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1. 发明授权

US5436221A Tumor metastasis inhibiting compounds and methods 失效
标题翻译：肿瘤转移抑制化合物及方法
公开(公告)号：US5436221A
公开(公告)日：1995-07-25
申请号：US834848
申请日：1992-02-13
申请人： Hiroshi Kitaguchi , Hiroyuki Komazawa , Masayoshi Kojima , Hideto Mori , Naoyuki Nishikawa , Hideaki Satoh , Atsushi Orikasa , Mitsunori Ono , Ichiro Azuma , Ikuo Saiki
发明人： Hiroshi Kitaguchi , Hiroyuki Komazawa , Masayoshi Kojima , Hideto Mori , Naoyuki Nishikawa , Hideaki Satoh , Atsushi Orikasa , Mitsunori Ono , Ichiro Azuma , Ikuo Saiki
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/48 , A61P35/00 , C07K5/08 , C07K5/09 , C07K5/10 , C07K5/11 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K14/78 , C07K17/08 , C07K17/10 , C08F289/00 , C08G69/10 , C07K5/00 , C07K7/00
CPC分类号： A61K38/06 , A61K38/07 , A61K38/08 , A61K47/48238 , C07K14/001 , C07K14/78 , C07K5/0817 , C07K5/1019 , C07K9/001 , C08F289/00 , C08G69/10
摘要： A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;[Z]--Arg--X--Asp--[Y] [I]wherein Arg represents L- or D-arginine residue, Asp represents L-aspartic acid residue, X represents L- or D-leucine, D-isoleucine, L- or D-norleucine, L- or D-phenylalanine, D-phenylglycine or D-alanine residue, and [Z] and [Y] each represents an amino acid or a peptide residue, which may be present or absent, selected from glycine, L-serine, L-threonine, L- and D-aspartic acid, L-alanine, L- and D-glutamic acid, L-proline residues and a peptide residue constituted by the foregoing amino acid residues, and a pharmaceutical composition comprising the peptide derivative. The composition of the present invention is useful as an agent for inhibiting tumor metastasis.
摘要翻译：含有1〜20个单元的由下列通式[I]表示的肽单元的肽衍生物或其药学上可接受的盐; [Z] -Arg-X-Asp- [Y] [I]其中Arg表示L-或D-精氨酸残基，Asp表示L-天冬氨酸残基，X表示L-或D-亮氨酸，D-异亮氨酸，或D-正亮氨酸，L-或D-苯丙氨酸，D-苯基甘氨酸或D-丙氨酸残基，[Z]和[Y]各自表示可以存在或不存在的氨基酸或肽残基，其选自甘氨酸， L-丝氨酸，L-苏氨酸，L-和D-天冬氨酸，L-丙氨酸，L-和D-谷氨酸，L-脯氨酸残基和由上述氨基酸残基构成的肽残基，以及药物组合物，肽衍生物。本发明的组合物可用作抑制肿瘤转移的药剂。

2. 发明授权

US5095090A Polypeptide thin film from amphiphilic compounds 失效
标题翻译：来自两亲化合物的多肽薄膜
公开(公告)号：US5095090A
公开(公告)日：1992-03-10
申请号：US507540
申请日：1992-04-11
申请人： Mitsunori Ono , Tsutomu Miyasaka , Naoyuki Nishikawa
发明人： Mitsunori Ono , Tsutomu Miyasaka , Naoyuki Nishikawa
IPC分类号： C07K14/00 , C08G69/10
CPC分类号： B82Y30/00 , B82Y40/00 , B82Y5/00 , C07K14/001 , C08G69/10
摘要： A polypeptide thin film obtained by polymerizing a monomolecular film comprising a monomer mixture of(a) an amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety having an amino acid ester structure per molecule, the conjugated acid of the elimination group of the ester having a pKa of not higher than 14, and(b) an amphiphilic compound having two amino groups per molecule or an amphiphilic compound having two ester structures per molecule, the conjugated acid of the elimination group of the ester having a pKa of not higher than 16,or a built-up film of the monomolecular film; and a process for preparing a material carrying the polypeptide thin film.
摘要翻译：通过使包含单体混合物（a）具有疏水部分的两亲性化合物和每分子具有氨基酸酯结构的亲水部分的单体混合物聚合获得的多肽薄膜，所述酯的消除基团的共轭酸具有 pKa不高于14，和（b）每分子具有两个氨基的两亲化合物或每分子具有两个酯结构的两亲化合物，所述酯的消除基团的共轭酸的pKa不高于16，或单分子膜的叠层膜; 以及制备携带多肽薄膜的材料的方法。

