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1. 发明申请

WO2004089964A8 LIPID-REGULATING AGENT AND USE THEREOF 审中-公开
标题翻译：脂质调节剂及其用途
公开(公告)号：WO2004089964A8
公开(公告)日：2004-12-29
申请号：PCT/JP2004004079
申请日：2004-03-24
申请人： HAYASHIBARA BIOCHEM LAB , OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A23D9/007 , A23K1/16 , A23L1/30 , A61K31/702 , A61P1/00 , A61P1/10 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P35/00 , C07H3/06 , A23D9/00 , A23L1/307
CPC分类号： A23D9/007 , A23K20/163 , A23L33/10 , A61K31/702 , C07H3/06
摘要： A lipid-regulating agent and a composition for lipid control which contains the lipid-regulating agent. The lipid-regulating agent comprises as an active ingredient a cyclic tetrasaccharide and/or a glucide derivative thereof.
摘要翻译：一种脂质调节剂和含有脂质调节剂的用于脂质控制的组合物。脂质调节剂包含作为活性成分的环状四糖和/或其糖苷衍生物。

2. 发明申请

WO02051424A8 DRUGS AGAINST ARTICULAR FAILURE 审中-公开
标题翻译：药物对相关的失败
公开(公告)号：WO02051424A8
公开(公告)日：2002-08-01
申请号：PCT/JP0111147
申请日：2001-12-19
申请人： HAYASHIBARA BIOCHEM LAB , FUKUDA SHIGEHARU , ARIO TAKESHI , MIYAKE TOSHIO
发明人： FUKUDA SHIGEHARU , ARIO TAKESHI , MIYAKE TOSHIO
IPC分类号： A23G4/00 , A23G4/10 , A23L1/09 , A23L1/29 , A23L1/30 , A23L2/52 , A61K8/00 , A61K8/60 , A61K8/72 , A61K8/73 , A61K31/7008 , A61K31/7016 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/737 , A61P19/02 , A61P29/00 , A61P29/02 , A61P43/00 , A61Q19/10
CPC分类号： A23G4/10 , A23L2/52 , A23L29/30 , A23L33/10 , A23L33/40 , A61K8/60 , A61K8/735 , A61K31/7008 , A61K31/7016 , A61K31/727 , A61K31/728 , A61K2800/59 , A61Q19/10 , A61K2300/00
摘要： It is intended to provide compositions which exert an effect of restoring articular failure at a level superior to aminosugars and glycosaminoglycan. This problem is solved by providing drugs against articular failure which contain as the active ingredients an aminosugar and trehalose.
摘要翻译：旨在提供发挥恢复关节衰竭效果优于氨基糖和糖胺聚糖的效果的组合物。通过提供针对关节衰竭的药物来解决该问题，所述药物包含作为活性成分的氨基糖和海藻糖。

3. 发明专利

JP2012140468A Peritoneal dialysis fluid 有权
标题翻译： PERITONEAL DIALYSIS FLUID
公开(公告)号：JP2012140468A
公开(公告)日：2012-07-26
申请号：JP2012093372
申请日：2012-03-30
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OTA HITOMI , HANATANI TOSHIHARU , FUKUDA SHIGEHARU , MIWA NAOKATSU , MIYAKE TOSHIO
IPC分类号： A61K31/702 , A61K31/7042 , A61P7/08
CPC分类号： A61K31/716 , A61K31/702 , A61K31/7048 , A61M1/287 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a peritoneal dialysis fluid, which is excellent in a water removal performance, has high biocompatibility, and is excellent in storage stability.SOLUTION: The peritoneal dialysis fluid contains one or more substances selected from cyclonigerosyl nigerose, cyclomaltosyl maltose and L-ascorbic acid 2-glucoside.
