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1. 发明专利

JPS62195277A PROCESSING OF LIVE SAMPLE 失效
公开(公告)号：JPS62195277A
公开(公告)日：1987-08-28
申请号：JP3298386
申请日：1986-02-19
申请人： HITACHI LTD , RIKAGAKU KENKYUSHO
发明人： KANEKIYO HIROSHI , HOSOMI NOBUYUKI , MURAKAMI SEI , KAWAMOTO MUNEO , KASUYA KEIKO , TSUKAGOSHI MIKIRO
IPC分类号： C12M1/00 , C12M1/42 , C12N1/00 , C12N5/00 , C12N13/00 , C12Q1/04 , G01N33/48
摘要： PURPOSE:To make it possible to realize processing suitable for the aimed live sample, by subjecting image signals obtained by taking photographs of the live sample with a camera to image processing, extracting characteristic and judging the resultant characteristic with predetermined characteristic information about the sample. CONSTITUTION:Image signals obtained by taking photographs of a live sample 1 with a TV camera 11 are subjected to image processing to extract characteristic (F3), which is then compared with predetermined characteristic information about the aimed live sample to distinguish the live sample from the sample other than the aimed sample whether the similarity of both is a permissible value or above. Processing is then carried out according to the distinction. In some cases, the aimed live sample is kept alive after the processing and the live sample other than the aimed one is killed after the processing. Perforating, cutting, removing, joining, etc., may be cited as the processing.

2. 发明专利

JPS62192290A LASER BEAM MACHINE 失效
公开(公告)号：JPS62192290A
公开(公告)日：1987-08-22
申请号：JP3298486
申请日：1986-02-19
申请人： HITACHI LTD , RIKAGAKU KENKYUSHO
发明人： HOSOMI NOBUYUKI , KANEKIYO HIROSHI , MURAKAMI SEI , KASUYA KEIKO , TSUKAGOSHI MIKIRO
IPC分类号： C12N15/09 , B23K26/382 , C12M1/00 , C12N1/00 , C12N5/00 , C12N5/10 , C12N13/00 , C12N15/00
摘要： PURPOSE:To perform the laser beam machining properly for various samples by projecting the laser light from one direction of a sample by the 1st optical path, by projecting on the sample from another direction by the 2nd optical path by providing an optical path switching means. CONSTITUTION:The sample case 20 containing a sample is set on a sample base 2, the image picked up by a TV camera 25 is displayed on a monitor TV 40 and a table driving part 3 is roughly set to the position suitable for the work by driving the table driving part 3 with watching this display. The alignment of the position where the laser light of each sample is projected and the laser light projecting position is then performed. Shutters 52, 53 are closed at the completion time of this alignment. The laser light emitted from a laser light source (YAG laser) 1 selects the shutters 52, 53 of an optical path shifting device 5, thereafter, the work is executed by projecting the laser light on the sample through the selected optical path by the shutter 7 or 8, or shutters 7 and 8.

3. 发明专利

JPS62195278A LASER PROCESSING OF LIVE SAMPLE 失效
公开(公告)号：JPS62195278A
公开(公告)日：1987-08-28
申请号：JP3298586
申请日：1986-02-19
申请人： HITACHI LTD , RIKAGAKU KENKYUSHO
发明人： MURAKAMI SEI , HOSOMI NOBUYUKI , KANEKIYO HIROSHI , KASUYA KEIKO , TSUKAGOSHI MIKIRO
IPC分类号： C12N15/09 , B23K26/00 , C12M1/00 , C12N1/00 , C12N5/00 , C12N5/04 , C12N13/00 , C12N15/00
摘要： PURPOSE:To survive a live sample after laser processing, by observing the shape of the live sample and reducing the quantity of laser beam irradiation when there is no repair on shape of the live sample. CONSTITUTION:For example, cells are irradiated with laser beams to transfect a substance, e.g. gene, etc., into the live cells and the surface shape of the irradiated part is modified and processed into a state for incorporation of the substance. In the process, the condition of the live cells is imaged to compare the shape with that before irradiation of the laser beams. If the shape is not repaired to that before the irradiation, the quantity of laser beam irradiation is reduced.

