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1. 发明授权

US4845082A 3'4'-dideoxy-3'-fluorokanamycin B and production thereof 失效
标题翻译： 3'4'-二脱氧-3'-氟霉素B及其制备
公开(公告)号：US4845082A
公开(公告)日：1989-07-04
申请号：US899100
申请日：1986-08-22
申请人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Yoshihiko Kobayashi
发明人： Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya , Yoshihiko Kobayashi
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236
CPC分类号： C07H15/234 , Y02P20/55
摘要： New compound, 3',4'-dideoxy-3'-fluorokanamycin B is now provided, which is useful as antibacterial agent.3',4'-Dideoxy-3'-fluorokanamycin B is prepared by a process comprising halogenating an N,O-protected derivative of 3'-deoxy-3'-fluoro-4'-O-sulfonylkanamycin B with a metal halide, reducing the resulting 4'- halogenated 3'-deoxy-3'-fluorokanamycin B derivative to convert its 4'-halo group into a hydrogen atom, and thereby to produce an N,O-protected derivative of 3',4'-dideoxy-3'-fluorokanamycin B, and removing the remaining amino-protecting groups and the remaining hydroxyl-protecting groups from the reduction product by conventional deprotecting methods.
摘要翻译：现在提供新的化合物3'，4'-二脱氧-3'-氟卡那霉素B，其可用作抗菌剂。 3'，4'-二脱氧-3'-氟卡那霉素B通过包括用金属卤化物卤化3'-脱氧-3'-氟-4'-O-磺酰基卡那霉素B的N，O-保护的衍生物的方法制备，减少所得的4'-卤代3'-脱氧-3'-氟卡那霉素B衍生物以将其4'-卤基转化成氢原子，从而产生3'，4'-二脱氧的N，O-保护的衍生物 -3'-氟卡那霉素B，并通过常规去保护方法从还原产物中除去剩余的氨基保护基团和剩余的羟基保护基团。

2. 发明授权

US4873225A 1-n-(4-amino-3-fluoro-2-hydroxybutyryl)-kanamycins 失效
标题翻译： 1-正（4-氨基-3-氟-2-羟基丁酰） - 卡那霉素
公开(公告)号：US4873225A
公开(公告)日：1989-10-10
申请号：US158628
申请日：1988-02-22
申请人： Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Kazuo Umezawa , Yoshiaki Takahashi , Tetsuo Shitara , Yoshihiko Kobayashi , Yasushi Takagi
发明人： Sumio Umezawa , Tsutomu Tsuchiya , Tomio Takeuchi , Kazuo Umezawa , Yoshiaki Takahashi , Tetsuo Shitara , Yoshihiko Kobayashi , Yasushi Takagi
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236
CPC分类号： C07H15/234
摘要： As new compound are now provided ten compounds, namely 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}kanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxykanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-2',3'-dideoxy-2'-fluorokanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin A; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-kanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3'-deoxykanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3',4'-dideoxykanamycin B; 1-N-{(2R,3R) -4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin B; 1-N-{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3'-dideoxy-5-fluorokanamycin B; and 1-N{(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3',4'-trideoxy-5-fluorokanamycin B, which are all useful as antibacterial agent in the therapeutic treatment of bacterial infections.

