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1. 发明申请

US20070161645A1 Thiazole inhibitors targeting resistant kinase mutations 审中-公开
标题翻译：噻唑抑制剂靶向抗性激酶突变
公开(公告)号：US20070161645A1
公开(公告)日：2007-07-12
申请号：US11591252
申请日：2006-10-31
申请人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
IPC分类号： A61K31/506 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/428 , C07D417/14
CPC分类号： C07D417/12 , C07D239/42 , C07D253/06 , C07D277/42 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/14 , C07D417/06 , C07D417/14
摘要： A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophbic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.
摘要翻译：提供具有通式（A）的化合物：其中A为芳基或杂芳基，Y为亲水连接部分，L为取代基。化合物（A）可用于治疗各种血管生成相关或血液学疾病，例如对不含有激酶抑制治疗反应的患者中的骨髓增生性疾病，其包括施用目前使用的药物。

2. 发明申请

US20070149508A1 Six membered heteroaromatic inhibitors targeting resistant kinase mutations 审中-公开
标题翻译：靶向抗性激酶突变的六元杂芳族抑制剂
公开(公告)号：US20070149508A1
公开(公告)日：2007-06-28
申请号：US11591076
申请日：2006-10-31
申请人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
IPC分类号： A61K31/551 , A61K31/53 , A61K31/506 , C07D403/02
CPC分类号： C07D417/12 , C07D239/42 , C07D253/06 , C07D277/42 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/14 , C07D417/06 , C07D417/14
摘要： A compound is provided, having the general structure (A): wherein A is an (un)substituted aryl or (un)substituted heteroaryl moiety, G is N, CH, or CR, R is an unsubstituted or substituted lower alkyl, Y is a hydrophobic linking moiety, and L is a substitutent as defined. The compound (A) can be used for treatment of various angiogenic and hematological-associated disorders, such as myeloproliferative disorder in patients who do not respond to kinase-inhibition therapy that comprises administering approved medications.
摘要翻译：提供具有一般结构（A）的化合物：其中A是（未）取代的芳基或（未）取代的杂芳基部分，G是N，CH或CR，R是未取代或取代的低级烷基，Y是疏水连接部分，L是如所定义的取代基。化合物（A）可用于治疗各种血管生成和血液学相关疾病，例如对不包括施用批准药物的激酶抑制治疗无反应的患者中的骨髓增生性疾病。

3. 发明申请

US20070191405A1 Bi-aryl meta-pyrimidine inhibitors of kinases 有权
公开(公告)号：US20070191405A1
公开(公告)日：2007-08-16
申请号：US11588638
申请日：2006-10-26
申请人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
发明人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
IPC分类号： A61K31/506 , C07D403/02 , C07D407/02
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

4. 发明申请

US20070259904A1 Bi-aryl meta-pyrimidine inhibitors of kinases 有权
标题翻译：激酶的双芳基间 - 嘧啶抑制剂
公开(公告)号：US20070259904A1
公开(公告)日：2007-11-08
申请号：US11796717
申请日：2007-04-26
申请人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
发明人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
IPC分类号： A61K31/506 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P3/10 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P37/08 , A61P41/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/10 , C07D239/46 , G09F3/00
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。

5. 发明申请

US20060247250A1 Pyrimidine inhibitors of kinases 审中-公开
标题翻译：嘧啶嘧啶抑制剂
公开(公告)号：US20060247250A1
公开(公告)日：2006-11-02
申请号：US11377234
申请日：2006-03-15
申请人： Jianguo Cao , Richard Soll , Glenn Noronha , Kathy Barrett , Colleen Gritzen , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Ute Splittgerber , Binqi Zeng
发明人： Jianguo Cao , Richard Soll , Glenn Noronha , Kathy Barrett , Colleen Gritzen , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Ute Splittgerber , Binqi Zeng
IPC分类号： A61K31/506 , C07D403/14 , C07D403/02
CPC分类号： C07D239/48 , C07D239/49 , C07D401/12 , C07D417/12
摘要： The invention provides pyrimidine compounds having formula A. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式A的嘧啶化合物。本发明的嘧啶化合物能够抑制激酶，例如Src激酶家族的成员和各种其它特异性受体和非受体激酶。

6. 发明申请

US20050245524A1 Benzotriazine inhibitors of kinases 有权
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US20050245524A1
公开(公告)日：2005-11-03
申请号：US11102405
申请日：2005-04-07
申请人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Ute Splittgerber , Wolfgang Wrasdilo , Ningning Zhao , Elena Dneprovskaia
发明人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Ute Splittgerber , Wolfgang Wrasdilo , Ningning Zhao , Elena Dneprovskaia
IPC分类号： A61K31/53 , C07D43/14
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