4. 发明专利

JPS62192289A LIGHTING METHOD FOR OBSERVATION OF LASER BEAM PIERCING DEVICE 失效
公开(公告)号：JPS62192289A
公开(公告)日：1987-08-22
申请号：JP3298286
申请日：1986-02-19
申请人： HITACHI LTD , RIKAGAKU KENKYUSHO
发明人： MURAKAMI SEI , HOSOMI NOBUYUKI , KANEKIYO HIROSHI , KIMURA NOBUO , KASUYA KEIKO , TSUKAGOSHI MIKIRO
IPC分类号： C12N15/09 , B23K26/12 , B23K26/382 , C12M1/00 , C12N1/00 , C12N13/00 , C12N15/00
摘要： PURPOSE:To correctly perform a piercing at the aiming position of a sample by eliminating the slippage between the image plain face of an observing image and the condensing position of laser light, by using the monochromatic light having the same wavelength as that of the laser light for piercing for the lighting light source for observation. CONSTITUTION:The laser light for piercing the sample 6 of the raw cell, etc., to be placed on a sample base 4 is projected from a laser oscillator 7, reflected by a half mirror 2 and condensed on the sample 6 through an objective lens 3. On the other hand, only the light component in the same wavelength as that of the laser light is selectively made translucent by a filter 11 on the lighting light emitted from a light source 10 to irradiate the sample 6 from the lower part. In this way the image of the sample 6 can be observed by an observer from an eyepiece 1 through the objective lens 3 and can be observed by a display device 9 via TV camera 8. Since the wavelengths of the light for observation and the laser beam become the same, the focus distance becomes the same and consequently the slippage between the image plain face of the observing image and the condensing position of the laser light is eliminated and the control of the piercing position of the sample is facilitated.

5. 发明专利

DE4002994A1 Cultivating cells and their biological prods. with fermenter - and controlled membrane sepn. of unwanted components 未知
公开(公告)号：DE4002994A1
公开(公告)日：1990-08-16
申请号：DE4002994
申请日：1990-02-01
申请人： HITACHI LTD
发明人： NAKANO RYUSEI , TAKAI MASAO , SASAKI KIYOSHI , MATSUZAKI HARUMI , ISHIDA MASASHIKO , FURUKAWA TOKINOBU , MURAKAMI SEI , KATOH KENJI
IPC分类号： C12M3/02 , C12N5/02
摘要： Prior to return to a fermenter, cells cultivated in a broth are sepd. by a hydrophobic membrane, made e.g. of hollow fibres and sterilisable by steam. The membrane is suitable for materials of specific molecular wt. ranges. While waste prods. are similarly removed, together with materials which could impede cell growth, one or more medium components of a useful substance produced by the cell and whose molecular wt. is less than that of the medium component(s), are similarly removed and returned to the fermenter. These include expensive high molecular wt. medium components of sera, whose return facilitates high density cell cultivation to reduce operating costs. Between upper and lower ends of a container, cultivation is accelerated by the intensive mixing derived by internal jets delivering fast gas streams, without damaging cells. USE/ADVANTAGE - Produces wide range of useful prods., e.g. Interferon, enzymes, and immunoglobin in economically desirable amts.

6. 发明专利

CA2061905A1 APPARATUS AND METHOD FOR APPLYING A LASER BEAM THROUGH A MICROSCOPE 未知
公开(公告)号：CA2061905A1
公开(公告)日：1992-08-28
申请号：CA2061905
申请日：1992-02-26
申请人： HITACHI LTD
发明人： MURAKAMI SEI , TAKAI MASAO , NAKANO RYUSEI , KIMURA NOBUO
IPC分类号： G02B21/00 , G02B21/06
摘要： The present invention relates to an inverted microscope which is adapted so that a specimen thereon, e.g. cells, can be irradiated by a laser beam. The laser beam is guided from a laser source by a series of adjustably movable reflectors which introduce it into the microscope optical pathway at a parallel-beam region thereof, and through the objective lens of the microscope. A point to be irradiated can be selected by moving the reflectors which may be galvanometricallymovable. The laser beam can be focused together with the microscope image. The movable reflectors are kept within 200 mm behind the objective lens principal plane to ensure that the laser can be applied all over the microscope viewing field.

7. 发明专利

SG11201800936WA SINGLE-USE CELL CULTURING APPARATUS AND CULTURING BAG 未知
公开(公告)号：SG11201800936WA
公开(公告)日：2018-03-28
申请号：SG11201800936W
申请日：2016-07-01
申请人： HITACHI LTD , FUJIMORI KOGYO CO LTD
发明人： NANBA MASARU , ANDOU TAKASHI , SUGITA YUI , MURAKAMI SEI , MATSUDA HIROYUKI
IPC分类号： C12M1/02 , C12M1/06 , C12M3/00
摘要： A single-use cell culturing apparatus and a culturing bag are provided, each of which can improve efficiency of stirring a culture solution and further reduce a possibility of leakage of the culture solution. The single-use cell culturing apparatus of the present invention includes a housing that accommodates the culturing bag which is flexible and can seal the culture solution inside thereof. The housing has, on an inner surface thereof, a curved convex-shaped protrusion provided at a portion of a contact face at which the housing is in contact with the culturing bag. The culturing bag of the present invention is accommodated in the housing of the single-use cell culturing apparatus; is flexible; and can seal the culture solution inside thereof. The culturing bag includes a concave portion having a shape corresponding to the curved convex protrusion disposed on a part of the housing.

