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1. 发明授权

US5725864A Composition for suppressing infection and growth of human immunodeficiency virus 失效
标题翻译：用于抑制人体免疫缺陷病毒感染和生长的组合物
公开(公告)号：US5725864A
公开(公告)日：1998-03-10
申请号：US361862
申请日：1994-12-22
申请人： Naoki Yamamoto , Hideki Nakashima , Wataru Motsuchi , Shigeaki Tanaka , Shunichi Dosako , Hiroshi Shinmoto
发明人： Naoki Yamamoto , Hideki Nakashima , Wataru Motsuchi , Shigeaki Tanaka , Shunichi Dosako , Hiroshi Shinmoto
IPC分类号： A61K38/16 , A61K38/00 , A61K38/01 , A61K38/40 , A61K47/48 , A61P31/12 , A61P31/18 , A61P37/00 , C07K14/79 , A01N37/18 , C07K2/00
CPC分类号： A61K47/483 , C07K14/79 , A61K38/00
摘要： The invention relates to compositions and methods for inhibiting infection or suppressing growth of human immunodeficiency virus. The composition comprises, as an effective component, an iron-binding protein (e.g., lactoferrin, transferrin, ovotransferrin), a chemically modified compound of the iron-binding protein, or a hydrolyzed compound of the iron-binding protein. The effective components are safe and can be easily prepared from inexpensive raw materials. The composition can be orally administered, injected or applied to the skin, eye, ear, nose or used as a preparation for vagina affusion, mouth washing or suppositories, and can effectively inhibit infection or suppress growth of human immunodeficiency virus.
摘要翻译：本发明涉及抑制人体免疫缺陷病毒感染或抑制生长的组合物和方法。该组合物包含铁结合蛋白（例如乳铁蛋白，转铁蛋白，转铁蛋白），铁结合蛋白的化学修饰化合物或铁结合蛋白的水解化合物作为有效成分。有效的组分是安全的，可以从廉价的原料容易地制备。该组合物可以口服给药，注射或施用于皮肤，眼睛，耳朵，鼻子或用作阴道注射，口腔清洗或栓剂的制剂，并可有效抑制人体免疫缺陷病毒的感染或抑制生长。

2. 发明授权

US5565425A Viral infection and proliferation inhibitors 失效
标题翻译：病毒感染和增殖抑制剂
公开(公告)号：US5565425A
公开(公告)日：1996-10-15
申请号：US204487
申请日：1994-03-02
申请人： Naoki Yamamoto , Hideki Nakashima , Wataru Motsuchi , Shigeaki Tanaka , Shun'ichi Dosako , Yoshihiro Kawasaki , Toshiaki Uchida
发明人： Naoki Yamamoto , Hideki Nakashima , Wataru Motsuchi , Shigeaki Tanaka , Shun'ichi Dosako , Yoshihiro Kawasaki , Toshiaki Uchida
IPC分类号： A61K38/00 , A61P31/12 , A61P31/16 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/79
CPC分类号： C07K14/79 , A61K38/00
摘要： This invention relates to inhibitors against viral infection and proliferation composed of peptides shown by below mentioned amino acid sequence (1) or (2). ##STR1## The inhibitors against viral infection and proliferation of the present invention can suppress the infection and proliferation of influenza virus or cytomegalo virus, and are useful for the prevention and treatment of diseases caused by these viruses.
摘要翻译：本发明涉及由下述氨基酸序列（1）或（2）所示的肽组成的病毒感染和增殖抑制剂。（1）（2）本发明的针对病毒感染和增殖的抑制剂可以抑制流感病毒或巨细胞病毒的感染和增殖，并且可用于预防和治疗的这些病毒引起的疾病。

3. 发明授权

US5614554A Reverse transcriptase inhibitors and antiviral agents 失效
标题翻译：逆转录酶抑制剂和抗病毒剂
公开(公告)号：US5614554A
公开(公告)日：1997-03-25
申请号：US467158
申请日：1995-06-06
申请人： Keijiro Uchino , Takashi Mizuno , Sachie Murakami , Hideki Nakashima , Naoki Yamamoto , Hiroshi Ogawara
发明人： Keijiro Uchino , Takashi Mizuno , Sachie Murakami , Hideki Nakashima , Naoki Yamamoto , Hiroshi Ogawara
IPC分类号： A61K31/195 , A61K31/255 , A61K31/185
CPC分类号： A61K31/255 , A61K31/195
摘要： The present invention provides a reverse transcriptase inhibitor and an antiviral agent comprising at least one member selected from the group consisting of sulfated tyrosines and physiologically acceptable salts thereof as an effective component; and exhibiting less toxicity and a remarkable inhibitory effect against a reverse transcriptase existing in viruses as well as a remarkable anti-AIDS viral activity.
摘要翻译：本发明提供一种逆转录酶抑制剂和抗病毒剂，其包含选自硫酸化酪氨酸及其生理学上可接受的盐中的至少一种作为有效成分; 并且对病毒中存在的逆转录酶以及显着的抗艾滋病病毒活性表现出较小的毒性和显着的抑制作用。

