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1. 发明授权

US5698560A Imidazoquinazoline derivatives 失效
标题翻译：咪唑喹唑啉衍生物
公开(公告)号：US5698560A
公开(公告)日：1997-12-16
申请号：US727598
申请日：1996-10-23
申请人： Yasuo Onoda , Shin-ichi Sasaki , Daisuke Machii , Haruki Takai , Tetsuji Ohno , Koji Yamada , Michio Ichimura , Hiroshi Kase
发明人： Yasuo Onoda , Shin-ichi Sasaki , Daisuke Machii , Haruki Takai , Tetsuji Ohno , Koji Yamada , Michio Ichimura , Hiroshi Kase
IPC分类号： C07D487/04 , A61K31/505 , A61K31/535 , C07D417/02 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to imidazoquinazoline derivatives represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heteroaryl, R.sup.2 and R.sup.3 represent independently hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heteroaryl, or R.sup.2 and R.sup.3 are combined to represent a heterocyclic group containing a nitrogen atom, R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl, X represents O or S, Y represents a single bond or O, n represents 0, 1, 2, or 3, and pharmaceutically acceptable salts thereof.
摘要翻译： PCT No.PCT / JP96 / 00497 Sec。 371日期：1996年10月23日 102（e）日期1996年10月23日PCT 1996年3月1日PCT公布。第WO96 / 26940号公报日本1996年9月6日本发明涉及由式（I）表示的咪唑并喹唑啉衍生物：其中R1表示氢，取代或未取代的低级烷基，环烷基，低级烯基，取代或未取代的芳烷基，取代或未取代的芳基取代或未取代的芳基，取代或未取代的杂芳基，或取代或未取代的杂芳基，或者取代或未取代的杂芳基，或者取代或未取代的杂芳基，或R 2和R 3 合并表示含有氮原子的杂环基，R4表示氢或取代或未取代的低级烷基，X表示O或S，Y表示单键或O，n表示0,1,2或3，以及药学上可接受的的盐。

2. 发明授权

US5605900A Benzotriazines having adenosine uptake inhibitor activity 失效
标题翻译：具有腺苷摄取抑制剂活性的苯并三嗪
公开(公告)号：US5605900A
公开(公告)日：1997-02-25
申请号：US430227
申请日：1995-04-28
申请人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
发明人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
IPC分类号： C07D401/14 , C07D491/04 , C07D401/04 , A61K31/445 , A61K31/50 , A61K31/53
CPC分类号： C07D401/14 , C07D491/04
摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C-R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物：（I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

4. 发明授权

US5891902A Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US5891902A
公开(公告)日：1999-04-06
申请号：US676177
申请日：1996-07-15
申请人： Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
发明人： Daisuke Machii , Haruki Takai , Nobuo Kosaka , Hisakatsu Seo , Tomomi Sugiyama , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi , Soichiro Sato , Masako Uchii , Koji Suzuki
IPC分类号： C07D209/30 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D521/00 , A61K31/40 , C07D209/12 , C07D209/14
CPC分类号： C07D231/12 , C07D209/30 , C07D209/42 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, --O--(CH.sub.2).sub.n --OR.sup.5, or ##STR2## R.sup.3 represents hydrogen, lower alkyl, or ##STR3## R.sup.4 represents hydroxy, lower alkoxy, substituted or unsubstituted aryloxy, or --NR.sup.10 R.sup.11, and X represents CO or SO.sub.2, with the proviso that when R.sup.3 is hydrogen or lower alkyl, and X is CO, R.sup.4 is --NR.sup.10 R.sup.11, or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由式（I）表示的吲哚衍生物：其中R1和R2独立地表示氢，低级烷基，羟基，低级烷氧基，卤素，-O-（CH2）n-OR5或 R 3表示氢，低级烷基或R 4表示羟基，低级烷氧基，取代或未取代的芳氧基或-NR 10 R 11，X表示CO或SO 2，条件是当R 3为氢或低级烷基时，X 是CO，R 4是-NR 10 R 11，或其药学上可接受的盐。

5. 发明授权

US5658917A Isoquinolines having adenosine uptake inhibitor activity 失效
标题翻译：具有腺苷摄取抑制剂活性的异喹啉
公开(公告)号：US5658917A
公开(公告)日：1997-08-19
申请号：US430234
申请日：1995-04-28
申请人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
发明人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
IPC分类号： C07D401/14 , C07D491/04 , A61K31/445 , A61K31/50 , A61K31/505
CPC分类号： C07D401/14 , C07D491/04
摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物：（I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

