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1. 发明授权

US09342382B2 Program processing method, program processing apparatus, and computer program 有权
标题翻译：程序处理方法，程序处理装置和计算机程序
公开(公告)号：US09342382B2
公开(公告)日：2016-05-17
申请号：US13579126
申请日：2011-02-02
申请人： Kenji Soejima
发明人： Kenji Soejima
IPC分类号： G06F9/54 , G06F9/44
CPC分类号： G06F9/54 , G06F8/316
摘要： Internal processes of specified components are connected to each other when an application is executed regardless of interface definition between the components and a new process is executed. A program processing apparatus (100) includes an aspect application unit (102) which generates a routing unit (201) and a connector unit (301) and applies the routing unit (201) and the connector unit (301), respectively to a component (200) and a component (300) which are included in an activated program, and a configuration management unit (101) which causes the routing unit (201) applied to the component (200) and the connector unit (301) applied to the component (300) to establish a communication connection with each other and causes the component (300) to send a process result of an process instruction in the component (300) to the component (200) through the established communication connection.
摘要翻译：指定组件的内部进程在执行应用程序时彼此连接，而不管组件之间的接口定义如何，并且执行新的进程。程序处理装置（100）包括生成路由单元（201）和连接器单元（301）的方面应用单元（102），并将路由单元（201）和连接器单元（301）分别应用于组件（200）和包括在激活程序中的组件（300），以及配置管理单元（101），其将应用于组件（200）和连接器单元（301）的路由单元（201）组件（300），以建立彼此的通信连接，并使组件（300）通过建立的通信连接将组件（300）中的处理指令的处理结果发送到组件（200）。

2. 发明授权

US08679783B2 Recombinant factor X with no glycosylation and method for preparing the same 有权
标题翻译：无糖基化的重组因子X及其制备方法
公开(公告)号：US08679783B2
公开(公告)日：2014-03-25
申请号：US13404747
申请日：2012-02-24
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C12P21/06 , C07H21/02 , C12N1/20 , C12N15/00
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，重组通过所述方法获得的没有糖基化的FX。

3. 发明申请

US20130111498A1 PROGRAM PROCESSING METHOD, PROGRAM PROCESSING APPARATUS, AND COMPUTER PROGRAM 有权
标题翻译：程序处理方法，程序处理设备和计算机程序
公开(公告)号：US20130111498A1
公开(公告)日：2013-05-02
申请号：US13579126
申请日：2011-02-02
申请人： Kenji Soejima
发明人： Kenji Soejima
IPC分类号： G06F9/54
CPC分类号： G06F9/54 , G06F8/316
摘要： Internal processes of specified components are connected to each other when an application is executed regardless of interface definition between the components and a new process is executed. A program processing apparatus (100) includes an aspect application unit (102) which generates a routing unit (201) and a connector unit (301) and applies the routing unit (201) and the connector unit (301), respectively to a component (200) and a component (300) which are included in an activated program, and a configuration management unit (101) which causes the routing unit (201) applied to the component (200) and the connector unit (301) applied to the component (300) to establish a communication connection with each other and causes the component (300) to send a process result of an process instruction in the component (300) to the component (200) through the established communication connection.
摘要翻译：指定组件的内部进程在执行应用程序时彼此连接，而不管组件之间的接口定义如何，并且执行新的进程。程序处理装置（100）包括生成路由单元（201）和连接器单元（301）的方面应用单元（102），并将路由单元（201）和连接器单元（301）分别应用于组件（200）和包括在激活程序中的组件（300），以及配置管理单元（101），其将应用于组件（200）和连接器单元（301）的路由单元（201）组件（300），以建立彼此的通信连接，并使组件（300）通过建立的通信连接将组件（300）中的处理指令的处理结果发送到组件（200）。

4. 发明授权

US08173777B2 Recombinant Factor X with no glycosylation and method for preparing the same 有权
标题翻译：没有糖基化的重组因子X及其制备方法
公开(公告)号：US08173777B2
公开(公告)日：2012-05-08
申请号：US12682445
申请日：2008-10-08
申请人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
发明人： Kenji Soejima , Takayuki Imamura , Ryoichi Kawamura , Hiroshi Nakatake , Arisa Maeyashiki , Hitomi Togo
IPC分类号： C07K16/00 , C12P21/06
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，其包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，重组通过所述方法获得的没有糖基化的FX。

