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1. 发明申请

US20100044518A1 METHOD AND DEVICE FOR PROVIDING AUTOMATIC LOAD ALLEVIATION TO A HIGH LIFT SURFACE SYSTEM, IN PARTICULAR TO A LANDING FLAP SYSTEM, OF AN AIRCRAFT 有权
标题翻译：用于向自动负载表示系统提供自动负载校正的方法和装置，特别是对于飞机的飞行板系统
公开(公告)号：US20100044518A1
公开(公告)日：2010-02-25
申请号：US12086467
申请日：2006-12-08
申请人： Andreas Fleddermann , Wolfgang Hartwig , Alexandre Darbois , Martin Richter
发明人： Andreas Fleddermann , Wolfgang Hartwig , Alexandre Darbois , Martin Richter
IPC分类号： B64C13/16
CPC分类号： B64C13/16
摘要： A method and a device for providing automatic load alleviation to a high lift surface system, in particular to a landing flap system, of an aircraft when a blockage occurs, wherein in response to a control signal emitted by a control device at least one high lift surface, which is actuated by means of a local mechanical final control element, is brought to a predetermined position by a central drive unit that is connected by way of a rotary shaft arrangement to the local final control element by generating a torque transmitted by the central drive unit to the rotary shaft arrangement. If a signal is registered that indicates that there is a blockage within the high lift surface system, the torque transmitted by the central drive unit to the rotary shaft arrangement is automatically reduced to a predetermined low torque value, and the position of the high lift surface system is fixed.
摘要翻译：一种方法和装置，用于在发生堵塞时向飞行器的高升力表面系统（特别是着陆挡板系统）提供自动负载减轻，其中响应于由控制装置发射的控制信号，至少一个高升程通过局部机械终控制元件致动的表面通过中心驱动单元被带到预定位置，该中心驱动单元通过旋转轴装置连接到局部最终控制元件，通过产生由中心传递的扭矩驱动单元到旋转轴装置。如果登记指示高升力面系统内存在阻塞的信号，则由中央驱动单元传递给旋转轴装置的扭矩自动降低到预定的低扭矩值，并且高升程面的位置系统固定。

2. 发明授权

US06239155B1 Phenyl-substituted 1,4-dihydropyridines 失效
公开(公告)号：US06239155B1
公开(公告)日：2001-05-29
申请号：US08348399
申请日：1994-12-02
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： C07D21186
CPC分类号： C07D401/12 , C07D211/90
摘要： Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with &bgr;-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.

3. 发明授权

US4841042A Process for the preparation of carbapenem intermediates 失效
标题翻译：碳青霉烯中间体的制备方法
公开(公告)号：US4841042A
公开(公告)日：1989-06-20
申请号：US838237
申请日：1986-03-10
申请人： Dieter Habich , Wolfgang Hartwig
发明人： Dieter Habich , Wolfgang Hartwig
IPC分类号： C07D205/08 , C07D205/085 , C07D209/48 , C07D403/12 , C07D409/04 , C07D409/06 , C07D409/14 , C07D411/04 , C07D411/14 , C07D477/00 , C07D477/04 , C07D499/06 , C07D521/00 , C07F7/18 , C07F9/40
CPC分类号： C07D403/12 , C07C321/00 , C07C327/00 , C07D205/08 , C07D205/085 , C07D477/04 , C07F7/186 , C07F9/4006
摘要： A process for the preparation of a 4-[3-carboxy-3-diazo-2-oxopropyl]azetidin-2-one of the formula ##STR1## comprising reacting a 4-acetoxy-2-azetininone of the formula ##STR2## with a compound of the formula ##STR3## in an inert solvent, in the presence of a base and of a silylating agent, in a one-pot process.Many of the products are new. The products are useful in the synthesis of carbapenem antibiotics.
摘要翻译：制备式IMAGE的4- [3-羧基-3-重氮基-2-氧代丙基]氮杂环丁烷-2-酮的方法，包括使下式的图像形成的4-乙酰氧基-2-氮杂环丁酮与在惰性溶剂中，在碱和甲硅烷基化剂的存在下，在一锅法中制备式IMA的化合物。许多产品是新的。该产品可用于合成碳青霉烯类抗生素。

