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1. 发明专利

AU8999098A Transporter genes 未知
公开(公告)号：AU8999098A
公开(公告)日：1999-03-29
申请号：AU8999098
申请日：1998-09-07
申请人： AKIRA TSUJI , CHUGAI PHARMACEUTICAL CO LTD
发明人： NEZU JUN-ICHI , OKU ASUKA
IPC分类号： C07K14/47 , C12N15/12 , C07K16/18 , C12N5/10 , C12P21/02

2. 发明专利

JPS59137061A Removal of unpleasant odor generated from autoclave (automatic high pressure pasturizer) 失效
标题翻译：从AUTOCLAVE（自动高压过滤器）中除去不均匀的气味
公开(公告)号：JPS59137061A
公开(公告)日：1984-08-06
申请号：JP1214983
申请日：1983-01-27
申请人： Akira Tsuji
发明人： TSUJI AKIRA , USHIO SHIYOUZOU
IPC分类号： A61L2/06 , A61L9/00

3. 发明专利

JP2010280705A Agent for improving proton-driven transporter-mediated gastrointestinal absorption, and method for production thereof 审中-公开
标题翻译：用于改进驱动型运输机介质吸收式吸收剂的试剂及其生产方法
公开(公告)号：JP2010280705A
公开(公告)日：2010-12-16
申请号：JP2010181074
申请日：2010-08-12
申请人： Otsuka Pharmaceut Co Ltd , Akira Tsuji , 大塚製薬株式会社 , 彰辻
发明人： TSUJI AKIRA , TAMAI IKUMI , SAI YOSHIMICHI , KOTOMI MASAAKI , TOYOFUKU SHUICHI
IPC分类号： A61K45/08 , A61K31/545 , A61K31/546 , A61K47/32 , A61K47/38 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00
CPC分类号： A61K47/32 , A61K9/0053 , A61K9/08 , A61K31/545 , A61K31/546
摘要： PROBLEM TO BE SOLVED: To provide a medicinal preparation which improves the absorption of a medicinal compound in a digestive tract to give such a concentration in blood as potentially achieving a sufficient therapeutic effect in oral administration or the like, and to provide a method for production thereof. SOLUTION: The medicinal preparation showing excellent gastrointestinal absorption contains a compound which is recognized by a proton-driven transporter and a pH-sensitive polymer, wherein the pH-sensitive polymer is contained in an amount sufficient for controlling the pH value in the digestive tract to the optimum level for the uptake of the compound into cells by the proton-driven transporter. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种药物制剂，其可改善消化道中的药物化合物的吸收，从而在血液中提供如在口服给药等方面具有充分治疗效果的浓度，并提供生产方法。解决方案：显示出优异胃肠道吸收的药物制剂含有由质子驱动的转运蛋白和pH敏感性聚合物识别的化合物，其中pH敏感性聚合物的含量足以控制pH值在消化道达到由质子驱动转运体吸收化合物进入细胞的最佳水平。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2014083774A Laminated lumber utilizing bamboo 审中-公开
标题翻译： LAMINATED LUMBER使用BAMBOO
公开(公告)号：JP2014083774A
公开(公告)日：2014-05-12
申请号：JP2012234882
申请日：2012-10-24
申请人： Akira Tsuji , 晶辻 , Technote Co Ltd , 株式会社テクノート
发明人： TSUJI AKIRA
IPC分类号： B27J1/00 , B27K9/00 , B27M3/00
摘要： PROBLEM TO BE SOLVED: To provide a new method for manufacturing bamboo laminated lumber, which is intended as a construction material, a vehicular material, and a furniture material etc. and is manufactured from a raw material made by processing bamboo to have a cross section of a fixed size, under present circumstances in which it is hard to obtain naturally growing bamboo having a material of a fixed size, in which it is difficult to utilize bamboo as it is due to differences in size and thickness, curvature and flatness of the material, etc., and in which utilization of bamboo in advanced countries has declined and bamboo is seldom used.SOLUTION: Round bamboo is subjected to a cutting process in a fiber direction to have a fixed width in order to obtain rod-like split bamboo, which is processed so that its one face has a flat plane and so that two inclined planes form a fixed angle with a flat-surface from both end faces in a width direction of the flat plane toward an inner side, and thereby a rod-like bamboo material is produced. The inclined planes are joined together and glued to be laminated in order to compose bamboo laminated lumber having a rod-like shape with a polygonal cross section or a tubular shape. Further, bamboo laminated lumber having a cross section of a fixed size is provided that is composed by using the bamboo laminated lumber having the rod-like shape or the tubular shape as a base unit and integrating a plurality of the base units.
摘要翻译：要解决的问题：提供一种用于制造作为建筑材料，车辆材料和家具材料等的竹材层压木材的新方法，并且由通过加工竹制成的原材料制成具有横截面在目前的情况下，难以获得具有固定尺寸的材料的自然生长的竹子，其中由于尺寸和厚度，曲率和平坦度的差异而难以利用竹子是困难的。材料等，先进国家的竹子利用率下降，竹子很少使用。解决方案：圆竹在纤维方向上进行切割加工，以固定宽度，以获得棒状分裂竹被处理成使得其一个面具有平坦平面，并且使得两个倾斜平面在平面的宽度方向上朝向内侧的两个端面与平坦表面形成固定角度，从而产生棒状竹材料。倾斜平面接合在一起并粘合以层压以便组成具有多边形横截面或管状形状的棒状形状的竹层压木材。此外，提供了具有固定尺寸的横截面的竹层压板，其通过使用具有杆状或管状的竹层压板作为基座单元并且整合多个基座单元。

