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1. 发明授权

US06639103B1 3-oxopropane-1-sulphonic acids and sulphonates 失效
标题翻译： 3-氧代丙烷-1-磺酸和磺酸盐
公开(公告)号：US06639103B1
公开(公告)日：2003-10-28
申请号：US10069167
申请日：2002-07-16
申请人： Hans Wijnberg , Kees Pouwer , Jose Nieuwenhuijzen , Ton Rene Vries
发明人： Hans Wijnberg , Kees Pouwer , Jose Nieuwenhuijzen , Ton Rene Vries
IPC分类号： C07C30900
CPC分类号： C07C309/24 , C07B57/00 , C07B2200/07
摘要： The invention relates to 1,3-disubstituted-3-oxopropane-1-sulfonic acids and sulfonates and enantiomerically inriched forms thereof. The invention further relates to the use of these enantiomerically inriched compounds to resolve mixtures of enantiomers, in particular mixtures of enantiomers of amino-functionalized compounds.
摘要翻译：本发明涉及1,3-二取代-3-氧代丙烷-1-磺酸和磺酸盐及其对映异构体形式。本发明还涉及这些对映体富集的化合物用于分解对映异构体的混合物，特别是氨基官能化化合物的对映异构体的混合物的用途。

2. 发明授权

US06294680B1 Process for the production of semi synthetic statins via novel intermediates 失效
标题翻译：通过新型中间体生产半合成他汀类药物的方法
公开(公告)号：US06294680B1
公开(公告)日：2001-09-25
申请号：US09341809
申请日：2000-01-05
申请人： Ton Rene Vries , Hans Wijnberg , Wijnand Sjourd Faber , Venetka Ivanova Kalkman-Agayn , Mieke Ivanova Sibeyn
发明人： Ton Rene Vries , Hans Wijnberg , Wijnand Sjourd Faber , Venetka Ivanova Kalkman-Agayn , Mieke Ivanova Sibeyn
IPC分类号： C07D31906
CPC分类号： C07F5/025 , C07D309/30 , C07F9/65742
摘要： A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared during said process, has been provided.
摘要翻译：已经提供了一种制备半合成他汀类药物的方法，例如具有高产率的辛伐他汀，另一种他汀类药物，优选天然的他汀类药物，如洛伐他汀。还提供了在所述方法期间制备的许多新型中间体化合物。

3. 发明授权

US5919951A Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound used therein 失效
公开(公告)号：US5919951A
公开(公告)日：1999-07-06
申请号：US158630
申请日：1998-09-22
申请人： Knut H. Chmii , Adam R. Brown , Dagobert M. De Leeuw , Edsko E. Havinga , Anita Pomp , Wolter Ten Hoeve , Hans Wijnberg
发明人： Knut H. Chmii , Adam R. Brown , Dagobert M. De Leeuw , Edsko E. Havinga , Anita Pomp , Wolter Ten Hoeve , Hans Wijnberg
IPC分类号： C08G61/12 , C07D409/14
CPC分类号： C08G61/126
摘要： The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.

4. 发明授权

US5380807A Electrically conductive alternating copolymer and method of preparing such a copolymer 失效
标题翻译：导电交替共聚物和制备这种共聚物的方法
公开(公告)号：US5380807A
公开(公告)日：1995-01-10
申请号：US2432
申请日：1993-01-08
申请人： Edsko E. Havinga , Wolter Ten Hoeve , Hans Wijnberg
发明人： Edsko E. Havinga , Wolter Ten Hoeve , Hans Wijnberg
IPC分类号： C08G61/10 , C08G61/12 , C08G73/06 , H01B1/12 , C08G16/00 , C08G12/00
CPC分类号： H01B1/127 , C08G61/12 , C08G73/0688 , H01B1/128
摘要： Polycondensation of, for example, squaric acid with a benzodihydropyrrole, benzodithiazole, neocuproine, terthienyl or an aromatic diamine gives a semiconductive alternating copolymer having a small band gap. It is alternatively possible to use croconic acid or 5,6-dihydroxy-5-cyclohexene-1,2,3,4-tetraone instead of squaric acid. An alternating copolymer of croconic acid and a methyl-substituted benzodithiazole has the following repetititve unit: ##STR1##
摘要翻译：例如，方酸与苯并二氢吡咯，苯并二噻唑，新亚甲基，三苯基或芳族二胺的缩聚得到具有小带隙的半导体交替共聚物。或者可以使用克罗酸或5,6-二羟基-5-环己烯-1,2,3,4-四酮代替方酸。克罗酸和甲基取代的苯并二噻唑的交替共聚物具有以下重复单元：

