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1. 发明授权

US06355027B1 Flexible microcatheter 有权
标题翻译：柔性微导管
公开(公告)号：US06355027B1
公开(公告)日：2002-03-12
申请号：US09328761
申请日：1999-06-09
申请人： Hieu V. Le , John Edward Morris , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , John Edward Morris , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M2500
CPC分类号： A61M25/0054 , A61M25/005 , A61M25/0053 , A61M2025/0042
摘要： Flexible microcatheter having regions of different flexibility integrally and strategically placed along and about the length of a one-piece composite catheter tube. Distally the flexible microcatheter exhibits pronounced flexibility with respect to locations or regions of flexibility located proximally for navigation along tortuous vascular paths. Different regions of flexibility are formed by applying resins of different Shore hardness readings either singularly or in combination along and about a braid which overlies an inner resin layer. The encapsulated braid provides resistance to kinking and bending of the flexible microcatheter as well as providing for torque transmission and pushability along the length of the flexible microcatheter.
摘要翻译：柔性微导管具有不同柔性的区域，整体地并且沿着并且围绕一体式复合导管的长度有策略地放置。远端地，柔性微导管相对于靠近曲折的血管路径导航的近端位置或柔性区域具有显着的灵活性。不同的柔性区域通过单独或组合地施加不同邵氏硬度读数的树脂形成，并且围绕着位于内层树脂层上的编织物。封装的编织物提供柔性微导管的扭结和弯曲的抗性，以及沿着柔性微导管的长度提供扭矩传递和推压性。

2. 发明授权

US5989210A Rheolytic thrombectomy catheter and method of using same 失效
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US5989210A
公开(公告)日：1999-11-23
申请号：US19728
申请日：1998-02-06
申请人： John Edward Morris , Cindy M. Setum , William J. Drasler , Hieu V. Le , Robert G. Dutcher
发明人： John Edward Morris , Cindy M. Setum , William J. Drasler , Hieu V. Le , Robert G. Dutcher
IPC分类号： A61B17/22 , A61B19/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/32075 , A61B2090/034
摘要： A surgical device and method for removal of tissue, such as thrombus, from a vessel in the body. The device has a first tube with a distal open end and an inward directed stop and a second tube with an outward directed stop for engaging the inward directed stop and thereby regulating the relationship between a retrograde jet and the distal open end. Thrombus is dislodged, entrained, and broken into pieces which are evacuated through the first tube.
摘要翻译：用于从体内的血管中去除诸如血栓的组织的手术装置和方法。该装置具有第一管，其具有远端开口端和向内指向的止动件，以及具有向外定向止动件的第二管，用于接合向内指向的止动件，从而调节逆行射流与远端开口端之间的关系。血栓被移出，夹带并分解成通过第一管排出的碎片。

3. 发明授权

US06224570B1 Rheolytic thrombectomy catheter and method of using same 有权
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US06224570B1
公开(公告)日：2001-05-01
申请号：US09188633
申请日：1998-11-09
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. Several embodiments are disclosed. All embodiments include an outer catheter having a lumen and an inner high pressure tube of a size to enable it to be passed through the lumen of the catheter. The distal end of the inner high pressure tube extends beyond the distal end of the catheter and carries a jet cap for directing one or more jets of saline proximally toward the distal end of the catheter. In some embodiments, the catheter has a distally located inwardly directed stationary stop and the inner high pressure tube includes a distally located outwardly directed transitional stop for engaging the inwardly directed stationary stop to thereby position the jet cap at a defined distance from the distal end of the catheter. In other embodiments, a stationary stop is located at the proximal end of the catheter and a transitional stop is carried on the proximal end of the inner high pressure tube. In the embodiments having the stationary and transitional stops located proximally, the inner high pressure tube includes a flow director at its distal end. In use, thrombus is dislodged, entrained, and broken into pieces by the saline jets and evacuated proximally through the lumen of the catheter.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。公开了几个实施例。所有实施例包括具有内腔和内部高压管的外导管，其尺寸使其能够穿过导管的内腔。内部高压管的远端延伸超过导管的远端，并且携带用于将一个或多个盐水向近端引导到导管的远端的喷射帽。在一些实施例中，导管具有远侧定位的向内指向的固定止动件，并且内部高压管包括远侧定位的向外指向的过渡止动件，用于接合向内指向的固定止动件，从而将喷射盖定位在距离导管。在其他实施例中，静止止动件位于导管的近端处，并且过渡停止件承载在内部高压管的近端上。在具有位于近侧的静止和过渡止动件的实施例中，内部高压管在其远端包括导流器。在使用中，血栓被移出，夹带并通过盐水喷射器破碎成碎片，并通过导管的内腔向近端排出。

