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1. 发明授权

US06239155B1 Phenyl-substituted 1,4-dihydropyridines 失效
公开(公告)号：US06239155B1
公开(公告)日：2001-05-29
申请号：US08348399
申请日：1994-12-02
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： C07D21186
CPC分类号： C07D401/12 , C07D211/90
摘要： Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with &bgr;-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.

2. 发明授权

US5502064A 4-heterocyclyl-substituted dihydropyridines 失效
标题翻译： 4-杂环基取代的二氢吡啶
公开(公告)号：US5502064A
公开(公告)日：1996-03-26
申请号：US141846
申请日：1993-10-22
申请人： Bodo Junge , Wolfgang Hartwig , Heinrich Meier , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Bodo Junge , Wolfgang Hartwig , Heinrich Meier , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/455 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P25/28 , C07D401/04 , C07D409/04
CPC分类号： C07D401/04 , C07D409/04
摘要： 4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with .beta.-keto esters and aminocrotonic acid esters, or by esterifying 4-hetero-cyclyl-substituted dihydropyridinecarboxylic acids. The 4-heterocyclyl-substituted dihydropyridines can be employed in medicaments, in particular for the treatment of disorders of the central nervous system.
摘要翻译：通过使适当的醛与β-酮酯和氨基巴豆酸酯反应，或通过酯化4-杂环羰基取代的二氢吡啶羧酸来制备4-杂环基取代的二氢吡啶。 4-杂环基取代的二氢吡啶可用于药物中，特别是用于治疗中枢神经系统疾病。

3. 发明授权

US06630494B2 Phenyl-substituted 1,4-dihydropyridines 失效
标题翻译：苯基取代的1,4-二氢吡啶
公开(公告)号：US06630494B2
公开(公告)日：2003-10-07
申请号：US09781516
申请日：2001-02-12
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K3144
CPC分类号： C07D401/12 , C07D211/90
摘要： Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with &bgr;-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.
摘要翻译：通过卤代苯基 - 醛与β-酮酯反应制备的新型苯基取代的1,4-二氢吡啶，如果合适的话，分离亚基化合物和烯胺。这些物质可以用作药物中的活性化合物，特别是在脑活性组合物中。

4. 发明授权

US5731333A 4-phenyl-3-substituted 1,4-dihydropyridine esters 失效
公开(公告)号：US5731333A
公开(公告)日：1998-03-24
申请号：US348696
申请日：1994-12-02
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/4427 , A61K31/455 , A61P9/08 , A61P25/24 , A61P25/26 , A61P25/28 , C07D211/90 , C07D401/12 , C07D211/86
CPC分类号： C07D401/12 , C07D211/90
摘要： 4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols. The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.

5. 发明授权

US5658934A Aryl-substituted alkoxycarbonyl-1,4-dihydropyridine-5-carboxylic acid esters 失效
标题翻译：芳基取代的烷氧羰基-1,4-二氢吡啶-5-羧酸酯
公开(公告)号：US5658934A
公开(公告)日：1997-08-19
申请号：US349753
申请日：1994-12-05
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Ulrich Niewohner , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Ulrich Niewohner , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/505 , A61P25/28 , C07D211/90 , C07D401/12 , C07D405/12 , C07D409/12 , C07D211/86
CPC分类号： C07D211/90
摘要： The invention relates to new aryl-substituted alkoxycarbonyl-1,4-dihydropyridine-5-carboxylic acid esters, processes for their preparation and their use in medicaments, in particular as agents having a cerebral action.
摘要翻译：本发明涉及新的芳基取代的烷氧基羰基-1,4-二氢吡啶-5-羧酸酯，其制备方法及其在药物中的用途，特别是具有脑作用的试剂。

6. 发明授权

US6066655A 4-phenyl-3-substituted 1,4-dihydropyridine esters 失效
标题翻译： 4-苯基-3-取代的1,4-二氢吡啶酯
公开(公告)号：US6066655A
公开(公告)日：2000-05-23
申请号：US988114
申请日：1997-12-10
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/4427 , A61K31/455 , A61P9/08 , A61P25/24 , A61P25/26 , A61P25/28 , C07D211/90 , C07D401/12 , C07D211/86
CPC分类号： C07D401/12 , C07D211/90
摘要： 4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols.The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.
摘要翻译：通过苯甲醛与酮酯和烯胺的反应制备4-苯基-3-取代的1,4-二氢吡啶酯，如果合适地分离亚基中间体产物，或通过相应的二氢吡啶羧酸与醇的酯化反应。新的4-苯基-3-取代的1,4-二氢吡啶酯可用作药物中的活性化合物，用于治疗中枢神经系统，特别是作为脑治疗剂。

