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1. 发明申请

WO2010104597A2 SCALE-UP OF MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流量装置的升级
公开(公告)号：WO2010104597A2
公开(公告)日：2010-09-16
申请号：PCT/US2010000753
申请日：2010-03-12
申请人： HARVARD COLLEGE , ROMANOWSKY MARK , ABATE ADAM R , WEITZ DAVID A
发明人： ROMANOWSKY MARK , ABATE ADAM R , WEITZ DAVID A
IPC分类号： B01J19/00
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F2215/0037 , B01J19/0093 , B01J2219/00015 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01J2219/00975 , B01L3/502784 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , Y10T137/0318 , Y10T137/8593
摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.
摘要翻译：描述了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置的并行使用。在一些方面，本发明一般涉及流动聚焦型技术，还涉及微流体，更具体地说，并行使用布置成控制分散剂内分散相的微流体系统，以及尺寸和尺寸分布分散相在多相流体系统中，以及用于将流体组分输送到多个这样的装置的系统。

2. 发明申请

WO2010151776A3 FLUID INJECTION 审中-公开
标题翻译：流体注射
公开(公告)号：WO2010151776A3
公开(公告)日：2011-04-28
申请号：PCT/US2010040006
申请日：2010-06-25
申请人： HARVARD COLLEGE , WEITZ DAVID A , ABATE ADAM R , HUNG TONY , MARY PASCALINE
发明人： WEITZ DAVID A , ABATE ADAM R , HUNG TONY , MARY PASCALINE
IPC分类号： G01N35/10 , B01F5/06 , B01F13/00 , B01J19/00 , B05C9/00
CPC分类号： B01F5/0471 , B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00837 , B01J2219/00853 , B01J2219/00862 , B01J2219/00889 , B01L3/50273 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , F16K99/0042 , F16K99/0051 , G01N27/44791 , G01N2035/1034 , Y10T137/0391 , Y10T137/206
摘要： The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.
摘要翻译：本发明一般涉及用于控制流体的系统和方法，并且在一些情况下涉及将流体流入和/或流出其它流体的系统和方法。作为示例，流体可以被注入到包含在流体通道内的液滴中，或者可以将流体注入到流体通道中以产生液滴。在一些实施例中，电极可用于将电场施加到一个或多个流体通道，例如至少两个流体通道的相交处。例如，可以通过电场促进第一流体进入和/或流出第二流体。在一些情况下，电场可能破坏第一流体和至少一种其它流体之间的界面。可以通过控制流体和/或流体液滴的各种性质（例如流体液滴的曲率）来控制被推入和/或流出第二流体的第一流体的体积，流速等性质，和/或控制所施加的电场。

3. 发明申请

WO2009020633A3 METAL OXIDE COATING ON SURFACES 审中-公开
标题翻译：金属氧化物涂层在表面上
公开(公告)号：WO2009020633A3
公开(公告)日：2009-08-06
申请号：PCT/US2008009477
申请日：2008-08-07
申请人： HARVARD COLLEGE , WEITZ DAVID A , HOLTZE CHRISTIAN , ABATE ADAM R , LEE DAEYEON , DO THAO
发明人： WEITZ DAVID A , HOLTZE CHRISTIAN , ABATE ADAM R , LEE DAEYEON , DO THAO
IPC分类号： C23C18/12 , C03B19/12 , C03C1/00
CPC分类号： C23C18/1295 , C03C1/008 , C23C18/1216 , C23C18/1233 , C23C18/1254 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744
摘要： The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the reactive PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfiuidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
摘要翻译：本发明提供一种在PDMS表面上涂覆金属氧化物的方法。该方法包括制备含有溶胶 - 凝胶前体的混合物，使混合物反应以形成预转化的溶胶 - 凝胶前体，其中预转化的溶胶 - 凝胶前体不扩散到PDMS中并且不是凝胶形式，将预转化的溶胶 - 凝胶前体施加到反应性PDMS表面上，将预转化的溶胶 - 凝胶前体与反应性PDMS表面结合，并将结合的预转化的溶胶 - 凝胶前体转化为金属氧化物，以形成金属氧化物涂层 PDMS表面。本发明还提供了一种PDMS微流体装置，其中微流体装置的一个或多个通道设置有仅在一个或多个通道的表面上共价结合的金属氧化物涂层。

