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1. 发明申请

WO2004089964A8 LIPID-REGULATING AGENT AND USE THEREOF 审中-公开
标题翻译：脂质调节剂及其用途
公开(公告)号：WO2004089964A8
公开(公告)日：2004-12-29
申请号：PCT/JP2004004079
申请日：2004-03-24
申请人： HAYASHIBARA BIOCHEM LAB , OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A23D9/007 , A23K1/16 , A23L1/30 , A61K31/702 , A61P1/00 , A61P1/10 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P35/00 , C07H3/06 , A23D9/00 , A23L1/307
CPC分类号： A23D9/007 , A23K20/163 , A23L33/10 , A61K31/702 , C07H3/06
摘要： A lipid-regulating agent and a composition for lipid control which contains the lipid-regulating agent. The lipid-regulating agent comprises as an active ingredient a cyclic tetrasaccharide and/or a glucide derivative thereof.
摘要翻译：一种脂质调节剂和含有脂质调节剂的用于脂质控制的组合物。脂质调节剂包含作为活性成分的环状四糖和/或其糖苷衍生物。

2. 发明专利

JP2010202882A BRANCHED α-GLUCAN, α-GLUCOSYL TRANSFERASE FOR PRODUCING THE SAME, AND MANUFACTURING METHOD AND USE THEREFOR 审中-公开
标题翻译：分支的α-GLUCAN，用于生产α-葡聚糖的α-葡萄糖转移酶及其制备方法和用途
公开(公告)号：JP2010202882A
公开(公告)日：2010-09-16
申请号：JP2010132649
申请日：2010-06-10
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： WATANABE HIKARU , YAMAMOTO TAKUO , NISHIMOTO TOMOYUKI , TSUZAKI KEIJI , OKU KAZUYUKI , CHAEN HIROTO , FUKUDA SHIGEHARU
IPC分类号： C08B30/12 , A23L1/30 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/10 , C12P19/16 , C12P19/18
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： PROBLEM TO BE SOLVED: To provide glucan useful as a water-soluble dietary fiber, a manufacturing method and use therefor. SOLUTION: The branched α-glucan is an α-glucan making glucose as a constitution sugar and has a branched structure with a glucose polymerization degree of 1 or more connected to at least a non-reduction terminal end in a linear glucan with a glucose polymerization degree of 3 or more connected through an α-1,4 bond through a bond other than the α-1,4 bond, specifically is the branched α-glucan having the following characteristic in methylation analysis. The branched α-glucan characterized in that (1) a ratio of 2,3,6-trimethyl-1,4,5-triacetylglucitol to 2,3,4-trimethyl-1,5,6-triacetylglucitol is in a range of 1:0.6 to 1:4, (2) a total of 2,3,6-trimethyl-1,4,5-triacetylglucitol and 2,3,4-trimethyl-1,5,6-triacetylglucitol occupies 60% or more of a partially methylated glucitolacetate, (3) 2,4,6-trimethyl-1,3,5-triacetylglucitol is ≥0.5% and COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供可用作水溶性膳食纤维的葡聚糖，其制备方法和用途。解决方案：支链α-葡聚糖是制备葡萄糖作为构成糖的α-葡聚糖，并且具有葡萄糖聚合度为1以上的支链结构，其连接至线性葡聚糖中的至少非还原末端，通过α-1,4键之外的键通过α-1,4键连接3个以上的葡萄糖聚合度，特别是在甲基化分析中具有以下特征的支链α-葡聚糖。支链α-葡聚糖，其特征在于（1）2,3,6-三甲基-1,4,5-三乙酰基葡萄糖醇与2,3,4-三甲基-1,5,6-三乙酰基葡萄糖醇的比例在 1：0.6〜1：4，（2）总共2,3,6-三甲基-1,4,5-三乙酰基葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰葡萄糖醇占60％以上的部分甲基化葡萄糖醇乙酸酯，（3）2,4,6-三甲基-1,3,5-三乙酰基葡萄糖醇的部分甲基化葡萄糖醇乙酸酯的含量为≥0.5％和<10％，（4）2,4-二甲基-1,2-二 3,5,6-四乙酰基葡萄糖醇是部分甲基化葡萄糖醇乙酸盐的0.5％以上，用于制造支链α-葡聚糖的新的α-葡糖基转移酶，其制造方法和用途。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2005281188A Regulant of in vivo lipid 有权