5. 发明授权

US06235927B1 Process for the separation of a mixture of enantiomers 失效
标题翻译：分离对映异构体混合物的方法
公开(公告)号：US06235927B1
公开(公告)日：2001-05-22
申请号：US08955612
申请日：1997-10-22
申请人： Ton R. Vries , Hans Wijnberg , Erik Van Echten , Lumbertus A. Hulshof , Quirinus B. Broxterman
发明人： Ton R. Vries , Hans Wijnberg , Erik Van Echten , Lumbertus A. Hulshof , Quirinus B. Broxterman
IPC分类号： C07B5500
CPC分类号： C07D295/023 , C07B57/00 , C07C51/487 , C07C209/80 , C07C213/10 , C07C227/34 , C07C253/34 , C07C2602/08 , C07F9/65742 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/44 , C07C215/50 , C07C229/34 , C07C229/36 , C07C255/42
摘要： A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process pets the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an onantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at lea one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.
摘要翻译：公开了通过分离对映异构体的方法获得的非对映异构体复合物，其中可快速进行分离，使得以高e.e。获得对映异构体。价值观。该方法可以分离其中使用多于一种拆分剂的对映异构体混合物，其中至少一种拆分剂是光学活性的，并且其产生含有至少两种旋光活性形式的拆分剂的非对映异构体复合物。该方法特别提供了具有至少三种化合物的非对映异构体复合物，其中至少两种化合物是旋光活性形式的拆分剂，并且至少一种化合物是光学活性形式的对映异构体。还提供了具有至少三种化合物的非对映异构体复合物，其中一种化合物是旋光活性形式的拆分剂，以及至少两种为光学活性形式的对映异构体的化合物。

6. 发明授权

US5232630A Method of manufacturing conductive heterocyclic polymers by reacting new polymeric intermediate products with NH.sub.3, a NH.sub.3 producing substance, P.sub.2 S.sub.5 or Lawesson's reagent 失效
标题翻译：通过用NH3，生成NH3的生物物质，P2S5或者LAWESSON的试剂反应新的聚合物中间产物来制造导电性杂环聚合物的方法
公开(公告)号：US5232630A
公开(公告)日：1993-08-03
申请号：US339439
申请日：1989-04-17
申请人： Kornelis L. Pouwer , Ton R. Vries , Egbert W. Meijer , Edsko E. Havinga , Hans Wijnberg
发明人： Kornelis L. Pouwer , Ton R. Vries , Egbert W. Meijer , Edsko E. Havinga , Hans Wijnberg
IPC分类号： C08G16/02 , C08G16/04 , C08G61/10 , C08G61/12
CPC分类号： C08G16/04 , C08G16/0231 , C08G61/123
摘要： The polymers are prepared by using the new intermediate product which forms a polymeric precursor, and which is converted into the desired heterocyclic polymer by ring closure.

7. 发明授权

US4814477A Dioxaphosphorinanes, their preparation and use for resolving optically active compounds 失效
标题翻译：二氧杂磷杂环丁烷，它们的制备和用于拆分光学活性化合物的用途
公开(公告)号：US4814477A
公开(公告)日：1989-03-21
申请号：US65121
申请日：1987-06-19
申请人： Hans Wijnberg , Wolter T. Hoeve
发明人： Hans Wijnberg , Wolter T. Hoeve
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07F9/6574 , C07F9/21
CPC分类号： C07F9/65744 , C07F9/65742
摘要： A new family of compounds known as dioxaphosphorinanes having the formula: ##STR1## wherein, M represents a hydrogen atom, a metal ion or an ammonium ion; R1 and R2, individually, represents a hydrogen atom, a halogen atom, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms or a nitro group or, together, represent a methylene dioxy group; and R3 and R4, individually, represents a halogen atom, an alkyl group having from 1 to 4 carbon atoms or a hydrogen atom so long as only one of the groups R3 and R4 represents a hydrogen atom or, together, represent a cyclohexyl group.A method for preparing these dioxaphosphorinanes by reacting phosphoryl chloride with a substituted 1-phenyl-1,3-dihydroxypropane is described. Also described is a method for resolving the new dioxaphosphorinanes into their optical isomers by reacting them with an optically active amino-compound. Similarly, a method for resolving the racemates of several amino-compounds, such as hydroxyphenylglycine and phenylalanine, into optically active isomers by reacting with a dioxaphosphorinane is described.
摘要翻译：已知为二氧杂磷杂环壬烷的新家族化合物，具有下式：其中M表示氢原子，金属离子或铵离子; R 1和R 2分别表示氢原子，卤素原子，具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基或硝基，或者一起表示亚甲基二氧基; R 3和R 4各自表示卤素原子，具有1至4个碳原子的烷基或氢原子，只要R3和R4中只有一个表示氢原子，或者一起代表环己基。描述了通过使磷酰氯与取代的1-苯基-1,3-二羟基丙烷反应来制备这些二氧杂磷杂环丁烷的方法。还描述了通过使它们与光学活性氨基化合物反应来将新的二氧杂磷杂环丁烷分解成它们的光学异构体的方法。类似地，描述了将几种氨基化合物如羟基苯基甘氨酸和苯丙氨酸的外消旋体与二氧杂磷杂环丁烷反应转化为旋光异构体的方法。