3. 发明授权

US5198224A Polypeptide thin film 失效
标题翻译：多肽薄膜
公开(公告)号：US5198224A
公开(公告)日：1993-03-30
申请号：US614484
申请日：1990-11-16
申请人： Mitsunori Ono , Naoyuki Nishikawa
发明人： Mitsunori Ono , Naoyuki Nishikawa
IPC分类号： B05D1/20 , A61K9/127 , B01J13/02 , C07F9/09 , C07F9/10 , C07K14/00 , C08G69/10 , C09K3/00
CPC分类号： C07F9/10 , A61K9/1273 , C07F9/091 , Y10T428/268 , Y10T428/2984
摘要： A polypeptide thin film produced by polymerizing a monomolecular film or a built-up film comprising an amphipatic phospholipid compound, wherein the amphipatic phospholipid compound has a hydrophobic portion and a hydrophilic portion having an amino acid ester structure in the molecule, the amino acid ester structure containing a splitting-off group with a pKa value of the conjugated acid thereof being 16 or below.
摘要翻译：通过聚合单分子膜或包含两性磷脂化合物的叠层膜制备的多肽薄膜，其中所述两性磷脂化合物在分子中具有疏水部分和具有氨基酸酯结构的亲水部分，所述氨基酸酯结构含有共轭酸的pKa值为16以下的剥离基。

4. 发明授权

US5190822A Surface-modifiable liposome and process for producing surface-modified liposome 失效
标题翻译：表面改性脂质体和生产表面改性脂质体的方法
公开(公告)号：US5190822A
公开(公告)日：1993-03-02
申请号：US687799
申请日：1991-04-19
申请人： Naoyuki Nishikawa , Mitsunori Ono
发明人： Naoyuki Nishikawa , Mitsunori Ono
IPC分类号： A61K9/127 , A61K47/48 , C07D263/26 , C07D277/14 , C07D277/16
CPC分类号： C07D277/16 , A61K47/48815 , A61K9/1272 , C07D263/26 , C07D277/14 , Y10S436/829 , Y10T428/2984
摘要： A surface-modifiable liposome comprising a compound represented by formula (I) or (II): ##STR1## and a lipid capable of forming a liposome, wherein R.sub.1 represents a hydrophobic group;R.sub.2 and R.sub.3 represent each an organic group including a hydrogen atom) R.sub.2 and R.sub.3 optionally combined with each other to form a double bond or a ring;X and Y each represents an oxygen atom or a sulfur atom; R.sub.2 ' and R.sub.3 ' each represents a hydrogen atom or an organic group; W represents a linking group; n represents 0 or 1; and Z represents a hydrophilic group;and a process for producing a surface-modified liposome by using the surface-modifiable liposome.
摘要翻译：包含由式（I）或（II）表示的化合物：能够形成脂质体的脂质的表面改性脂质体，其中R1表示疏水基团; R2和R3各自表示包含氢原子的有机基团）R 2和R 3彼此相互结合以形成双键或环; X和Y各自表示氧原子或硫原子; R2'和R3'各自表示氢原子或有机基团; W表示连接基团; n表示0或1; Z表示亲水基团; 以及通过使用表面改性脂质体制造表面改性脂质体的方法。

5. 发明授权

US5138026A Polypeptide thin film 失效
标题翻译：多肽薄膜
公开(公告)号：US5138026A
公开(公告)日：1992-08-11
申请号：US480699
申请日：1990-02-15
申请人： Tsutomu Miyasaka , Mitsunori Ono , Naoyuki Nishikawa
发明人： Tsutomu Miyasaka , Mitsunori Ono , Naoyuki Nishikawa
IPC分类号： C08G69/10
CPC分类号： C08G69/10 , Y10T428/31504 , Y10T428/31725 , Y10T428/31728
摘要： A polypeptide thin film obtained by polymerizing a monomolecular film comprising an amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety having an amino acid ester structure per molecule, the conjugated acid of the elimination group of said ester having a pKa of not higher than 14, or a built-up film of said monomolecular film; and a process for preparing a material on which said polypeptide thin film is carried.
摘要翻译：通过聚合包含具有疏水部分的两亲化合物和每分子具有氨基酸酯结构的亲水部分的单分子膜，所述酯的消除基团的共轭酸的pKa不高于14，获得的多肽薄膜，或所述单分子膜的叠层膜; 以及制备其上携带所述多肽薄膜的材料的方法。

6. 发明授权

US5589510A Method for inhibiting retroviral infection by administering a naphthalenesulfonic acid compound 失效
标题翻译：通过施用萘磺酸化合物抑制逆转录病毒感染的方法
公开(公告)号：US5589510A
公开(公告)日：1996-12-31
申请号：US441219
申请日：1995-05-15
申请人： Mitsunori Ono , Yumiko Wada , Yaming Wu , Hiroshi Kitaguchi , Yumiko Jimbo , Ryoichi Nemori , Stephen Gillies , Kin-Ming Lo
发明人： Mitsunori Ono , Yumiko Wada , Yaming Wu , Hiroshi Kitaguchi , Yumiko Jimbo , Ryoichi Nemori , Stephen Gillies , Kin-Ming Lo
IPC分类号： A61K9/00 , A61K31/185 , A61K31/655 , A61P31/12 , A61P31/18 , A61P37/04 , A61K31/175 , A61K31/10 , A61K31/16
CPC分类号： A61K31/185 , Y10S514/934
摘要： A method for inhibiting retroviral infection in a subject comprising administering to said subject a therapeutically effective amount of a naphthalenesulfonic acid compound or a pharmaceutically acceptable salt thereof, as herein defined.
摘要翻译：一种用于抑制受试者逆转录病毒感染的方法，包括向所述受试者施用治疗有效量的如本文所定义的萘磺酸化合物或其药学上可接受的盐。