标题翻译：生殖器疱疹
公开(公告)号：JP2005281188A
公开(公告)日：2005-10-13
申请号：JP2004097373
申请日：2004-03-30
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKU KAZUYUKI , KAYANO MAYUMI , HASHIMOTO TAKAHARU , FUKUDA SHIGEHARU
IPC分类号： A23K1/16 , A23K1/175 , A23L1/30 , A61K31/7016 , A61K31/702 , A61P1/10 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P35/00 , C07H3/04 , C07H3/06
摘要： PROBLEM TO BE SOLVED: To obtain a regulant of in vivo lipid for preventing or treating progress of life-style related diseases such as circulatory disease and diabetic to critical states by the progress of obesity, hyperlipemia, hypercholesterolemia, or the like, caused by the increase in the blood or the accumulation in a tissue or an organ of a living body of a lipid ingested as a food and drink, or the like, or a lipid synthesized in vivo; and to obtain a composition for regulation of the lipid obtained by formulating the regulant. SOLUTION: The regulant of the in vivo lipid contains a koji-oligosaccharide as an active ingredient. The composition for regulating the lipid is obtained by formulating the regulant. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了通过肥胖，高脂血症，高胆固醇血症等的进展，获得用于预防或治疗诸如循环系统疾病和糖尿病等生命方式相关疾病进入临界状态的体内脂质调节剂，由摄入食物和饮料等的脂质的生物体的组织或器官中的血液的增加或者体内的脂质的积累引起; 并获得用于调节由配制调节剂获得的脂质的组合物。解决方案：体内脂质的调节剂含有曲霉寡糖作为活性成分。用于调节脂质的组合物通过配制调节剂获得。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2003160495A INHIBITOR OF REDUCTION OF ACTIVE OXYGEN-SCAVENGING ACTIVITY 审中-公开
公开(公告)号：JP2003160495A
公开(公告)日：2003-06-03
申请号：JP2001355273
申请日：2001-11-20
申请人： HAYASHIBARA BIOCHEM LAB
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA YOSHIATSU , MIYAKE TOSHIO
IPC分类号： A23L1/30 , A23B7/14 , A61K8/00 , A61K8/60 , A61K8/96 , A61K31/702 , A61K36/18 , A61P9/10 , A61P17/16 , A61P19/02 , A61P25/16 , A61P25/28 , A61P35/00 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C07H3/06 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a new inhibitor of the reduction of active oxygen- scavenging activities, and a new method for inhibiting the reduction of the active oxygen-scavenging activities, and further to provide a vegetable edible material inhibiting reduction of the active oxygen-scavenging activities and/or a vegetable antioxidant-containing composition by adopting the method. SOLUTION: This inhibitor of the reduction of the active oxygen-scavenging activities contains a cyclic tetrasaccharide represented by chemical formula 1 as an active ingredient. COPYRIGHT: (C)2003,JPO

