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1. 发明授权

US4668771A Method for separating bovine lactoferrin from cow's milk and purifying same 失效
标题翻译：从牛奶中分离牛乳铁蛋白并进行纯化的方法
公开(公告)号：US4668771A
公开(公告)日：1987-05-26
申请号：US808899
申请日：1985-12-13
申请人： Hiroshi Kawakami , Hiroshi Shinmoto , Shunichi Dosako , Kenkichi Ahiko
发明人： Hiroshi Kawakami , Hiroshi Shinmoto , Shunichi Dosako , Kenkichi Ahiko
IPC分类号： C12N15/02 , A61K38/00 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/79 , C07K16/18 , C12P21/08 , A23J1/20 , C07K15/06
CPC分类号： C07K14/79 , C07K16/18 , A61K38/00 , Y10S530/809 , Y10S530/832
摘要： This invention discloses a method for separating a highly pure form of bovine lactoferrin from cow's milk and purifying same which comprises preparing an affinity-chromatographic column by fixing a monoclonal antibody against bovine lactoferrin to an insoluble carrier; passing milk or a solution of bovine lactoferrin derived from cow'milk through the affinity-chromatographic column; and then eluting the bovine lactoferrin adsorbed to the affinity-chromatographic column.
摘要翻译：本发明公开了一种从牛奶中分离出高纯度形式的牛乳铁蛋白和纯化方法，包括通过将牛乳铁蛋白的单克隆抗体固定在不溶性载体上制备亲和层析柱; 将来自牛奶的牛乳铁蛋白通过亲和色谱柱通过牛奶或牛血清铁蛋白溶液; 然后洗脱吸附到亲和色谱柱上的牛乳铁蛋白。

2. 发明授权

US5725864A Composition for suppressing infection and growth of human immunodeficiency virus 失效
标题翻译：用于抑制人体免疫缺陷病毒感染和生长的组合物
公开(公告)号：US5725864A
公开(公告)日：1998-03-10
申请号：US361862
申请日：1994-12-22
申请人： Naoki Yamamoto , Hideki Nakashima , Wataru Motsuchi , Shigeaki Tanaka , Shunichi Dosako , Hiroshi Shinmoto
发明人： Naoki Yamamoto , Hideki Nakashima , Wataru Motsuchi , Shigeaki Tanaka , Shunichi Dosako , Hiroshi Shinmoto
IPC分类号： A61K38/16 , A61K38/00 , A61K38/01 , A61K38/40 , A61K47/48 , A61P31/12 , A61P31/18 , A61P37/00 , C07K14/79 , A01N37/18 , C07K2/00
CPC分类号： A61K47/483 , C07K14/79 , A61K38/00
摘要： The invention relates to compositions and methods for inhibiting infection or suppressing growth of human immunodeficiency virus. The composition comprises, as an effective component, an iron-binding protein (e.g., lactoferrin, transferrin, ovotransferrin), a chemically modified compound of the iron-binding protein, or a hydrolyzed compound of the iron-binding protein. The effective components are safe and can be easily prepared from inexpensive raw materials. The composition can be orally administered, injected or applied to the skin, eye, ear, nose or used as a preparation for vagina affusion, mouth washing or suppositories, and can effectively inhibit infection or suppress growth of human immunodeficiency virus.
摘要翻译：本发明涉及抑制人体免疫缺陷病毒感染或抑制生长的组合物和方法。该组合物包含铁结合蛋白（例如乳铁蛋白，转铁蛋白，转铁蛋白），铁结合蛋白的化学修饰化合物或铁结合蛋白的水解化合物作为有效成分。有效的组分是安全的，可以从廉价的原料容易地制备。该组合物可以口服给药，注射或施用于皮肤，眼睛，耳朵，鼻子或用作阴道注射，口腔清洗或栓剂的制剂，并可有效抑制人体免疫缺陷病毒的感染或抑制生长。

