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1. 发明专利

DE68928157T2 未知
公开(公告)号：DE68928157T2
公开(公告)日：1998-02-26
申请号：DE68928157
申请日：1989-09-13
申请人： HITACHI LTD
发明人： MIYAKE RYO , OHKI HIROSHI , YAMAZAKI ISAO , KANEKO TOSHIO , HORIUCHI HIDEYUKI , SAKURABA SHINICHI , YASUDA KAORI
IPC分类号： G01N15/12 , G01N15/14 , G01N35/10 , G01N1/10 , B01L3/02
摘要： Particles contained in a liquid sample (17) are analysed by moving the particles along a detection passage (12,13) past a detector by means of a liquid flow in said passage. To reduce the time required for each sample, the sample is delivered at an input location (7,8,9) at the upstream end of the detection passage by movement of a movable container (2) carrying said sample to said input location. Immediately after commencement of the delivery of the liquid sample, the liquid flow is caused to occur in the detection passage. Washing liquid is supplied to the input location (7,8,9) by means different from said container which carries the sample.

2. 发明专利

DE68928157D1 未知
公开(公告)号：DE68928157D1
公开(公告)日：1997-08-14
申请号：DE68928157
申请日：1989-09-13
申请人： HITACHI LTD
发明人： MIYAKE RYO , OHKI HIROSHI , YAMAZAKI ISAO , KANEKO TOSHIO , HORIUCHI HIDEYUKI , SAKURABA SHINICHI , YASUDA KAORI
IPC分类号： G01N15/12 , G01N15/14 , G01N35/10 , G01N1/10 , B01L3/02
摘要： Particles contained in a liquid sample (17) are analysed by moving the particles along a detection passage (12,13) past a detector by means of a liquid flow in said passage. To reduce the time required for each sample, the sample is delivered at an input location (7,8,9) at the upstream end of the detection passage by movement of a movable container (2) carrying said sample to said input location. Immediately after commencement of the delivery of the liquid sample, the liquid flow is caused to occur in the detection passage. Washing liquid is supplied to the input location (7,8,9) by means different from said container which carries the sample.

3. 发明专利

JPH02304333A FLOWING CELL ANALYZING INSTRUMENT 失效
公开(公告)号：JPH02304333A
公开(公告)日：1990-12-18
申请号：JP12553089
申请日：1989-05-18
申请人： HITACHI LTD
发明人： YAMAZAKI ISAO , OKI HIROSHI , MIYAKE AKIRA , YASUDA KAORI
IPC分类号： G01N15/14
摘要： PURPOSE:To improve measurement accuracy and to reduce the size of the instrument by providing the 1st slit disposed with a long side in the direction perpendicular to the flow of a particle to be inspected on the imaging face of the particle to be inspected and disposing a 2nd slit in parallel with the 1st slit in the route of the scattered light. CONSTITUTION:The slit 7S of a 1st slit plate 7 placed on the image forming face of the light diverged by a cell at an observation point 5 of a flow cell 1 acts on a particle equivalently to a central position even if the position of the image of the particle deviates transversely. The slit allows the transmission of the scattered light from the particle equivalently to the passage in the central position at the time when the particle passes a detecting region. The scattered light transmitted through the slit 7S is bisected by a half mirror 8 and is further limited only to the scattered light of a specific angle by slits 9aS, 9bS of 2nd slit plates 9a, 9b and is guided to photodetectors 10a, 10b. Since the slits 9aS, 9bS have also the shape long in the direction orthogonal with the flow of a sample, the forward scattered light is accurately measured and analyzed and since there is no need for detecting the sideward scattered light, the reduction in the size of the instrument is possible.