3. 发明申请

US20080008221A1 SEMICONDUCTOR LASER DEVICE 有权
标题翻译：半导体激光器件
公开(公告)号：US20080008221A1
公开(公告)日：2008-01-10
申请号：US11769818
申请日：2007-06-28
申请人： Takashi Ueda , Koji Yamada , Tomoki Nozawa , Yoshihiko Kobayashi
发明人： Takashi Ueda , Koji Yamada , Tomoki Nozawa , Yoshihiko Kobayashi
IPC分类号： H01S5/026
CPC分类号： H01S5/0683 , H01L2224/45144 , H01L2224/48091 , H01S5/02252 , H01S5/02276 , H01L2924/00014 , H01L2924/00
摘要： A semiconductor laser device of the invention is provided with: a supporting substrate, on the surface of which there is formed a wiring pattern; a LD that is fixed on the surface of the supporting substrate and that has a signal output section that emits signal laser light and a monitoring output section that emits monitoring laser light; and a monitoring PD. The monitoring PD has: a semiconductor substrate having a region that transmits light of the wavelength of the monitoring laser light; and a light receiving section for photoelectric conversion formed on the surface of the semiconductor substrate, one incident surface of the side surfaces of the semiconductor substrate being arranged in a position to which the monitoring laser light can be made incident, the light receiving section being arranged in a position higher than the monitoring output section, and a back surface of the semiconductor substrate and the wiring pattern being fixed on the supporting substrate so as to oppose to each other.
摘要翻译：本发明的半导体激光装置设置有：支撑基板，其表面上形成有布线图案; 固定在支撑基板的表面上并且具有发射信号激光的信号输出部分和发出监视激光的监视输出部分的LD; 和监控PD。监视PD具有：具有透射监测激光的波长的光的区域的半导体衬底; 以及形成在所述半导体衬底的表面上的用于光电转换的光接收部分，所述半导体衬底的侧表面的一个入射表面被布置在可以使所述监控激光入射的位置，所述光接收部分被布置在比监视输出部分高的位置上，并且半导体衬底的背面和布线图案被固定在支撑衬底上以彼此相对。

4. 发明授权

US07143595B2 Supercritical refrigerant cycle system 有权
标题翻译：超临界制冷循环系统
公开(公告)号：US07143595B2
公开(公告)日：2006-12-05
申请号：US11029392
申请日：2005-01-06
申请人： Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
发明人： Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
IPC分类号： F25B49/02
CPC分类号： F25B9/008 , F25B2309/061 , F25B2600/21 , F25B2600/2513 , F25B2700/197 , F25B2700/2104 , F25B2700/2106 , F25B2700/21175
摘要： An object of the present invention is to improve a heat exchanging capability in an evaporator in a refrigerant cycle system in which a high pressure side is operated at a supercritical pressure. The refrigerant cycle system is a refrigerant cycle system in which a compressor, a gas cooler, an expansion valve and an evaporator are sequentially connected in a cyclic form and a high pressure side is operated at a supercritical pressure, wherein the degree of opening of the expansion valve is adjusted based on the temperature and pressure of a refrigerant at an outlet of the evaporator so as to control the degree of superheat at the outlet of the evaporator. An abstract of the present invention is to make large the degree of superheat at the outlet of the evaporator by means of the expansion valve.
摘要翻译：本发明的目的是提高制冷剂循环系统中的蒸发器中的高压侧在超临界压力下运行的热交换能力。制冷剂循环系统是一种制冷剂循环系统，其中压缩机，气体冷却器，膨胀阀和蒸发器以循环状态顺序连接，高压侧以超临界压力运行，其中，基于蒸发器出口处的制冷剂的温度和压力来调节膨胀阀，以便控制蒸发器出口处的过热度。本发明的摘要是通过膨胀阀使蒸发器出口处的过热度变大。

5. 发明申请

US20050150240A1 Supercritical refrigerant cycle system 有权
标题翻译：超临界制冷循环系统
公开(公告)号：US20050150240A1
公开(公告)日：2005-07-14
申请号：US11029392
申请日：2005-01-06
申请人： Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
发明人： Shigetoshi Doi , Toshiyuki Ebara , Yoshiaki Kurosawa , Mitsuhiko Ishino , Eiji Fukuda , Yoshihiko Kobayashi , Aritomo Yoshida
IPC分类号： F25B9/00 , F25B41/04
CPC分类号： F25B9/008 , F25B2309/061 , F25B2600/21 , F25B2600/2513 , F25B2700/197 , F25B2700/2104 , F25B2700/2106 , F25B2700/21175
摘要： An object of the present invention is to improve a heat exchanging capability in an evaporator in a refrigerant cycle system in which a high pressure side is operated at a supercritical pressure. The refrigerant cycle system is a refrigerant cycle system in which a compressor, a gas cooler, an expansion valve and an evaporator are sequentially connected in a cyclic form and a high pressure side is operated at a supercritical pressure, wherein the degree of opening of the expansion valve is adjusted based on the temperature and pressure of a refrigerant at an outlet of the evaporator so as to control the degree of superheat at the outlet of the evaporator. An abstract of the present invention is to make large the degree of superheat at the outlet of the evaporator by means of the expansion valve.
摘要翻译：本发明的目的是提高制冷剂循环系统中的蒸发器中的高压侧在超临界压力下运行的热交换能力。制冷剂循环系统是一种制冷剂循环系统，其中压缩机，气体冷却器，膨胀阀和蒸发器以循环状态顺序连接，高压侧以超临界压力运行，其中，基于蒸发器出口处的制冷剂的温度和压力来调节膨胀阀，以便控制蒸发器出口处的过热度。本发明的摘要是通过膨胀阀使蒸发器出口处的过热度变大。

