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1. 发明授权

US5523307A Cyclic amine and pharmacological composition 失效
标题翻译：环胺和药理组成
公开(公告)号：US5523307A
公开(公告)日：1996-06-04
申请号：US258798
申请日：1994-06-07
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
IPC分类号： C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04 , C07D401/12 , A61K31/44 , A61K31/445 , A61K31/47
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --0--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat a mental symptoms associated with a cerebrovascular disease.
摘要翻译：环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ Y是-O - ， - CO-或-NH-，Z是苯基，萘基，吡啶基，烷基或环烷基。治疗与脑血管疾病相关的精神症状是有用的。

2. 发明授权

US5196439A Piperidine compounds useful to treat cerebrovascular diseases 失效
标题翻译：可用于治疗脑血管疾病的哌啶化合物
公开(公告)号：US5196439A
公开(公告)日：1993-03-23
申请号：US825423
申请日：1992-01-24
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
IPC分类号： C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04 , C07D401/12
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --O--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat mental symptoms associated with a cerebrovascular disease.
摘要翻译：环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ ，Y为-O-，-CO-或-NH-，Z为苯基，萘基，吡啶基，烷基或环烷基。治疗与脑血管病相关的精神症状是有用的。

3. 发明授权

US4921863A Cyclic amine derivatives 失效
标题翻译：环胺衍生物
公开(公告)号：US4921863A
公开(公告)日：1990-05-01
申请号：US177662
申请日：1988-02-17
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizou Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizou Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu
IPC分类号： C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07D215/12 , C07D295/02 , C07D295/03 , C07D295/108 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D295/03 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07D215/12 , C07D295/108 , C07D401/06 , C07D405/06 , C07D409/06
摘要： Cyclic amine derivatives of the formula: ##STR1## or the pharmacologically acceptable salts thereof, wherein the symbols are as defined in the specification, as effective in relieving, curing or preventing mental symptoms due to cerebral vascular disorders.
摘要翻译： PCT No.PCT / JP86 / 00502 Sec。 371日期1988年2月17日 102（e）日期1988年2月17日PCT提交1986年9月30日PCT公布。公开号WO88 / 02365 日期：1988年4月7日。下式的环胺衍生物或其药理学上可接受的盐，其中符号如本说明书中所定义，有效缓解，治愈或预防由于脑血管病症引起的精神症状。

4. 发明授权

US4551273A Analgesic peptide and process for the preparation thereof 失效
标题翻译：止痛肽及其制备方法
公开(公告)号：US4551273A
公开(公告)日：1985-11-05
申请号：US575804
申请日：1984-01-31
申请人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
发明人： Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
IPC分类号： C07K14/655 , A61K38/00 , A61P25/04 , C07C231/02 , C07K7/08 , C07K14/575 , C07K14/665 , C07C103/52
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55
摘要： A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.
摘要翻译：具有一级结构的新型肽：N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH2（其中D. Ile和D.Leu分别表示D-Ile和D-Leu残基，氨基酸的其它缩写代表每个L-氨基酸残基，Me表示甲基），其在外周施用时显示出显着的镇痛作用。还公开了通过固相法制备其方法。

