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1. 发明授权

US5246958A Antihypertensive thiocarbamoylascetonitrile compounds 失效
标题翻译：抗生素甲硫氨酸胆碱化合物
公开(公告)号：US5246958A
公开(公告)日：1993-09-21
申请号：US664053
申请日：1991-03-04
申请人： Hiromi Okushima , Akihiro Tobe , Makio Kobayashi , Tetsuro Shimpuku , Hideki Bessho , Junko Hayashi , Asami Seino
发明人： Hiromi Okushima , Akihiro Tobe , Makio Kobayashi , Tetsuro Shimpuku , Hideki Bessho , Junko Hayashi , Asami Seino
IPC分类号： A61K31/275 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/505 , A61P9/12 , C07C327/44 , C07D207/32 , C07D207/337 , C07D209/20 , C07D213/59 , C07D215/52 , C07D233/61 , C07D233/64 , C07D235/08 , C07D235/16 , C07D237/08 , C07D239/26 , C07D241/12 , C07D277/64 , C07D333/24 , C07D521/00
CPC分类号： C07D207/337 , C07C327/44 , C07D213/59 , C07D231/12 , C07D233/56 , C07D235/16 , C07D249/08 , C07D277/64 , C07D333/24
摘要： Disclosed are antihypertensive pharmaceutical compositions and compounds which include the thiocarbamoylacetonitrile having the formula: ##STR1## wherein: R.sup.1 is selected from the group consisting of hydrogen, a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.6 cycloalkyl or --(CH.sub.2).sub.n --A (where A is selected from the group consisting of a C.sub.6 to C.sub.12 aryl, a 5- or 6-membered heterocyclic group or a fused heterocyclic group constituted by 9 or 10 atoms, each of which may be substituted by at least one substitute group selected from a C.sub.1 to C.sub.6 alkyl and a halogen and n is 0 or an integer of 1 to 6),R.sup.2 represents a C.sub.1 to C.sub.10 alkyl, and Ar represents an aryl, a 5- or 6-membered heterocyclic group or a fused heterocyclic group, each of which may be substituted by at least one substituent group selected from the group consisting of a C.sub.1 to C.sub.6 alkyl, a C.sub.1 to C.sub.6 alkoxy, a C.sub.2 to C.sub.7 alkylcarbonyl, a C.sub.7 to C.sub.6 dialkylamino, amino, formylamino, a C.sub.2 to C.sub.7 alkylcarbonylamino, a halogen, cyano, nitro, hydroxyl, a C.sub.1 to C.sub.6 alkylthio, a C.sub.6 to C.sub.12 arylsulfinyl, a C.sub.1 to C.sub.6 alkylsulfinyl, a C.sub.6 to C.sub.12 alkylsulfonyl, a C.sub.6 to C.sub.12 arylsulfonyl, aminosulfonyl, a C.sub.1 to C.sub.6 alkylaminosulfonyl, a C.sub.2 to C.sub.6 dialkylaminosulfonyl, trifluoromethyl and imidazolyl.

2. 发明授权

US5439927A Imidazoyl-.beta.-oxo-.beta.-benzenepropanethiomide derivative, compositions and method of use thereof 失效
标题翻译：咪唑酰-β-氧代-β-苯丙烷三醇衍生物，组合物及其使用方法
公开(公告)号：US5439927A
公开(公告)日：1995-08-08
申请号：US231123
申请日：1994-04-22
申请人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino
发明人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino
IPC分类号： A61K31/16 , A61K31/18 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/496 , A61K31/50 , A61K31/505 , A61P1/00 , A61P9/08 , A61P9/12 , A61P11/00 , A61P11/08 , A61P29/00 , C07C327/42 , C07C327/44 , C07C327/46 , C07D207/327 , C07D213/59 , C07D231/12 , C07D233/54 , C07D233/58 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/84 , C07D233/90 , C07D237/08 , C07D263/32 , C07D277/20 , C07D277/30 , C07D233/96 , A61K31/165
CPC分类号： C07C327/46 , C07C327/44 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要： The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.
摘要翻译：本发明的β-氧代-β-苯丙烷硫代酰胺衍生物具有钾通道开放作用，可用于治疗高血压，哮喘，过敏性结肠综合征和肠炎，包括血管扩张，支气管扩张，胃肠道松弛等药理作用平滑肌等。本发明还包括含有本发明化合物作为有效成分的药物组合物及其制造方法。