8. 发明授权

US06465684B2 Process for the separation of a mixture of enantiomers 失效
标题翻译：分离对映异构体混合物的方法
公开(公告)号：US06465684B2
公开(公告)日：2002-10-15
申请号：US09784083
申请日：2001-02-16
申请人： Ton R. Vries , Hans Wijnberg , Erik Van Echten , Lumbertus A. Hulshof , Quirinus B. Broxterman
发明人： Ton R. Vries , Hans Wijnberg , Erik Van Echten , Lumbertus A. Hulshof , Quirinus B. Broxterman
IPC分类号： C07C33100
CPC分类号： C07D295/023 , C07B57/00 , C07C51/487 , C07C209/80 , C07C213/10 , C07C227/34 , C07C253/34 , C07C2602/08 , C07F9/65742 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/44 , C07C215/50 , C07C229/34 , C07C229/36 , C07C255/42
摘要： A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process permits the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an enantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at least one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.
摘要翻译：公开了通过分离对映异构体的方法获得的非对映异构体复合物，其中可快速进行分离，使得以高e.e。获得对映异构体。价值观。该方法允许分离其中使用多于一种拆分剂的对映异构体的混合物，其中至少一种拆分剂是光学活性的，并且其产生含有至少两种光学活性形式的拆分剂的非对映异构体复合物。该方法特别提供了具有至少三种化合物的非对映异构体复合物，其中至少两种化合物是旋光活性形式的拆分剂，并且至少一种化合物是光学活性形式的对映异构体。还提供了具有至少三种化合物的至少三种化合物的非对映异构体复合物，其中至少一种化合物是光学活性形式的拆分剂，以及至少两种是光学活性形式的对映异构体的化合物。

9. 发明授权

US06184540B2 Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound and use thereof for making semiconductor device 失效
标题翻译：制备含噻吩或呋喃的共轭化合物和前体化合物的方法及其制备半导体器件的用途
公开(公告)号：US06184540B2
公开(公告)日：2001-02-06
申请号：US09249968
申请日：1999-02-12
申请人： Knut H. Chmii , Adam R. Brown , Dagobert M. De Leeuw , Edsko E. Havinga , Anita Pomp , Wolter Ten Hoeve , Hans Wijnberg
发明人： Knut H. Chmii , Adam R. Brown , Dagobert M. De Leeuw , Edsko E. Havinga , Anita Pomp , Wolter Ten Hoeve , Hans Wijnberg
IPC分类号： C07D40714
CPC分类号： C07D409/14 , C07D333/34 , C08G61/125 , C08G61/126 , Y10T428/31533
摘要： The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.
摘要翻译：本发明涉及制备含噻吩或呋喃的共轭化合物如聚噻吩的方法。该方法使用具有四氢噻吩或具有芳硫基或烷硫基取代基的四氢呋喃前体单元的前体化合物。前体单元可以热转化成噻吩或呋喃单元。由于前体单元的存在，前体化合物是可溶的，并且可以与溶液中的相应的共轭化合物不同。

10. 发明授权

US6124475A Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound used therein 失效
标题翻译：制备含噻吩或呋喃的共轭化合物及其中使用的前体化合物的方法
公开(公告)号：US6124475A
公开(公告)日：2000-09-26
申请号：US39599
申请日：1998-03-16
申请人： Knut H. Chmil , Adam R. Brown , Dagobert M. De Leeuw , Edsko E. Havinga , Anita Pomp , Wolter Ten Hoeve , Hans Wijnberg
发明人： Knut H. Chmil , Adam R. Brown , Dagobert M. De Leeuw , Edsko E. Havinga , Anita Pomp , Wolter Ten Hoeve , Hans Wijnberg
IPC分类号： C07D333/34 , C07D409/14 , C08G61/12
CPC分类号： C07D409/14 , C07D333/34 , C08G61/125 , C08G61/126 , Y10T428/31533
摘要： The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.
摘要翻译：本发明涉及制备含噻吩或呋喃的共轭化合物如聚噻吩的方法。该方法使用具有四氢噻吩或具有芳硫基或烷硫基取代基的四氢呋喃前体单元的前体化合物。前体单元可以热转化成噻吩或呋喃单元。由于前体单元的存在，前体化合物是可溶的，并且可以与溶液中的相应的共轭化合物不同。

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