5. 发明专利

JP2011015694A Transporter gene oatp-b, c, d, and e 有权
标题翻译：运输基因OATP-B，C，D和E
公开(公告)号：JP2011015694A
公开(公告)日：2011-01-27
申请号：JP2010197853
申请日：2010-09-03
申请人： Chugai Pharmaceut Co Ltd , Akira Tsuji , 中外製薬株式会社 , 彰辻
发明人： NEZU JUNICHI , OSE ASUKA , TSUJI AKIRA
IPC分类号： C12N15/09 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/02 , C12Q1/68
CPC分类号： C07K14/47 , C07K14/705 , C12Q1/6883
摘要： PROBLEM TO BE SOLVED: To provide new transporter genes belonging to OATP family, proteins encoded by the genes and uses thereof.SOLUTION: Four new transporter genes are successfully cloned by screening new transporter genes based on the human OATP transporter gene sequence. These transporters are useful in the development of drugs by taking advantage of the transportation activity to biological substances and various drugs. It is also found that these transporter genes have single nucleotide polymorphisms (SNP). Gene diagnosis based on the polymorphisms (such as SNP) in these transporter genes enables one to judge, for example, the efficacy of a drug therapy.
摘要翻译：要解决的问题：提供属于OATP家族的新的转运蛋白基因，由该基因编码的蛋白质及其用途。解决方案：通过基于人OATP转运蛋白基因序列筛选新的转运蛋白基因，成功克隆了四种新的转运蛋白基因。这些转运蛋白通过利用生物物质和各种药物的运输活动来发挥药物的作用。还发现这些转运蛋白基因具有单核苷酸多态性（SNP）。基于这些转运蛋白基因多态性（例如SNP）的基因诊断使得人们能够判断药物疗法的功效。

6. 发明授权

US10412001B2 Communication terminal, communication method, and program 有权
公开(公告)号：US10412001B2
公开(公告)日：2019-09-10
申请号：US14346952
申请日：2012-09-06
申请人： Takahiro Iihoshi , Shuichi Karino , Akira Tsuji
发明人： Takahiro Iihoshi , Shuichi Karino , Akira Tsuji
IPC分类号： H04L12/721 , H04L12/717 , H04W24/08
摘要： The communication terminal of the present invention, which is controlled by a control device, includes a first storage means for associating information identifying a packet with processing of the packet and storing it as an entry, a searching means for searching processing corresponding to a received packet from the first storage means, and an inquiry means for determining the control device of which is inquired, based on the entry corresponding to the received packet, the entry being stored in the first storage means, if the searched processing is the inquiry to the control device, and for performing the inquiry addressed to the determined control device.

7. 发明申请

US20090220967A1 Systemic Carnitine Deficiency Gene and Uses Thereof 审中-公开
标题翻译：全身性肉碱缺乏基因及其用途
公开(公告)号：US20090220967A1
公开(公告)日：2009-09-03
申请号：US12193654
申请日：2008-08-18
申请人： Jun-Ichi Nezu , Akira Tsuji , Asuka Ose
发明人： Jun-Ichi Nezu , Akira Tsuji , Asuka Ose
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/566 , G01N33/68 , C12Q1/02 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/47 , Y10T436/143333
摘要： The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2 gene and its protein.
摘要翻译：发现引起全身肉碱缺乏的基因是涉及有机阳离子运输的OCTN2基因。本发明能够通过检测OCTN2基因是否具有突变来测试该疾病。此外，可以使用正常的OCTN2基因及其蛋白质治疗系统性肉碱缺乏症。

