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1. 发明申请

US20110223160A1 COMPOSITIONS AND METHODS RELATING TO GLUCAGON RECEPTOR ANTIBODIES 有权
标题翻译：与GLUCAGON受体抗体相关的组合物和方法
公开(公告)号：US20110223160A1
公开(公告)日：2011-09-15
申请号：US13113996
申请日：2011-05-23
申请人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
发明人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
IPC分类号： A61K39/395 , C12P21/06 , C12N5/16 , C12N15/63 , C07K16/28 , C07H21/04 , A61P3/10 , A61P3/08
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译：本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。

2. 发明申请

US20090041784A1 Compositions and methods relating to glucagon receptor antibodies 有权
标题翻译：与胰高血糖素受体抗体相关的组合物和方法
公开(公告)号：US20090041784A1
公开(公告)日：2009-02-12
申请号：US11903481
申请日：2007-09-20
申请人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
发明人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/79 , C12N5/06 , C12P21/04 , A61P1/00
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译：本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。

3. 发明授权

US08158759B2 Compositions and methods relating to glucagon receptor antibodies 有权
标题翻译：与胰高血糖素受体抗体相关的组合物和方法
公开(公告)号：US08158759B2
公开(公告)日：2012-04-17
申请号：US13113996
申请日：2011-05-23
申请人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
发明人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
IPC分类号： C12P21/06
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译：本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。

4. 发明授权

US07947809B2 Compositions and methods relating to glucagon receptor antibodies 有权
标题翻译：与胰高血糖素受体抗体相关的组合物和方法
公开(公告)号：US07947809B2
公开(公告)日：2011-05-24
申请号：US11903481
申请日：2007-09-20
申请人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
发明人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
IPC分类号： C12P21/08
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译：本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。

5. 发明授权

US09873917B2 Oligodendroglioma drive genes 有权
公开(公告)号：US09873917B2
公开(公告)日：2018-01-23
申请号：US14233296
申请日：2012-07-18
申请人： Bert Vogelstein , Kenneth W. Kinzler , Chetan Bettegowda , Nishant Agrawal , Nickolas Papadopoulos , Darell Bigner , Hai Yan , Roger McLendon
发明人： Bert Vogelstein , Kenneth W. Kinzler , Chetan Bettegowda , Nishant Agrawal , Nickolas Papadopoulos , Darell Bigner , Hai Yan , Roger McLendon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.

6. 发明授权

US09695479B2 Medulloblastoma genes as targets for diagnosis and therapeutics 有权
公开(公告)号：US09695479B2
公开(公告)日：2017-07-04
申请号：US13884154
申请日：2011-11-08
申请人： Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Donald Williams Parsons , Rebecca J. Leary , Meng Li , Xiaosong Zhang , Sian Jones , Gregory J. Riggins , Victor Velculescu , Darell Bigner , Hai Yan
发明人： Bert Vogelstein , Kenneth Kinzler , Nickolas Papadopoulos , Donald Williams Parsons , Rebecca J. Leary , Meng Li , Xiaosong Zhang , Sian Jones , Gregory J. Riggins , Victor Velculescu , Darell Bigner , Hai Yan
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57407
摘要： Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

7. 发明授权

US09074221B2 Homozygous and heterozygous IDH1 gene-defective cell lines derived from human colorectal cells 有权
标题翻译：衍生自人结肠直肠细胞的纯合和杂合IDH1基因缺陷型细胞系
公开(公告)号：US09074221B2
公开(公告)日：2015-07-07
申请号：US13881417
申请日：2011-10-25
申请人： Hai Yan , Darell Bigner , Christopher Gentry Duncan
发明人： Hai Yan , Darell Bigner , Christopher Gentry Duncan
IPC分类号： C12N15/85 , C12N15/90 , C12N5/09
CPC分类号： C12N15/85 , C12N5/0693 , C12N15/902 , C12N2510/00 , C12N2799/025 , C12N2800/30
摘要： IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellular metabolic profiles. These cell lines can be used to test potential therapeutic targets and to screen potential therapeutic agents. Kits and xenografts are also contemplated.
摘要翻译： IDH1基因缺陷型细胞系（例如，IDH1R132H杂合子）已经从稳健的细胞系HCT116制备出来。 IDH1基因缺陷细胞系可用于确定IDH1R132H对细胞生物学，肿瘤发生和细胞代谢特征的影响。这些细胞系可用于测试潜在的治疗靶点和筛选潜在的治疗剂。也可以考虑试剂盒和异种移植物。

