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1. 发明授权

US5726325A Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US5726325A
公开(公告)日：1998-03-10
申请号：US849399
申请日：1997-06-06
申请人： Makoto Yoshida , Shin-ichi Sasaki , Shigeru Aono , Shigeki Fujiwara , Haruki Takai , Tsuyoshi Yamagata , Ken Nagashima , Akira Karasawa
发明人： Makoto Yoshida , Shin-ichi Sasaki , Shigeru Aono , Shigeki Fujiwara , Haruki Takai , Tsuyoshi Yamagata , Ken Nagashima , Akira Karasawa
IPC分类号： C07C235/16 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D313/02
CPC分类号： C07D491/04 , C07C235/16 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D493/04 , C07D495/04 , C07C2103/16 , C07C2103/18 , C07C2103/32
摘要： The present invention relates to tricyclic compounds represented by general formula (I) which are useful as therapeutic agents for urinary incontinence: ##STR1## wherein R.sup.1 represents hydrogen and the like; --X.sup.1 --X.sup.2 --X.sup.3 -- represents --CR.sup.2 .dbd.CR.sup.3 --CR.sup.4 .dbd.CR.sup.5 -- (wherein R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represent hydrogen and the like) and the like; and Y represents --CH.sub.2 O-- and the like.
摘要翻译： PCT No.PCT / JP96 / 02997 Sec。 371日期：1997年6月6日 102（e）日期1996年6月6日PCT PCT 1996年10月16日PCT公布。公开号WO97 / 14672 日期：1997年04月24日本发明涉及可用作尿失禁治疗剂的通式（I）表示的三环化合物：其中R1表示氢等; -X1-X2-X3-表示-CR2 = CR3-CR4 = CR5-（其中R2，R3，R4和R5表示氢等）等; Y表示-CH 2 O-等。

2. 发明授权

US5523464A Benzenesulfonamide derivatives 失效
标题翻译：苯磺酰胺衍生物
公开(公告)号：US5523464A
公开(公告)日：1996-06-04
申请号：US256232
申请日：1994-06-30
申请人： Iwao Kinoshita , Haruki Takai , Nobuo Kosaka , Katsura Sugawara , Akio Ishii , Hiroyuki Ishida , Katsushige Gomi
发明人： Iwao Kinoshita , Haruki Takai , Nobuo Kosaka , Katsura Sugawara , Akio Ishii , Hiroyuki Ishida , Katsushige Gomi
IPC分类号： C07D211/06 , A61K31/18 , C07C311/29 , C07C323/49 , C07D211/10 , C07D211/58 , C07D211/96 , C07D241/04 , C07D277/46 , C07D277/48 , C07D277/52 , C07D295/22 , C07D295/26 , C07D295/28
CPC分类号： C07C323/49 , C07C311/29 , C07D211/58 , C07D277/46 , C07D295/26 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： The present invention relates to benzenesulfonamide derivatives represented by Formula (I): ##STR1## in which R.sup.1 and R.sup.2 independently represent hydrogen or lower alkanoyl; and R.sup.3 and R.sup.4 independently represent hydrogen, lower alkyl, cycloalkyl, substituted or unsubstituted polycycloalkyl, substituted aryl, or a substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted aliphatic heterocyclic group, or a pharmaceutically acceptable salt thereof. The derivatives are useful as therapeutic agents for osteoporosis.
摘要翻译： PCT No.PCT / JP92 / 01429 Sec。 371日期1994年1月30日 102（e）日期1994年1月30日PCT 1991年11月5日PCT公布。公开号WO94 / 10135 本发明涉及由式（I）表示的苯磺酰胺衍生物：本发明的氢或低级烷酰基; 并且R 3和R 4独立地表示氢，低级烷基，环烷基，取代或未取代的多环烷基，取代的芳基或取代或未取代的杂环基，或者R 3和R 4与相邻的氮原子一起形成取代或未取代的脂族杂环基，或其药学上可接受的盐。该衍生物可用作骨质疏松症的治疗剂。

