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1. 发明申请

US20070135434A1 Sulfonyloxy derivatives 失效
标题翻译：磺酰氧基衍生物
公开(公告)号：US20070135434A1
公开(公告)日：2007-06-14
申请号：US10590404
申请日：2005-02-23
申请人： Hiroshi Tomori , Hiroshi Miyamoto , Keijiro Kobayashi
发明人： Hiroshi Tomori , Hiroshi Miyamoto , Keijiro Kobayashi
IPC分类号： A61K31/5375 , A61K31/445 , C07D265/32 , C07D211/06
CPC分类号： C07D211/22 , C07D265/30 , C07D413/06 , C07D495/10
摘要： A compound having the formula (I) shown below wherein R1 is a substituted phenyl, R2 is a phenyl substituted with halogen atoms, R3 is a substituted phenyl, D is an oxygen or a methylene, and n is 0 or 1. The compound is a synthetic intermediate for a neurokinin receptor antagonist.
摘要翻译：具有下式的式（I）的化合物其中R 1是取代的苯基，R 2是被卤素原子取代的苯基，R 3 O >是取代的苯基，D是氧或亚甲基，n是0或1.化合物是神经激肽受体拮抗剂的合成中间体。

2. 发明授权

US07560549B2 Sulfonyloxy derivatives 失效
标题翻译：磺酰氧基衍生物
公开(公告)号：US07560549B2
公开(公告)日：2009-07-14
申请号：US10590404
申请日：2005-02-23
申请人： Hiroshi Tomori , Hiroshi Miyamoto , Keijiro Kobayashi
发明人： Hiroshi Tomori , Hiroshi Miyamoto , Keijiro Kobayashi
IPC分类号： C07D265/30 , C07D211/06
CPC分类号： C07D211/22 , C07D265/30 , C07D413/06 , C07D495/10
摘要： A compound having the formula (I) wherein R1 is a substituted phenyl, R2 is a phenyl substituted with halogen atoms, R3 is a substituted phenyl, D is an oxygen or a methylene, and n is 0 or 1. The compound is a synthetic intermediate for a neurokinin receptor antagonist.
摘要翻译：具有式（I）的化合物，其中R 1是取代的苯基，R 2是被卤素原子取代的苯基，R 3是取代的苯基，D是氧或亚甲基，n是0或1.化合物是合成的神经激肽受体拮抗剂的中间体。

3. 发明授权

US07012147B2 Indoline derivative and process for producing the same 失效
标题翻译：二氢吲哚衍生物及其制备方法
公开(公告)号：US07012147B2
公开(公告)日：2006-03-14
申请号：US10635040
申请日：2003-07-31
申请人： Hiroshi Tomori , Hiroshi Miyamoto , Hiroshi Fukuhara , Katsuhiko Fujimoto , Masakazu Wakayama , Ryoichi Sonobe , Motoko Miura , Kazuhiko Shimura
发明人： Hiroshi Tomori , Hiroshi Miyamoto , Hiroshi Fukuhara , Katsuhiko Fujimoto , Masakazu Wakayama , Ryoichi Sonobe , Motoko Miura , Kazuhiko Shimura
IPC分类号： C07D209/08
CPC分类号： C07D209/08 , Y02P20/55
摘要： The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof.
摘要翻译：本发明提供了用于生产表现出优异的ACAT抑制活性的二氢吲哚衍生物的新型合成中间体及其制备方法。

4. 发明申请

US20060014965A1 Indoline derivative and process for producing the same 审中-公开
公开(公告)号：US20060014965A1
公开(公告)日：2006-01-19
申请号：US11221003
申请日：2005-09-07
申请人： Hiroshi Tomori , Hiroshi Miyamoto , Hiroshi Fukuhara , Katsuhiko Fujimoto , Masakazu Wakayama , Ryoichi Sonobe , Motoko Miura , Kazuhiko Shimura
发明人： Hiroshi Tomori , Hiroshi Miyamoto , Hiroshi Fukuhara , Katsuhiko Fujimoto , Masakazu Wakayama , Ryoichi Sonobe , Motoko Miura , Kazuhiko Shimura
IPC分类号： C07D209/18
CPC分类号： C07D209/08 , Y02P20/55
摘要： The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof.