3. 发明授权

US5075424A Process for producing .kappa.-casein glycomacropeptides 失效
标题翻译：生产（KAPPA）-Casein GLYCOMACROPEPTITIDES的方法
公开(公告)号：US5075424A
公开(公告)日：1991-12-24
申请号：US476196
申请日：1990-02-07
申请人： Morimasa Tanimoto , Yoshihiro Kawasaki , Hiroshi Shinmoto , Shunichi Dosako , Akira Tomizawa
发明人： Morimasa Tanimoto , Yoshihiro Kawasaki , Hiroshi Shinmoto , Shunichi Dosako , Akira Tomizawa
IPC分类号： A23L1/305 , A23J1/20 , A23J3/08 , A23J3/34 , A61K38/17 , A61P1/02 , A61P3/04 , A61P31/04 , A61P31/12 , A61P31/16 , C07K1/34 , C07K14/47
CPC分类号： A23J1/202 , C07K14/4732
摘要： A process for producing .kappa.-casein glycomacropeptides which comprises adjusting the pH of a solution of milk starting materials containing the .kappa.-casein glycomacropeptides to below 4, treating the solution by ultrafiltration with a membrane having a fraction molecular weight of 10,000-50,000, and concentrating the obtained filtrate with a membrane having a fraction molecular weight of 50,000 or less.

4. 发明授权

US5017559A Agent for blocking nonspecific adsorption, process for preparing thereof and method of blocking nonspecific adsorption 失效
标题翻译：用于阻断非特异性吸附的试剂，其制备方法和阻断非特异性吸附的方法
公开(公告)号：US5017559A
公开(公告)日：1991-05-21
申请号：US314897
申请日：1989-02-24
申请人： Shunichi Dosako , Hiroshi Shinmoto
发明人： Shunichi Dosako , Hiroshi Shinmoto
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , Y10S530/833
摘要： The present invention provides an agent utilizing for immunological assays in medical fields for blocking nonspecific adsorption, a process for preparing thereof and a method of blocking nonspecific adsorption.The agent contains a combination of milk protein as an effective constituent and a buffer solution containing one or more principal constituents selected from the group of organic acids and their salts.

5. 发明授权

US5330975A Bacterial toxin neutralizer 失效
标题翻译：细菌毒素中和剂
公开(公告)号：US5330975A
公开(公告)日：1994-07-19
申请号：US913500
申请日：1992-07-14
申请人： Hiroko Isoda , Yoshihiro Kawasaki , Morimasa Tanimoto , Shunichi Dosako , Tadashi Idota
发明人： Hiroko Isoda , Yoshihiro Kawasaki , Morimasa Tanimoto , Shunichi Dosako , Tadashi Idota
IPC分类号： C07H7/033 , A61K31/70 , A61K31/7012 , A61K38/00 , A61K38/17 , A61K38/40 , A61P31/04 , A61P39/02 , C07K14/00 , C07K14/005 , C07K14/195 , A61K31/715
CPC分类号： A61K38/40 , A61K31/70 , A61K38/1709
摘要： Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligo-saccharides are active ingredients of a novel bacterial enterotoxin neutralizer and interfere with the binding of enterotoxins, including cholera toxin, to receptors so as to exert an effect of neutralizing the toxicity, thus being utilized as an effective neutralizer and are safe and available cheaply and abundantly from by-products produced during the processing of cow's milk which renders the enterotoxin neutralizer economically advantageous for commercial use.
摘要翻译：唾液酸结合蛋白，唾液酸结合肽和含唾液酸的寡糖是新型细菌肠毒素中和剂的活性成分，并干扰肠毒素（包括霍乱毒素）与受体的结合，从而发挥中和毒性作用，因此被用作有效的中和剂，并且从牛奶加工过程中产生的副产物廉价和大量地安全和可用，这使得肠毒素中和剂在经济上有利于商业用途。

