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1. 发明申请

US20060115196A1 Controllable electro-optic device having substrate trenches between electrodes 有权
标题翻译：在电极之间具有衬底沟槽的可控电光器件
公开(公告)号：US20060115196A1
公开(公告)日：2006-06-01
申请号：US11001440
申请日：2004-12-01
申请人： Gilbert Feke , Hirotoshi Nagata , Karl Kissa
发明人： Gilbert Feke , Hirotoshi Nagata , Karl Kissa
IPC分类号： G02F1/035 , G02B6/26 , G02B6/42 , G02F1/295
CPC分类号： G02F1/035 , G02F1/225
摘要： An optical modulator which has substantially low loss and has an improvement in voltage reduction is disclosed having an electro-optic lithium niobate substrate. The substrate has first, second and third ridges extending along its surface. Extending along the first and second ridges are first and second waveguides. A first RF electrode extends over the first waveguide and a second slotted electrode including a first section extends over the second waveguide. A second section of the slotted extends parallel to and adjacent to the first section on the third ridge. In summary, this invention provides a slotted ground electrode wherein a slot is formed in the substrate between the slotted electrode.
摘要翻译：公开了一种具有实质上低损耗并且具有降低电压的改进的光调制器，其具有电光铌酸锂衬底。衬底具有沿其表面延伸的第一，第二和第三脊。沿着第一和第二脊延伸的是第一和第二波导。第一RF电极在第一波导上延伸，并且包括第一部分的第二开槽电极在第二波导上延伸。开槽的第二部分平行于并邻近第三脊上的第一部分延伸。总之，本发明提供了一种开槽接地电极，其中在开槽电极之间的衬底中形成槽。

2. 发明授权

US08203132B2 Apparatus and method for imaging ionizing radiation 有权
标题翻译：用于成像电离辐射的装置和方法
公开(公告)号：US08203132B2
公开(公告)日：2012-06-19
申请号：US12324092
申请日：2008-11-26
申请人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
发明人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
IPC分类号： G01N23/04
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将从源的电离辐射转换成可见光; 提供电影或数字捕获装置用于使用可见光捕获图像; 并且荧光屏逐渐移动以便于减少荧光屏斑点。

3. 发明授权

US08113702B2 Variable condenser for delivery of illumination including recursively nested circle to-line fiber optic converter cable 失效
标题翻译：用于交付照明的可变冷凝器，包括递归嵌套的圆形到线光纤转换器电缆
公开(公告)号：US08113702B2
公开(公告)日：2012-02-14
申请号：US12431823
申请日：2009-04-29
申请人： Gilbert Feke
发明人： Gilbert Feke
IPC分类号： F21V7/04
CPC分类号： G02B6/04 , G02B6/0008 , G02B26/103
摘要： A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input.
摘要翻译：用于传输照明的可变电容器，包括递归嵌套的圆形到光纤形状转换电缆和可调焦输入透镜系统。在光纤电缆的输入端，各组光纤包括相对较小的环，其相对于公共中心递归地嵌套。在光纤电缆的输出处，各组光纤包括一对线段，其以线中点递归地嵌套，由此线段对的嵌套级别具有与嵌套级别的精确或近似对应关系环形输出可以被分成多条线，由此各组光纤分布在多条线之间。输入透镜系统具有单个可调节聚焦装置，以改变入射到光纤光缆圆输入端的照明点的半径。

4. 发明授权

US08041409B2 Method and apparatus for multi-modal imaging 有权
标题翻译：多模态成像的方法和装置
公开(公告)号：US08041409B2
公开(公告)日：2011-10-18
申请号：US12460010
申请日：2009-07-10
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于成像受试动物的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