8. 发明公开

EP3045521A4 CELL CULTURING APPARATUS AND CELL CULTURING METHOD 有权
标题翻译： ZELLKULTURVORRICHTUNG UND ZELLKULTURVERFAHREN
公开(公告)号：EP3045521A4
公开(公告)日：2017-04-26
申请号：EP14842701
申请日：2014-08-01
申请人： HITACHI LTD
发明人： NANBA MASARU , HAGA RYOUICHI , MURAKAMI SEI , SUZUKI HARUO
IPC分类号： C12M1/00 , C12M1/34
CPC分类号： C12M41/30 , C12M23/14 , C12M23/22 , C12M23/26 , C12M37/00 , C12M41/36
摘要： A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus (1) includes: a flexible and transparent sterile bag (2) that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution (4) is cultured; and a turbidity sensor (3) that includes a light emitter (31) which emits light to the cell culture solution (4) in the sterile bag (2) via a portion (2a) of the sterile bag (2), a light receiver (32) which receives the light transmitted through the cell culture solution (4) via another portion (2b) of the sterile bag (2), and that is configured to place the light emitter (31), the portion (2a) of the sterile bag (2), another portion (2b) of the sterile bag (2), and the light receiver (32), optically on a same straight line.
摘要翻译：提供了一种细胞培养装置，其能够连续且准确地测量细胞培养液的浊度并培养细胞，而无需将浊度传感器从外部插入无菌袋中。细胞培养装置（1）具有：设置于细胞培养装置内的规定位置且培养细胞培养液（4）中含有的细胞的柔软且透明的无菌袋（2）和浊度传感器（3），所述浊度传感器包括经由无菌袋（2）的一部分（2a）向无菌袋（2）中的细胞培养液（4）发光的光发射器（31），光接收器（32），其经由所述无菌袋（2）的另一部分（2b）接收透过所述细胞培养液（4）的光，并且被配置为放置所述光发射器（31），所述光发射器无菌袋（2），无菌袋（2）的另一部分（2b）和光接收器（32）在光学上位于同一直线上。

9. 发明公开

EP3018475A4 SEPARATION DEVICE AND SEPARATION METHOD 有权转让
标题翻译： TRENNVORRICHTUNG UND TRENNVERFAHREN
公开(公告)号：EP3018475A4
公开(公告)日：2017-03-15
申请号：EP14820358
申请日：2014-06-19
申请人： HITACHI LTD
发明人： SHIBUYA KEISUKE , TADA YASUHIKO , KONDO TAKEYUKI , MURAKAMI SEI
IPC分类号： G01N30/46 , B01D15/08 , B01D15/20 , B01D15/22 , C07K1/22 , G01N30/26 , G01N30/88
CPC分类号： B01D15/22 , B01D15/08 , B01D15/1821 , B01D15/1885 , B01D15/20 , C07K1/22 , G01N2030/8813

10. 发明专利

JP2015052552A 液漏れ検知部材、有用物質製造装置、および有用物質製造システム审中-公开
标题翻译：液体泄漏检测部件，有用的材料生产装置和系统
公开(公告)号：JP2015052552A
公开(公告)日：2015-03-19
申请号：JP2013186036
申请日：2013-09-09
申请人：株式会社日立製作所 , Hitachi Ltd
发明人： SHIBUYA KEISUKE , TADA YASUHIKO , MATSUO TOSHIAKI , SUZUKI HARUO , MURAKAMI SEI
IPC分类号： G01N31/00 , C12M1/00 , G01N31/22
摘要：【課題】培養や分離精製の際に生じる微量な液漏れの検出が可能な液漏れ検知部材、有用物質製造装置、および有用物質製造システムを提供する。【解決手段】培養処理および分離精製処理のうち少なくとも1つの処理において使用する有用物質製造装置120または前記有用物質製造装置に接続される配管の外側表面に付され、前記有用物質製造装置120または前記配管から外部に漏れる液体と接触することにより反応して性質が変化することを特徴とする液漏れ検知部材10により上記課題を解決する。【選択図】図2
摘要翻译：要解决的问题：提供一种能够检测在培养和分离精炼期间产生的痕量的液体泄漏的液体泄漏检测构件，并提供有用的材料生产装置和有用的材料生产系统。解决方案：提供了一种有用的用于至少一种处理和分离精炼处理的处理材料生产装置120，或者设置在与有用材料生产装置连接的管道的外表面上的液体泄漏检测构件10，其接触从有用材料生产泄漏的液体装置120或来自外部的管，并且与液体反应以改变构件的性质，从而解决问题。

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