3. 发明授权

US5332833A .beta.-oxo-.beta.-benzenepropanethioamide compounds 失效
标题翻译： β-氧代-β-苯丙烷硫代酰胺化合物
公开(公告)号：US5332833A
公开(公告)日：1994-07-26
申请号：US996404
申请日：1992-12-23
申请人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino
发明人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino
IPC分类号： A61K31/16 , A61K31/18 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/496 , A61K31/50 , A61K31/505 , A61P1/00 , A61P9/08 , A61P9/12 , A61P11/00 , A61P11/08 , A61P29/00 , C07C327/42 , C07C327/44 , C07C327/46 , C07D207/327 , C07D213/59 , C07D231/12 , C07D233/54 , C07D233/58 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/84 , C07D233/90 , C07D237/08 , C07D263/32 , C07D277/20 , C07D277/30 , C07C327/38 , A61K31/165 , C07C327/48 , C07D233/96
CPC分类号： C07C327/46 , C07C327/44 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要： The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.
摘要翻译：本发明的β-氧代-β-苯丙烷硫代酰胺衍生物具有钾通道开放作用，可用于治疗高血压，哮喘，过敏性结肠综合征和肠炎，包括血管扩张，支气管扩张，胃肠道松弛等药理作用平滑肌等。本发明还包括含有本发明化合物作为有效成分的药物组合物及其制造方法。

4. 发明授权

US5763161A Assay method of testing for the presence of cytomegalovirus antigen 失效
标题翻译：测定巨细胞病毒抗原存在的测定方法
公开(公告)号：US5763161A
公开(公告)日：1998-06-09
申请号：US577248
申请日：1995-12-22
申请人： Takashi Kurihara , Junko Hayashi , Akio Ito , Takayoshi Asai
发明人： Takashi Kurihara , Junko Hayashi , Akio Ito , Takayoshi Asai
IPC分类号： C12P21/08 , G01N33/569 , G01N33/68 , C12Q1/70 , G01N33/53 , G01N33/567
CPC分类号： G01N33/6857 , G01N33/56994 , G01N2333/045
摘要： Disclosed are a method for testing for the presence of a cytomegalovirus antigen by using an antibody which specifically recognizes cytomegalovirus Lower matrix protein pp65, as a primary antibody, which comprises using an alkaline phosphatase-labeled antibody as a secondary antibody and a method for testing for the presence of a cytomegalovirus antigen which comprises using an alkaline phosphatase-labeled antibody which specifically recognizes cytomegalovirus Lower matrix protein pp65, or (Fab').sub.2 or Fab' fragment of the antibody which specifically recognizes cytomegalovirus Lower matrix protein pp65 as a primary antibody.
摘要翻译：公开了通过使用特异性识别作为第一抗体的细胞巨细胞病毒下基质蛋白pp65的抗体来检测巨细胞病毒抗原的存在的方法，所述抗体包含使用碱性磷酸酶标记的抗体作为第二抗体，巨细胞病毒抗原的存在包括使用特异性识别巨细胞病毒下基质蛋白pp65的碱性磷酸酶标记抗体或者特异性识别巨细胞病毒下基质蛋白pp65作为第一抗体的抗体的（Fab'）2或Fab'片段。

5. 发明授权

US06997952B2 Artificial sphincter 失效
公开(公告)号：US06997952B2
公开(公告)日：2006-02-14
申请号：US10889154
申请日：2004-07-12
申请人： Akihisa Furukawa , Toshiyuki Takagi , Hidetoshi Matsuki , Yun Luo , Junko Hayashi , Tomoyuki Yambe , Takamichi Kamiyama , Shintaro Amae , Motoshi Wada
发明人： Akihisa Furukawa , Toshiyuki Takagi , Hidetoshi Matsuki , Yun Luo , Junko Hayashi , Tomoyuki Yambe , Takamichi Kamiyama , Shintaro Amae , Motoshi Wada
IPC分类号： A61F2/08
CPC分类号： A61F2/0036 , A61F2210/0033
摘要： With an object of providing an artificial sphincter for which repeated shape changes are possible, and for which the quantity of shape change is sufficient so as to be used as a substitute for a large natural sphincter, an artificial sphincter 11 that opens and closes, as required, either the anus of a living body or part of the intestine 19 led outside the body is provided, wherein this artificial sphincter 11 comprises a pair of shape memory alloy elements 13 that change reversibly between two opposite shapes upon changes in temperature and hinges 15 that link the shape memory alloy elements 1 together in a cylindrical shape.