6. 发明授权

US5509730A Brake fluid pressure control apparatus 失效
标题翻译：制动液压力控制装置
公开(公告)号：US5509730A
公开(公告)日：1996-04-23
申请号：US390477
申请日：1995-02-17
申请人： Hiromi Ando , Kenji Sano , Yoshihiko Kobayashi
发明人： Hiromi Ando , Kenji Sano , Yoshihiko Kobayashi
IPC分类号： B60T8/48 , B60T8/40 , B60T8/42 , B60T8/50 , B60T8/32
CPC分类号： B60T8/4291 , B60T8/404 , B60T8/5012 , B60T8/5037 , Y10S303/901
摘要： A brake fluid pressure control apparatus includes a second pump communicating port disposed to face a first pump communicating port approximately perpendicularly to the direction of movement of a spool. The first and second pump communicating ports are connected to a master cylinder, and a check valve is provided between the master cylinder and the first and second pump communicating ports. The check valve is adapted to open when the master cylinder-side brake fluid pressure becomes a predetermined value higher than the pump discharge-side brake fluid pressure. A master cylinder communicating port is provided to extend along the direction of movement of the spool. A cut-off valve is provided between the master cylinder communicating port and the master cylinder. The cut-off valve is closed when the spool is moved to provide communication between the pump communicating ports and a wheel cylinder communicating port.
摘要翻译：一种制动液压控制装置包括：第二泵连通口，设置成与阀芯的运动方向近似垂直的第一泵连通口。第一和第二泵连通口连接到主缸，并且止回阀设置在主缸和第一和第二泵连通口之间。当主缸侧制动器流体压力变得高于泵排出侧制动液压力的预定值时，止回阀适于打开。主缸连通口设置成沿着阀芯的移动方向延伸。在主缸连通口和主缸之间设有截止阀。当阀芯移动时，截止阀关闭，以提供泵连通口和轮缸连通口之间的连通。

7. 发明授权

US5355862A Evaporated fuel control system in internal combustion engine 失效
标题翻译：内燃机蒸发燃料控制系统
公开(公告)号：US5355862A
公开(公告)日：1994-10-18
申请号：US38093
申请日：1993-03-30
申请人： Hiroaki Muramatsu , Shinichi Kitajima , Hiroshi Kitagawa , Teruo Wakashiro , Toshikatsu Takanohashi , Yoshihiko Kobayashi , Hiroshi Maruyama
发明人： Hiroaki Muramatsu , Shinichi Kitajima , Hiroshi Kitagawa , Teruo Wakashiro , Toshikatsu Takanohashi , Yoshihiko Kobayashi , Hiroshi Maruyama
IPC分类号： F02D41/00 , F02D41/02 , F02D45/00 , F02M25/08
CPC分类号： F02D41/0045 , F02M25/08 , F02D41/0032
摘要： An evaporated fuel control system in internal combustion engines includes a canister filled with an adsorbent for adsorbing an evaporated fuel in a fuel tank, a purge amount control device provided in the middle of a purge passage connecting an intake passage and the canister, and a fuel supply device. The purge flow rate from the start of purging is integrated, and the purge amount is reduced to a larger extent in response to a purge amount integration value becoming smaller. This improves the nature of an exhaust gas immediately after the start of purging and the like.
摘要翻译：内燃机中的蒸发燃料控制系统包括填充有用于吸附燃料箱中的蒸发燃料的吸附剂的罐，设置在连接进气通道和罐的净化通道中间的清洗量控制装置，以及燃料供应装置。净化开始时的净化流量积分，并且随着吹扫量积分值变小而使清洗量减少到更大程度。这样可以在清洗开始之后立即改善废气的性质等。

