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1. 发明授权

US4352928A 5,6-Alkylenepyrimidine derivative 失效
标题翻译： 5,6-亚烷基嘧啶衍生物
公开(公告)号：US4352928A
公开(公告)日：1982-10-05
申请号：US160080
申请日：1980-06-16
申请人： Hidetoshi Hiranuma , Tetsuo Sekiya , Susumu Mizogami , Motokuni Mori , Mitsuo Hanatsuka , Toshiji Kanayama
发明人： Hidetoshi Hiranuma , Tetsuo Sekiya , Susumu Mizogami , Motokuni Mori , Mitsuo Hanatsuka , Toshiji Kanayama
IPC分类号： A61K31/505 , A61K31/517 , A61P3/08 , A61P7/02 , A61P9/12 , A61P29/00 , C07D239/70 , C07D239/95 , C07D401/04 , C07D405/06 , C07D409/06 , C07D403/04 , C07D405/14 , C07D413/04
CPC分类号： C07D239/95 , C07D239/70
摘要： There are provided a novel compound, i.e., a 2-piperazino-4-substituted-5,6-alkylenepyrimidine derivative represented by the formula: ##STR1## wherein Y, Z and n are defined in the specification and claims, and a pharmaceutically acceptable acid addition salt thereof.The compounds of the present invention show, an anti-inflammatory effect, a blood sugar level lowering effect, a blood platelet aggregation suppressive effect, an anorexigenic action and a Serotonin effect.
摘要翻译：提供了一种新的化合物，即由下式表示的2-哌嗪基-4-取代-5,6-亚烷基嘧啶衍生物：其中Y，Z和n在说明书和权利要求书中定义，其药学上可接受的其酸加成盐。本发明的化合物显示出抗炎作用，血糖降低作用，血小板聚集抑制作用，厌食作用和血清素作用。

2. 发明授权

US4189484A Antihypertensive quinazoline derivatives 失效
标题翻译：抗高血压喹唑啉衍生物
公开(公告)号：US4189484A
公开(公告)日：1980-02-19
申请号：US956326
申请日：1978-10-31
申请人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
发明人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
IPC分类号： C07D239/95 , C07D295/185 , C07D307/54 , C07D317/60 , A61K31/505 , C09B23/16 , C09B55/00
CPC分类号： C07D295/185 , C07D239/95 , C07D307/54 , C07D317/60
摘要： Novel quinazoline compounds and antihypertensive compositions containing said compounds are disclosed; said compounds having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group having 1-5 carbon atoms;R.sup.2 is a group of the formula ##STR2## in which Y is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, an alkenyloxy group, a methylenedioxy group, a nitro group, a halogen atom, a trifluoromethyl group, an acyloxy group, a hydroxy group, an unsubstituted or substituted amino group or a condensed benzene nucleus and m is an integer of 1-3 inclusive, or a group of the formula ##STR3## in which X is an oxygen atom, a sulfur atom or a carbon-nitrogen double bond and Z is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, a nitro group or a halogen atom; and n is an integer of 2-3 inclusive;provided that, when R.sup.2 is the said group ##STR4## n is 2 and R.sup.1 is a hydrogen atom or, when R.sup.2 is the said group ##STR5## n is 2 or 3 and R.sup.1 is a hydrogen atom or the said alkyl group and a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：公开了含有所述化合物的新型喹唑啉化合物和抗高血压组合物; 所述具有下式的化合物：其中R 1是氢原子或具有1-5个碳原子的烷基; R2是式中Y为氢原子，1-5个碳原子的烷基，1-5个碳原子的烷氧基，烯氧基，亚甲二氧基，硝基，卤素原子，三氟甲基，酰氧基，羟基，未取代或取代的氨基或稠合的苯核，m是1-3的整数，或下式的组合：IMAGE>其中X 是氧原子，硫原子或碳 - 氮双键，Z是氢原子，1-5个碳原子的烷基，1-5个碳原子的烷氧基，硝基或卤素原子; n为2-3以下的整数。条件是当R2是所述基团时，n是2，R 1是氢原子，或者当R 2是所述基团时，n是2或3，并且R 1是氢原子或所述烷基和其药学上可接受的酸加成盐。