4. 发明申请

WO2012162296A2 CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS 审中-公开
标题翻译：乳液控制，包括多种乳剂
公开(公告)号：WO2012162296A2
公开(公告)日：2012-11-29
申请号：PCT/US2012038957
申请日：2012-05-22
申请人： HARVARD COLLEGE , BASF SE , ROTEM ASSAF , WEITZ DAVID A , ABATE ADAM R , HOLTZE CHRISTIAN
发明人： ROTEM ASSAF , WEITZ DAVID A , ABATE ADAM R , HOLTZE CHRISTIAN
IPC分类号： B01F13/00 , B01F3/08
CPC分类号： B01F3/0811 , B01F3/0807 , B01F13/0062 , B01F13/0084 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels, where a first fluid flows through one channel, a second fluid flows through two channels, and a third or carrying fluid flows through two more channels, such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳液，更具体地说涉及双重和其它多重乳液。本发明的某些方面通常涉及在微流体通道的共同连接处产生双重乳液和其它多重乳液。在一些情况下，共同连接处的微流体通道可具有基本上相同的疏水性。在一组实施例中，装置可以包括六个或更多个通道的公共接头，其中第一流体流过一个通道，第二流体流过两个通道，并且第三或承载流体流过两个以上通道，使得包含在第二流体的第二液滴中的第一流体的第一液滴的双重乳液由携带流体包含，通过第六通道从公共接头流出。本发明的其它方面通常涉及制造和使用这种系统的方法，涉及这种系统的试剂盒，使用这种系统产生的乳液等。

5. 发明申请

WO2012087350A2 SPRAY DRYING TECHNIQUES 审中-公开
标题翻译：喷雾干燥技术
公开(公告)号：WO2012087350A2
公开(公告)日：2012-06-28
申请号：PCT/US2011001993
申请日：2011-12-20
申请人： HARVARD COLLEGE , BASF SE , ABATE ADAM R , THIELE JULIAN W P , WEITZ DAVID A , WINDBERGS MAIKE , HOLTZE CHRISTIAN
发明人： ABATE ADAM R , THIELE JULIAN W P , WEITZ DAVID A , WINDBERGS MAIKE , HOLTZE CHRISTIAN
IPC分类号： B01J2/04 , B05B7/04
CPC分类号： B01D1/18 , A61K31/58 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfiuidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.
摘要翻译：本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。在一些方面，使用含有一种或多种通道或微流体通道的制品在喷雾干燥之前混合一种或多种流体。在流体通过喷嘴或其它开口排出到喷雾干燥器的干燥区域之前，混合可能发生。在一组实施例中，例如，第一流体暴露于第二流体，然后在通过喷嘴排出之前将流体暴露于空气或其它气体。在某些情况下，第一流体可以含有在暴露于第二流体时可能沉淀的溶解物质; 这种沉淀可能在通过喷嘴或其他开口排出之前立即发生，从而导致作为喷雾干燥过程的一部分的受控沉淀。

6. 发明申请

WO2011028764A3 MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES 审中-公开
标题翻译：使用喷射和其他技术创建多个乳液
公开(公告)号：WO2011028764A3
公开(公告)日：2011-09-29
申请号：PCT/US2010047467
申请日：2010-09-01
申请人： HARVARD COLLEGE , WEITZ DAVID A , THIELE JULIAN W P , ABATE ADAM R
发明人： WEITZ DAVID A , THIELE JULIAN W P , ABATE ADAM R
IPC分类号： B01F5/02 , B01F3/08 , B01F5/26 , B01F15/04
CPC分类号： B01F3/0807 , B01F13/0062 , B01F13/0084 , B01F2003/0838 , B01F2215/045 , B01F2215/0459 , Y10T137/0318 , Y10T137/85938
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed by urging a fluid into a channel, e.g., by causing the fluid to enter the channel as a "jet." Side channels can be used to encapsulate the fluid with a surrounding fluid. In some cases, multiple fluids may flow through a channel collinearly before multiple emulsion droplets are formed. The fluidic channels may also, in certain embodiments, include varying degrees of hydrophilicity or hydrophobicity. As examples, the fluidic channel may be relatively hydrophilic upstream of an intersection (or other region within the channel) and relatively hydrophobic downstream of the intersection, or vice versa. In some cases, the average cross-sectional dimension may change, e.g., at an intersection. For instance, the average cross-sectional dimension may increase at the intersection. Surprisingly, a relatively small increase in dimension, in combination with a change in hydrophilicity of the fluidic channel, may delay droplet formation of a stream of collinearly-flowing multiple fluids under certain flow conditions; accordingly, the point at which multiple emulsion droplets are formed can be readily controlled within the fluidic channel. In some cases, the multiple droplet may be formed from the collinear flow of fluids at (or near) a single location within the fluidic channel. In addition, unexpectedly, systems such as those described herein may be used to encapsulate fluids in single or multiple emulsions that are difficult or impossible to encapsulate using other techniques, such as fluids with low surface tension, viscous fluids, or viscoelastic fluids. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明总体上涉及乳液，并且更具体地涉及多重乳液。在一个方面，通过例如通过使流体作为“射流”进入通道而促使流体进入通道来形成多重乳液。侧通道可以用于将流体与周围的流体一起封装。在一些情况下，在形成多个乳液液滴之前，多种流体可以共线地流过通道。在某些实施例中，流体通道还可以包括不同程度的亲水性或疏水性。作为示例，流体通道可以在交叉点（或通道内的其他区域）上游相对亲水，并且在交叉点下游相对疏水，或者反之亦然。在一些情况下，平均横截面尺寸可以例如在交叉点处改变。例如，交叉点处的平均横截面尺寸可能会增加。令人惊奇的是，尺寸的相对小的增加与流体通道的亲水性的变化相结合可以在某些流动条件下延迟共线流动的多种流体的流的液滴形成; 因此，可以容易地在流体通道内控制形成多个乳液液滴的点。在一些情况下，多个液滴可以由在流体通道内的单个位置处（或靠近）的共线流体流形成。另外，出乎意料地，诸如本文描述的那些的系统可用于将流体封装在使用其他技术（例如具有低表面张力的流体，粘性流体或粘弹性流体）难以或不可能包封的单一或多重乳液中。本发明的其他方面通常涉及制造和使用这样的系统的方法，涉及这种系统的试剂盒，使用这种系统创建的乳剂等。