8. 发明申请

US20140221219A1 OLIGODENDROGLIOMA DRIVE GENES 审中-公开
标题翻译： OLIGODENDROGLIOMA驱动基因
公开(公告)号：US20140221219A1
公开(公告)日：2014-08-07
申请号：US14233296
申请日：2012-07-18
申请人： Bert Vogelstein , Kenneth W. Kinzler , Chetan Bettegowda , Nishant Agrawal , Nickolas Papadopoulos , Darell Bigner , Hai Yan , Roger Mclendon
发明人： Bert Vogelstein , Kenneth W. Kinzler , Chetan Bettegowda , Nishant Agrawal , Nickolas Papadopoulos , Darell Bigner , Hai Yan , Roger Mclendon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.
摘要翻译：少突神经胶质瘤是成人中第二常见的恶性脑肿瘤。这些肿瘤通常包含染色体异常，涉及染色体1和染色体1的致晕体融合，导致前者的整个短臂和后者的长臂的损失。为了确定这种改变的分子遗传基础，我们对染色体1p和19q损失进行了7个分离性少突胶质细胞瘤的外切测序。在其他变化中，我们发现在七种病例中的六种中，染色体19q上的CIC（果蝇基因capicua的同系物）被体细胞突变，并且染色体1p上的FUBP1（远上游元件（FUSE）结合蛋白）在两个体内被突变的七例。另外27例少突胶质细胞瘤的检查显示有12例和3例分别具有CIC和FUBP1突变的肿瘤，其中58％预计会导致编码蛋白的截短。这些结果表明这些基因在少突胶质细胞的生物学和病理学中的关键作用。

9. 发明申请

US20140147919A1 HOMOZYGOUS AND HETEROZYGOUS IDH1 GENE-DEFECTIVE CELL LINES DERIVED FROM HUMAN COLORECTAL CELLS 有权
标题翻译：人类和异源性IDH1从人类细胞细胞衍生的基因缺陷细胞系
公开(公告)号：US20140147919A1
公开(公告)日：2014-05-29
申请号：US13881417
申请日：2011-10-25
申请人： Hai Yan , Darell Bigner , Christopher Gentry Duncan
发明人： Hai Yan , Darell Bigner , Christopher Gentry Duncan
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C12N5/0693 , C12N15/902 , C12N2510/00 , C12N2799/025 , C12N2800/30
摘要： IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellular metabolic profiles. These cell lines can be used to test potential therapeutic targets and to screen potential therapeutic agents. Kits and xenografts are also contemplated.
摘要翻译： IDH1基因缺陷型细胞系（例如，IDH1R132H杂合子）已经从稳健的细胞系HCT116制备出来。 IDH1基因缺陷细胞系可用于确定IDH1R132H对细胞生物学，肿瘤发生和细胞代谢特征的影响。这些细胞系可用于测试潜在的治疗靶点和筛选潜在的治疗剂。也可以考虑试剂盒和异种移植物。

10. 发明申请

US20130134295A1 IMAGING SYSTEMS WITH SELECTABLE COLUMN POWER CONTROL 有权
标题翻译：具有可选列功率控制的成像系统
公开(公告)号：US20130134295A1
公开(公告)日：2013-05-30
申请号：US13485867
申请日：2012-05-31
申请人： Hai Yan , Ashirwad Bahukhandi
发明人： Hai Yan , Ashirwad Bahukhandi
IPC分类号： H01L27/146
CPC分类号： H01L27/146 , H04N5/345 , H04N5/3698
摘要： Electronic devices may include image sensors having image pixel arrays with image pixels arranged in pixel rows and pixel columns. Each pixel column may be coupled to a column line having column readout circuitry. The column readout circuitry on each column line may include signal processing circuitry and a latch circuit. The latch circuit on each column line may be used to selectively enable and disable the signal processing circuitry on that column line. Each latch circuit may be coupled to first and second signal lines for globally enabling and disabling the signal processing circuitry on all of the column lines. Each latch circuit may be coupled to column decoder circuitry. The column decoder circuitry may provide a column-select signal to latch circuits on a chosen subset of column lines that enables the signal processing circuitry on those column lines by setting those latch circuits.
摘要翻译：电子设备可以包括具有图像像素阵列的图像传感器，图像像素排列成像素行和像素列。每个像素列可以耦合到具有列读出电路的列线。每列列线上的列读出电路可以包括信号处理电路和锁存电路。每个列线上的锁存电路可以用于选择性地启用和禁用该列线路上的信号处理电路。每个锁存电路可以耦合到第一和第二信号线，以全局启用和禁用所有列线路上的信号处理电路。每个锁存电路可以耦合到列解码器电路。列解码器电路可以通过设置这些锁存电路来在选定的列线子集上的锁存电路上提供列选择信号，从而使这些列线路上的信号处理电路能够实现。

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