5. 发明申请

US20080153132A1 GENETIC RECOMBINANT ECARIN AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：遗传重组蛋白及其制备方法
公开(公告)号：US20080153132A1
公开(公告)日：2008-06-26
申请号：US11950638
申请日：2007-12-05
申请人： Hiroshi YONEMURA , Takayuki IMAMURA , Hiroshi NAKATAKE , Kenji SOEJIMA , Chikateru NOZAKI
发明人： Hiroshi YONEMURA , Takayuki IMAMURA , Hiroshi NAKATAKE , Kenji SOEJIMA , Chikateru NOZAKI
IPC分类号： C12P21/04 , C07K16/00
CPC分类号： C12N9/6418
摘要： A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.
摘要翻译：一种特异性激活凝血酶原的重组ecarin蛋白，所述蛋白通过遗传工程技术有效地制备，包括以下步骤：（1）培养用表达载体转化的转化体微生物或动物细胞，其中将编码ecarin的基因并入到促进剂，以在培养上清液或所述转化体内产生和积累ecarin并回收所产生的ecarin; 和（2）纯化含有回收的ecarin的溶液以获得纯化的ecarin。本发明允许以工业规模生产重组ecarin。

6. 发明申请

US20060240476A1 Construct comprising recognition domain of antibody against von willebrand factor-specific cleaving enzyme 有权
标题翻译：构建体包含抗von willebrand因子特异性切割酶的抗体的识别结构域
公开(公告)号：US20060240476A1
公开(公告)日：2006-10-26
申请号：US10549317
申请日：2004-03-17
申请人： Kenji Soejima , Tomohiro Nakagaki , Masanori Matsumoto
发明人： Kenji Soejima , Tomohiro Nakagaki , Masanori Matsumoto
IPC分类号： G01N33/53 , C07K16/40
CPC分类号： C12N9/6489 , A61K2039/505 , C07K16/40
摘要： The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as ADAMTS-13) specific to von Willebrand factor (hereinafter, also referred to as vWF), and a polypeptide comprising the epitope region. The present invention also provides a polypeptide located in a region from position 449 to position 687 in an amino acid sequence composing the ADAMTS-13, which is recognized by the anti-ADAMTS-13 antibody, or a peptide fragment derived from the polypeptide.
摘要翻译：本发明提供了针对von Willebrand因子特异性的切割蛋白酶（以下也称为ADAMTS-13）的抗体（以下也称为抗ADAMTS-13抗体）所识别的表位（以下也称为至vWF）和包含表位区的多肽。本发明还提供了位于构成ADAMTS-13的氨基酸序列中的449位至687位的多肽，其被抗ADAMTS-13抗体识别，或源自该多肽的肽片段。

7. 发明申请

US20130041137A1 von Willebrand Factor (vWF) - Cleaving Protease 审中-公开
标题翻译： von Willebrand因子（vWF） - 切割蛋白酶
公开(公告)号：US20130041137A1
公开(公告)日：2013-02-14
申请号：US13271761
申请日：2011-10-12
申请人： Kenji SOEJIMA , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji SOEJIMA , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C07K16/40
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val（SEQ ID NO：1）作为部分序列的多肽链，更优选包含具有成熟蛋白的部分N-末端氨基酸序列的Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val（SEQ ID NO：2），并且在还原或非还原条件下，在SDS-PAGE中具有105至160kDa的分子量。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