4. 发明专利

JPH02181632A SHEATH FLOW CELL 失效
公开(公告)号：JPH02181632A
公开(公告)日：1990-07-16
申请号：JP34989
申请日：1989-01-06
申请人： HITACHI LTD
发明人： KANEKO NORIO , HORIUCHI HIDEYUKI , SAKURABA SHINICHI , YASUDA KAORI , OKI HIROSHI , MIYAKE AKIRA , YAMAZAKI ISAO
IPC分类号： G01N21/64 , G01N15/14 , G01N21/05 , G01N21/53
摘要： PURPOSE:To reduce the shortening and pressure loss of a capillary by forming a flow passage of three-dimensional structure with a sheath flow formation part and providing the capillary separated from the flow passage with rectangular section having transmissive surfaces in the traveling direction of a light beam for analysis and its orthogonal direction. CONSTITUTION:The sheath flow formation part 10 is provided with a sheath liquid port 12 by pinching a sample liquid port 11. Those three flow passages come together at the part of the nozzle 13 of the port 11 and connect with the capillary 30 with the transmissive rectangular section through a flow reduction part 14. A sheath flow 20 is guided to the capillary 30, and analyzed and then discharged through a drain tube 40. A light source 50 for analysis irradiates cells and particles flowing in the sheath flow 21 with light. Forward scattered or fluorescent light obtained by the irradiation is detected by a front detection optical system 60 and sideward scattered or fluorescent light is detected by a sideward detection optical system 70 to analyze the cells, etc. The surface of the flow cell of this constitution is flat, so the detection optical systems can be put close to the flow cell main body, so that the capillary can be shortened.

5. 发明专利

JPH0280937A FLOW CELL DEVICE 失效
公开(公告)号：JPH0280937A
公开(公告)日：1990-03-22
申请号：JP23246288
申请日：1988-09-19
申请人： HITACHI LTD
发明人： MIYAKE AKIRA , OKI HIROSHI , YAMAZAKI ISAO , KANEKO NORIO , HORIUCHI HIDEYUKI , SAKURABA SHINICHI , YASUDA KAORI
IPC分类号： G01N15/12 , G01N15/14 , G01N35/10
摘要： PURPOSE:To shorten a measuring time by providing a sample flow passage equipped with a required sheath fluid flow passage and a discharge flow passage to a flow cell chamber while driving and moving the sample solution probe connected to a pump in a predetermined manner. CONSTITUTION:A part of the sheath fluid flowing through a sheath fluid flow passage formed from a contraction part 10 and a discharge port 14 flows out through the discharge piping 15 provided in a sample flow passage and forming the discharge passage connected to a valve to wash the sample flow passage. Subsequently, the probe 2 connected to a pump 5 and equipped with a rubber sphere 6 sucking a sample is driven so as to be moved downwardly to press the sphere 6. A required amount of the sample is supplied to the discharge port 14 through the nozzle 9 and capillary tube 13 of the sample flow passage and the residual sample is discharged through the piping 15 to further wash the probe 2 or flow passage in the same way. By this automatic washing in succession to the replenishment of the sample, a measuring time per one sample is shortened as a whole.

6. 发明专利

JPH0354471A METHOD AND APPARATUS FOR ANALYZING BLOOD 失效
公开(公告)号：JPH0354471A
公开(公告)日：1991-03-08
申请号：JP18876189
申请日：1989-07-24
申请人： HITACHI LTD
发明人： YASUDA KAORI , SAKURABA SHINICHI , MIYAKE AKIRA
IPC分类号： G01N33/49 , G01N35/02 , G01N35/10
摘要： PURPOSE:To reduce the cost and power consumption related to a mechanism system by providing an inclined passage for allowing a tightly closed container having a blood sample sealed therein to fall and move under rotation and simultaneously performing feeding and stirring. CONSTITUTION:A plurality of slopes 3 having inclination are arranged in an apparatus and the total length thereof is several 10 times of the circumference of a tightly closed container 6 and the containers 6 introduced from a container charging port 1 are stored on the first stage slope 3 by a plurality of the stoppers a10 between the lower part of said slope 3 and a side wall 9. A sensor 12 senses that the container 6 is not present on the stopper b11 of the lowermost part of the slope and the semicircular stoppers a10 are rotated by the signal of the sensor to allow each of the containers 6 to fall. Since the container 6 moves on the slopes 3 under rotation, the blood therein is sufficiently stirred. When the container 6 reaches the stopper b11 and this state is detected by the sensor 12, a container content collecting part 8 is operated to collect the blood in the container 6. After collection, the stopper b11 falls downwardly and the container 6 is received in a lower container rack 5.