5. 发明授权

US09115661B2 Fuel injection amount control system and fuel injection amount control device for multi-cylinder internal combustion engine 有权
标题翻译：燃油喷射量控制系统和多缸内燃机燃油喷射量控制装置
公开(公告)号：US09115661B2
公开(公告)日：2015-08-25
申请号：US13194922
申请日：2011-07-30
申请人： Yasushi Iwazaki , Hiroshi Miyamoto
发明人： Yasushi Iwazaki , Hiroshi Miyamoto
IPC分类号： G06F7/00 , G06F17/00 , F02D41/30 , F02D41/14 , F02D41/24
CPC分类号： F02D41/1441 , F02D41/2493 , F02D2041/1432 , Y02T10/22
摘要： A fuel injection amount control system corrects the amount of fuel injected from each fuel injection valve in a feedback manner, based on an output value of an upstream air-fuel ratio sensor, so that the air-fuel ratio of exhaust gas flowing into a three-way catalyst coincides with a target air-fuel ratio. Also, the control system performs a high-pass filtering operation on the output value of the upstream air-fuel ratio sensor, so as to obtain a post-high-pass-filtering output value by removing a component that varies with variations in the center air-fuel ratio of the engine, from the output value of the upstream air-fuel ratio sensor. Then, the control system acquires an air-fuel ratio imbalance index value that increases as the degree of ununiformity in the air-fuel ratio among cylinders is larger, based on the post-high-pass-filtering output value.
摘要翻译：燃料喷射量控制系统基于上游空燃比传感器的输出值，以反馈方式校正从每个燃料喷射阀喷射的燃料量，使得流入三个燃料喷射量的排气的空燃比 - 催化剂与目标空燃比一致。此外，控制系统对上游空燃比传感器的输出值进行高通滤波操作，以便通过去除随中心变化而变化的分量来获得后高通滤波输出值发动机的空燃比从上游空燃比传感器的输出值。然后，控制系统基于后高通滤波输出值，获取随着气缸中的空燃比的不均匀程度越大而增加的空燃比不平衡指数值。

6. 发明授权

US08965665B2 Air-fuel ratio imbalance determining apparatus among cylinders for an internal combustion engine 有权
标题翻译：用于内燃机的气缸中的空燃比不平衡确定装置
公开(公告)号：US08965665B2
公开(公告)日：2015-02-24
申请号：US13389082
申请日：2009-08-06
申请人： Yasushi Iwazaki , Hiroshi Miyamoto , Fumihiko Nakamura , Hiroshi Sawada , Toru Kidokoro
发明人： Yasushi Iwazaki , Hiroshi Miyamoto , Fumihiko Nakamura , Hiroshi Sawada , Toru Kidokoro
IPC分类号： F02D41/22 , F02D41/00 , F02D41/14
CPC分类号： F02D41/008 , F02D41/1456
摘要： An air-fuel ratio imbalance among cylinders determining apparatus according to the present invention obtains an output Vabyfs of an air-fuel ratio sensor disposed at a portion downstream of an exhaust gas aggregated portion of an exhaust gas passage, and obtains a second-order differential value d2AF (a change rate of a change rate of a detected air-fuel ratio abyfs) of a detected air-fuel ratio abyfs represented by the air-fuel ratio sensor output Vabyfs. The imbalance determining apparatus determines that an air-fuel ratio imbalance state among cylinders is occurring when a detected air-fuel ratio second-order differential corresponding value (for example, a second-order differential value d2AF per se) obtained in accordance with the second-order differential value d2AF is larger than a first threshold value.
摘要翻译：根据本发明的气缸确定装置之间的空燃比不平衡获得设置在排气通道的排气集中部分下游的空燃比传感器的输出Vabyfs，并获得二阶微分由空燃比传感器输出Vabyfs表示的检测空燃比abyfs的值d2AF（检测空燃比abyfs的变化率的变化率）。不平衡确定装置确定当根据第二个所获得的检测到的空燃比二阶差分对应值（例如，二阶差分值d2AF本身）发生气缸之间的空燃比不平衡状态时 - 阶微分值d2AF大于第一阈值。