4. 发明授权

US4731456A Process for the preparation of clausenamide 失效
标题翻译：制备克劳森酰胺的方法
公开(公告)号：US4731456A
公开(公告)日：1988-03-15
申请号：US915309
申请日：1986-10-03
申请人： Wolfgang Hartwig
发明人： Wolfgang Hartwig
IPC分类号： C07D207/26 , C07D207/267 , C07D207/273 , C07D207/28 , C07D207/12
CPC分类号： C07D207/26 , C07D207/273 , C07D207/28
摘要： A new synthetic route to clausenamide having the formula ##STR1## has been found. It has been found that a compound of the formula ##STR2## can be oxidized to provide the stereochemically correctly configured product, clasuenamide. A number of new compounds useful in the total synthesis of clausenamide have also been found. These compounds have the general formula ##STR3## wherein R is ##STR4## and CH.sub.2 OH.
摘要翻译：已经找到了具有式“IMAGE”的新的克劳森酰胺的合成路线。已经发现，式“化合物”的化合物可以被氧化以提供立体化学正确构型的产物巴拉那胺。还发现了许多用于全合成克劳森酰胺的新化合物。这些化合物具有通式“IMAGE”，其中R是＆lt; IMAGE＆gt;和CH2OH。

5. 发明授权

US4616084A Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-carboxylic acids and 7-acylamino-3-hydroxy-1-dethia-1-oxacephem-4-carboxylic acids 失效
标题翻译：制备7-酰基氨基-3-羟基 - 头孢烯-4-羧酸和7-酰基氨基-3-羟基-1-脱硫-1-氧代四氢-4-羧酸的方法
公开(公告)号：US4616084A
公开(公告)日：1986-10-07
申请号：US636470
申请日：1984-07-31
申请人： Dieter Habich , Wolfgang Hartwig
发明人： Dieter Habich , Wolfgang Hartwig
IPC分类号： C07C205/42 , C07D205/085 , C07D501/02 , C07D501/59 , C07D503/00 , C07D505/00 , A61K31/545
CPC分类号： C07D505/00 , C07C201/12 , C07D205/085 , C07D503/00 , Y02P20/55
摘要： A process for the preparation of a 7-acylamino-3-hydroxy-2-cephem-4-carboxylic acid, 7-acylamino-3-hydroxy-1-dethia-1-oxa-3-cephem-4-carboxylic acid or derivative thereof of the general formula ##STR1## in which R.sup.1 is hydrogen or optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aryl, heteroaryl, heteroaralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, arylthioalkyl, heteroarylthioalkyl, alkylthioalkyl, alkoxy, aryloxy, alkylthio or arylthio,R.sup.2 is hydrogen, a carboxy-protective group or a pharmaceutically useful ester radical, andX is sulphur or oxygen,which comprises:(a) reacting a compound of the formula ##STR2## with (i) a compound of the formula ##STR3## in which R.sup.2 and X have the abovementioned meaning and Y represents diazo (N.sub.2) or hydrogen (H.sub.2) in an inert solvent in the presence of a Lewis acid or proton acid catalyst, or(ii) a compound of the formulaHX--CH.sub.2 --C.tbd.C--COOR.sup.2 to form an intemediate compound having a triple bond, and hydrating the triple bond, the compounds thus obtained, for Y being hydrogen (H.sub.2)--(in case of Y=diazo (N.sub.2) directly the compounds of general formula (2) are obtained) thereby to produce a compound of the formula ##STR4## (b) reacting such compound with an azide in a solvent in the presence of a base to give a compound of the formula ##STR5## (c) converting said compound to the desired product by (i) irradiation in an inert solvent, or(ii) warming in the presence of a catalyst.The end products are, or can be converted to, known .beta.-lactam antibiotics.
摘要翻译：制备7-酰基氨基-3-羟基-2-头孢烯-4-羧酸，7-酰基氨基-3-羟基-1-脱硫-1-氧杂-3-头孢烯-4-羧酸或其衍生物的方法烯基，炔基，芳烷基，芳基，杂芳基，杂芳烷基，芳氧基烷基，杂芳基氧基烷基，烷氧基烷基，芳硫基烷基，杂芳硫基烷基，烷硫基烷基，烷氧基，芳氧基，烷硫基或芳硫基，其中R 1为氢或任选取代的烷基， R2是氢，羧基保护基或药学上有用的酯基，X是硫或氧，其包括：（a）使式（IMAGE）的化合物与（i）下式化合物其中R2和X具有上述含义，Y代表重氮（N 2）或氢（H 2）在惰性溶剂中，在路易斯酸或质子酸催化剂存在下，或（ii）式HX-CH2- C 3 C COR CO 2，以形成具有三键的中间体化合物，并且使三键水合，该共聚物（H）在（Y =重氮（N 2）的情况下直接得到通式（2）的化合物），得到下式的化合物：（b）使此在碱的存在下在溶剂中与叠氮化合物反应，得到下式的化合物：（c）通过（i）在惰性溶剂中照射将所述化合物转化为所需产物，或（ii）在存在催化剂。最终产品是或可以转化为已知的β-内酰胺抗生素。