7. 发明专利

JPH0298653A FLOW CELL DEVICE 失效
公开(公告)号：JPH0298653A
公开(公告)日：1990-04-11
申请号：JP24985888
申请日：1988-10-05
申请人： HITACHI LTD
发明人： OKI HIROSHI , MIYAKE AKIRA , YAMAZAKI ISAO , HORIUCHI HIDEYUKI , KANEKO NORIO , SAKURABA SHINICHI , YASUDA KAORI
IPC分类号： G01N21/05 , G01N27/02
摘要： PURPOSE:To prevent carry-over of a sample liquid even if there is no back sheath by providing a sample passage which is opened so that a part of a sheath passage is left in the upper and the lower parts of its opening part, in the sheath passage. CONSTITUTION:A sheath fluid 4 is led into a flow cell device 1 from two inlets 3. The sheath fluid 4 is brought to contraction in a passage 5, and flows into a constricted passage 6 in a laminar flow state. On the other hand, a sample fluid 9 flows into the device 1 from an inlet 8. The sample fluid 9 is brought to contraction in a passage 10, and flows into a confluence point 11 of the passage 5. In this case, since a part of the passage 5 is left in the upper and the lower parts of an opening 12, the sample fluid 9 is surrounded by the sheath fluid 4 from not only the right and the left directions but also the upper and the lower directions, becomes a thin flow 14 on the cross section center of the constricted passage 6 and flows. Since the thin flow 14 is a laminar flow, a particle selected by the sample fluid 4, for instance, a cell flows into a suspension one by one.

8. 发明专利

JPH02176562A ANALYSIS APPARATUS 失效
公开(公告)号：JPH02176562A
公开(公告)日：1990-07-09
申请号：JP33403188
申请日：1988-12-28
申请人： HITACHI LTD
发明人： YAMAZAKI ISAO , OKI HIROSHI , MIYAKE AKIRA , KANEKO NORIO , HORIUCHI HIDEYUKI , SAKURABA SHINICHI , YASUDA KAORI
IPC分类号： G01N33/49 , C12M1/34 , G01N15/14
摘要： PURPOSE:To shorten the time for analyses by using a flow cell having >=2 sample liquid inlets, by which just one time of washing of sample liquid flow passages is merely necessitated after the end of the analyses of plural kinds. CONSTITUTION:A sample liquid nozzle 6 projects into a flow chamber 3 of the flow cell. The sample liquid nozzle 6 has the structure of double circular tubes consisting of nozzles 6a and 6b. Sample flows 15a, 16b are, therefore, formed in the same position in a capillary 8 even if the sample is passed from any side. The accuracy of the analyses is thus enhanced. The tips of the nozzles 6a, 6b are gradually reduced in thickness and do not disturb the flow and, therefore, the stable flow of sheath flow is possible. The accuracy of the analyses is thus enhanced.

9. 发明专利

JPH02162234A PARTICLE COUNTING APPARATUS 失效
公开(公告)号：JPH02162234A
公开(公告)日：1990-06-21
申请号：JP31639688
申请日：1988-12-16
申请人： HITACHI LTD
发明人： HORIUCHI HIDEYUKI , KANEKO NORIO , SAKURABA SHINICHI , YASUDA KAORI , OKI HIROSHI , MIYAKE AKIRA , YAMAZAKI ISAO
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14
摘要： PURPOSE:To shorten the time of measurement by dividing a particle counting time, correcting the number of particles counted in each divided time with simultaneous passing, and adding the counted values after the correction sequentially. CONSTITUTION:A particle pulse signal which is converted into an electric signal in a particle detector is inputted into a counter 1. The particle pulse signals within a particle counting time formed with a timer 2 are counted. The number of the particles is corrected in a simultaneous-pass correcting circuit 3 based on the number of the particles counted with in the measuring time which is divided with the timer 2. The numbers of the particles are sequentially added in an adding circuit 4. The total measuring time can be found with a timer counter 5. The measured data are evaluated with a CPU which analyzes the data based on the output of the circuit 4. In this way, the measuring time can be shortened.

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