3. 发明授权

US5413997A Triphenylmethane derivatives 失效
标题翻译：三苯甲烷衍生物
公开(公告)号：US5413997A
公开(公告)日：1995-05-09
申请号：US7104
申请日：1993-01-21
申请人： Iwao Kinoshita , Daisuke Machii , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Katsuichi Shuto , Katsushige Gomi , Makoto Morimoto , Akio Ishii
发明人： Iwao Kinoshita , Daisuke Machii , Yasuo Onoda , Haruki Takai , Nobuo Kosaka , Katsuichi Shuto , Katsushige Gomi , Makoto Morimoto , Akio Ishii
IPC分类号： A61K31/09 , A61K31/135 , A61K31/165 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/472 , A61P3/00 , A61P9/00 , A61P19/10 , C07C217/58 , C07C217/60 , C07C233/11 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/65 , C07C233/75 , C07C235/44 , C07C235/46 , C07C235/54 , C07C235/56 , C07C235/64 , C07C237/32 , C07C237/40 , C07C323/42 , C07D207/09 , C07D211/58 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/06 , C07D217/04 , C07D221/20 , C07D223/20 , C07D225/08 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/82 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/205 , C07D307/00 , C07D311/00 , C07D333/20 , C07D333/38 , C07D401/04 , C07D413/04 , A01N43/00 , A01N33/02 , A01N43/40 , A01N43/62 , C07C43/21 , C07C211/45 , C07C229/42 , C07D215/28 , C07D215/36 , C07D215/38
CPC分类号： C07D213/75 , C07C217/58 , C07C217/60 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/44 , C07C235/56 , C07C235/64 , C07C237/40 , C07C323/42 , C07D211/58 , C07D213/74 , C07D215/06 , C07D217/04 , C07D221/20 , C07D225/08 , C07D277/46 , C07D277/82 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/135 , C07D295/192 , C07D295/205 , C07D307/00 , C07D333/20 , C07D333/38 , C07D413/04 , C07C2101/02 , C07C2101/08 , C07C2101/18 , C07C2102/08 , C07C2102/42 , C07C2103/18 , C07C2103/74
摘要： A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.
摘要翻译：由以下通式表示的三苯甲烷衍生物：表现出骨吸收抑制作用，可用作治疗骨质疏松症的药物。

4. 发明授权

US4390536A Piperidine derivatives 失效
公开(公告)号：US4390536A
公开(公告)日：1983-06-28
申请号：US352762
申请日：1982-02-26
申请人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
发明人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
IPC分类号： C07D211/58 , C07D417/04 , A61K31/54
CPC分类号： C07D211/58
摘要： New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.

5. 发明授权

US4344945A Piperidine derivatives 失效
标题翻译：哌啶衍生物
公开(公告)号：US4344945A
公开(公告)日：1982-08-17
申请号：US241727
申请日：1981-03-09
申请人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
发明人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
IPC分类号： C07D211/58 , C07D413/04 , A61K31/445 , A61K31/535 , C07D498/14
CPC分类号： C07D211/58
摘要： New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
摘要翻译：制备具有有用药理活性如降血压活性的新的哌啶衍生物。

6. 发明授权

US06211227B1 Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US06211227B1
公开(公告)日：2001-04-03
申请号：US09417626
申请日：1999-10-14
申请人： Makoto Yoshida , Takashi Seishi , Shigeru Aono , Tsuyoshi Yamagata , Kaoru Atsuki , Toshiaki Kumazawa , Haruki Takai , Koji Suzuki , Akira Karasawa
发明人： Makoto Yoshida , Takashi Seishi , Shigeru Aono , Tsuyoshi Yamagata , Kaoru Atsuki , Toshiaki Kumazawa , Haruki Takai , Koji Suzuki , Akira Karasawa
IPC分类号： A61K3138
CPC分类号： C07D495/04 , C07D313/12 , C07D337/12
摘要： The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I): (wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; X1—X2—X3 represents CR5═CR6—CR7═CR8 (wherein R5, R6, R7 and R8, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, hydroxy, substituted or unsubstituted lower alkoxy, etc.), N(O)m═CR5—CR6═CR7 (wherein R5, R6 and R7 have the same significances as defined above, and m represents 0 or 1), S—CR7═CR8 (wherein R7 and R8 have the same significances as defined above), etc.; and when R2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, a substituted or unsubstituted N-substituted heterocyclic group, (wherein n is 0 or 1; R3 and R4, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, trifluoromethyl, etc., or R3 and R4 may be combined together to form cyclic alkyl; and Q represents hydroxy, halogen, etc.), etc., Y represents —CH2SO2—, —SCH2—, —SOCH2—, —SO2CH2—, etc.) and pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供可用于治疗尿频和尿失禁的三环化合物，其由通式（I）表示：其中R 1表示氢，取代或未取代的低级烷基等; X 1 -X 2 -X 3表示CR 5 = CR6-CR7 = CR8（其中R5，R6，R7和R8可以相同或不同，各自表示氢，取代或未取代的低级烷基，羟基，取代或未取代的低级烷氧基等），N（O）m = CR5-CR6 = CR7（其中R5，R6和R7具有与上述相同的含义，m表示0或1），S-CR 7 = CR 8（其中R 7和R 8具有与上述相同的含义）等 ;当R 2表示氢时，取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的N-取代的杂环基，（其中n为0或1; R 3和R 4各自可相同或不同）代表氢，取代或未取代的低级烷基，三氟甲基脲基甲基等，或者R 3和R 4可以组合在一起形成环烷基; 和Q表示羟基，卤素等）等，Y表示-CH 2 SO 2 - ， - CH 2 - ， - SOCH 2 - ， - SO 2 CH 2 - 等）及其药学上可接受的盐。

7. 发明授权

US5648353A Quinazolines and phthalazines having adenosine uptake inhibitor activity 失效
标题翻译：喹唑啉和具有腺苷摄取抑制剂活性的酞嗪酮
公开(公告)号：US5648353A
公开(公告)日：1997-07-15
申请号：US446235
申请日：1995-05-22
申请人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
发明人： Shigeki Fujiwara , Daisuke Machii , Haruki Takai , Hiromi Nonaka , Hiroshi Kase , Kozo Yao , Michiyo Kawakage , Hideaki Kusaka , Akira Karasawa
IPC分类号： C07D401/14 , C07D491/04 , C07D401/04 , A61K31/445 , A61K31/50 , A61K31/505
CPC分类号： C07D401/14 , C07D491/04
摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物：（I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

