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1. 发明申请

US20060127460A1 Trombin-carrying bioabsorbable synthetic nonwoven fabric 审中-公开
标题翻译：含凝血因子的生物可吸收合成无纺布
公开(公告)号：US20060127460A1
公开(公告)日：2006-06-15
申请号：US10534715
申请日：2003-11-12
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/00 , B32B27/04 , B32B27/12
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

2. 发明授权

US08043629B2 Bioabsorbable synthetic nonwoven fabric holding thrombin 有权
标题翻译：生物可吸收的合成无纺布保持凝血酶
公开(公告)号：US08043629B2
公开(公告)日：2011-10-25
申请号：US11941779
申请日：2007-11-16
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/32 , A61K9/70 , A61K38/48 , C12N9/74
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

3. 发明申请

US20080286347A1 BIOABSORBABLE SYNTHETIC NONWOVEN FABRIC HOLDING THROMBIN 有权
标题翻译：生物可溶性合成非织造织物保持薄膜
公开(公告)号：US20080286347A1
公开(公告)日：2008-11-20
申请号：US11941779
申请日：2007-11-16
申请人： Takanori UCHIDA , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori UCHIDA , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/00 , A61K38/48 , A61P7/04 , B32B27/04
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

4. 发明申请

US20060051340A1 Hemostatic materials 审中-公开
标题翻译：止血材料
公开(公告)号：US20060051340A1
公开(公告)日：2006-03-09
申请号：US10542577
申请日：2004-01-16
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu
IPC分类号： B32B27/04 , B32B27/12 , B32B5/02 , A61K38/48 , A61L15/00
CPC分类号： A61L15/32 , A61F13/36 , A61F2013/00472 , A61L15/26 , A61L2400/04 , Y10T442/2508 , Y10T442/2525 , Y10T442/2861 , Y10T442/696 , C08L65/04
摘要： A safe and effective hemostatic material is provided. A hemostatic material comprising as an effective ingredient thrombin and fibrinogen characterized in that a bioabsorbable synthetic nonwoven fabric is used as a supporting material. The use of the hemostatic material of the present invention allows for quick and thorough hemostasis for both projectile bleeding and exudative bleeding.
摘要翻译：提供安全有效的止血材料。一种止血材料，其包含作为有效成分的凝血酶和纤维蛋白原，其特征在于使用生物可吸收的合成非织造织物作为支撑材料。使用本发明的止血材料可以快速和彻底地止血用于射弹出血和渗出性出血。

5. 发明授权

US06251370B1 Tissue adhesive suitable for spray application 失效
标题翻译：适用于喷涂应用的组织粘合剂
公开(公告)号：US06251370B1
公开(公告)日：2001-06-26
申请号：US09299916
申请日：1999-04-28
申请人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
发明人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
IPC分类号： A61L904
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , Y10S514/822
摘要： An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.
摘要翻译：公开了能够均匀地形成高浓度纤维蛋白以提供高闭合效果的用于组织的粘合剂。用于组织的粘合剂包括纤维蛋白原溶液和溶液彼此分离的凝血酶溶液。将粘合剂混合并用无菌气体喷涂，并且纤维蛋白原溶液与凝血酶溶液的体积比为约2:1至10:1。该粘合剂将与无菌气体一起喷洒以用于人或动物的活组织的粘附或闭合。

6. 发明授权

US5980866A Tissue adhesive suitable for spray application 失效
标题翻译：适用于喷涂应用的组织粘合剂
公开(公告)号：US5980866A
公开(公告)日：1999-11-09
申请号：US945882
申请日：1997-11-13
申请人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
发明人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
IPC分类号： A61B17/00 , A61L24/10 , A61L9/14 , A61L15/58 , A61L25/00
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , Y10S514/822
摘要： An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.
摘要翻译： PCT No.PCT / JP97 / 00818 Sec。 371日期：1997年11月13日 102（e）1997年11月13日PCT PCT 1997年3月14日PCT公布。公开号WO97 / 33633 1997年9月18日公开了能够均匀地形成高浓度纤维蛋白以提供高闭合效果的组织的粘合剂。用于组织的粘合剂包括纤维蛋白原溶液和溶液彼此分离的凝血酶溶液。将粘合剂混合并用无菌气体喷涂，并且纤维蛋白原溶液与凝血酶溶液的体积比为约2:1至10:1。该粘合剂将与无菌气体一起喷洒以用于人或动物的活组织的粘附或闭合。

