10 , C12N15/57
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

7. 发明申请

US20120039863A1 RECOMBINANT FACTOR X WITH NO GLYCOSYLATION AND METHOD FOR PREPARING THE SAME 有权
标题翻译：没有糖苷化的重组因子X及其制备方法
公开(公告)号：US20120039863A1
公开(公告)日：2012-02-16
申请号：US13235076
申请日：2011-09-16
申请人： Kenji SOEJIMA , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji SOEJIMA , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： A61K38/48 , A61P7/02 , C12N9/50
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，重组通过所述方法获得的没有糖基化的FX。

8. 发明申请

US20060127460A1 Trombin-carrying bioabsorbable synthetic nonwoven fabric 审中-公开
标题翻译：含凝血因子的生物可吸收合成无纺布
公开(公告)号：US20060127460A1
公开(公告)日：2006-06-15
申请号：US10534715
申请日：2003-11-12
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/00 , B32B27/04 , B32B27/12
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

9. 发明申请

US20070224251A1 Hemostatic material 审中-公开
标题翻译：止血材料
公开(公告)号：US20070224251A1
公开(公告)日：2007-09-27
申请号：US11385750
申请日：2006-03-22
申请人： Masao Tanihara , Hisao Kinoshita , Takayuki Imamura , Chikateru Nozaki
发明人： Masao Tanihara , Hisao Kinoshita , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61K38/48 , A61L15/00
CPC分类号： A61K38/4833 , A61L15/225 , A61L15/32 , A61L24/043 , A61L24/10 , A61L2400/04
摘要： The present invention provides a hemostatic material which is excellent in hemostatic property, biodegradability and bioabsorbability, uniformity and stability of the quality, as well as reduces a risk of contamination with a pathogenic organism derived from an animal. The hemostatic material comprises a thrombin and a synthetic polypeptide capable of forming a triple helical structure. The polypeptide may show a peak of the molecular weight in the range from 5×104 to 100×104 in the molecular weight distribution. The polypeptide may contain at least a peptide unit represented by the formula: -Pro-X-Gly- (in the formula, X represents Pro or Hyp). The thrombin may be a recombinant. In the hemostatic material, the proportion of the thrombin may be about 0.1 to 500 units (U) relative to 1 mg of the polypeptide. The hemostatic material may further comprise a binder component having biodegradability and bioabsorbability. The hemostatic material may be formed on a substrate.
摘要翻译：本发明提供止血性，生物降解性和生物吸收性，质量的均匀性和稳定性优异的止血材料，并且降低了来自动物的病原体的污染的风险。止血材料包含能够形成三重螺旋结构的凝血酶和合成多肽。多肽可以在分子量分布中显示分子量在5×10 4至100×10 4范围内的峰。多肽可以至少含有由下式表示的肽单元：-Pro-X-Gly-（在该式中，X表示Pro或Hyp）。凝血酶可以是重组体。在止血材料中，相对于1mg多肽，凝血酶的比例可以为约0.1至500单位（U）。止血材料还可以包含具有生物降解性和生物吸收性的粘合剂组分。止血材料可以形成在基底上。

10. 发明授权

US08043629B2 Bioabsorbable synthetic nonwoven fabric holding thrombin 有权
标题翻译：生物可吸收的合成无纺布保持凝血酶
公开(公告)号：US08043629B2
公开(公告)日：2011-10-25
申请号：US11941779
申请日：2007-11-16
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/32 , A61K9/70 , A61K38/48 , C12N9/74
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

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