摘要翻译：要解决的问题：提供一种除水性能优异的腹膜透析液，具有高的生物相容性，并且储存稳定性优异。解决方案：腹膜透析液含有一种或多种选自旋风黑素黑素，环麦芽糖基麦芽糖和L-抗坏血酸2-葡萄糖苷的物质。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2010046075A Method of inhibiting acrylamide formation and use thereof 有权
标题翻译：抑制丙烯酰胺形成及其用途的方法
公开(公告)号：JP2010046075A
公开(公告)日：2010-03-04
申请号：JP2009239315
申请日：2009-10-16
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A23L5/20 , A23L19/18 , A61K8/44 , A61K8/49 , A61K8/60 , A61K8/73 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To establish a method of positively reducing the amount of acrylamide formed by heating an edible material at a high temperature and the use of the acrylamide to thereby provide foods, drinks, cosmetics, drugs and intermediates thereof having improved safety. SOLUTION: There are provided: a method of inhibiting the formation of acrylamide comprising, in heating an edible material with a risk of forming acrylamide during heating, adding an organic substance capable of inhibiting the formation of acrylamide to the edible material and then heating: compositions such as foods, drinks, cosmetics, drugs and intermediates thereof which are produced by the above method and in which the formation of acrylamide is inhibited: and compositions such as foods, drinks, cosmetics, drugs and intermediates thereof which contain an organic substance having amino group and/or a saccharide capable of forming acrylamide together with an organic substance capable of inhibiting the formation of acrylamide and have an ability to inhibit the formation of acrylamide. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：建立一种积极地减少在高温下加热可食用材料形成的丙烯酰胺的量的方法，以及使用丙烯酰胺从而提供具有改进的食品，饮料，化妆品，药物及其中间体安全。提供：抑制丙烯酰胺形成的方法，其包括在加热可能的材料中加热可能形成丙烯酰胺的可食用材料，加入能够抑制丙烯酰胺形成的有机物质到可食用材料中，然后加热：通过上述方法制备并且其中抑制丙烯酰胺形成的食品，饮料，化妆品，药物和中间体的组合物，以及含有有机物的食品，饮料，化妆品，药物及其中间体的组合物具有氨基的物质和/或能够形成丙烯酰胺的糖类与能够抑制丙烯酰胺形成的有机物质并具有抑制丙烯酰胺形成能力的物质。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2009161522A Inhibitor for renal dysfunction 有权
标题翻译：抑制剂用于肾功能衰竭
公开(公告)号：JP2009161522A
公开(公告)日：2009-07-23
申请号：JP2008313985
申请日：2008-12-10
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： ARAI CHIKAKO , IWAKI KANZO , FUKUDA SHIGEHARU
IPC分类号： A61K36/18 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/7016 , A61K31/702 , A61K31/718 , A61K31/719 , A61K31/721 , A61K31/724 , A61P3/10 , A61P13/12
摘要： PROBLEM TO BE SOLVED: To provide a renal dysfunction ameliorator which is easy to take in and is safe even in prolonged chronic use. SOLUTION: The problem is solved by providing (1) a renal dysfunction inhibitor comprising an extract Kothala himbutu as an active ingredient and (2) a renal dysfunction inhibitor comprising an extract Kothala himbutu and one or more members selected from among dextrins, pullulans, cyclic tetroses, lactosucroses, trehaloses, maltitols, maltotriitols, maltotetraitols, and glycosylated vitamins. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供即使在长期使用中也容易摄入并且是安全的肾功能障碍改善剂。解决方案：通过提供（1）包含提取物Kothala himbutu作为活性成分的肾功能障碍抑制剂和（2）包含提取物Kothala himbutu的一种或多种成分的肾功能障碍抑制剂和选自糊精，支链淀粉，环状四唑，乳糖苷，海藻糖，麦芽醇，麦芽三醇，麦芽三糖和糖基化维生素。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2009034028A β-GLUCOSIDASE, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING β-TYPE GLYCOSIDE USING THE SAME 审中-公开
标题翻译： β-GLUCOSIDASE，其生产方法，以及使用该β-葡糖苷酶生产β型糖苷的方法
公开(公告)号：JP2009034028A
公开(公告)日：2009-02-19
申请号：JP2007200296
申请日：2007-08-01
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKURA TAKANORI , NISHIMOTO TOMOYUKI , CHAEN HIROTO , FUKUDA SHIGEHARU
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/42 , C12P19/44 , C12R1/01
