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1. 发明授权

US06129697A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US06129697A
公开(公告)日：2000-10-10
申请号：US351610
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/22 , A61B17/32 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, or from a natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one orifice at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the distal end of the catheter.
摘要翻译：一种用于从心血管系统或从患者人体中发现的天然或合成的小管或腔中除去血栓或其它组织沉积物的装置，而不需要通过切口手术地进入血栓或其它组织沉积物的位置下降或其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端的至少一个孔口。至少一个射流指向大排气腔或其他靶的开口。该喷气机负责提供局部负压，其将组织夹带到喷射器中从碎片的分解中。该射流还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎屑驱出排气腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的正排量泵将高压盐水提供给导管的远端。

2. 发明授权

US5370609A Thrombectomy device 失效
标题翻译：血栓切除装置
公开(公告)号：US5370609A
公开(公告)日：1994-12-06
申请号：US6076
申请日：1993-01-15
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.
摘要翻译：一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。导管的远端在荧光透视下前进到血栓沉积部位。气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。

3. 发明授权

US06558366B1 Thrombectomy method 失效
标题翻译：血栓切除术
公开(公告)号：US06558366B1
公开(公告)日：2003-05-06
申请号：US08349665
申请日：1994-12-05
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61M3100
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.
摘要翻译：一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。导管的远端在荧光透视下前进到血栓沉积部位。气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。

4. 发明授权

US6096001A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US6096001A
公开(公告)日：2000-08-01
申请号：US351616
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

5. 发明授权

US06471683B2 Thrombectomy and tissue removal method 失效
公开(公告)号：US06471683B2
公开(公告)日：2002-10-29
申请号：US08351605
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61M3100
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guidewire or inside a guide catheter. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus or tissue deposit. Alternatively, the catheter may be positioned at the desired location by surgical procedure. An elastic balloon may be inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A dilatation balloon may be inflated perioperatively to dilate the underlying vessel or tubule lesion. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.

6. 发明授权

US06258061B1 Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US06258061B1
公开(公告)日：2001-07-10
申请号：US08351604
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61M3700
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

7. 发明授权

US5496267A Asymmetric water jet atherectomy 失效
标题翻译：不对称水喷射粥样斑块切除术
公开(公告)号：US5496267A
公开(公告)日：1996-03-05
申请号：US610846
申请日：1990-11-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61M1/00 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3207 , A61B17/320783 , A61B2217/005 , A61B2217/007
摘要： A technique for ablation and removal of plaque deposits from the arterial, venous, vascular graft or other tissue wall of a patient. Ablation is accomplished by directing a high pressure jet of sterile saline solution at the plaque deposit. The high pressure jet is located at the distal end of a catheter which is advanced through the vascular system to the site of the plaque deposit. Removal of the debris is via an evacuation lumen within the catheter.The arterial wall is protected from damage by the catheter design which directs the high pressure jet towards a portion of the distal end of the catheter which serves as a target. The distal end of the catheter is placed such that the plaque or other deposit to be ablated is positioned between the high pressure jet and the target.An optional ultrasonic transducer array located adjacent the high pressure jet and the evacuation lumen permits the attending physician to monitor the procedure.A balloon may be used to hold the catheter against the deposit allowing it to protrude into the ablation jet and be removed from the vessel.
摘要翻译：一种用于从患者的动脉，静脉，血管移植物或其他组织壁消融和去除斑块沉积物的技术。消融通过在斑块沉积物处引导无菌盐水溶液的高压射流来实现。高压喷射器位于导管的远端，该导管通过血管系统前进到斑块沉积物的位置。通过导管内的抽空腔去除碎片。通过导管设计保护动脉壁免受损伤，该导管设计将高压射流引导到用作靶的导管的远端的一部分。将导管的远端放置成使待消融的斑块或其它沉积物位于高压射流和靶之间。位于邻近高压射流和排空腔的可选的超声换能器阵列允许主治医师监视该过程。可以使用气球来保持导管抵抗沉积物，使其能够突出到消融射流中并从容器中移出。

8. 发明授权

US06984239B1 Thrombectomy and tissue removal method 失效
标题翻译：血栓切除术和组织清除法
公开(公告)号：US06984239B1
公开(公告)日：2006-01-10
申请号：US08351602
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B12/32
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

9. 发明授权

US6135977A Rheolytic catheter 失效
标题翻译：流变导管
公开(公告)号：US6135977A
公开(公告)日：2000-10-24
申请号：US377995
申请日：1995-01-25
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/22 , A61B19/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B2090/3784
摘要： A technique for treatment of plaque deposits on the arterial wall of a patient. The technique employs a high pressure jet of sterile saline solution directed at the plaque deposit. The high pressure jet is located at the distal end of a guide wire or catheter which is advanced through the vascular system to the site of the plaque deposit. Optional removal of the debris is via an evacuation lumen within the catheter. This particular technique directs the high pressure jet of fluid distal to the distal tip of the guide wire or catheter. This permits treatment of arteries, which are totally occluded, because the device need not transit the lesion to be effective. Some applications will use the high pressure jet of fluid to open a sufficient passage within the occlusion to permit further dilatation using a balloon integral to or passed over the device. An ultrasonic transducer array located adjacent the high pressure jet permits the attending physician to monitor the procedure. This may be particularly important for those embodiments for which the high pressure jet of fluid may be inadvertently directed toward the vessel wall at short range. The ultrasound device ensures that the jet of fluid is directed at plaque, rather than the native vessel.
摘要翻译：一种治疗患者动脉壁上斑块沉积物的技术。该技术采用针对斑块沉积物的无菌盐水溶液的高压射流。高压喷射器位于导丝或导管的远端，导丝或导管通过血管系统前进到斑块沉积物的位置。通过导管内的抽空腔可选地去除碎屑。这种特殊技术引导流体远离引导线或导管远端的高压射流。这允许治疗完全闭塞的动脉，因为该装置不需要将损伤转移到有效的位置。一些应用将使用高压喷射流体在堵塞内打开足够的通道，以允许使用集成在或穿过该装置的球囊进一步扩张。位于邻近高压射流的超声换能器阵列允许主治医师监视手术。对于那些高压喷射流体可能在短时间内无意地指向血管壁的实施例，这可能是特别重要的。超声装置确保流体射流指向斑块，而不是天然血管。

10. 发明授权

US5785675A Thrombectomy device 失效
标题翻译：血栓切除装置
公开(公告)号：US5785675A
公开(公告)日：1998-07-28
申请号：US349664
申请日：1994-12-05
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.
摘要翻译：一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。导管的远端在荧光透视下前进到血栓沉积部位。气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。

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