6. 发明授权

US08256718B2 Method and device for providing automatic load alleviation to a high lift surface system, in particular to a landing flap system, of an aircraft 有权
标题翻译：一种提供自动负载减轻的方法和装置，用于飞机的高升力面系统，特别是降落翼系统
公开(公告)号：US08256718B2
公开(公告)日：2012-09-04
申请号：US12086467
申请日：2006-12-08
申请人： Andreas Fleddermann , Wolfgang Hartwig , Alexandre Darbois , Martin Richter
发明人： Andreas Fleddermann , Wolfgang Hartwig , Alexandre Darbois , Martin Richter
IPC分类号： B64C13/00 , G05D1/00
CPC分类号： B64C13/16
摘要： A method and a device for providing automatic load alleviation to a high lift surface system, in particular to a landing flap system, of an aircraft when a blockage occurs, wherein in response to a control signal emitted by a control device at least one high lift surface, which is actuated by means of a local mechanical final control element, is brought to a predetermined position by a central drive unit that is connected by way of a rotary shaft arrangement to the local final control element by generating a torque transmitted by the central drive unit to the rotary shaft arrangement. If a signal is registered that indicates that there is a blockage within the high lift surface system, the torque transmitted by the central drive unit to the rotary shaft arrangement is automatically reduced to a predetermined low torque value, and the position of the high lift surface system is fixed.
摘要翻译：一种方法和装置，用于在发生堵塞时向飞行器的高升力表面系统（特别是着陆翼片系统）提供自动负载减轻，其中响应于由控制装置发射的控制信号，至少一个高升程通过局部机械终控制元件致动的表面通过中心驱动单元被带到预定位置，该中心驱动单元通过旋转轴装置连接到局部最终控制元件，通过产生由中心传递的扭矩驱动单元到旋转轴装置。如果登记指示高升力面系统内存在阻塞的信号，则由中央驱动单元传递给旋转轴装置的扭矩自动降低到预定的低扭矩值，并且高升程面的位置系统固定。