7. 发明申请

WO2009139898A8 VALVES AND OTHER FLOW CONTROL IN FLUIDIC SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：流体系统中的阀门和其他流量控制，包括微流体系统
公开(公告)号：WO2009139898A8
公开(公告)日：2010-04-22
申请号：PCT/US2009003024
申请日：2009-05-15
申请人： HARVARD COLLEGE , ABATE ADAM R , WEITZ DAVID A
发明人： ABATE ADAM R , WEITZ DAVID A
IPC分类号： F16K99/00 , B01L3/00
CPC分类号： B01L3/502738 , B01L3/0268 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2200/0636 , B01L2200/146 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F16K99/0017 , F16K99/0026 , F16K99/0055 , Y10T436/2575
摘要： Articles and methods for controlling flow in fluidic Systems, especially in microfluidic Systems, are provided. A microfluidic System includes a configuration such that the actuation of a single valve can allow the switching of fluids from a first fluid path (e.g., a first channel section) to a second fluid path (e.g., a second channel section). This may be achieved by incorporating a valve (38) with a first channel section (24), which may have a lower hydrodynamic resistance than a second channel section (28)prior to actuation of the valve. Actuation of the valve (38) can cause only the hydrodynamic resistance of the first channel section (24) to increase, thereby redirecting fluid flow into the second channel section (28) (which now has a relatively lower hydrodynamic resistance). The valve comprises a control channel (40) for introducing a positive or reduced pressure, and is adapted to modulate fluid flow in an adjacent channel section by constricting or expanding the channel section (24).
摘要翻译：提供了用于控制流体系统流动的文章和方法，特别是在微流体系统中。微流体系统包括使得单个阀的致动允许流体从第一流体路径（例如，第一通道部分）切换到第二流体路径（例如，第二通道部分）的构造。这可以通过在阀致动之前并入具有第一通道部分（24）的阀（38）来实现，其可以具有比第二通道部分（28）更低的流体动力阻力。阀（38）的致动可以仅使第一通道部分（24）的流体动力阻力增加，从而将流体流转向第二通道部分（28）（其现在具有相对较低的流体动力阻力）。阀包括用于引入正压或减压的控制通道（40），并且适于通过收缩或扩大通道部分（24）来调制相邻通道部分中的流体流动。

8. 发明申请

WO2012027366A3 ACOUSTIC WAVES IN MICROFLUIDICS 审中-公开
标题翻译： MICROFLUIDICS中的声波
公开(公告)号：WO2012027366A3
公开(公告)日：2012-08-16
申请号：PCT/US2011048804
申请日：2011-08-23
申请人： HARVARD COLLEGE , UNIV AUGSBURG , WEITZ DAVID A , FRANKE THOMAS , WIXFORTH ACHIM , SCHMID LOTHAR , AGRESTI JEREMY , ABATE ADAM R
发明人： WEITZ DAVID A , FRANKE THOMAS , WIXFORTH ACHIM , SCHMID LOTHAR , AGRESTI JEREMY , ABATE ADAM R
IPC分类号： B01J19/10 , C12M1/42
CPC分类号： C12M23/16 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0421 , B01L2400/0436 , B01L2400/0487 , B01L2400/0496 , C12M47/04 , F17D3/01 , G01N2015/1006 , G01N2015/1081 , Y10T137/0391
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.
摘要翻译：本发明的各个方面涉及例如在微流体系统中的流体物质的控制和操纵。在一组实施例中，可以使用表面声波对液滴进行分类。液滴可能含有细胞或其他物种。在一些情况下，表面声波可以使用诸如叉指换能器的表面声波发生器和/或诸如压电基板的材料来产生。除了在液滴分选位置处或附近之外，压电基底可以与微流体基底分离，例如分离成第一或第二微流体通道。在这样的位置处，微流体衬底可以通过一个或多个耦合区域耦合到压电衬底（或其他材料）。在一些情况下，可以实现相对高的分选速率，例如以至少约1,000Hz，至少约10,000Hz或至少约100,000Hz的速率，并且在一些实施方式中，在分选后具有高细胞存活力。