6. 发明授权

US5374634A Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US5374634A
公开(公告)日：1994-12-20
申请号：US84480
申请日：1993-07-01
申请人： Iwao Kinoshita , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Akio Ishii , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi
发明人： Iwao Kinoshita , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Akio Ishii , Joji Nakamura , Hiroyuki Ishida , Katsushige Gomi
IPC分类号： A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07D213/74 , C07D213/81 , C07D401/12 , A61K31/495 , C07D211/78 , C07D401/00
CPC分类号： A61K31/54 , A61K31/44 , A61K31/445 , A61K31/535 , C07D213/74 , C07D213/81 , C07D401/12
摘要： There is provided a pyridine derivative represented by the formula (I) ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or lower alkyl and each of R.sup.3 and R.sup.4 independently represents hydrogen, lower alkyl, alicyclic alkyl, substituted or unsubstituted polycyclic alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined with nitrogen atom adjacent thereto to form a substituted or unsubstituted alicyclic heterocyclic group, or pharmaceutically acceptable salt thereof. The pyridine derivative exhibits bone resorption inhibiting effect and is useful as a medicament for treating osteoporosis.
摘要翻译：提供由式（I）表示的吡啶衍生物，其中R 1和R 2各自独立地表示氢或低级烷基，R 3和R 4各自独立地表示氢，低级烷基，脂环族烷基，取代或未取代的多环烷基，取代或未取代的芳基或取代或未取代的杂环基，或R 3和R 4与与其相邻的氮原子合并形成取代或未取代的脂环族杂环基或其药学上可接受的盐。吡啶衍生物显示骨吸收抑制作用，可用作治疗骨质疏松症的药物。

7. 发明授权

US4797678A Device for predicting unique word detection positions in a TDMA station by using latest valid detection positions 失效
标题翻译：用于通过使用最新的有效检测位置来预测TDMA站中的唯一字检测位置的装置
公开(公告)号：US4797678A
公开(公告)日：1989-01-10
申请号：US744377
申请日：1985-06-13
申请人： Akira Tsuji , Haruki Takai
发明人： Akira Tsuji , Haruki Takai
IPC分类号： H04J3/06 , H04B7/155 , H04B7/212 , H04J3/00 , H04L7/04 , H04L7/08 , H04B7/185
CPC分类号： H04B7/2125 , H04L7/042 , H04L7/08
摘要： One of patterns representative of instants along each TDMA frame is selected as a selected pattern in response to a unique word detection pulse produced in a current frame. With the unique word detection pulse used as a write pulse, a memory memorizes the selected pattern as a memorized pattern in a memory cell accessed by one of burst identifying flags which identify time slots in the current frame, respectively. The memorized pattern is produced as a read-out pattern when accessed by the burst identifying flag which corresponds in a next succeeding frame to the above-mentioned one burst identifying flag. A calculator produces offset representing patterns. Upon coincidence of each read-out pattern and one of the offset representing patterns, a comparator produces a receive position predicting pulse predictive of a position or a unique word detection window in the next succeeding frame. The write pulse is preferably obtained by giving the unique word detection pulse a delay which is equal to a predetermined fraction of each time slot. The offset representing patterns represent the respective instants plus an offset which is equal to a duration of each frame minus a half of a duration of each unique word detection window.
摘要翻译：响应于在当前帧中产生的唯一字检测脉冲，选择代表每个TDMA帧的时刻的一种模式作为选择的模式。利用用作写入脉冲的唯一字检测脉冲，存储器将所选择的模式作为存储单元存储在由标识当前帧中的时隙的突发识别标志之一分别访问的存储单元中。当由下一个后续帧中对应的突发识别标志访问上述一个突发识别标志时，存储的模式作为读出模式产生。计算器产生偏移表示模式。在每个读出模式和偏移表示模式中的一个一致时，比较器产生预测在下一个后续帧中的位置或唯一字检测窗口的脉冲预测的接收位置。写入脉冲优选地通过给予唯一字检测脉冲一个等于每个时隙的预定分数的延迟来获得。偏移表示图案表示相应的时刻加上等于每帧的持续时间减去每个唯一字检测窗口的持续时间的一半的偏移。

8. 发明授权

US5726325A Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US5726325A
公开(公告)日：1998-03-10
申请号：US849399
申请日：1997-06-06
申请人： Makoto Yoshida , Shin-ichi Sasaki , Shigeru Aono , Shigeki Fujiwara , Haruki Takai , Tsuyoshi Yamagata , Ken Nagashima , Akira Karasawa
发明人： Makoto Yoshida , Shin-ichi Sasaki , Shigeru Aono , Shigeki Fujiwara , Haruki Takai , Tsuyoshi Yamagata , Ken Nagashima , Akira Karasawa
IPC分类号： C07C235/16 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D313/02
CPC分类号： C07D491/04 , C07C235/16 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D493/04 , C07D495/04 , C07C2103/16 , C07C2103/18 , C07C2103/32
摘要： The present invention relates to tricyclic compounds represented by general formula (I) which are useful as therapeutic agents for urinary incontinence: ##STR1## wherein R.sup.1 represents hydrogen and the like; --X.sup.1 --X.sup.2 --X.sup.3 -- represents --CR.sup.2 .dbd.CR.sup.3 --CR.sup.4 .dbd.CR.sup.5 -- (wherein R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represent hydrogen and the like) and the like; and Y represents --CH.sub.2 O-- and the like.
摘要翻译： PCT No.PCT / JP96 / 02997 Sec。 371日期：1997年6月6日 102（e）日期1996年6月6日PCT PCT 1996年10月16日PCT公布。公开号WO97 / 14672 日期：1997年04月24日本发明涉及可用作尿失禁治疗剂的通式（I）表示的三环化合物：其中R1表示氢等; -X1-X2-X3-表示-CR2 = CR3-CR4 = CR5-（其中R2，R3，R4和R5表示氢等）等; Y表示-CH 2 O-等。