4. 发明授权

US06755803B1 Single operator exchange fluid jet thrombectomy device 有权
标题翻译：单一操作者交换流体喷射血栓切除装置
公开(公告)号：US06755803B1
公开(公告)日：2004-06-29
申请号：US09888455
申请日：2001-06-25
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. Embodiments include an outer catheter assembly common to any mode of usage having a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a flow director are passed and advanced. For use as a rheolytic thrombectomy catheter, thrombus is dislodged, entrained, and broken into pieces by jets and evacuated through the lumen of the guide catheter. For use as a crossflow thrombectomy catheter, a flow director having outflow and inflow orifices is provided.
摘要翻译：单个操作者交换流体喷射血栓切除装置，其具有外导管组件和内导管组件形式的可分离和可更换组件，其允许作为溶血性血栓切除术导管或横流血栓切除术导管。实施例包括与任何使用模式共同的外导管组件，其具有具有内腔的引导导管，引导线和携带导流器的下管的较大部分通过该内腔通过并前进。为了用作溶解性血栓切除术导管，血栓被移出，夹带并通过射流破碎成碎片，并通过导管的内腔排出。为了用作横流血栓切除术导管，提供了具有流出和流入孔的导流器。

5. 发明授权

US06676637B1 Single operator exchange fluid jet thrombectomy method 有权
标题翻译：单操作者交换流体喷射血栓切除术
公开(公告)号：US06676637B1
公开(公告)日：2004-01-13
申请号：US09888454
申请日：2001-06-25
申请人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
发明人： Michael J. Bonnette , Hieu V. Le , John Edward Morris , Stephen E. Weisel , Debra M. Kozak , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034 , Y10T83/0443 , Y10T83/0453
摘要： A single operator exchange fluid jet thrombectomy method employing a single operator exchange fluid jet thrombectomy device having an outer catheter assembly and separable and exchangeable components in the form of an inner catheter assembly allowing functioning as a rheolytic thrombectomy catheter or as a crossflow thrombectomy catheter. The outer catheter assembly is common to any mode of usage and includes a guide catheter having a lumen through which a guidewire and the greater portion of a hypo-tube carrying a jet emanator and a flow director are passed and advanced. In the method, thrombus is dislodged, entrained, and broken into pieces by fluid jets and evacuated through the lumen of the guide catheter.
摘要翻译：单个操作者交换流体喷射血栓切除术方法，其使用具有外部导管组件的单个操作者交换流体喷射血栓切除装置，以及允许作为溶血性血栓切除术导管或横流血栓切除术导管起作用的内部导管组件形式的可分离和可更换部件。外导管组件对于任何使用模式都是共同的，并且包括具有内腔的引导导管，通过该导管将导丝和携带喷射发生器和导流器的下管的较大部分通过并前进。在该方法中，通过流体射流将血栓移出，夹带并分裂成碎片，并通过引导导管的内腔排出。

6. 发明授权

US06558366B1 Thrombectomy method 失效
标题翻译：血栓切除术
公开(公告)号：US06558366B1
公开(公告)日：2003-05-06
申请号：US08349665
申请日：1994-12-05
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61M3100
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.
摘要翻译：一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。导管的远端在荧光透视下前进到血栓沉积部位。气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。