4. 发明授权

US5159069A Sulfated tannins and their salts 失效
标题翻译：硫化鞣剂及其销售
公开(公告)号：US5159069A
公开(公告)日：1992-10-27
申请号：US450912
申请日：1989-12-14
申请人： Fukushi Hirayama , Keijiro Uchino , Masaya Iwamoto , Akira Fukuchi , Masashi Hiramoto , Hirokazu Yamamoto , Naoki Yamamoto , Hideki Nakashima , Shigenobu Kadota , Hiroshi Ogawara
发明人： Fukushi Hirayama , Keijiro Uchino , Masaya Iwamoto , Akira Fukuchi , Masashi Hiramoto , Hirokazu Yamamoto , Naoki Yamamoto , Hideki Nakashima , Shigenobu Kadota , Hiroshi Ogawara
IPC分类号： C07H13/08
CPC分类号： C07H13/08
摘要： Sulfated tannins or salts thereof are herein disclosed. These compounds can be prepared by a method which comprises reacting tannin with a sulfonating agent under a basic condition. These compounds show antiviral activity and reverse transcriptase inhibitor, effects and can be used to treat patients infected with a variety of virus such as AIDS virus, herpesvirus, influenza virus or rhinovirus.

5. 发明授权

US5498602A Oligosaccharide aromatic glycoside and sulfate thereof 失效
标题翻译：寡糖芳香糖苷及其硫酸盐
公开(公告)号：US5498602A
公开(公告)日：1996-03-12
申请号：US944077
申请日：1992-09-11
申请人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
发明人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61P31/12 , A61P31/18 , C07H15/203 , C08B37/00 , C07G3/00 , C07H11/00
CPC分类号： C07H15/203 , C08B37/006
摘要： Oligosaccharide aromatic glycoside sulfates and physiologically acceptable salts thereof, are disclosed. Further, antiviral agents having these sulfate compounds as the active components, and particularly an antiviral agent, wherein the virus is one which causes AIDS (Acquired Immune Deficiency Syndrome), are disclosed. The active components or the glycoside sulfates, and the salts thereof, are characterized by an oligosaccharide aromatic glycoside sulfate in which the hydrogen of the position-1 hydroxyl group of the terminal sugar of an oligosaccharide is substituted with a specified formula having an alkyl group consisting of 1 to 18 carbons, an oxygen or no oxygen, and an allylene group. The number of constituent monosaccharides in the oligosaccharide portion is preferably within a range of 2 to 20. Further, 10% or more of the remaining hydroxyl groups of the sugar subunits are subjected to sulfated esterification. In addition the antiviral agent exhibits low toxicity and is useful in the treatment of AIDS. Furthermore, an oligosaccharide is also disclosed as described above with the exception that it is the hydrogen atom of the position 1 hydrogen group at the terminal sugar residue which is substituted with the specified formula, also described above. However, in addition the remaining hydroxyl groups of the sugar portion of this oligosaccharide are protected by acyl groups or are present in an unprotected form. Also disclosed is a method for the production of an oligosaccharide aromatic glycoside sulfate synthesized by sulfation using a sulfating agent.
摘要翻译：公开了寡糖芳香糖苷硫酸盐及其生理上可接受的盐。此外，公开了具有这些硫酸盐化合物作为活性成分的抗病毒剂，特别是其中病毒是引起AIDS（获得性免疫缺陷综合征）的抗病毒剂。活性成分或糖苷硫酸盐及其盐的特征在于寡糖芳香糖苷硫酸盐，其中寡糖末端糖的位置1羟基的氢被具有烷基的特定式所取代， 1至18个碳，氧或无氧，以及烯丙基。寡糖部分中的构成单糖的数量优选在2〜20的范围内。此外，将糖亚基的剩余羟基的10％以上进行硫酸化酯化。此外，抗病毒剂的毒性低，可用于治疗艾滋病。此外，还公开了如上所述的寡糖，不同之处在于它是上述也被指定式取代的末端糖残基上的1位氢原子的氢原子。然而，此外，该寡糖的糖部分的剩余羟基由酰基保护或以未保护的形式存在。还公开了通过使用硫酸化剂硫酸化合成的寡糖芳香族糖苷硫酸盐的制造方法。