7. 发明授权

US5117034A Phosphatidylserine derivatives 失效
标题翻译：磷脂酰丝氨酸衍生物
公开(公告)号：US5117034A
公开(公告)日：1992-05-26
申请号：US602557
申请日：1990-10-24
申请人： Mitsunori Ono , Hideto Mori
发明人： Mitsunori Ono , Hideto Mori
IPC分类号： C07F9/09 , C07F9/12
CPC分类号： C07F9/12 , C07F9/091 , Y02P20/55
摘要： A phosphatidylserine derivative represented by formulae (I), (II), and (III): ##STR1## wherein R represents a protective group which can be removed by an acid; and R' represents a straight chain or branched alkyl group having from 8 to 24 carbon atoms and may contain a substituent group, or may be unsaturated, provided that if an asymmetric carbon is present, the phosphatidylserine derivative is a racemic mixture or an optically active isomer thereof. Preferably, R represents a tertiary butoxycarbonyl group; R' represents a straight chain or branched alkyl group having 14, 16, or 18 carbon atoms; and the substituent is an alkylcarbonyl group, an alkoxycarbonyl group, a halogen atom, or an aryl group.
摘要翻译：（I），（II）和（III）表示的磷脂酰丝氨酸衍生物：其中R表示可被酸除去的保护基， ; 并且R'表示具有8至24个碳原子并且可以含有取代基的直链或支链烷基，或可以是不饱和的，条件是如果存在不对称碳，则磷脂酰丝氨酸衍生物是外消旋混合物或光学活性异构体。优选地，R表示叔丁氧基羰基; R'表示具有14,16或18个碳原子的直链或支链烷基; 取代基是烷基羰基，烷氧基羰基，卤素原子或芳基。

8. 发明授权

US08173651B2 Pyridine compounds 有权
标题翻译：吡啶化合物
公开(公告)号：US08173651B2
公开(公告)日：2012-05-08
申请号：US12722066
申请日：2010-03-11
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Howard P. Ng , Zachary Demko
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Howard P. Ng , Zachary Demko
IPC分类号： A61K31/5377
CPC分类号： C07D413/12 , C04B35/632 , C07D213/77 , C07D401/12 , C07D405/12
摘要： This invention features compounds of formula (I): pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12-related diseases and disorders.
摘要翻译：本发明的特征在于式（I）化合物：化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

9. 发明申请

US20110250191A1 COMPOSITION FOR ENHANCING PHYSICAL PERFORMANCE 有权
标题翻译：用于增强身体健康的组合物
公开(公告)号：US20110250191A1
公开(公告)日：2011-10-13
申请号：US12901991
申请日：2010-10-11
申请人： Thomas Christian Lines , Mitsunori Ono
发明人： Thomas Christian Lines , Mitsunori Ono
IPC分类号： A61K38/43 , A61K31/525 , A61K31/675 , A61P39/00 , A61P39/06
CPC分类号： A61K31/352 , A23L2/02 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K31/185 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/445 , A61K31/455 , A61K31/51 , A61K31/522 , A61K31/525 , A61K31/675 , A61K31/7048 , A61K31/714 , A61K36/16 , A61K36/185 , A61K36/48 , A61K45/06 , A61K2300/00 , A23V2250/214 , A23V2250/2116 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/704 , A23V2250/7052 , A23V2250/706 , A23V2250/712 , A23V2250/70 , A23V2200/322 , A23V2250/21168 , A23V2200/33 , A23V2200/30
摘要： This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, and epigallocatechin.
摘要翻译：本发明涉及含有槲皮素，维生素B1，维生素B2，维生素B3，维生素B6，维生素B12，维生素C，咖啡因，表没食子儿茶素没食子酸酯，表儿茶素，表儿茶素没食子酸酯和表没食子儿茶素的组合物。

10. 发明授权

US07935698B2 Heteroaryl-hydrazone compounds 有权
标题翻译：杂芳基腙化合物
公开(公告)号：US07935698B2
公开(公告)日：2011-05-03
申请号：US10985716
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Elena Kostik , Howard P. Ng
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Elena Kostik , Howard P. Ng
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D213/74 , C07D239/47 , C07D251/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12
摘要： This invention relates to compounds having a formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is —C(Rg)═N-A. The invention also relates to methods of treating IL-12 overproduction-related disorders, methods of treating or preventing disorders related with excessive bone loss, methods for inhibiting osteoclast formation, and methods for treating or preventing a disorder associated with excessive bone resorption.
摘要翻译：本发明涉及具有式（I）的化合物或其药学上可接受的盐，溶剂合物，包合物，水合物，前药或多晶型物，其中X为-C（R g）= N-A。本发明还涉及治疗IL-12过度生产相关疾病的方法，治疗或预防与过度骨丢失相关的障碍的方法，用于抑制破骨细胞形成的方法，以及用于治疗或预防与过度骨吸收相关的病症的方法。

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