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1. 发明授权

US4352928A 5,6-Alkylenepyrimidine derivative 失效
标题翻译： 5,6-亚烷基嘧啶衍生物
公开(公告)号：US4352928A
公开(公告)日：1982-10-05
申请号：US160080
申请日：1980-06-16
申请人： Hidetoshi Hiranuma , Tetsuo Sekiya , Susumu Mizogami , Motokuni Mori , Mitsuo Hanatsuka , Toshiji Kanayama
发明人： Hidetoshi Hiranuma , Tetsuo Sekiya , Susumu Mizogami , Motokuni Mori , Mitsuo Hanatsuka , Toshiji Kanayama
IPC分类号： A61K31/505 , A61K31/517 , A61P3/08 , A61P7/02 , A61P9/12 , A61P29/00 , C07D239/70 , C07D239/95 , C07D401/04 , C07D405/06 , C07D409/06 , C07D403/04 , C07D405/14 , C07D413/04
CPC分类号： C07D239/95 , C07D239/70
摘要： There are provided a novel compound, i.e., a 2-piperazino-4-substituted-5,6-alkylenepyrimidine derivative represented by the formula: ##STR1## wherein Y, Z and n are defined in the specification and claims, and a pharmaceutically acceptable acid addition salt thereof.The compounds of the present invention show, an anti-inflammatory effect, a blood sugar level lowering effect, a blood platelet aggregation suppressive effect, an anorexigenic action and a Serotonin effect.
摘要翻译：提供了一种新的化合物，即由下式表示的2-哌嗪基-4-取代-5,6-亚烷基嘧啶衍生物：其中Y，Z和n在说明书和权利要求书中定义，其药学上可接受的其酸加成盐。本发明的化合物显示出抗炎作用，血糖降低作用，血小板聚集抑制作用，厌食作用和血清素作用。

2. 发明授权

US4189484A Antihypertensive quinazoline derivatives 失效
标题翻译：抗高血压喹唑啉衍生物
公开(公告)号：US4189484A
公开(公告)日：1980-02-19
申请号：US956326
申请日：1978-10-31
申请人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
发明人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
IPC分类号： C07D239/95 , C07D295/185 , C07D307/54 , C07D317/60 , A61K31/505 , C09B23/16 , C09B55/00
CPC分类号： C07D295/185 , C07D239/95 , C07D307/54 , C07D317/60
摘要： Novel quinazoline compounds and antihypertensive compositions containing said compounds are disclosed; said compounds having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group having 1-5 carbon atoms;R.sup.2 is a group of the formula ##STR2## in which Y is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, an alkenyloxy group, a methylenedioxy group, a nitro group, a halogen atom, a trifluoromethyl group, an acyloxy group, a hydroxy group, an unsubstituted or substituted amino group or a condensed benzene nucleus and m is an integer of 1-3 inclusive, or a group of the formula ##STR3## in which X is an oxygen atom, a sulfur atom or a carbon-nitrogen double bond and Z is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, a nitro group or a halogen atom; and n is an integer of 2-3 inclusive;provided that, when R.sup.2 is the said group ##STR4## n is 2 and R.sup.1 is a hydrogen atom or, when R.sup.2 is the said group ##STR5## n is 2 or 3 and R.sup.1 is a hydrogen atom or the said alkyl group and a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：公开了含有所述化合物的新型喹唑啉化合物和抗高血压组合物; 所述具有下式的化合物：其中R 1是氢原子或具有1-5个碳原子的烷基; R2是式中Y为氢原子，1-5个碳原子的烷基，1-5个碳原子的烷氧基，烯氧基，亚甲二氧基，硝基，卤素原子，三氟甲基，酰氧基，羟基，未取代或取代的氨基或稠合的苯核，m是1-3的整数，或下式的组合：IMAGE>其中X 是氧原子，硫原子或碳 - 氮双键，Z是氢原子，1-5个碳原子的烷基，1-5个碳原子的烷氧基，硝基或卤素原子; n为2-3以下的整数。条件是当R2是所述基团时，n是2，R 1是氢原子，或者当R 2是所述基团时，n是2或3，并且R 1是氢原子或所述烷基和其药学上可接受的酸加成盐。