5. 发明授权

US4707468A Polypeptide 失效
公开(公告)号：US4707468A
公开(公告)日：1987-11-17
申请号：US796390
申请日：1985-11-08
申请人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
发明人： Hiroshi Yoshino , Yutaka Tsuchiya , Takeru Kaneko , Takahiro Nakazawa , Masuhiro Ikeda , Shin Araki , Kiyomi Yamatsu , Shinro Tachibana , Yoshihiro Arakawa
IPC分类号： C07K1/14 , A61K38/00 , A61K38/08 , A61P25/04 , C07K7/06 , C07K14/665 , C07K14/675 , C07K7/12
CPC分类号： C07K14/665 , A61K38/00 , Y02P20/55 , Y10S514/809 , Y10S930/26
摘要： A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl or lower alkenyl group, A represents a D-amino acid, Gly or Sar provided that when the D-amino acid is D-Cys, it is bonded with L-Cys or D-Cys in position 5 through a S--S bond to effect intramolecular ring closure, B represents L-Phe or D-Phe in which the benzene ring may be substituted or an .alpha.-N-alkyl derivative thereof, C represents an L-amino acid, D-Cys or an .alpha.-N-alkyl derivative thereof, D and E each represent an L- or D-basic amino acid or an .alpha.-N-alkyl derivative thereof, F represents a group of the formula --OR.sup.3 (in which R.sup.3 is H or a lower alkyl group), a group of the formula: ##STR2## (in which R.sup.4 and R.sup.5 are the same or different and each represents H or a lower alkyl group), a group of the formula: --G--OR.sup.6 (in which G is an L- or D-amino acid or Gly or an .alpha.-N-alkyl derivative thereof and R.sup.6 represents H or a lower alkyl group), a group of the formula: ##STR3## (in which G is as defined above and R.sup.7 and R.sup.8 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--L--Arg--OR.sup.9 or --G--D--Arg--OR.sup.9 (in which G is as defined above and R.sup.9 represents H or a lower alkyl group or a group of the formula: ##STR4## (in which G is as defined above and R.sup.10 and R.sup.11 may be the same or different and each represents H or a lower alkyl group), a group of the formula: --G--J--OR.sup.12 in which G is defined as above, J is a neutral amono acid group or an acidic amino acid group and R.sup.12 is hydrogen or a lower alkyl group; or a group of the formula: --G--Arg--M--OR.sup.13 in which M is D-amino acid group and R.sup.13 is hydrogen or a lower alkyl group, provided that all of the amino acids constituting the polypeptide of the above formula do not represent at the same time an L-amino acid of the general formula: ##STR5## (in which R represents a group corresponding to a structural formula of an amino acid deprived of a group of the formula: ##STR6## or pharmacologically acceptable salts of them.

6. 发明授权

US08936837B2 Anti-glare film manufacturing method 有权
标题翻译：防眩膜制造方法
公开(公告)号：US08936837B2
公开(公告)日：2015-01-20
申请号：US13411064
申请日：2012-03-02
申请人： Hideaki Kagawa , Takahiro Nakazawa , Kazuhiro Oki
发明人： Hideaki Kagawa , Takahiro Nakazawa , Kazuhiro Oki
IPC分类号： C08F2/48 , G02B27/00 , G02B13/20 , G02B5/02 , B05D3/06 , B05D5/02 , B05D3/02
CPC分类号： G02B5/0226 , B05D3/0209 , B05D3/067 , B05D5/02
摘要： The method includes: forming a coating film including particles and an ultraviolet curable resin on a film substrate; and curing the ultraviolet curable resin by ultraviolet irradiation to form an anti-glare layer constituted by the particles and the ultraviolet curable resin. A ratio of a thickness A of the anti-glare layer to a diameter B of the particles is in the range of 1.5 to 2.4. The ultraviolet irradiation is performed with two or more ultraviolet irradiation units, the first unit irradiation amount is 49 mJ/cm2 or less, the second and subsequent units irradiation amount is greater than 50 mJ/cm2, and the total irradiation amount is 100 mJ/cm2 or greater. The oxygen concentration at a position which is 1 mm above a surface of the coating film is 1 ppm to 2000 ppm. The first unit irradiation is performed above a roller with surface temperature of 10° C. to 24° C.
摘要翻译：该方法包括：在膜基材上形成包含颗粒和紫外线固化树脂的涂膜; 并通过紫外线照射固化紫外线固化树脂，以形成由该颗粒和紫外线固化树脂构成的防眩层。抗眩光层的厚度A与颗粒的直径B之比为1.5〜2.4。用两个以上的紫外线照射单元进行紫外线照射，第一单位照射量为49mJ / cm 2以下，第二次照射量和后续单位照射量大于50mJ / cm 2，总照射量为100mJ / cm2以上。在涂膜表面1mm以上的位置的氧浓度为1ppm〜2000ppm。在表面温度为10℃至24℃的辊上方进行第一单元照射。

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