8. 发明授权

US5186149A System for controlling fuel supply for internal combustion engine 失效
标题翻译：用于控制内燃机燃料供应的系统
公开(公告)号：US5186149A
公开(公告)日：1993-02-16
申请号：US810065
申请日：1991-12-19
申请人： Shinichi Kitajima , Yoshihiko Kobayashi
发明人： Shinichi Kitajima , Yoshihiko Kobayashi
IPC分类号： F02D19/08 , F02D41/00 , F02D41/02 , F02D41/06
CPC分类号： F02D41/0025 , F02D19/061 , F02D19/084 , F02D19/087 , F02D41/06 , F02D2200/0611 , Y02T10/36
摘要： A system for controlling supply of fuel to a hybrid fuel powered engine during starting. The system has a sensor detecting the alcohol concentration of the fuel, a device for calculating an alcohol correction factor from the detected alcohol concentration, a device for correcting a basic amount of fuel supply in accordance with the alcohol correction factor, a device for increasing or decreasing the factor in increments of a magnitude determined on the basis of the engine coolant temperature once per interval determined on the basis of the engine coolant temperature, and a device for reversing the direction of the increments each time the factor reaches an upper limit value or a lower limit value, whereby the factor is swept over a prescribed range until the engine starts.
摘要翻译：一种用于在起动期间控制混合动力燃料发动机的燃料供应的系统。该系统具有检测燃料的酒精浓度的传感器，用于根据检测到的酒精浓度计算酒精校正因子的装置，用于根据酒精校正因子校正燃料供应的基本量的装置，用于增加或以基于发动机冷却剂温度确定的基于每个间隔的发动机冷却剂温度确定的大小的增量的增量的因子，以及每当因子达到上限值时反转增量的方向的装置，或下限值，从而将系数扫过规定范围直到发动机起动。

9. 发明授权

US5183021A Air-fuel ratio control system for internal combustion engines 失效
标题翻译：内燃机空燃比控制系统
公开(公告)号：US5183021A
公开(公告)日：1993-02-02
申请号：US858738
申请日：1992-03-27
申请人： Toshiyuki Suga , Shinichi Kitajima , Yoshihiko Kobayashi
发明人： Toshiyuki Suga , Shinichi Kitajima , Yoshihiko Kobayashi
IPC分类号： F02D19/08 , F02D41/00 , F02D41/04 , F02D45/00
CPC分类号： F02D41/0025 , F02D19/061 , F02D19/084 , F02D19/087 , F02D41/04 , F02D2200/0611 , Y02T10/36
摘要： An air-fuel ratio control system for internal combustion engine using fuel containing alcohol corrects an amount of fuel supplied to the engine by a correction amount dependent on load on the engine when the engine is in a predetermined high load region. The concentration of alcohol in the fuel is detected, and the correction amount is decreased to a smaller value as the detected concentration of alcohol in the fuel is higher.
摘要翻译：使用含有酒精的内燃机的内燃机的空燃比控制系统，在发动机处于规定的高负荷区域时，根据发动机的负荷修正供给发动机的燃料量。检测到燃料中的醇的浓度，并且随着检测到的燃料中的醇浓度较高，校正量降低到较小值。

10. 发明授权

US08148504B2 Aminoglycoside antibiotics 有权
标题翻译：氨基糖苷类抗生素
公开(公告)号：US08148504B2
公开(公告)日：2012-04-03
申请号：US12227861
申请日：2007-06-01
申请人： Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
发明人： Yoshihiko Kobayashi , Yoshihisa Akiyama , Takeshi Murakami , Nobuto Minowa , Masaki Tsushima , Yukiko Hiraiwa , Shoichi Murakami , Mitsuhiro Abe , Kazushige Sasaki , Shigeru Hoshiko , Toshiaki Miyake , Yoshiaki Takahashi , Daishiro Ikeda
IPC分类号： C07H13/02
CPC分类号： C07H15/234 , C07H15/224
摘要： This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
摘要翻译：本发明涉及对细菌具有强力抗微生物活性的新型氨基糖苷类抗生素，其诱导感染性疾病，特别是MRSA，并且没有显着的肾毒性，以及生产它们的方法。更具体地，本发明涉及由式（Ia）表示的化合物或其药理学上可接受的盐或溶剂合物或其非对映体混合物，包含它们的抗微生物剂及其制备方法。

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