7. 发明授权

US6096001A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US6096001A
公开(公告)日：2000-08-01
申请号：US351616
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

8. 再颁专利

USRE32227E "J" Stylet wire 失效
标题翻译： “J”铁丝网
公开(公告)号：USRE32227E
公开(公告)日：1986-08-19
申请号：US723698
申请日：1985-04-16
申请人： Robert G. Dutcher
发明人： Robert G. Dutcher
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A body implantable lead having a two-piece stylet. An inner solid portion of the stylet enables a shape to be imparted to the stylet to allow proper maneuvering of the lead during implant. A second portion of the stylet is slideably located coaxially about the first portion. The second portion of the stylet permits the imposition of a torque at the distal end of the implantable lead by the turning of a knob fixedly attached to the proximal end of the second portion of the stylet. The second portion of the stylet is a helically wound coil. The two-piece stylet is inserted into the proximal end of the body implantable lead. The distal end of the body implantable lead is located in the position desired through the use of the solid inner first portion of the stylet in which a bend or other desired shape has been introduced. The body implantable lead is permanently attached to the muscle tissue by a fixation device activated through the torque supplied by the second portion of the stylet. The two portions of the stylet may be fabricated from a variety of materials.

9. 发明授权

US4146036A Body-implantable lead with protector for tissue securing means 失效
标题翻译：用于组织固定装置的保护器的可植入生物体的铅
公开(公告)号：US4146036A
公开(公告)日：1979-03-27
申请号：US839954
申请日：1977-10-06
申请人： Robert G. Dutcher , Albert S. Benjamin
发明人： Robert G. Dutcher , Albert S. Benjamin
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0573
摘要： A body-implantable, intravascular lead affixed with a pin or pins at its proximal end adapted to be connected to a pulse generator and with an electrode or electrodes at its distal end electrically connected via conductor means and adapted to be securely and permanently attached to a body organ. Electrode means in the form of an elongated member having a circumferential electrode formed on one end thereof and an opening passing therethrough from its proximal to distal end is affixed to the distal end of the conductor means. Tissue securing means extending beyond the opening in the distal end of the electrode means are provided for securing the electrode means into firm engagement with the tissue at the desired location. Movable means located in the opening in the electrode means are provided for protecting the tissue securing means from causing injury to a body vessel, heart valve, or other tissue as the lead is inserted and guided through a vessel to the desired location. Various types of stylet means may be used to move the movable means into the position for protecting the tissue securing means.
摘要翻译：可植入的血管内引线，其固定在其近端处的针或销，其适于连接到脉冲发生器，并且其远端处的电极或电极通过导体装置电连接并且适于牢固地并永久地附接到身体器官电极是指具有在其一端形成的周向电极的细长构件的形式，并且从其近端至远端穿过的开口被固定到导体装置的远端。提供了延伸超过电极装置远端的开口的组织固定装置，用于将电极装置固定在所需位置与组织的牢固接合。设置在电极装置中的开口中的可移动装置被设置成用于在引线插入并引导通过容器到期望位置时，保护组织固定装置不会对身体容器，心脏瓣膜或其他组织造成伤害。可以使用各种类型的探针装置将可移动装置移动到用于保护组织固定装置的位置。

10. 发明授权

US06129697A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US06129697A
公开(公告)日：2000-10-10
申请号：US351610
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/22 , A61B17/32 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, or from a natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one orifice at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the distal end of the catheter.
摘要翻译：一种用于从心血管系统或从患者人体中发现的天然或合成的小管或腔中除去血栓或其它组织沉积物的装置，而不需要通过切口手术地进入血栓或其它组织沉积物的位置下降或其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端的至少一个孔口。至少一个射流指向大排气腔或其他靶的开口。该喷气机负责提供局部负压，其将组织夹带到喷射器中从碎片的分解中。该射流还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎屑驱出排气腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的正排量泵将高压盐水提供给导管的远端。

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