3. 发明授权

US4777042A Cholesterol level-lowering agents 失效
标题翻译：胆固醇降低剂
公开(公告)号：US4777042A
公开(公告)日：1988-10-11
申请号：US102767
申请日：1987-09-25
申请人： Hideo Toda , Kunio Kihara , Susumu Mizogami , Munehiro Hashimoto
发明人： Hideo Toda , Kunio Kihara , Susumu Mizogami , Munehiro Hashimoto
IPC分类号： C07D233/60 , A61K31/415 , A61K31/785 , A61P3/06 , B01J41/12 , C07D405/14 , C08G59/00 , C08G59/10 , C08G59/14 , C08G59/20 , C08G59/22 , C08G59/50 , C08G59/62 , A61K31/74
CPC分类号： C08G59/10 , A61K31/785 , C08G59/226 , C08G59/5073 , C08G59/62
摘要： There is disclosed a cholesterol level-lowering agent which comprises as a main component a strongly basic anion exchange resin having imidazolium salts as functional groups, said resin being a copolymer of (A) a high molecular quaternary salt and (B) a polyfunctional epoxy compound having two or more oxirane rings.
摘要翻译：公开了一种胆固醇水平降低剂，其包含作为主要成分的具有咪唑鎓盐作为官能团的强碱性阴离子交换树脂，所述树脂是（A）高分子季盐和（B）多官能环氧化合物具有两个或多个环氧乙烷环。

4. 发明授权

US4607034A Quinazoline derivatives and pharmaceutical composition thereof 失效
标题翻译：喹唑啉衍生物及其药物组合物
公开(公告)号：US4607034A
公开(公告)日：1986-08-19
申请号：US199565
申请日：1980-10-21
申请人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
发明人： Susumu Mizogami , Hidetoshi Hiranuma , Tetsuo Sekiya , Mitsuo Hanazuka
IPC分类号： C07D239/95 , C07D295/215 , A61K31/505 , C07D403/04
CPC分类号： C07D295/215 , C07D239/95
摘要： There are presented novel quinazoline derivatives, namely 2-(4-substituted-carbamoyl-piperazin-1-yl)quinazoline derivatives, 2-(4-substituted-carbamoyl-homopiperazin-1-yl)quinazoline derivatives, 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives and 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives, having excellent antihypertensive activities.
摘要翻译：提出了新的喹唑啉衍生物，即2-（4-取代 - 氨基甲酰基 - 哌嗪-1-基）喹唑啉衍生物，2-（4-取代 - 氨基甲酰基 - 高哌嗪-1-基）喹唑啉衍生物，2-（4-取代 - 硫代氨基甲酰基 - 哌嗪-1-基）喹唑啉衍生物和具有优异抗高血压活性的2-（4-取代 - 硫代氨基甲酰基 - 哌嗪-1-基）喹唑啉衍生物。

5. 发明授权

US4016193A Novel substituted phenylacetic acid derivatives and a process for preparing thereof 失效
标题翻译：新型取代苯乙酸衍生物及其制备方法
公开(公告)号：US4016193A
公开(公告)日：1977-04-05
申请号：US592946
申请日：1975-07-03
申请人： Toshihiko Kobayashi , Hidetoshi Hiranuma , Susumu Mizogami , Hiroyoshi Nishi , Mamoru Higuchi , Masatoshi Onoya
发明人： Toshihiko Kobayashi , Hidetoshi Hiranuma , Susumu Mizogami , Hiroyoshi Nishi , Mamoru Higuchi , Masatoshi Onoya
IPC分类号： A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , C07C67/00 , C07C201/00 , C07C205/56 , C07C205/59 , C07C79/46
CPC分类号： C07C255/00 , C07C205/56
摘要： Novel substituted phenylacetic acid derivatives having the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or lower alkyl radical and R.sub.3 represents an alkenyl or alkynyl radical having 3 - 4 carbon atoms with excellent anti-inflammatory and analgesic activities.
摘要翻译：具有下式的新型取代的苯乙酸衍生物：其中R 1表示氢原子或低级烷基，R 3表示具有3-4个碳原子的烯基或炔基，具有优异的抗炎和止痛活性。

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