7. 发明授权

US07189801B2 Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function 有权
标题翻译：肽和肽模拟物与人p53的结构相似性激活p53功能
公开(公告)号：US07189801B2
公开(公告)日：2007-03-13
申请号：US10160290
申请日：2002-06-04
申请人： Thanos Halazonetis , Wolfgang Hartwig
发明人： Thanos Halazonetis , Wolfgang Hartwig
IPC分类号： C07K5/00
CPC分类号： A61K38/1709 , C07K14/4746 , C07K14/82
摘要： The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360–386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
摘要翻译：本发明提供了对应于人p53的残基360-386所包含的部分或整个区域的肽和肽模拟物，所述肽和肽模拟物的特征在于活化野生型p53和选择性肿瘤衍生物的DNA结合的能力 p53突变体。还提供了本发明化合物的药物组合物和治疗性使用这些组合物的方法。

8. 发明授权

US06245886B1 Peptides and peptidomimetics with structural similarity to human P53 that activate P53 function 失效
标题翻译：肽和肽模拟物与人类P53的结构相似性激活P53功能
公开(公告)号：US06245886B1
公开(公告)日：2001-06-12
申请号：US08894327
申请日：1997-12-04
申请人： Thanos Halazonetis , Wolfgang Hartwig
发明人： Thanos Halazonetis , Wolfgang Hartwig
IPC分类号： A61K3800
CPC分类号： A61K38/1709 , C07K14/4746 , C07K14/82
摘要： The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
摘要翻译：本发明提供了对应于人p53的残基360-386所包含的部分或全部区域的肽和肽模拟物，所述肽和肽模拟物的特征在于活化野生型p53的DNA结合的能力，并选择肿瘤衍生的 p53突变体。还提供本发明化合物的药物组合物和治疗性使用这些组合物的方法。

9. 发明授权

US06169073A Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function 失效
标题翻译：肽和肽模拟物与人p53的结构相似性激活p53功能
公开(公告)号：US06169073A
公开(公告)日：2001-01-02
申请号：US08392542
申请日：1995-02-16
申请人： Thanos Halazonetis , Wolfgang Hartwig
发明人： Thanos Halazonetis , Wolfgang Hartwig
IPC分类号： A61K3800
CPC分类号： A61K38/1709 , C07K14/4746 , C07K14/82
摘要： The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
摘要翻译：本发明提供了对应于人p53的残基360-386所包含的部分或整个区域的肽和肽模拟物，所述肽和肽模拟物的特征在于活化野生型p53和选择性肿瘤衍生物的DNA结合的能力 p53突变体。还提供本发明化合物的药物组合物和治疗性使用这些组合物的方法。

10. 发明授权

US5721238A 2,8-disubstituted quinazolinones 失效
标题翻译： 2,8-二取代喹唑啉酮
公开(公告)号：US5721238A
公开(公告)日：1998-02-24
申请号：US584865
申请日：1996-01-11
申请人： Fred Robert Heiker , Ulrich Niewohner , Wolfgang Hartwig , Helmuth Schutz , Erwin Bischoff , Elisabeth Perzborn , Matthias Schramm
发明人： Fred Robert Heiker , Ulrich Niewohner , Wolfgang Hartwig , Helmuth Schutz , Erwin Bischoff , Elisabeth Perzborn , Matthias Schramm
IPC分类号： A61K31/505 , A61K31/517 , A61K31/535 , A61K31/655 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P13/08 , A61P29/00 , A61P43/00 , C07D239/91 , C07D405/04 , C07D413/12 , C07D413/14 , C07D239/80
CPC分类号： C07D405/04 , C07D239/91
摘要： 2,8-Disubstituted quinazolinones are prepared by first subjecting the quinazolinone basic skeleton to condensation by customary reactions and then introducing the desired substituents into the 8-position. The compounds are suitable as active compounds in medicaments, in particular for the treatment of inflammations, thromboembolic diseases and cardiovascular diseases.
摘要翻译：通过首先使喹唑啉酮碱性骨架通过常规反应冷凝，然后将所需的取代基引入8-位来制备2,8-二取代喹唑啉酮。该化合物适合作为药物中的活性化合物，特别是用于治疗炎症，血栓栓塞性疾病和心血管疾病。

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