8. 发明申请

US20120064057A1 NOVEL ADAMTS-13 MUTANT 有权
标题翻译：新款ADAMTS-13 MUTANT
公开(公告)号：US20120064057A1
公开(公告)日：2012-03-15
申请号：US12666051
申请日：2008-06-19
申请人： Kenji Soejima
发明人： Kenji Soejima
IPC分类号： A61K38/46 , C12N9/14
CPC分类号： C12N9/6489 , A61K38/00 , A61K38/4886 , C12Y304/24087
摘要： The present invention provides a method of enhancing an enzymatic activity of ADAMTS-13 and/or a method of reducing reactivity to an anti-ADAMTS-13 neutralizing antibody as well as a mutant of ADAMTS-13 prepared by the methods. The method of the present invention is characterized by substituting at least one charged amino acid in a disintegrin-like domain, a cysteine-rich domain or a spacer domain of ADAMTS-13 other than the following amino acids with a different amino acid: arginine at position 326, aspartic acid at position 330, aspartic acid at position 343 and arginine at position 349 in the disintegrin-like domain, aspartic acid at position 480, arginine at position 488, arginine at position 498, arginine at position 507, aspartic acid at position 533 and aspartic acid at position 543 in the cysteine-rich domain, and glutamic acid at position 641 and arginine at position 660 in the spacer domain. The present invention also provides a therapeutic agent for thrombotic disease comprising as an active ingredient the mutant of ADAMTS-13 prepared by the method.
摘要翻译：本发明提供增强ADAMTS-13的酶活性的方法和/或降低与抗ADAMTS-13中和抗体的反应性的方法以及通过该方法制备的ADAMTS-13突变体。本发明的方法的特征在于用不同于氨基酸的精氨酸替代不同于以下氨基酸的ADAMTS-13的去蛋白样结构域，富含半胱氨酸的结构域或间隔区中的至少一个带电荷的氨基酸：位置326，位置330处的天冬氨酸，位置343处的天冬氨酸和解联蛋白样结构域中的349位的精氨酸，位置480处的天冬氨酸，位置488的精氨酸，第498位的精氨酸，第507位的精氨酸，第507位的精氨酸，天冬氨酸位置533和富含半胱氨酸的结构域中位置543处的天冬氨酸和位置641处的谷氨酸和间隔区结构域中位置660处的精氨酸。本发明还提供了一种用于血栓形成疾病的治疗剂，其包含通过该方法制备的ADAMTS-13的突变体作为活性成分。

9. 发明申请

US20110314158A1 SYSTEM, METHOD, AND PROGRAM FOR APPLICATION ALLOCATION 审中-公开
标题翻译：用于应用程序分配的系统，方法和程序
公开(公告)号：US20110314158A1
公开(公告)日：2011-12-22
申请号：US13148827
申请日：2010-02-15
申请人： Kenji Soejima
发明人： Kenji Soejima
IPC分类号： G06F15/16
CPC分类号： G06F9/5044
摘要： An application allocation system is provided, by which a supposed execution environment can be obtained when an application is actually executed even in a case where the computer resources of the allocation destination dynamically varies. The allocation originating server obtains an execution condition of each component as application information, determines a component group having possibility to be allocated as an allocation candidate component group, generates a resource subscription request indicating an execution condition of the allocation candidate component group and transmits it to each allocation candidate server, and determines the allocation destination server of each component from the allocation candidate component group. Each allocation candidate server determines the executability of each allocation candidate component and transmits an application attendance request which indicates an executable allocation candidate component as an attendance object component to the allocation originating server.
摘要翻译：提供了一种应用分配系统，即使在分配目的地的计算机资源动态变化的情况下，也可以在实际执行应用时获得假定的执行环境。分配始发服务器获取每个组件的执行条件作为应用信息，确定具有被分配为分配候选组件组的可能性的组件组，生成指示分配候选组件组的执行条件的资源订阅请求并将其发送到每个分配候选服务器，并且从分配候选组件组确定每个组件的分配目的地服务器。每个分配候选服务器确定每个分配候选组件的可执行性，并将指示可执行分配候选组件的应用考勤请求作为考勤对象组件发送给分配始发服务器。

10. 发明授权

US08067221B2 Von Willebrand factor (vWF)-cleaving protease 有权
标题翻译： Von Willebrand因子（vWF） - 切蛋白酶
公开(公告)号：US08067221B2
公开(公告)日：2011-11-29
申请号：US12103899
申请日：2008-04-16
申请人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C12N9/48 , C12N1/20 , C12N15/00 , C12Q1/37 , C12Q1/00 , C12P21/04 , C07H21/04
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val（SEQ ID NO：1）作为部分序列的多肽链，更优选包含具有成熟蛋白的部分N-末端氨基酸序列的Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val（SEQ ID NO：2），并且在还原或非还原条件下，在SDS-PAGE中具有105至160kDa的分子量。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

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