3. 发明授权

US4607034A Quinazoline derivatives and pharmaceutical composition thereof 失效
标题翻译：喹唑啉衍生物及其药物组合物
公开(公告)号：US4607034A
公开(公告)日：1986-08-19
申请号：US199565
申请日：1980-10-21
申请人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
发明人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
IPC分类号： C07D239/95 , C07D295/215 , A61K31/505 , C07D403/04
CPC分类号： C07D295/215 , C07D239/95
摘要： There are presented novel quinazoline derivatives, namely 2-(4-substituted-carbamoyl-piperazin-1-yl)quinazoline derivatives, 2-(4-substituted-carbamoyl-homopiperazin-1-yl)quinazoline derivatives, 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives and 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives, having excellent antihypertensive activities.
摘要翻译：提出了新的喹唑啉衍生物，即2-（4-取代 - 氨基甲酰基 - 哌嗪-1-基）喹唑啉衍生物，2-（4-取代 - 氨基甲酰基 - 高哌嗪-1-基）喹唑啉衍生物，2-（4-取代 - 硫代氨基甲酰基 - 哌嗪-1-基）喹唑啉衍生物和具有优异抗高血压活性的2-（4-取代 - 硫代氨基甲酰基 - 哌嗪-1-基）喹唑啉衍生物。

4. 发明授权

US4524401A Magnetic transducer head utilizing magneto resistance effect with a bias field and partial saturation 失效
标题翻译：磁传感器头利用具有偏置场和部分饱和的磁阻效应
公开(公告)号：US4524401A
公开(公告)日：1985-06-18
申请号：US333423
申请日：1981-12-22
申请人： Hiroyuki Uchida , Takehiro Nagaki , Shigeyoshi Imakoshi , Yutaka Soda , Junkichi Sugita , Tetsuo Sekiya
发明人： Hiroyuki Uchida , Takehiro Nagaki , Shigeyoshi Imakoshi , Yutaka Soda , Junkichi Sugita , Tetsuo Sekiya
IPC分类号： G11B5/39 , G11B5/30
CPC分类号： G11B5/3903
摘要： A magnetic transducer head utilizing a thin film magneto-resistance effect element is disclosed in which the amount of a DC bias magnetic field is so selected that only the end portion of the thin film magneto-resistance effect element serving as a contact surface with a magnetic medium is effectively given with sensitivity and the element is saturated in the vicinity of its central portion in its width direction.
摘要翻译：公开了一种利用薄膜磁阻效应元件的磁转换头，其中直流偏置磁场的量如此选择，使得只有薄膜磁阻效应元件的端部作为具有磁性的接触表面介质有效地被赋予灵敏度，元件在其中心部分的宽度方向附近饱和。

5. 发明授权

US4077373A Ignition timing control device for an internal combustion engine 失效
标题翻译：用于内燃机的点火正时控制装置
公开(公告)号：US4077373A
公开(公告)日：1978-03-07
申请号：US531313
申请日：1974-12-10
申请人： Soichi Nakano , Yohji Ishii , Tetsuo Sekiya , Akira Fujimura
发明人： Soichi Nakano , Yohji Ishii , Tetsuo Sekiya , Akira Fujimura
IPC分类号： H04M3/42 , F02D35/00 , F02P5/10 , H04M3/64 , H04Q3/555 , F02P5/04
CPC分类号： F02P5/106 , F02P5/103
摘要： A spark-advance mechanism for an internal combustion engine is operated by vacuum pressure in the engine intake manifold. A conduit connecting the spark-advance mechanism to the intake manifold includes a solenoid operated valve which is normally open, and which is closed by either of two switches connected in parallel. One of the switches is closed when the engine temperature is low, and the other is closed when the engine RPM is high. When the solenoid valve is energized by either or both switches to close the conduit, atmospheric air is bled through an orifice to cause slow advance of the spark timing.
摘要翻译：用于内燃机的火花提前机构通过发动机进气歧管中的真空压力来操作。将火花提前机构连接到进气歧管的导管包括一个常开的电磁阀，并且由并联连接的两个开关中的任一个关闭。当发动机温度低时，其中一个开关闭合，另一个在发动机转速高时关闭。当电磁阀由一个或两个开关通电以关闭导管时，大气通过孔排出，导致火花正时的缓慢提前。