7. 发明申请

US20070231372A1 Tissue Sealant 审中-公开
标题翻译：组织密封剂
公开(公告)号：US20070231372A1
公开(公告)日：2007-10-04
申请号：US11597321
申请日：2005-05-18
申请人： Takayuki Imamura , Noriko Shinya , Ryoichi Kawamura , Chikateru Nazaki
发明人： Takayuki Imamura , Noriko Shinya , Ryoichi Kawamura , Chikateru Nazaki
IPC分类号： A61L24/00
CPC分类号： A61K38/363 , A61K38/4833 , A61K45/06 , A61L24/0042 , A61L24/106
摘要： The present invention relates to a tissue sealant which is safe and effective. In accordance with the present invention, a tissue sealant comprising as an effective ingredient thrombin and fibrinogen characterized in that a bioabsorbable synthetic nonwoven fabric is used as a supporting material; use of a combination of a bioabsorbable synthetic nonwoven fabric as a supporting material and thrombin and fibrinogen as an effective ingredient for a tissue sealant; use of a combination of a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient, and fibrinogen as an effective ingredient for a tissue sealant; a tissue sealing kit comprising a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient, and a container comprising fibrinogen as an effective ingredient; and a tissue sealing kit comprising a bioabsorbable synthetic nonwoven fabric as a substrate, a container comprising thrombin as an effective ingredient and a container comprising fibrinogen as an effective ingredient are provided.
摘要翻译：本发明涉及安全有效的组织密封剂。根据本发明，包含作为有效成分凝血酶和纤维蛋白原的组织密封剂，其特征在于使用生物可吸收合成无纺布作为支撑材料; 使用生物可吸收合成无纺布作为支撑材料和凝血酶和纤维蛋白原的组合作为组织密封剂的有效成分; 使用保持凝血酶作为有效成分的生物可吸收性合成无纺布和纤维蛋白原作为组织密封剂的有效成分的组合; 包含保持凝血酶作为有效成分的生物可吸收合成无纺布的组织密封试剂盒和包含纤维蛋白原作为有效成分的容器; 提供了包含生物可吸收合成非织造织物作为底物的组织密封套件，包含凝血酶作为有效成分的容器和包含纤维蛋白原作为有效成分的容器。

8. 发明申请

US20120177718A1 WOUND-COVERING MATERIAL 审中-公开
标题翻译：覆盖材料
公开(公告)号：US20120177718A1
公开(公告)日：2012-07-12
申请号：US13377757
申请日：2010-06-11
申请人： Ryo Asato , Noriko Shinya , Yuki Ishizawa , Satomi Harano
发明人： Ryo Asato , Noriko Shinya , Yuki Ishizawa , Satomi Harano
IPC分类号： A61K9/70 , A61F13/00 , A61K38/48
CPC分类号： A61K38/363 , A61K9/7092 , A61K38/4833 , A61K45/06 , A61L15/26 , A61L15/32 , A61L15/44 , A61L26/0042 , C08L67/04 , A61K2300/00
摘要： A new wound-covering material that protects and repairs a wound area caused by an operation, trauma, burn, and the like is provided. The present invention relates to a wound-covering material comprising thrombin, fibrinogen and a bioabsorbable supporting material. The wound-covering material may further be overlaid with a covering material for retaining moisture. The wound-covering material may be consisted of a kit of either (1) a bioabsorbable supporting material holding thrombin, and fibrinogen; or (2) a bioabsorbable supporting material holding thrombin, and a bioabsorbable supporting material holding fibrinogen; or (3) thrombin, fibrinogen and a bioabsorbable supporting material. Besides, each of the kits may be combined with a covering material for retaining moisture.
摘要翻译：提供了一种新的伤口覆盖材料，其保护和修复由手术，创伤，烧伤等引起的伤口区域。本发明涉及包含凝血酶，纤维蛋白原和生物可吸收支持材料的伤口覆盖材料。伤口覆盖材料可以进一步覆盖用于保持水分的覆盖材料。伤口覆盖材料可以由（1）保持凝血酶的生物可吸收支持材料和纤维蛋白原的试剂盒组成; 或（2）保持凝血酶的生物吸收性支持材料和保持纤维蛋白原的生物可吸收支持材料; 或（3）凝血酶，纤维蛋白原和生物可吸收的支持物质。此外，每个试剂盒可以与用于保持水分的覆盖材料组合。

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