7. 发明申请

US20070259876A1 Kinase inhibitors and methods of use thereof 有权
标题翻译：激酶抑制剂及其使用方法
公开(公告)号：US20070259876A1
公开(公告)日：2007-11-08
申请号：US11789832
申请日：2007-04-25
申请人： John Doukas , Chi Mak , Elena Dneprovskaia , Glenn Noronha
发明人： John Doukas , Chi Mak , Elena Dneprovskaia , Glenn Noronha
IPC分类号： A61K31/525 , C07D475/04
CPC分类号： C07D475/08
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗死，癌症，缺血/再灌注损伤，自身免疫疾病如类风湿性关节炎，眼睛疾病如葡萄膜炎，视网膜病变或黄斑变性，黄斑水肿或其他玻璃体视网膜疾病，诸如自身免疫性疾病，血管渗漏综合征，水肿或涉及白细胞激活的疾病，移植排斥，呼吸系统疾病如哮喘，成人或急性呼吸窘迫综合征（ARDS），慢性阻塞性肺疾病等的炎性疾病。

8. 发明申请

US20060254220A1 Appliance for vacuum sealing food containers 有权
公开(公告)号：US20060254220A1
公开(公告)日：2006-11-16
申请号：US11487903
申请日：2006-07-17
申请人： Justin Patterson , Salvatore Siano , Chi Mak , Heather Jones , Francis Marino , Dave Bossa , Yigal Offir
发明人： Justin Patterson , Salvatore Siano , Chi Mak , Heather Jones , Francis Marino , Dave Bossa , Yigal Offir
IPC分类号： B65B31/00
CPC分类号： B65B31/046 , B65B31/06 , B65B51/146
摘要： A system for evacuating containers. The system includes a base housing defining a recess having a vacuum inlet port in communication with a vacuum source. An inner door is hinged to the base housing and is sized to cover the recess when in a closed position, and an outer door having a sealing member is hinged to close over the inner door. A vacuum nozzle extends at least partially between the inner and outer doors and is in communication with the recess. The inner and outer doors cooperate to retain a flexible container therebetween and around the nozzle so that the nozzle is positioned for fluid communication with an inside of the container. A removable drip pan is positioned to retain fluids drawn by the nozzle.

9. 发明申请

US20050218030A1 Packaging device and method 审中-公开
标题翻译：包装装置及方法
公开(公告)号：US20050218030A1
公开(公告)日：2005-10-06
申请号：US11089004
申请日：2005-03-24
申请人： Chi Mak
发明人： Chi Mak
IPC分类号： B65B11/50 , B65B11/58 , B65B23/00 , B65B31/00 , B65B31/06 , B65B55/20 , B65D25/10 , B65D81/05 , B65D81/07 , B65D81/107 , B65D85/30
CPC分类号： B65B11/50 , B65B11/58 , B65B23/00 , B65B31/06 , B65B55/20 , B65D81/052 , B65D81/075 , B65D81/1075
摘要： The invention basically includes an outer layer made of flexible sheets of synthetic resinous or impervious materials, and/or rigid and/or semi-rigid materials while the wrapping of each article may be held inside the packaging system by flexible linkages. The portion of the wrapping that is not directly wrapping the article should be considered as the flange of the wrapping which will become the “linkage” in the glossary of this invention. The wrapping may be designed with openings for the protruded, fragile or sharp members of the article to avoid damage to these parts. The wrapping may be made as a closed cell and a negative pressure (vacuum) may be applied to securely grasp the article. For those articles that are not suited for tight wrap, certain fluids (e.g., air) may be provided to the inside of the sealed wrapping to counteract the inflation pressure at the outside of the wrapping.
摘要翻译：本发明基本上包括由合成树脂或不渗透材料的柔性片材制成的外层，和/或刚性和/或半刚性材料，而每个制品的包装可通过柔性连接件保持在包装系统内。不直接包裹物品的包装部分应视为包装的法兰，这将成为本发明术语表中的“连接”。可以将包装设计成具有用于制品的突出，易碎或锋利构件的开口，以避免损坏这些部件。包装可以制成闭孔，并且可以施加负压（真空）以牢固地抓住物品。对于不适合紧密包裹的那些制品，可以将某些流体（例如空气）提供到密封的包装的内部，以抵消包装外部的充气压力。

10. 发明申请

US20050269770A1 3-Dimensional puzzle and method of forming same 审中-公开
标题翻译：三维拼图及其形成方法
公开(公告)号：US20050269770A1
公开(公告)日：2005-12-08
申请号：US11144128
申请日：2005-06-02
申请人： Chi Mak
发明人： Chi Mak
IPC分类号： A63F9/06 , A63F9/08
CPC分类号： A63F9/0838 , A63F9/0857
摘要： The present invention makes use of the spherical sectors, semi-spheres, cylindrical or circular sections of a solid object or the surface of an object, and breaks them into components. If no such spherical sectors, semi-spheres, cylindrical or circular sections are available on the object, or the existing ones cannot be used for any reason, one can create some adequate ones under allowable circumstances. The puzzle will come into being when any of its broken down components can be shared with (interchanged with components of) other flat or spherical or circular or cylindrical surfaces. The idea of the present invention is rather simple, however it may be applied in a versatile manner.
摘要翻译：本发明利用球形部分，半球体，固体物体的圆柱形或圆形部分或物体的表面，并将其分解成部件。如果物体上没有这样的球形扇形，半球形，圆柱形或圆形截面，或者由于任何原因不能使用现有的扇形，可以在允许的情况下创建一些足够的。当其任何破碎的部件可以与其他平面或球形或圆形或圆柱形表面共享（与其部件互换）时，这个难题将会形成。本发明的想法相当简单，但是它可以以通用的方式应用。

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