5. 发明专利

JP2010046075A Method of inhibiting acrylamide formation and use thereof 有权
标题翻译：抑制丙烯酰胺形成及其用途的方法
公开(公告)号：JP2010046075A
公开(公告)日：2010-03-04
申请号：JP2009239315
申请日：2009-10-16
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A23L5/20 , A23L19/18 , A61K8/44 , A61K8/49 , A61K8/60 , A61K8/73 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To establish a method of positively reducing the amount of acrylamide formed by heating an edible material at a high temperature and the use of the acrylamide to thereby provide foods, drinks, cosmetics, drugs and intermediates thereof having improved safety. SOLUTION: There are provided: a method of inhibiting the formation of acrylamide comprising, in heating an edible material with a risk of forming acrylamide during heating, adding an organic substance capable of inhibiting the formation of acrylamide to the edible material and then heating: compositions such as foods, drinks, cosmetics, drugs and intermediates thereof which are produced by the above method and in which the formation of acrylamide is inhibited: and compositions such as foods, drinks, cosmetics, drugs and intermediates thereof which contain an organic substance having amino group and/or a saccharide capable of forming acrylamide together with an organic substance capable of inhibiting the formation of acrylamide and have an ability to inhibit the formation of acrylamide. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：建立一种积极地减少在高温下加热可食用材料形成的丙烯酰胺的量的方法，以及使用丙烯酰胺从而提供具有改进的食品，饮料，化妆品，药物及其中间体安全。提供：抑制丙烯酰胺形成的方法，其包括在加热可能的材料中加热可能形成丙烯酰胺的可食用材料，加入能够抑制丙烯酰胺形成的有机物质到可食用材料中，然后加热：通过上述方法制备并且其中抑制丙烯酰胺形成的食品，饮料，化妆品，药物和中间体的组合物，以及含有有机物的食品，饮料，化妆品，药物及其中间体的组合物具有氨基的物质和/或能够形成丙烯酰胺的糖类与能够抑制丙烯酰胺形成的有机物质并具有抑制丙烯酰胺形成能力的物质。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2004305201A Method for controlling formation of acrylamide and use of the same 审中-公开
公开(公告)号：JP2004305201A
公开(公告)日：2004-11-04
申请号：JP2003282087
申请日：2003-07-29
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A23L1/30 , A23L1/00 , A23L1/015 , A23L1/03 , A23L1/09 , A23L1/16 , A23L1/172 , A23L1/216 , A23L1/2165 , A23L1/217 , A23L1/305 , A23L1/36 , A61K8/06 , A61K8/60 , A61K8/67 , A61K47/22 , A61K47/26 , A61Q1/00 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/676 , A23L5/27 , A23L7/111 , A23L7/152 , A23L19/13 , A23L19/15 , A23L19/18 , A23L25/20 , A23L29/045 , A23L29/30 , A23L33/175 , A23P20/12 , A23V2002/00 , A61K2800/52 , A61Q19/00 , A23V2250/0626 , A23V2250/0628 , A23V2250/0638 , A23V2250/0654 , A23V2250/0652 , A23V2250/061 , A23V2250/0632 , A23V2250/0648 , A23V2250/065 , A23V2250/636 , A23V2250/06 , A23V2250/708
摘要： PROBLEM TO BE SOLVED: To aggressively control an amount of acrylamide to be formed. SOLUTION: A method for controlling formation of the acrylamide comprises heat-treating an edible food material to which an organic substance having ability of controlling the formation of the acrylamide is added, when the edible food material which is feared to form the acrylamide by heat treatment is heat-treated. COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明专利

JPH10265390A COMPOSITION FOR INHIBITING ABDOMINAL DISORDER 失效
公开(公告)号：JPH10265390A
公开(公告)日：1998-10-06
申请号：JP9131597
申请日：1997-03-27
申请人： HAYASHIBARA BIOCHEM LAB
发明人： OKU KAZUYUKI , KASAGI TAKESHI , SAWATANI IKUO , FUKUDA SHIGEATSU , KURIMOTO MASASHI
IPC分类号： A61K47/12 , A61K31/70 , A61K33/06 , A61K33/42 , A61P1/00 , A61P1/08 , A61P1/12
摘要： PROBLEM TO BE SOLVED: To obtain a composition capable of relaxing or depressing abdominal disorders such as abdominal pain and diarrhea caused by the intake of lactose by including a specific ingredient. SOLUTION: This composition contains lactosucrose as an active ingredient. Therein, the lactosucrose is preferably contained in an amount of about 0.0001-1 g per g of the composition. When lactose is contained together with the lactosucrose, the lactosucrose and the lactose are preferably contained in a solid content ratio of 0.01:1 to 1:0.01. The lactosucrose is orally or enterally administered at a daily dose of about 0.1-50 g once to four times per day or once to ten times per week.