8. 发明授权

US4833674A Arrangement for processing received data in TDMA communications system and method therefor a TDMA communications system and method for retrieving received data in a preset order 失效
标题翻译：用于处理TDMA通信系统中的接收数据的装置及其方法，用于以预设顺序检索接收到的数据的TDMA通信系统和方法
公开(公告)号：US4833674A
公开(公告)日：1989-05-23
申请号：US790049
申请日：1985-10-22
申请人： Haruki Takai , Mikio Ujiie
发明人： Haruki Takai , Mikio Ujiie
IPC分类号： H04J3/14 , H04B7/15 , H04B7/212
CPC分类号： H04B7/212
摘要： In order to process data transmitted from a plurality of earth stations in a TDMA communications system with high speed, the data transmitted chronologically over a multiframe and written into a first memory according to first discriminating signals in a manner as to be grouped with respect to the earth stations, are then read out from the first memory according to second discriminating signals stored in a second memory irrespective of the received order. The data read out from the first memory are arranged in a manner as to be processed with ease in the subsequent unit.
摘要翻译：为了处理从TDMA通信系统中的多个地球站以高速发送的数据，数据按时间顺序在多帧上传输，并根据第一鉴别信号被写入第一存储器，以便相对于地球站然后根据存储在第二存储器中的第二鉴别信号从第一存储器中读出，而不管接收到的顺序如何。从第一存储器读出的数据以随后单元容易地处理的方式排列。

9. 发明授权

US4668683A Cardiotonic quinazoline derivatives 失效
标题翻译：强心喹唑啉衍生物
公开(公告)号：US4668683A
公开(公告)日：1987-05-26
申请号：US841656
申请日：1986-03-20
申请人： Haruki Takai , Yuji Nomoto , Tadashi Hirata , Tetsuji Ohno , Kazuhiro Kubo
发明人： Haruki Takai , Yuji Nomoto , Tadashi Hirata , Tetsuji Ohno , Kazuhiro Kubo
IPC分类号： A61K31/505 , A61P9/04 , C07D401/14 , C07D487/04 , C07D403/14
CPC分类号： C07D401/14 , C07D487/04
摘要： Quinazoline derivatives and their pharmaceutically acceptable acid addition salts having the general formula ##STR1## wherein R.sup.1 and R.sup.2 each represents hydrogen or alkyl;R.sup.3 represents alkyl or substituted alkyl;R.sup.7 and R.sup.8 each represent alkoxy;Z is oxygen or sulfur;m is zero or 1;n is zero or an integer from 1 to 5,exhibit a cardiotonic activity with little tendency to cause tachycardia.
摘要翻译：喹唑啉衍生物及其药学上可接受的具有通式（I）的酸加成盐，其中R 1和R 2各自代表氢或烷基; R3表示烷基或取代的烷基; R7和R8各自表示烷氧基; Z是氧或硫; m为零或1; n为零或1至5的整数，表现出强心剂活性，几乎不引起心动过速。

10. 发明授权

US4004162A Clock signal reproducing network for PCM signal reception 失效
标题翻译：用于PCM信号接收的时钟信号再现网络
公开(公告)号：US4004162A
公开(公告)日：1977-01-18
申请号：US651369
申请日：1976-01-22
申请人： Kotaro Kato , Haruki Takai
发明人： Kotaro Kato , Haruki Takai
IPC分类号： H04L1/00 , H03K3/86 , H03K5/00 , H03L7/00 , H03L7/06 , H04B7/155 , H04J3/06 , H04L5/22 , H04L7/02 , H04L7/027 , H03K3/78
CPC分类号： H04L7/027
摘要： A clock signal reproducing network for PCM signal reception is capable of reproducing a clock signal even if the clock component is absent in the input digital signal for a prolonged period of time. The network includes a clock signal component extracting circuit and a bandpass filter for extracting and band-limiting the clock signal component in a received digital signal. An envelope detection circuit and a level decision circuit are connected to receive the output of the bandpass filter to provide a control signal to an output switching circuit. When the amplitude of the envelope of the filter output is high, the output of the bandpass filter is used directly as a reproduced clock signal. When the amplitude of the envelope is low, the clock signal obtained immediately before the filter amplitude becomes small is derived repeatedly from a delay circuit as a substituted clock signal.
摘要翻译：即使长时间在输入数字信号中不存在时钟分量，用于PCM信号接收的时钟信号再现网络能够再现时钟信号。网络包括时钟信号分量提取电路和带通滤波器，用于提取和限制接收的数字信号中的时钟信号分量。连接包络检测电路和电平判定电路以接收带通滤波器的输出以向输出开关电路提供控制信号。当滤波器输出的包络的幅度高时，带通滤波器的输出被直接用作再现的时钟信号。当包络的振幅低时，紧接在滤波器幅度变小之前获得的时钟信号作为替代时钟信号从延迟电路重复地导出。

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