6. 发明授权

US5439927A Imidazoyl-.beta.-oxo-.beta.-benzenepropanethiomide derivative, compositions and method of use thereof 失效
标题翻译：咪唑酰-β-氧代-β-苯丙烷三醇衍生物，组合物及其使用方法
公开(公告)号：US5439927A
公开(公告)日：1995-08-08
申请号：US231123
申请日：1994-04-22
申请人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino
发明人： Tetsuo Sekiya , Mikio Tsutsui , Tetsuro Shimpuku , Tatsuo Nagano , Junko Hayashi , Asami Seino
IPC分类号： A61K31/16 , A61K31/18 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/496 , A61K31/50 , A61K31/505 , A61P1/00 , A61P9/08 , A61P9/12 , A61P11/00 , A61P11/08 , A61P29/00 , C07C327/42 , C07C327/44 , C07C327/46 , C07D207/327 , C07D213/59 , C07D231/12 , C07D233/54 , C07D233/58 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/84 , C07D233/90 , C07D237/08 , C07D263/32 , C07D277/20 , C07D277/30 , C07D233/96 , A61K31/165
CPC分类号： C07C327/46 , C07C327/44 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要： The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.
摘要翻译：本发明的β-氧代-β-苯丙烷硫代酰胺衍生物具有钾通道开放作用，可用于治疗高血压，哮喘，过敏性结肠综合征和肠炎，包括血管扩张，支气管扩张，胃肠道松弛等药理作用平滑肌等。本发明还包括含有本发明化合物作为有效成分的药物组合物及其制造方法。

7. 发明授权

US5424890A Magnetoresistance effect type thin film head 失效
标题翻译：磁阻效应型薄膜头
公开(公告)号：US5424890A
公开(公告)日：1995-06-13
申请号：US295229
申请日：1994-08-24
申请人： Hideo Suyama , Tetsuo Sekiya , Munekatsu Fukuyama , Norio Saito , Takuji Shibata
发明人： Hideo Suyama , Tetsuo Sekiya , Munekatsu Fukuyama , Norio Saito , Takuji Shibata
IPC分类号： G11B5/39 , G11B5/40
CPC分类号： G11B5/39 , G11B5/40
摘要： A magnetoresistance effect type thin film head (A) constructed in a manner that a magnetoresistance effect element, that is, an MR element (1) is disposed perpendicularly to a head surface a, and among two electrodes (2a) and (2b) led out from both ends of the MR element (1), the one electrode (2a) is exposed to the head surface a but the other electrode (2b) is not exposed to the head surface a, wherein the one electrode (2a) exposed to the head surface a is connected to a ground voltage Vss, thereby decreasing the change in voltage difference between the electrode (2a) of the MR element (1) and a disc surface b to prevent the electrical breakdown of the thin film head (A).
摘要翻译：以磁致电阻效应元件即MR元件（1）垂直于磁头表面a设置的磁阻效应型薄膜磁头（A），以及在两个电极（2a）和（2b）之间引导的磁阻效应型薄膜磁头从MR元件（1）的两端出来，一个电极（2a）暴露于头表面a，而另一个电极（2b）不暴露于磁头表面a，其中一个电极（2a）暴露于头表面a连接到接地电压Vss，从而减小MR元件（1）的电极（2a）与盘表面b之间的电压差的变化，以防止薄膜头（A）的电击穿，。

8. 发明授权

US5202351A 1-phenylalkyl-3-phenylurea derivative 失效
标题翻译： 1-苯甲基-3-苯基衍生物
公开(公告)号：US5202351A
公开(公告)日：1993-04-13
申请号：US643983
申请日：1991-01-22
申请人： Tetsuo Sekiya , Shinya Inoue , Chiaki Hyodo , Hiromi Okushima , Kohei Umezu , Kazuo Suzuki
发明人： Tetsuo Sekiya , Shinya Inoue , Chiaki Hyodo , Hiromi Okushima , Kohei Umezu , Kazuo Suzuki
IPC分类号： A61K31/17 , A61K31/335 , A61K31/357 , A61K31/36 , A61P3/06 , A61P9/10 , A61P43/00 , C07C275/28 , C07C275/30 , C07C275/32 , C07C335/16 , C07D317/58 , C07D319/18 , C07D321/10
CPC分类号： C07C275/28 , C07D317/58 , C07D319/18 , C07D321/10 , C07C2102/08 , C07C2102/10
摘要： A novel 1-phenylalkyl-3-phenylurea derivative represented by the following formula (I): ##STR1## wherein R.sup.1 and R.sup.5 represent independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.5 alkoxyl or halo; R.sup.2 represents hydrogen or C.sub.1 -C.sub.15 alkyl; R.sup.3 represents C.sub.1 -C.sub.15 alkyl or R.sup.3 represents together with R.sup.2 C.sub.2 -C.sub.9 alkylene; R.sup.4 and R.sup.5 represent independently C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxyl or halo; X represents oxygen or sulfur; Y represents --O--(CH.sub.2).sub.l --O-- wherein l is an integer of 1 to 3 or --(CH.sub.2).sub.p -- wherein p is an integer of 3 to 5; m is 0 or an integer of 1 to 5; and n is 0 or an integer of 1 to 3, is provided. The 1-phenylalkyl-3-phenylurea derivative (I) have the action of reducing cholesterol in blood by ACAT inhibition, and therefore, useful for treating hyperlipemia and atherosclerosis.