6. 发明授权

US5459257A Sulfated oligoglycoside acylate and antiviral agent containing the same as active ingredient 失效
标题翻译：硫酸低聚糖苷酰化物和含有与活性成分相同的抗病毒剂
公开(公告)号：US5459257A
公开(公告)日：1995-10-17
申请号：US179623
申请日：1994-01-07
申请人： Tadao Shoji , Akira Kasai , Osamu Misumi , Naoya Ikushima , Naoki Yamamoto , Hideki Nakashima , Kazuhiko Inazawa , Nahoko Takahashi
发明人： Tadao Shoji , Akira Kasai , Osamu Misumi , Naoya Ikushima , Naoki Yamamoto , Hideki Nakashima , Kazuhiko Inazawa , Nahoko Takahashi
IPC分类号： C07H15/04 , C07H15/203 , C07H17/065 , C07H13/12 , C07H11/00
CPC分类号： C07H15/203 , C07H15/04 , C07H17/065
摘要： A sulfated oligoglycoside acylate comprising monosaccharides of a single or two kinds as the constituents, wherein the hydrogen in the hydroxyl group at the 1-position of a reducing end sugar of the oligosaccharide formed via the glycoside bond of these monosaccharides has been substituted with an aglycon selected from a group consisting of alkyl groups, aromatic alkyl groups, aromatic alkoxy groups and tocopheryl groups; from 12 to 80% of the residual hydroxyl groups have been acylated with an acyl group selected from a group consisting of aliphatic acyl groups and aromatic acyl groups; and 88 to 20% thereof have been sulfated; or a physiologically acceptable salt thereof provided that compounds wherein the aglycon is an alkyl group and the acyl group is an aliphatic acyl group are excluded is disclosed. Further, an antiviral agent, which exerts a long-lasting antiviral action particularly on HIV, containing said compound as an active ingredient is disclosed.
摘要翻译：一种包含单一或两种单糖作为组分的硫酸化寡糖苷酰化物，其中通过这些单糖的糖苷键形成的寡糖的还原性末端糖在1位羟基中的氢被aglycon取代选自烷基，芳族烷基，芳族烷氧基和生育酚基; 残余羟基的12至80％已经用选自脂族酰基和芳族酰基的酰基酰化; 88％〜20％已被硫酸化; 或其生理学上可接受的盐，其中排除了糖苷配基是烷基和酰基是脂族酰基的化合物。此外，公开了以含有所述化合物作为有效成分的对HIV特别施加长效抗病毒作用的抗病毒剂。

7. 发明授权

US5512672A Curdlan sulfate 失效
标题翻译：硫酸曲霉素
公开(公告)号：US5512672A
公开(公告)日：1996-04-30
申请号：US76174
申请日：1993-06-14
申请人： Naoki Yamamoto , Hideki Nakashima , Toshiyuki Uryu , Takashi Yoshida , Kei Matsuzaki , Yutaro Kaneko , Toru Mimura
发明人： Naoki Yamamoto , Hideki Nakashima , Toshiyuki Uryu , Takashi Yoshida , Kei Matsuzaki , Yutaro Kaneko , Toru Mimura
IPC分类号： C08B37/00 , C07B37/00 , A61K31/70
CPC分类号： C08B37/0024
摘要： A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity.
摘要翻译：硫酸凝乳糖的β-1,3-葡聚糖，硫含量为12.4〜17％，平均分子量为27,000〜33万道尔顿。硫酸凝乳蛋白具有强烈的HIV抑制活性，抗凝血活性很小，毒性小。