7. 发明授权

US08911610B2 Process for producing metallic lithium 有权
标题翻译：金属锂制造方法
公开(公告)号：US08911610B2
公开(公告)日：2014-12-16
申请号：US13608561
申请日：2012-09-10
申请人： Eiji Nakamura , Hiroaki Takata , Yukihiro Yokoyama , Hiroshi Miyamoto
发明人： Eiji Nakamura , Hiroaki Takata , Yukihiro Yokoyama , Hiroshi Miyamoto
IPC分类号： C25C3/02 , C01D15/04
CPC分类号： C01D15/04 , C25C3/02
摘要： Provided is a safe and efficient method for producing lithium metal which facilitates efficient production of anhydrous lithium chloride without corrosion of the system materials by chlorine gas or molten lithium carbonate, and which allows production of lithium metal by molten salt electrolysis of the produced anhydrous lithium chloride as a raw material. The method includes the steps of (A) contacting and reacting lithium carbonate and chlorine gas in a dry process to produce anhydrous lithium chloride, and (B) subjecting the raw material for electrolysis containing the anhydrous lithium chloride to molten salt electrolysis under such conditions as to produce lithium metal, wherein the chlorine gas generated by the molten salt electrolysis in step (B) is used as the chlorine gas in step (A) to continuously perform steps (A) and (B).
摘要翻译：提供了一种安全有效的生产锂金属的方法，其有助于无氯氯化物的有效生产，而不会由于氯气或熔融碳酸锂而使系统材料腐蚀，并且通过熔融盐电解生产无机氯化锂的锂金属作为原料。该方法包括以下步骤：（A）在干法中使碳酸锂和氯气接触并反应生成无水氯化锂;（B）将含有无水氯化锂的电解原料进行熔融盐电解，为了生产锂金属，其中在步骤（B）中通过熔融盐电解产生的氯气用作步骤（A）中的氯气，以连续进行步骤（A）和（B）。

8. 发明申请

US20130144510A1 FUEL INJECTION AMOUNT CONTROL APPARATUS FOR AN INTERNAL COMBUSTION ENGINE 有权
标题翻译：燃油喷射量控制装置内燃机
公开(公告)号：US20130144510A1
公开(公告)日：2013-06-06
申请号：US13701922
申请日：2010-06-07
申请人： Yasushi Iwazaki , Hiroshi Miyamoto , Tatsuro Shimada , Isao Nakajima , Yoshihisa Oda , Takuya Matsumoto , Masashi Hakariya
发明人： Yasushi Iwazaki , Hiroshi Miyamoto , Tatsuro Shimada , Isao Nakajima , Yoshihisa Oda , Takuya Matsumoto , Masashi Hakariya
IPC分类号： F02D41/30
CPC分类号： F02D41/30 , F02D41/0085 , F02D41/0235 , F02D41/0245 , F02D41/0255 , F02D41/064 , F02D41/10 , F02D41/1441 , F02D41/1454 , F02D41/1475 , F02D41/182 , F02D41/2496 , F02D2200/02 , F02D2200/021 , F02D2200/04 , F02D2200/0802
摘要： A fuel injection amount control apparatus includes an air-fuel ratio sensor which is disposed between an exhaust gas merging portion HK and an upstream catalyst. The control apparatus performs a feedback correction on an amount of fuel to be injected by the fuel injection valve in such a manner that an air-fuel ratio represented by an output value of an upstream air-fuel ratio sensor becomes equal to a target air-fuel ratio which is set at stoichiometric air-fuel ratio. The control apparatus obtains an air-fuel ratio imbalance indicating value, which becomes larger as a difference in air-fuel ratio of each of the mixtures supplied to each of the combustion chambers among the cylinders becomes larger, and performs an increasing correction to the amount of fuel to be injected by the injection valve in such a manner that an air-fuel ratio becomes a richer air-fuel ratio than the stoichiometric air-fuel ratio as the obtained air-fuel ratio imbalance indicating value becomes larger.
摘要翻译：燃料喷射量控制装置包括设置在废气合流部HK和上游催化剂之间的空燃比传感器。控制装置对由燃料喷射阀喷射的燃料量进行反馈校正，使得由上游空燃比传感器的输出值表示的空燃比变得等于目标空气燃料比传感器，燃料比设定为化学计量空燃比。控制装置获得空气 - 燃料比不平衡指示值变大，随着供给到各气缸中的每个燃烧室的混合物的空燃比的差异变大，并且对量的增加校正的燃料，以使空燃比成为比所获得的空燃比不平衡指示值变大的理论空燃比高得多的空燃比的方式由喷射阀喷射。