9. 发明申请

WO2011008233A8 METHODS AND APPARATUS FOR FLUORESCENCE SENSING EMPLOYING FRESNEL ZONE PLATES 审中-公开
标题翻译：用于使用菲森区域板进行荧光检测的方法和设备
公开(公告)号：WO2011008233A8
公开(公告)日：2011-09-22
申请号：PCT/US2010001372
申请日：2010-05-07
申请人： HARVARD COLLEGE , CROZIER KENNETH B , WEITZ DAVID A , SCHONBRUN ETHAN , ABATE ADAM R
发明人： CROZIER KENNETH B , WEITZ DAVID A , SCHONBRUN ETHAN , ABATE ADAM R
IPC分类号： A01N31/00
CPC分类号： G01N21/6458 , B01L3/502715 , B01L3/502784 , B01L2300/0654 , B01L2300/0877
摘要： Methods and apparatus for high-throughput fluorescence detection using integrated microfabricated optical element arrays are described. In one example, the optical element arrays may comprise one or more microfabricated Fresnel zone plates, which may be configured to collect light from samples flowing in microfluidic channels. Multiple samples may be inspected in parallel at significantly high rates (e.g., about 200,000 samples per second or higher). A relay lens combined with high numerical aperture integrated microfabricated optical elements provides significant signal enhancement (e.g., on the order of at least 200 times that of conventional fluorescence detection methods).
摘要翻译：描述了使用集成的微制造光学元件阵列进行高通量荧光检测的方法和设备。在一个示例中，光学元件阵列可以包括一个或多个微制造的菲涅耳波带片，其可以被配置为收集来自在微流体通道中流动的样本的光。可以以相当高的速率并行检查多个样本（例如，每秒约200,000个样本或更高）。与高数值孔径集成微制造光学元件组合的中继透镜提供显着的信号增强（例如，至少是常规荧光检测方法的200倍）。

10. 发明申请

WO2009139898A3 VALVES AND OTHER FLOW CONTROL IN FLUIDIC SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：流体系统中的阀门和其他流量控制，包括微流体系统
公开(公告)号：WO2009139898A3
公开(公告)日：2010-03-04
申请号：PCT/US2009003024
申请日：2009-05-15
申请人： HARVARD COLLEGE , ABATE ADAM R , WEITZ DAVID A
发明人： ABATE ADAM R , WEITZ DAVID A
IPC分类号： F16K99/00 , B01L3/00
CPC分类号： B01L3/502738 , B01L3/0268 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2200/0636 , B01L2200/146 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F16K99/0017 , F16K99/0026 , F16K99/0055 , Y10T436/2575
摘要： Articles and methods for controlling flow in fluidic systems, especially in microfluidic systems, are provided. A microfluidic system includes a configuration such that the actuation of a single valve can allow the switching of fluids from a first fluid path (e.g., a first channel section) to a second fluid path (e.g., a second channel section). This may be achieved by incorporating a valve (58) with a first channel section (24), which may have a lower hydrodynamic resistance than a second channel section (28) prior to actuation of the valve. Actuation of the valve (58) can cause only the hydrodynamic resistance of the first channel section (24) to increase, thereby redirecting fluid flow into the second channel section (28) (which now has a relatively lower hydrodynamic resistance). The valve comprises a control channel (40) for introducing a positive or reduced pressure, and is adapted to modulate fluid flow in an adjacent channel section by constricting or expanding the channel section(24).
摘要翻译：提供了用于控制流体系统流动的文章和方法，特别是在微流体系统中。微流体系统包括使得单个阀的致动允许流体从第一流体路径（例如，第一通道部分）切换到第二流体路径（例如，第二通道部分）的构造。这可以通过在阀致动之前并入具有第一通道部分（24）的阀（58）来实现，该第一通道部分（24）可具有比第二通道部分（28）更低的流体动力阻力。阀（58）的致动可以仅引起第一通道部分（24）的流体动力阻力增加，从而将流体流转向第二通道部分（28）（其现在具有相对较低的流体动力阻力）。阀包括用于引入正压或减压的控制通道（40），并且适于通过收缩或扩大通道部分（24）来调制相邻通道部分中的流体流动。

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