8. 发明专利

JP2012087125A AGGREGATE OF α-GLYCOSYL α,α-TREHALOSE WITH IONIC METAL COMPOUND 有权
标题翻译： α-GLYCOSYLα，α-TREHALOSE与离子金属化合物的合成
公开(公告)号：JP2012087125A
公开(公告)日：2012-05-10
申请号：JP2011243900
申请日：2011-10-20
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： A61K47/36 , A23K1/16 , A23K1/175 , A23L1/09 , A23L1/20 , A23L1/22 , A23L1/236 , A23L1/237 , A23L1/238 , A23L1/304 , A23L1/337 , A23L2/00 , A23L2/39 , A61K8/19 , A61K8/73 , A61K9/14 , A61K47/02 , A61P3/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C05G1/06 , C05G3/00 , C05G5/00 , C07H1/00 , C07H3/06
CPC分类号： C07H3/06 , A23L27/33 , A23L27/50 , A23L29/30 , A23L33/165 , A23V2002/00 , C07H1/00 , A23V2250/636 , A23V2250/156
摘要： PROBLEM TO BE SOLVED: To provide a preparation of an ionic metal compound which is improved in properties such as deliquescence, reducing power, oxidizing power and slight solubility in water, which are not desirable for the industrial use thereof and are inherent in the ionic metal compound, and to provide a method for preparing the preparation, and use thereof.SOLUTION: There are provided an association product of α-glycosyl α,α-trehalose with an ionic metal compound, a method for preparing the same, and a use thereof.
摘要翻译：要解决的问题：提供离子金属化合物的制备，其具有改善的性质如潮解，降低功率，氧化能力和在水中的轻微溶解性，这对于其工业应用是不希望的，并且是固有的离子金属化合物，并提供制备方法及其用途。解决方案：提供α-糖基α，α-海藻糖与离子金属化合物的结合产物，其制备方法及其用途。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2009280580A Association compound of trehalose or maltitol with metal ion compound 有权
标题翻译：含金属离子化合物的硫酸盐或马来酸盐的联合化合物
公开(公告)号：JP2009280580A
公开(公告)日：2009-12-03
申请号：JP2009130640
申请日：2009-05-29
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： OKU KAZUYUKI , KUBOTA MICHIO , FUKUDA SHIGEHARU , MIYAKE TOSHIO
IPC分类号： C07H3/04 , A01G7/00 , A23C11/10 , A23C20/02 , A23K1/16 , A23K1/175 , A23L1/00 , A23L1/01 , A23L1/015 , A23L1/054 , A23L1/09 , A23L1/20 , A23L1/211 , A23L1/22 , A23L1/237 , A23L1/238 , A23L1/304 , A23L1/39 , A23L2/52 , A61K8/19 , A61K8/34 , A61K8/60 , A61K9/14 , A61K31/7012 , A61K33/06 , A61K35/02 , A61K47/10 , A61K47/26 , A61K47/48 , A61P3/02 , A61P3/10 , A61P9/12 , A61P19/10 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07H15/04 , C07H23/00
CPC分类号： A61K8/345 , A23C11/103 , A23C20/025 , A23K20/163 , A23K20/24 , A23K20/30 , A23L2/52 , A23L5/19 , A23L5/27 , A23L11/09 , A23L11/34 , A23L23/00 , A23L27/40 , A23L27/50 , A23L27/86 , A23L29/274 , A23L29/30 , A23L29/37 , A23L33/16 , A23P20/20 , A23V2002/00 , A61K8/19 , A61K8/60 , A61K31/7012 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07H3/04 , C07H15/04 , C07H23/00 , A23V2250/636 , A23V2250/6416 , A23V2250/1578 , A23V2250/7056 , A23V2250/708 , A23V2250/161 , A23V2250/1612