7. 发明授权

US6001857A Heterocyclyl substituted dihydropyridines 失效
标题翻译：杂环取代的二氢吡啶
公开(公告)号：US6001857A
公开(公告)日：1999-12-14
申请号：US903508
申请日：1997-07-30
申请人： Bodo Junge , Wolfgang Hartwig , Heinrich Meier , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Bodo Junge , Wolfgang Hartwig , Heinrich Meier , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： C07D401/04 , C07D409/04 , A61K31/44
CPC分类号： C07D401/04 , C07D409/04
摘要： 4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with .beta.-keto esters and aminocrotonic acid esters, or by esterifying 4-heterocyclyl-substituted dihydropyridinecarboxylic acids. The 4-heterocyclyl-substituted dihydropyridines can be employed in medicaments, in particular for the treatment of disorders of the central nervous system.
摘要翻译：通过使适当的醛与β-酮酯和氨基巴豆酸酯反应，或通过酯化4-杂环基取代的二氢吡啶羧酸来制备4-杂环基取代的二氢吡啶。 4-杂环基取代的二氢吡啶可用于药物中，特别是用于治疗中枢神经系统疾病。

8. 发明授权

US5665740A Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate 失效
标题翻译： 4-（2-氯-3-氰基 - 苯基）-1,4-二氢-2,6-二甲基 - 吡啶-3,5-二甲酸异丙酯2-甲氧基乙酯
公开(公告)号：US5665740A
公开(公告)日：1997-09-09
申请号：US348436
申请日：1994-12-02
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/44 , A61K31/45 , A61K31/455 , A61P9/08 , A61P25/24 , A61P25/26 , A61P25/28 , C07C255/56 , C07D211/90 , C07D211/86
CPC分类号： C07D211/90
摘要： The present invention relates to the new compound rac-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)1,4 -dihydro-2,6-dimethylpyridine-3,5-dicarboxylate and its pure enantiomers, processes for their preparation and their use as medicaments, in particular for the treatment of cerebral and neuronal disorders, and a new intermediate for their preparation.
摘要翻译：本发明涉及新的化合物外消旋 - 异丙基2-甲氧基乙基4-（2-氯-3-氰基 - 苯基）1,4-二氢-2,6-二甲基吡啶-3,5-二羧酸酯及其纯对映体，方法用于制备和用作药物，特别是用于治疗脑和神经元疾病，以及用于其制备的新的中间体。

9. 发明授权

US5403849A 4-heterocyclophenyl-substituted dihydropyridines 失效
标题翻译： 4-杂环基苯基取代的二氢吡啶
公开(公告)号：US5403849A
公开(公告)日：1995-04-04
申请号：US141837
申请日：1993-10-22
申请人： Rudolf Schohe-Loop , Wolfgang Hartwig , Bodo Junge , Heinrich Meier , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Rudolf Schohe-Loop , Wolfgang Hartwig , Bodo Junge , Heinrich Meier , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/445 , A61K31/44 , A61K31/4427 , A61P9/10 , A61P25/00 , C07D401/10 , C07D413/10
CPC分类号： C07D401/10 , C07D413/10
摘要： 4-Heterocyclophenyl-substituted dihydropyridines ##STR1## are prepared either by reacting suitable aldehydes with amino esters and .beta.-keto esters, or preparing the heterocyclic substituents of the 4-phenyl by cyclization of corresponding amidines or hydrazides, or esterifying dihydropyridinecarboxylic acids, which are already substituted by heterocyclic radicals, with corresponding alcohols. The 4-heterocyclophenyl-substituted dihydropyridines can be employed in medicaments, in particular for treatment of diseases of the central nervous system.
摘要翻译： 4-杂环戊烯基取代的二氢吡啶通过使合适的醛与氨基酯和β-酮酯反应或通过相应的脒或酰肼的环化或通过酯化二氢吡啶羧酸制备4-苯基的杂环取代基来制备（I）已经被杂环取代，与相应的醇。 4-杂环基苯基取代的二氢吡啶可用于药物中，特别是用于治疗中枢神经系统疾病。

10. 发明授权

US06810174B2 Optical filter and optical filtering method 失效
标题翻译：光滤波器和光滤波方法
公开(公告)号：US06810174B2
公开(公告)日：2004-10-26
申请号：US10244806
申请日：2002-09-16
申请人： Zhan Gao , Reinhold Noé
发明人： Zhan Gao , Reinhold Noé
IPC分类号： G02B642
CPC分类号： H04B10/25133 , H04B10/2572
摘要： An optical signal alternately traverses a total of n couplers and n−1 DGD units, arranged therebetween, with a differential group delay between two signal modes. The power division between the two signal modes is measured in each DGD unit in a power division controller, and a signal that is proportional to the difference between the powers in the two signal modes is obtained. The signal is led to an integrating controller whose control signal is led to a differential phase shifter that is accommodated in the DGD unit present upstream in the beam path. The difference between the powers of the two signal modes is thereby brought to zero at least approximately. This has the consequence that it is essentially only the chromatic dispersion that is generated or equalized, but no other disturbing distortions of the optical signal are produced.
摘要翻译：光信号在两个信号模式之间交替地穿过总共n个耦合器和n-1个DGD单元，其间布置有差分组延迟。在功率分配控制器中的每个DGD单元中测量两个信号模式之间的功率分配，并且获得与两个信号模式中的功率之间的差成比例的信号。信号被引导到积分控制器，其控制信号被引导到容纳在存在于光束路径上游的DGD单元中的差分移相器。因此，两个信号模式的功率之间的差异至少约为零。这样做的结果是基本上仅仅是产生或均衡的色散，而不产生光信号的其它干扰失真。

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