8. 发明授权

US5280111A Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients 失效
标题翻译：硫酸化生育酚低聚糖和包括与活性成分相同的抗病毒剂
公开(公告)号：US5280111A
公开(公告)日：1994-01-18
申请号：US856710
申请日：1992-03-24
申请人： Tadao Shoji , Naoya Ikushima , Kaname Katsuraya , Nahoko Takahashi , Fusayo Kobayashi , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima
发明人： Tadao Shoji , Naoya Ikushima , Kaname Katsuraya , Nahoko Takahashi , Fusayo Kobayashi , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/12 , A61P31/18 , C07H17/065 , C07H15/20 , A61K31/72 , C07H11/00 , C07H13/02 , C07H17/04
CPC分类号： C07H17/065 , A61K31/70
摘要： The present invention relates to novel tocopheryl oligosaccharides, acylated tocopheryl oligosaccharides, sulfated tocopheryl oligosaccharides, and antiviral agents including the sulfated tocopheryl oligosaccharides as active ingredients. In the tocopheryl oligosaccharide, the hydrogen atom of the hydroxy group at the 1-position in the terminal sugar moiety of an oligosaccharide which consists of 3.about.20 of identical or different repeating monosaccharide units selected from the group consisting of glucose, galactose, mannose, talose, idose, altrose, allose, glucose, xylose, arabinose, rhamnose, fucose, and fructose, which are glycoside-linked, is substituted by a tocopherol group. In the acylated tocopheryl oligosaccharides, each of any hydroxy group of the sugar moiety, other than the hydroxy group at the 1-position in the terminal sugar moiety of the oligosaccharide described above, is protected by an acyl group. The antiviral agents including the sulfated tocopheryl oligosaccharides or the biologically acceptable salt of the same as active ingredients have low toxicities and exhibit improved antiviral action, especially against the Human Immunodeficiency Virus.
摘要翻译：本发明涉及新的生育酚低聚糖，酰化生育酚低聚糖，硫酸生育酚寡糖，以及包含硫酸生育酚寡糖作为活性成分的抗病毒剂。在生育酚低聚糖中，低聚糖的末端糖部分的1位的羟基的氢原子由3〜20个相同或不同的重复单糖单元组成，所述重复单糖单元选自葡萄糖，半乳糖，甘露糖，与糖生成酚基取代的与糖苷连接的谷氨酸，阿糖，阿卓糖，阿洛糖，葡萄糖，木糖，阿拉伯糖，鼠李糖，岩藻糖和果糖。在酰化的生育酚低聚糖中，除了上述寡糖的末端糖部分的1位以外的除了羟基以外的糖部分的任何羟基都被酰基保护。包括硫酸生育酚寡糖或与生物活性成分相同的生物学上可接受的盐的抗病毒剂具有低毒性，并且表现出改善的抗病毒作用，特别是针对人类免疫缺陷病毒。

9. 发明授权

US07727415B2 Fine treatment agent and fine treatment method using same 失效
标题翻译：精细处理剂和精细处理方法使用相同
公开(公告)号：US07727415B2
公开(公告)日：2010-06-01
申请号：US11722120
申请日：2005-12-19
申请人： Hirohisa Kikuyama , Masahide Waki , Kanenori Ito , Takanobu Kujime , Keiichi Nii , Rui Hasebe , Hitoshi Tsurumaru , Hideki Nakashima
发明人： Hirohisa Kikuyama , Masahide Waki , Kanenori Ito , Takanobu Kujime , Keiichi Nii , Rui Hasebe , Hitoshi Tsurumaru , Hideki Nakashima
IPC分类号： C09K13/00 , C09K13/04 , C09K13/02
CPC分类号： H01L21/32134 , C23F1/26 , H01L27/124
摘要： A fine treatment agent according to the present invention is a fine treatment agent for the fine treatment of a multilayer film, including a tungsten film and a silicon oxide film comprising at least one from among hydrogen fluoride, nitric acid, ammonium fluoride and ammonium chloride. Thus, a fine treatment agent which makes fine treatment on a multilayer film, including a tungsten film and a silicon oxide film, possible by controlling the etching rate and a fine treatment method using the same can be provided.
摘要翻译：根据本发明的精细处理剂是用于精细处理包括钨膜和包含氟化氢，硝酸，氟化铵和氯化铵中的至少一种的氧化硅膜的多层膜的精细处理剂。因此，可以提供通过控制蚀刻速率和使用其的精细处理方法对包括钨膜和氧化硅膜在内的多层膜进行精细处理的精细处理剂。

10. 发明申请

US20050014649A1 Novel substituted pyrazole derivative, process for producing the same, and herbicidal composition containing the same 失效
标题翻译：新型取代的吡唑衍生物，其制备方法和含有它们的除草组合物
公开(公告)号：US20050014649A1
公开(公告)日：2005-01-20
申请号：US10499046
申请日：2002-12-18
申请人： Yoji Hirohara , Eiji Ikuta , Sayo Osanai , Hideki Nakashima , Teruhiko Ishii
发明人： Yoji Hirohara , Eiji Ikuta , Sayo Osanai , Hideki Nakashima , Teruhiko Ishii
IPC分类号： A01N43/56 , C07D231/12 , C07D231/14
CPC分类号： C07D231/12 , A01N43/56
摘要： Substituted pyrazole compounds of the formula (1). The compounds are synthesized from a pyrazole derivative and a haloalkyleneoxime ester derivative, and have excellent herbicidal effects. Herbicide compositions containing the substituted pyrazole derivatives or hydrazide derivatives thereof as active ingredients possess wide herbicidal spectra, work sufficiently in small dosages, and are sufficiently safe for certain important crops.
摘要翻译：取代的式（1）的吡唑化合物。该化合物由吡唑衍生物和卤代烷基肟酯衍生物合成，具有优异的除草效果。含有取代的吡唑衍生物或其酰肼衍生物作为活性成分的除草剂组合物具有宽的除草光谱，以小剂量充分起作用，对某些重要作物而言足够安全。

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