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a new glycosyltransferase which has wide receptor specificity, preferentially catalyzes a transfer reaction to a phenolic hydroxyl group, and has high glycoside-producing activity, and to provide a method for producing a β-type glycoside with the same. SOLUTION: Provided are a new β-glucosidase, a method for producing the same, and an industrially utilizable method for producing a β-type glycoside with the same, by which the β-type glycoside can selectively be produced at one step with an aryl β-glucoside as a donor. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：为了提供具有广泛受体特异性的新的糖基转移酶，优先催化对酚羟基的转移反应，并且具有高的糖苷生产活性，并提供生产β-型糖苷的方法用同样的解决方案：提供一种新的β-葡糖苷酶，其制备方法，以及用于制备具有该β-葡糖苷的β-型糖苷的工业上可利用的方法，通过该方法可以在一个步骤中选择性地生产β-型糖苷与α-葡萄糖苷作为供体。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2008120792A Skin and hair cosmetic having moisture retention and hairdressing activity and method for producing the same 审中-公开
标题翻译：具有水分保持性和发丝活性的皮肤和头发化妆品及其生产方法
公开(公告)号：JP2008120792A
公开(公告)日：2008-05-29
申请号：JP2007265595
申请日：2007-10-11
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： ANDO OSAMU , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A61K8/99 , A61K8/19 , A61K8/34 , A61K8/49 , A61K8/60 , A61Q5/06 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a skin and hair cosmetic having excellent moisture retention and hair dressing activity, composed mainly of natural ingredients, and containing practically no chemically synthesized ingredient which is compounded in conventional skin and hair cosmetics as an active ingredient, causes chapped skin and allergy on the skin and scalp, disturbs hair growth and hair fostering, and causes skin and scalp stimulation and hair fall, and to provide a method for producing the cosmetic. SOLUTION: A hair and skin cosmetic having moisture retention and hair dressing activity and containing, as active ingredients, extracts extracted from microorganism with an alcohol aqueous solution, is provided, wherein the microorganism is one or more selected from microorganisms belonging to genuses Aureobacidium, Bacillus, Saccharomyces, Zygosaccharomyces, Schizosaccharomyces, Pichia, Hansenula, Kluyveromyces, Bullera, Kloeckera, Rhodotorula and Sporobolomyces, and a method for producing the cosmetic is also provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种皮肤和头发化妆品，其主要由天然成分组成，并且几乎不含有以常规皮肤和头发化妆品中复合的化学合成成分作为活性成分，具有优异的保湿和护发活性会引起皮肤和头皮上的皮肤过敏和皮肤过敏，妨碍毛发生长和发育，并引起皮肤和头皮的刺激和毛发脱落，并提供一种生产化妆品的方法。解决方案：提供一种具有保湿和发丝活性并含有作为活性成分的用醇水溶液从微生物提取的提取物的头发和皮肤化妆品，其中微生物是选自属于属的微生物的一种或多种 Aureobacidium，Bacillus，Saccharomyces，Zygosaccharomyces，Schizosaccharomyces，Pichia，Hansenula，Kluyveromyces，Bullera，Kloeckera，Rhodotorula and Sporobolomyces，以及一种生产化妆品的方法。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2006316053A Cytotoxicity inhibitor and use thereof 审中-公开
标题翻译：细胞毒性抑制剂及其用途
公开(公告)号：JP2006316053A
公开(公告)日：2006-11-24
申请号：JP2006111293
申请日：2006-04-13
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： AGA YOSHIO , ARIYASU TOSHIO , ARAI NARIYUKI , FUKUDA SHIGEHARU
IPC分类号： A61K31/7016 , A23K1/16 , A23K1/18 , A23L1/30 , A61K8/60 , A61K8/65 , A61K8/67 , A61K8/73 , A61K31/702 , A61K31/7048 , A61K47/36 , A61K47/42 , A61P39/00 , A61P43/00 , A61Q11/00 , A61Q19/00 , C07H3/04 , C07H3/06
摘要： PROBLEM TO BE SOLVED: To provide a means for inhibiting cytotoxicity caused by cytotoxic substances. SOLUTION: A solution is achieved by a cytotoxicity inhibitor for the cytotoxic substances comprising a glucide derivative of an α-trehalose and/or an α,α-trehalose as an active ingredient or a composition for inhibiting the cytotoxicity obtained by formulating the cytotoxicity inhibitor. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供抑制细胞毒性物质引起的细胞毒性的方法。解决方案：通过细胞毒性抑制剂实现包含α-海藻糖和/或α，α-海藻糖的糖苷衍生物作为活性成分的细胞毒性抑制剂的溶液或用于抑制通过制备细胞毒性抑制剂。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2005210925A Method for transferring glucosyl group 审中-公开
标题翻译：转运葡萄糖基团的方法
公开(公告)号：JP2005210925A
公开(公告)日：2005-08-11
申请号：JP2004019118
申请日：2004-01-28
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： NISHIMOTO TOMOYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： C12P19/18 , C12P19/44
CPC分类号： C12P19/18 , C12P19/44
摘要： PROBLEM TO BE SOLVED: To provide a method for transferring a glucosyl group, by which a glucosyl-transferred polyalcohol, glucosyl-transferred glucuronic acid, or glucosyl-transferred glucose-6-saccharide derivative can be produced by the utilization of an enzymatic reaction.