6. 发明申请

US20060084058A1 Substrates for hybridization and method of using the same 审中-公开
标题翻译：用于杂交的底物及其使用方法
公开(公告)号：US20060084058A1
公开(公告)日：2006-04-20
申请号：US10508691
申请日：2003-03-27
申请人： Fumio Nakamura , Masahiko Hara , Junko Hayashi
发明人： Fumio Nakamura , Masahiko Hara , Junko Hayashi
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6837 , C12Q2565/525 , C12Q2565/518
摘要： A hybridization substrate having on a substrate surface thereof a branching nucleic acid strand comprising a principal strand of nucleic acid a portion of which is attached to the surface of the substrate and a portion of which is single-stranded, and a strand of single-stranded nucleic acid for probe that is partially hybridized to a portion of the single-stranded portion of the principal nucleic acid. A hybridization substrate having on a substrate surface thereof a branching nucleic acid strand comprising a principal strand of nucleic acid a portion of which is attached to the surface of the substrate and a portion of which is single-stranded; an accessory strand of nucleic acid that is single-stranded and partially hybridized to a portion of the single-stranded portion of the principal strand of nucleic acid; a strand of single-stranded nucleic acid for probe partially hybridized to a portion of the single-stranded portion of the principal strand of nucleic acid; and/or a strand of single-stranded nucleic acid for probe partially hybridized to a portion of the accessory strand of nucleic acid. A method comprising bringing target nucleic acid into contact with a surface upon which has been immobilized the branching nucleic acid strand of the above-mentioned substrate to test the complementarity of the target nucleic acid with the probe area of the branching nucleic acid strand. Provided are a hybridization substrate upon the surface of which DNA strands are immobilized and a complementarity test method employing this substrate.
摘要翻译：一种杂交基质，其在其基材表面上具有支链核酸链，其包含核酸的主链，其一部分连接到所述底物的表面，并且其一部分是单链的，并且单链的链与主要核酸的单链部分的一部分部分杂交的探针的核酸。一种杂交基质，其在其基材表面上具有分支核酸链，其包含核酸的主链，其一部分附着于基底的表面，其一部分是单链的; 与核酸的主链的单链部分的一部分单链并部分杂交的核酸的辅助链; 用于探针的单链核酸链与核酸主链的单链部分的一部分杂交; 和/或用于探针的单链核酸链与核酸的辅助链的一部分杂交。一种方法，包括使靶核酸与固定有上述底物的支化核酸链的表面接触，以测试靶核酸与分支核酸链的探针区的互补性。提供了在其表面上固定有DNA链的杂交底物和使用该底物的互补性测试方法。

7. 发明授权

US06830588B2 Artificial sphincter 失效
标题翻译：人造括约肌
公开(公告)号：US06830588B2
公开(公告)日：2004-12-14
申请号：US09866448
申请日：2001-05-25
申请人： Akihisa Furukawa , Toshiyuki Tagaki , Hidetoshi Matsuki , Yun Luo , Junko Hayashi , Tomoyuki Yambe , Takamichi Kamiyama , Shintaro Amae , Motoshi Wada
发明人： Akihisa Furukawa , Toshiyuki Tagaki , Hidetoshi Matsuki , Yun Luo , Junko Hayashi , Tomoyuki Yambe , Takamichi Kamiyama , Shintaro Amae , Motoshi Wada
IPC分类号： A61F208
CPC分类号： A61F2/0036 , A61F2210/0033
摘要： With an object of providing an artificial sphincter for which repeated shape changes are possible, and for which the quantity of shape change is sufficient so as to be used as a substitute for a large natural sphincter, an artificial sphincter 11 that opens and closes, as required, either the anus of a living body or part of the intestine 19 led outside the body is provided, wherein this artificial sphincter 11 comprises a pair of shape memory alloy elements 13 that change reversibly between two opposite shapes upon changes in temperature and hinges 15 that link the shape memory alloy elements 1 together in a cylindrical shape.
摘要翻译：为了提供可以重复形状变化的人造括约肌的目的，并且其形状变化量足以使其用作大的天然括约肌的替代物，打开和关闭的人造括约肌11作为需要提供一种生物体的肛门或引导到体外的肠的一部分19，其中该人造括约肌11包括一对形状记忆合金元件13，其在温度变化和铰链15上在两个相反形状之间可逆地改变将形状记忆合金元件1连接成圆柱形。

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