9. 发明授权

US5523464A Benzenesulfonamide derivatives 失效
标题翻译：苯磺酰胺衍生物
公开(公告)号：US5523464A
公开(公告)日：1996-06-04
申请号：US256232
申请日：1994-06-30
申请人： Iwao Kinoshita , Haruki Takai , Nobuo Kosaka , Katsura Sugawara , Akio Ishii , Hiroyuki Ishida , Katsushige Gomi
发明人： Iwao Kinoshita , Haruki Takai , Nobuo Kosaka , Katsura Sugawara , Akio Ishii , Hiroyuki Ishida , Katsushige Gomi
IPC分类号： C07D211/06 , A61K31/18 , C07C311/29 , C07C323/49 , C07D211/10 , C07D211/58 , C07D211/96 , C07D241/04 , C07D277/46 , C07D277/48 , C07D277/52 , C07D295/22 , C07D295/26 , C07D295/28
CPC分类号： C07C323/49 , C07C311/29 , C07D211/58 , C07D277/46 , C07D295/26 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： The present invention relates to benzenesulfonamide derivatives represented by Formula (I): ##STR1## in which R.sup.1 and R.sup.2 independently represent hydrogen or lower alkanoyl; and R.sup.3 and R.sup.4 independently represent hydrogen, lower alkyl, cycloalkyl, substituted or unsubstituted polycycloalkyl, substituted aryl, or a substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted aliphatic heterocyclic group, or a pharmaceutically acceptable salt thereof. The derivatives are useful as therapeutic agents for osteoporosis.
摘要翻译： PCT No.PCT / JP92 / 01429 Sec。 371日期1994年1月30日 102（e）日期1994年1月30日PCT 1991年11月5日PCT公布。公开号WO94 / 10135 本发明涉及由式（I）表示的苯磺酰胺衍生物：本发明的氢或低级烷酰基; 并且R 3和R 4独立地表示氢，低级烷基，环烷基，取代或未取代的多环烷基，取代的芳基或取代或未取代的杂环基，或者R 3和R 4与相邻的氮原子一起形成取代或未取代的脂族杂环基，或其药学上可接受的盐。该衍生物可用作骨质疏松症的治疗剂。

10. 发明授权

US5413997A Triphenylmethane derivatives 失效
标题翻译：三苯甲烷衍生物
公开(公告)号：US5413997A
公开(公告)日：1995-05-09
申请号：US7104
申请日：1993-01-21
申请人： Iwao Kinoshita , Daisuke Machii , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Katsuichi Shuto , Katsushige Gomi , Makoto Morimoto , Akio Ishii
发明人： Iwao Kinoshita , Daisuke Machii , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Katsuichi Shuto , Katsushige Gomi , Makoto Morimoto , Akio Ishii
IPC分类号： A61K31/09 , A61K31/135 , A61K31/165 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/472 , A61P3/00 , A61P9/00 , A61P19/10 , C07C217/58 , C07C217/60 , C07C233/11 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/65 , C07C233/75 , C07C235/44 , C07C235/46 , C07C235/54 , C07C235/56 , C07C235/64 , C07C237/32 , C07C237/40 , C07C323/42 , C07D207/09 , C07D211/58 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/06 , C07D217/04 , C07D221/20 , C07D223/20 , C07D225/08 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/82 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/205 , C07D307/00 , C07D311/00 , C07D333/20 , C07D333/38 , C07D401/04 , C07D413/04 , A01N43/00 , A01N33/02 , A01N43/40 , A01N43/62 , C07C43/21 , C07C211/45 , C07C229/42 , C07D215/28 , C07D215/36 , C07D215/38
CPC分类号： C07D213/75 , C07C217/58 , C07C217/60 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/44 , C07C235/56 , C07C235/64 , C07C237/40 , C07C323/42 , C07D211/58 , C07D213/74 , C07D215/06 , C07D217/04 , C07D221/20 , C07D225/08 , C07D277/46 , C07D277/82 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/205 , C07D307/00 , C07D333/20 , C07D333/38 , C07D413/04 , C07C2101/02 , C07C2101/08 , C07C2101/18 , C07C2102/08 , C07C2102/42 , C07C2103/18 , C07C2103/74
摘要： A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.
摘要翻译：由以下通式表示的三苯甲烷衍生物：表现出骨吸收抑制作用，可用作治疗骨质疏松症的药物。

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