6. 发明授权

US5139953A Rotary column reactor 失效
标题翻译：旋转柱反应器
公开(公告)号：US5139953A
公开(公告)日：1992-08-18
申请号：US569422
申请日：1990-08-20
申请人： Yoshikiko Honda , Morimasa Tanimoto , Kaoru Sato , Shunichi Dosako
发明人： Yoshikiko Honda , Morimasa Tanimoto , Kaoru Sato , Shunichi Dosako
IPC分类号： C12M1/00 , B01D15/02 , B01J8/10 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/79 , C07K16/00 , C07K16/06 , C12M1/02 , C12M1/40 , C12M3/00
CPC分类号： C07K14/79 , B01D15/02 , B01J8/10 , C07K1/16 , C07K16/065 , C12M21/18 , C12M23/06 , C12M23/34 , C12M23/38 , C12M27/10 , B01D2215/029 , B01J2219/182
摘要： A rotary column is rotatably mounted on a hollow shaft having orifices and the shaft is journaled in a reaction vessel. The rotary column has an outer net around the shaft and a space defined by this outer net within the rotary column is divided by partition plates provided with many through-holes into several compartments to be loaded with carriers and immobilized enzymes. The reaction vessel is provided radially outside the compartments with a top cover so that carriers and immobilized enzymes may be easily and evenly loaded into the rotary column. An end surface of the rotary column that is remote from the drive mechanism is provided with a lateral cover. There are provided hydraulic cylinders to tilt the rotary column. Within the reaction vessel, the outer net of the rotary column is provided with rollers adjacent to the lateral cover. Furthermore, there is provided a deaerating pipe within the rotary column and the orifices of the hollow shaft are so dimensioned that, nearer a solution outlet, the diameters of the orifices are larger.
摘要翻译：旋转柱可旋转地安装在具有孔口的中空轴上，并且轴在轴向安装在反应容器中。旋转柱具有围绕轴的外网，并且由旋转柱内的该外网限定的空间被设置有多个通孔的隔板分隔成几个室，以装载载体和固定化酶。反应容器在具有顶盖的隔室的径向外侧设置，使得载体和固定化酶可以容易且均匀地装载到旋转柱中。旋转柱的远离驱动机构的端面设置有侧盖。设有用于倾斜旋转柱的液压缸。在反应容器内，旋转柱的外网设有邻近侧盖的辊。此外，在旋转柱内设置脱气管，空心轴的孔的尺寸设计成使得孔的直径更靠近溶液出口。

7. 发明授权

US5344820A Infection protectant 失效
标题翻译：感染保护剂
公开(公告)号：US5344820A
公开(公告)日：1994-09-06
申请号：US879421
申请日：1992-05-07
申请人： Shunichi Dosako , Hiroko Kusano , Eiki Deya , Tadashi Idota
发明人： Shunichi Dosako , Hiroko Kusano , Eiki Deya , Tadashi Idota
IPC分类号： A61K38/00 , C07K14/47 , A61K37/16
CPC分类号： C07K14/4732 , A61K38/00 , Y10S514/837 , Y10S514/867 , Y10S514/888 , Y10S530/832
摘要： Disclosed herein is an infection protectant which is excellent in infection protective effects and is also safe. .kappa.-Casein, a sialic-acid-conjugated protein derived from cow milk, and a glycomacropeptide derived from .kappa.-casein, each of which is useful as an active ingredient in this invention, have been found to be effective for the prevention of adhesion of E. coli on cells and also for the inhibition of transformation of lymphocytes by EBV and also to have strong HI activity against virus. The infection protectant of this invention is hence believed to exhibit marked effects for the prevention of occurrence of infectious diarrhea, for mass protection against spreading of influenza, and also against canceration of lymphocytes. Since the active ingredient of the infection protectant is a substance derived from cow milk, it is free of any problem from the viewpoint of safety. Moreover, it is absolutely tasteless and odorless. It can therefore be added to foods for its application.
摘要翻译：本文公开了感染保护作用优异且也安全的感染保护剂。已经发现，kappa-casein是来源于牛奶的唾液酸共轭蛋白质和源自κ-酪蛋白的糖代谢肽，其各自可用作本发明的活性成分，大肠杆菌在细胞上，也用于通过EBV抑制淋巴细胞的转化，并且还具有针对病毒的强HI活性。因此，本发明的感染保护剂被认为对于预防感染性腹泻的发生具有显着的效果，用于大规模防止流感扩散以及抗淋巴细胞癌变。由于感染保护剂的活性成分是来自牛奶的物质，因此从安全性的观点出发，没有任何问题。此外，它绝对无味无味。因此可以将其添加到食品中以供应用。