SOLUTION: This method for transferring the glucosyl group is characterized by treating a glucose-containing sugar compound as a constituting sugar, and one or more polyalcohols selected from inositol, ribitol, erythritol and glycerol, glucuronic acid and/or its salt, or one or more glucose-6-saccharide derivatives selected from isomaltose, gentibiose, melibiose and isopanose, with trehalose phosphorylase.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供转移葡糖基的方法，通过该方法可以通过使用葡糖基转移的多元醇，葡糖基转移的葡萄糖醛酸或葡糖基转移的葡萄糖-6-糖衍生物酶反应。解决方案：这种转移葡糖基的方法的特征在于处理含葡萄糖的糖化合物作为构成糖，并且一种或多种选自肌醇，核糖醇，赤藓糖醇和甘油的多元醇，葡糖醛酸和/或其盐，或一种或多种选自异麦芽糖，龙胆糖，蜜二糖和异丙糖的葡萄糖-6-糖衍生物与海藻糖磷酸化酶。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2005162677A Cyclic pentose, glycosyl derivative thereof, method for producing the same and application thereof 有权
标题翻译：循环药，其衍生物，其生产方法及其应用
公开(公告)号：JP2005162677A
公开(公告)日：2005-06-23
申请号：JP2003404412
申请日：2003-12-03
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： WATANABE HIKARI , AGA SO , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A23K1/16 , A23C9/152 , A23G3/00 , A23G3/34 , A23G3/48 , A23G4/00 , A23L1/09 , A23L1/19 , A23L1/236 , A23L2/38 , A61K8/00 , A61K8/06 , A61K8/60 , A61K8/73 , A61K31/702 , A61K47/26 , A61Q11/00 , C07H3/06 , C12P19/16 , C12P19/18 , C12P19/20 , A61K7/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To provide a new cyclic glucide and a glycosyl derivative thereof to expand the width of selection of the cyclic glucide; and to provide a method for producing them, a composition containing the cyclic glucide, and an application thereof. SOLUTION: The new pentose represented by cycloä→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-glucopyranosyl-(1→4)-α-D-glucopyranosyl-(1→} and the glycosyl derivative thereof are provided. The method for producing them, the composition containing the cyclic pentose and/or the glycosyl derivative thereof, and the application thereof are also provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供新的环状糖和其糖基衍生物以扩大环状糖的选择宽度; 并提供其制备方法，含有环状糖的组合物及其应用。解决方案：由cycloa→6）-α-D-吡喃葡萄糖基 - （1→3）-α-D-吡喃葡萄糖基 - （1→6）-α-D-吡喃葡萄糖基 - （1→3） -α-吡喃葡萄糖基 - （1→4）-α-D-吡喃葡萄糖基 - （1→）及其糖基衍生物，其制备方法，含有环状戊糖和/或其糖基衍生物的组合物，也提供了其应用。版权所有（C）2005，JPO＆NCIPI

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