9. 发明授权

US08401766B2 Inter-cylinder air-fuel ratio imbalance determination apparatus for internal combustion engine 有权
标题翻译：用于内燃机的缸内空燃比不平衡确定装置
公开(公告)号：US08401766B2
公开(公告)日：2013-03-19
申请号：US13514764
申请日：2009-12-09
申请人： Yasushi Iwazaki , Hiroshi Sawada , Hiroshi Miyamoto , Fumihiko Nakamura , Keiichiro Aoki
发明人： Yasushi Iwazaki , Hiroshi Sawada , Hiroshi Miyamoto , Fumihiko Nakamura , Keiichiro Aoki
IPC分类号： G06F19/00 , F02D41/14 , G01N27/407
CPC分类号： F02D41/0085 , F02D41/1454 , F02D41/1494 , F02D2250/14
摘要： An inter-cylinder air-fuel ratio imbalance determination apparatus (determination apparatus) according to the present invention obtains, based on the output value of the air-fuel ratio sensor, an imbalance determination parameter which becomes larger as an air-fuel ratio fluctuation of an exhaust gas passing through a position at which the air-fuel ratio sensor is disposed becomes larger, during a parameter obtaining period. The determination apparatus energizes the heater of the air-fuel ratio sensor in such a manner that a temperature of the air-fuel ratio element during the parameter obtaining period is higher than a temperature of the air-fuel ratio element during a period other than the parameter obtaining period. Accordingly, the imbalance determination parameter is obtained while the responsiveness of the air-fuel ratio sensor is high, and thus, the inter-cylinder air-fuel-ratio imbalance determination having a high accuracy can be made.
摘要翻译：根据本发明的气缸内空燃比不平衡判定装置（判定装置），基于空燃比传感器的输出值，获得作为空燃比变动的空气比变动变大的不平衡判定参数在参数获取期间，通过设置有空燃比传感器的位置的排气变大。确定装置使空燃比传感器的加热器通电，使得参数获取期间的空燃比元件的温度比空燃比元件的温度高于空燃比元件的温度参数获取期。因此，在空燃比传感器的响应性高的同时获得不平衡确定参数，因此，可以进行具有高精度的气缸间空燃比不平衡确定。

10. 发明申请

US20130046225A1 IMMUNOACTIVATION BLOOD PERFUSION FILTER FOR THE TREATMENT OF MALIGNANT TUMORS 有权
标题翻译：用于治疗恶性肿瘤的免疫血液灌注过滤器
公开(公告)号：US20130046225A1
公开(公告)日：2013-02-21
申请号：US13394765
申请日：2010-10-07
申请人： Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba , Ako Nose
发明人： Yukihiko Nose , Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61K31/727 , A61K31/135 , A61M1/14 , A61M1/16 , A61M1/3486 , A61M1/3496 , A61M1/3621 , B01D15/00 , B01J20/00 , B01J20/22 , B01J2220/4825 , B01J2220/4831 , A61K2300/00
摘要： The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要翻译：本发明提供了一种通过使他与生物相容性生物材料进行约1小时的分离程序来在人体内产生天然的免疫活性状态的方法。为了安全地控制由该程序引起的免疫休克，将该人全身麻醉约6小时，包括分离时间，此后至少另外5小时。这种免疫激活可用于治疗恶性肿瘤和与免疫抑制相关的疾病，如艾滋病。本发明还提供使用含有血液灌注过滤器的生物相容性材料用于治疗恶性肿瘤和感染性疾病的单采血液柱。

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