8. 发明授权

US5061622A Process for the production of .kappa.-casein glycomacropeptide 失效
标题翻译：（KAPPA）-Casein GLYCOMACROPEPTIDE的生产方法
公开(公告)号：US5061622A
公开(公告)日：1991-10-29
申请号：US191140
申请日：1988-05-06
申请人： Shunichi Dosako , Tsuguaki Nishiya , Eiki Deya
发明人： Shunichi Dosako , Tsuguaki Nishiya , Eiki Deya
IPC分类号： G01N33/52 , A23J1/20 , A23J3/34 , A23L1/305 , A61K38/00 , A61K38/17 , A61P31/04 , C07K1/30 , C07K4/12 , C07K14/00 , C07K14/47
CPC分类号： C07K14/4732 , A23J1/202 , A23J3/344 , A61K38/00
摘要： Disclosed herein is a process for the efficient production of .kappa.-casein GMP on an industrial scale. The production of high-purity .kappa.-casein GMP is realized by using an effluent of rennet-casein curd free of whey proteins, lactose and the like as a starting effluent, adjusting the pH of the effluent to an acidic range to remove calcium phosphate and then subjecting the resulting effluent to a desalting treatment. .kappa.-Casein GMP is used as a standard substance for the assay of sialic acid. It has also attracted attention for its physiological activities and other properties.

9. 发明授权

US5278288A Process for producing .kappa.-casein glycomacropeptides 失效
标题翻译：生产κ-酪蛋白糖巨肽的方法
公开(公告)号：US5278288A
公开(公告)日：1994-01-11
申请号：US798482
申请日：1991-11-26
申请人： Yoshihiro Kawasaki , Shunichi Dosako
发明人： Yoshihiro Kawasaki , Shunichi Dosako
IPC分类号： C12P21/06 , A23J1/20 , A23J3/10 , A61K31/00 , A61K38/00 , A61K38/17 , A61P1/00 , A61P1/02 , A61P31/00 , A61P31/04 , C07K1/14 , C07K1/18 , C07K1/34 , C07K14/00 , C07K14/47 , C07K1/00 , C07K15/14
CPC分类号： A23J3/10 , A23J1/202 , C07K14/4732
摘要： The present invention provides a process for producing a .kappa.-casein glycomacropeptide comprising contacting milk raw materials containing the .kappa.-casein glycomacropeptide with an ion exchanger; collecting a fraction which does not adsorb on the ion exchanger; and concentrating and desalting the fraction to obtain the .kappa.-casein glycomacropeptide.
摘要翻译：本发明提供了一种生产（κ） - 酪蛋白糖巨肽的方法，包括将含有（κ） - 酪蛋白糖巨肽的乳原料与离子交换剂接触; 收集不吸附在离子交换器上的部分; 并浓缩和脱盐该级分以获得（κ） - 酪蛋白糖巨肽。

10. 发明授权

US5260280A Bacterial toxin neutralizer 失效
标题翻译：细菌毒素中和剂
公开(公告)号：US5260280A
公开(公告)日：1993-11-09
申请号：US913491
申请日：1992-07-14
申请人： Hiroko Isoda , Yoshihiro Kawasaki , Morimasa Tanimoto , Shunichi Dosako , Tadashi Idota
发明人： Hiroko Isoda , Yoshihiro Kawasaki , Morimasa Tanimoto , Shunichi Dosako , Tadashi Idota
IPC分类号： A61K31/70 , A61K38/17 , A61K38/40 , A61K31/715
CPC分类号： A61K38/40 , A61K31/70 , A61K38/1709
摘要： Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligo-saccharides are active ingredients of a novel bacterial enterotoxin neutralizer and interfere with the binding of enterotoxins, including cholera toxin, to receptors so as to exert an effect of neutralizing the toxicity, thus being utilized as an effective neutralizer and are safe and available cheaply and abundantly from by-products produced during the processing of cow's milk which renders the enterotoxin neutralizer economically advantageous for commercial use.
摘要翻译：唾液酸结合蛋白，唾液酸结合肽和含唾液酸的寡糖是新型细菌肠毒素中和剂的活性成分，并干扰肠毒素（包括霍乱毒素）与受体的结合，从而发挥中和毒性作用，因此被用作有效的中和剂，并且从牛奶加工过程中产生的副产物廉价和大量地安全和可用，这使得肠毒素中和剂在经济上有利于商业用途。

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