9. 发明授权

US5145259A Bearing system 失效
标题翻译：轴承系统
公开(公告)号：US5145259A
公开(公告)日：1992-09-08
申请号：US587041
申请日：1990-09-24
申请人： Kanji Murano , Tetsuo Sekiya , Akihiko Ohashi , Takehisa Ishida
发明人： Kanji Murano , Tetsuo Sekiya , Akihiko Ohashi , Takehisa Ishida
IPC分类号： F16C19/52 , F16C19/00 , G11B21/02
CPC分类号： F16C19/00
摘要： A rotational bearing system incorporates a ball bearing to support a freely rotatable shaft or housing through rolling contact with the ball bearing, the rotational bearing system comprises: vibratory elements adapted to excite in resonant vibration a fixed shaft or a fixed housing in rolling contact with the ball bearings to lower the frictional resistance of the ball bearing.
摘要翻译：旋转轴承系统包括滚珠轴承，以通过与滚珠轴承的滚动接触来支撑可自由旋转的轴或壳体，所述旋转轴承系统包括：振动元件，其适于以共振振动激励固定轴或与球轴承，以降低球轴承的摩擦阻力。

10. 发明授权

US4668682A 2-Phenylalkyl-3-aminoalkyl-4(3H)-quinazolinone compound 失效
标题翻译： 2-苯基烷基-3-氨基烷基-4（3H） - 喹唑啉酮化合物
公开(公告)号：US4668682A
公开(公告)日：1987-05-26
申请号：US753708
申请日：1985-07-10
申请人： Tetsuo Sekiya , Mikio Tsutsui , Daijiro Horii , Akira Ishibashi
发明人： Tetsuo Sekiya , Mikio Tsutsui , Daijiro Horii , Akira Ishibashi
IPC分类号： C07D239/91 , A61K31/505 , A61K31/517 , A61P3/00 , A61P3/14 , A61P9/08 , A61P9/12 , A61P11/08 , C07D239/90 , C07D401/06
CPC分类号： C07D239/90
摘要： Disclosed are a 2-phenylalkyl-3-aminoalkyl-4(3H)-quinazolinone compound of Formula (1): ##STR1## wherein, X represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a benzyloxy group, a halogen atom or a hydroxy group; Y represents an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a benzyloxy group, a halogen atom or a nitro group; R.sup.1 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; R.sup.2 represents an alkyl group having 1 to 5 carbon atoms or a group of Formula (2) ##STR2## [wherein, Z represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or a halogen atom; d is an integer of 1 to 3; and l is an integer of 1 to 5]; or R.sup.1 and R.sup.2 represent together with the nitrogen atom to which they are attached, a cyclic amino group of the formula: ##STR3## [wherein, A represents an alkylene group having 2 to 6 carbon atoms or a group of the formula --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --]; a and b are independently an integer of 1 to 3; and n and m are independently an integer of 1 to 5, or a pharmaceutically acceptable acid addition salt thereof, a process for preparing said compound, a composition comprising said compound as an active ingredient and a method of treatment by use of said compound.The compounds of the present invention have calcium antagonistic, vasodilative, and antihypertensive activities.
摘要翻译：公开了式（1）的2-苯基烷基-3-氨基烷基-4（3H） - 喹唑啉酮化合物：其中X表示氢原子，具有1至5个碳原子的烷基，具有1个至5个碳原子，苯氧基，苄氧基，卤原子或羟基; Y表示碳原子数1〜5的烷基，碳原子数1〜5的烷氧基，苄氧基，卤素原子或硝基。 R1表示氢原子或碳原子数1〜5的烷基。 R 2表示碳原子数1〜5的烷基或式（2）的基团[其中，Z表示氢原子，碳原子数1〜5的烷基，碳原子数1〜5的烷氧基或卤素原子; d为1〜3的整数， l为1〜5的整数]。或者R 1和R 2与它们所连接的氮原子一起表示下式的环状氨基：其中A表示碳原子数为2〜6的亚烷基或式 - （CH 2 ）2-O-（CH 2）2 - ]; a和b独立地为1〜3的整数; n和m独立地为1〜5的整数，或其药学上可接受的酸加成盐，制备所述化合物的方法，包含所述化合物作为活性成分的组合物和使用所述化合物的方法。本发明的化合物具有钙拮抗，血管扩张和抗高血压活性。

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