摘要： PROBLEM TO BE SOLVED: To provide a product of a modified metal ion compound improved in industrially undesirable properties inherent in metal compounds, such as deliquescence, reducing ability, oxidizing ability, and poor solubility in water, a method for producing the same, and uses thereof. SOLUTION: An associate-containing powder comprises an associate of trehalose or maltitol with a metal ion compound comprising a magnesium ion compound and/or a calcium ion compound or a bittern component. The method for producing the associate-containing powder comprises mixing maltitol with a metal ion compound comprising a magnesium ion compound and/or a calcium ion compound in an aqueous medium to form an associate, then pulverizing the associate, and collecting the pulverized associate. Food and drink, feed, a cosmetic or a drug comprises the associate-containing powder as a mineral-enriching agent, a mineral supplement, a flavor improver, a tofu coagulant, a humectant, a plant nutrient, a plant vitalizing agent or an allergic reaction inhibitor. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供改善金属化合物固有的工业上不希望的性质的改性金属离子化合物的产物，如潮解，还原能力，氧化能力和在水中的溶解性差，其制备方法，及其用途。解决方案：含有助剂的粉末包含海藻糖或麦芽糖醇与包含镁离子化合物和/或钙离子化合物或卤盐组分的金属离子化合物的缔合物。制造含有助剂的粉末的方法包括在水性介质中混合麦芽糖醇与包含镁离子化合物和/或钙离子化合物的金属离子化合物以形成助剂，然后粉碎助剂并收集粉碎的助剂。食品和饮料，饲料，化妆品或药物包括作为矿物质富集剂的附属粉末，矿物质补充剂，风味改良剂，豆腐凝结剂，湿润剂，植物营养物，植物活化剂或过敏性物质反应抑制剂版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2005006579A Method for stabilizing isothiocyanate and use of the same 审中-公开
标题翻译：用于稳定异硫氰酸酯的方法及其用途
公开(公告)号：JP2005006579A
公开(公告)日：2005-01-13
申请号：JP2003175725
申请日：2003-06-20
申请人： Hayashibara Biochem Lab Inc , 株式会社林原生物化学研究所
发明人： SAITO NORIYUKI , OKU KAZUYUKI , KUBOTA MICHIO , MIYAKE TOSHIO
IPC分类号： A23L27/10 , A23L27/18 , A23L1/221 , A23L1/225
摘要： PROBLEM TO BE SOLVED: To provide a method for stabilizing isothiocyanate capable of excellently stabilizing isothiocyanate with remarkable effect, contained and/or to be included in food and drink as the spicy component, and to provide the use of the method for food and drink. SOLUTION: This method for stabilizing isothiocyanate comprises including in isothiocyanate as the spice component at least one kind of glucide selected from cyclic tetrasaccharide having a structure of α-glycosylα, α-trehalose, isomaltitol and cyclo ä→6}-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}. The use of the method for food and drink is also provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种稳定异硫氰酸酯的方法，该异硫氰酸酯能够极好地稳定具有显着效果的异硫氰酸酯，其含有和/或作为辛酸成分包含在食品和饮料中，并提供食品方法的使用并喝酒。解决方案：用于稳定异硫氰酸酯的方法包括在异硫氰酸酯中作为香料成分，选自具有α-糖基α，α-海藻糖，异麦芽糖醇和环ä→6}-α-糖基结构的环状四糖中的至少一种糖， D-吡喃葡萄糖基 - （1→3）-α-D-吡喃葡萄糖基 - （1→6）-α-D-吡喃葡萄糖基 - （1→3）-α-D-吡喃葡萄糖基 - （1→} 也提供食品和饮料。版权所有（C）2005，JPO＆NCIPI

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