8. 发明申请

US20080119568A1 Gastrointestinal Absorption Enhancer Mediated By Proton-Coupled Transporter and Its Preparing Method 审中-公开
标题翻译：通过质子耦合转运体介导的胃肠吸收增强剂及其制备方法
公开(公告)号：US20080119568A1
公开(公告)日：2008-05-22
申请号：US11971243
申请日：2008-01-09
申请人： Akira TSUJI , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
发明人： Akira TSUJI , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
IPC分类号： A61K47/30
CPC分类号： A61K47/32 , A61K9/0053 , A61K9/08 , A61K31/545 , A61K31/546
摘要： The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.
摘要翻译：本发明提供了一种药物制剂，其可以改善胃肠道中药物化合物的吸收，并且通过口服给药或类似方法提供预期足够的补救效果的血液浓度，以及制备这种制剂的方法。本发明涉及显示出优异的胃肠吸收能力的药物制剂，其包含由质子偶联转运蛋白识别的化合物和pH敏感性聚合物，其量足以使胃肠道获得质子偶联转运蛋白最佳地吸收复合成细胞。

9. 再颁专利

USRE37179E1 Radiation sensitive resin composition 有权
标题翻译：辐射敏感树脂组合物
公开(公告)号：USRE37179E1
公开(公告)日：2001-05-15
申请号：US09420604
申请日：1999-10-21
申请人： Mikio Yamachika , Eiichi Kobayashi , Akira Tsuji , Toshiyuki Ota
发明人： Mikio Yamachika , Eiichi Kobayashi , Akira Tsuji , Toshiyuki Ota
IPC分类号： G03F7023
CPC分类号： G03F7/0045 , G03F7/039 , Y10S430/106 , Y10S430/11 , Y10S430/111
摘要： A radiation sensitive resin composition which comprises (A) a polymer which becomes alkali-soluble in the presence of an acid and (B) a radiation sensitive acid generator which generates an acid upon irradiation with a radiation, said polymer (A) comprising two recurring units represented by the general formulas (1) and (2) and a recurring unit which acts to reduce the solubility of the polymer is an alkali developer after the irradiation: wherein R1 represents a hydrogen atom or a methyl group and R2 represents a hydrogen atom or a methyl group. Said composition provides a chemically amplified positive resist which can give a fine pattern with a good pattern shape, and said resist is freed from volume shrinkage, peeling failure and adhesive failure, is excellent in dry etching resistance and effectively reacts with various radiations to give a good pattern shape which is excellent in photolithographic process stability, said pattern shape having no thinned portion at the upper part.
摘要翻译：一种辐射敏感性树脂组合物，其包含（A）在酸存在下变为碱溶性的聚合物和（B）辐射敏感的酸产生剂，其在辐射时产生酸，所述聚合物（A）包含两个重复由通式（1）和（2）表示的单元和降低聚合物溶解度的重复单元是照射后的碱显影剂：其中R1表示氢原子或甲基，R2表示氢原子或甲基。所述组合物提供化学放大的正性抗蚀剂，其可以产生具有良好图案形状的精细图案，并且所述抗蚀剂没有体积收缩，剥离破坏和粘合剂破坏，具有优异的耐干蚀刻性，并且与各种辐射有效反应以产生良好的图案形状，其光刻工艺稳定性优异，所述图案形状在上部没有变薄部分。

10. 发明授权

US6007961A Radiation-sensitive resin composition 失效
标题翻译：辐射敏感树脂组合物
公开(公告)号：US6007961A
公开(公告)日：1999-12-28
申请号：US988068
申请日：1997-12-10
申请人： Katsumi Inomata , Masahiro Akiyama , Shin-ichiro Iwanaga , Akira Tsuji
发明人： Katsumi Inomata , Masahiro Akiyama , Shin-ichiro Iwanaga , Akira Tsuji
IPC分类号： G03F7/022 , G03F7/023 , G03F7/30
CPC分类号： G03F7/022
摘要： A radiation-sensitive resin composition including an alkali soluble resin and a quinonediazide compound is provided. The quinonediazide compound has the formula (1), for example: ##STR1## wherein, R.sup.1 to R.sup.6 are an alkyl, cycloalkyl or aryl group; a and b are an integer of 1 to 3; D.sup.1 and D.sup.2 are independently a hydrogen atom or a 1,2-quinonediazidosulfonyl group, provided that at least one of D.sup.1 is a 1,2-quinonediazidosulfonyl group; A is a bonding such as single bond; and x and y are an integer of 0 to 2. The composition is suitable as a positive resist, which effectively restrains the occurrence of scum, and excellent in developability, pattern shape, sensitivity, resolution and focus latitude.
摘要翻译：提供了包含碱溶性树脂和醌二叠氮化合物的辐射敏感性树脂组合物。醌二叠氮化合物具有式（1），例如：其中，R 1至R 6为烷基，环烷基或芳基; a和b为1〜3的整数， D1和D2独立地为氢原子或1,2-醌二叠氮基磺酰基，条件是D1中的至少一个为1,2-醌二叠氮基磺酰基; A是单键键合; x和y为0〜2的整数。该组合物适合作为正性抗蚀剂，其有效地抑制浮渣的发生，显影性，图案形状，灵敏度，分辨率和聚焦纬度优异。

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