5. 发明申请

US20100046076A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译：可调光谱过滤装置
公开(公告)号：US20100046076A1
公开(公告)日：2010-02-25
申请号：US12248958
申请日：2008-10-10
申请人： Gilbert Feke , Douglas L. Vizard
发明人： Gilbert Feke , Douglas L. Vizard
IPC分类号： G02B27/00 , G01J3/45
CPC分类号： G02B5/285 , G02B26/002 , G02B26/008 , G02B26/023
摘要： A tunable spectral filtration device is disclosed that includes one or more pairs of interference filters in series, wherein each element of each pair is independently selected from one or more options, independently positioned to intersect a path of converging or diverging light, and independently tilted with respect to the light path. Each filter may be either of a bandpass type, a shortpass type, a longpass type, a notch type, or multiple combinations thereof. Each filter in the series may be independently selected and tilted to tune the net spectral output of the series. The elements in a pair of filters may be tilted in opposite directions so as to cancel angle-of incidence dependent broadening of the spectral output of the individual filters for noncollimated light, as well as cancel translational shift of the transmitted light rays. The elements in a pair of filters may be tilted through orthogonal tilt axes so as to cancel polarization dependent broadening of the spectral output of the individual filters for light whose polarization state is a superposition of nonzero parallel and perpendicular components relative to the tilt axes.
摘要翻译：公开了一种可调谐光谱过滤装置，其包括一对或多对串联的干涉滤光器，其中每对的每个元件独立地选自一个或多个选项，独立地定位成与会聚光或发散光的路径相交，并独立地倾斜与尊重光路。每个滤波器可以是带通型，短路型，长通型，陷波型或其多种组合中的任一种。可以独立地选择和倾斜系列中的每个滤光片以调节该系列的净光谱输出。一对滤波器中的元件可以在相反的方向上倾斜，以便消除入射角依赖于非准直光的各个滤光器的光谱输出的变宽，以及消除透射光线的平移移动。一对滤波器中的元件可以通过正交的倾斜轴倾斜，从而抵消偏振状态是相对于倾斜轴的非零平行和垂直分量的叠加的光的各个滤光器的光谱输出的偏振相关的加宽。

6. 发明申请

US20130217583A1 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 有权
标题翻译：微流体装置及其在纳米复合材料的形成与控制中的应用
公开(公告)号：US20130217583A1
公开(公告)日：2013-08-22
申请号：US13759660
申请日：2013-02-05
申请人： Darren Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
发明人： Darren Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
摘要翻译：本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。这样的方法可以包括通过将化合物的水溶液和独特的液体标签的水溶液乳化在微流体装置上来标记化合物文库，所述微流体装置包括整体地布置在微细加工的基底上的多个可电寻址的通道支承的流体模块，提供了用于不混溶流体流动的通道，由此每种化合物用独特的液体标记标记，汇集标记的乳液，将标记的乳液与含有特定细胞或酶的乳液聚结，从而形成纳米反应器，筛选纳米反应器以获得所需的反应在纳米反应器的内容物之间，并解码液体标签，从而从化合物文库鉴定单一化合物。

7. 发明申请

US20120051523A1 IMAGING TARGET FOR TESTING QUALITY OF MULTIPLE-MAGNIFICATION FOCUS AND IMAGE CO-REGISTRATION 有权
标题翻译：用于测试多重放大焦点和图像共同注册质量的成像目标
公开(公告)号：US20120051523A1
公开(公告)日：2012-03-01
申请号：US13235537
申请日：2011-09-19
申请人： Gilbert Feke
发明人： Gilbert Feke
IPC分类号： A61B6/08
CPC分类号： A61B6/583 , A61B5/0035 , A61B5/0059 , A61B6/5247 , A61B6/587 , A61B2562/17
摘要： An imaging target, suited for use in multi-modal imaging systems, includes test patterns for testing quality of focus and co-registration for multiple magnifications and multiple modalities of operation of a multimodal imaging system.
摘要翻译：适用于多模式成像系统的成像目标包括用于测试多重放大倍数和多模式成像系统的多种操作模式的聚焦质量和共同配准的测试模式。

8. 发明授权

US07706501B2 Method and apparatus for measuring long bone density of small-animals 失效
标题翻译：测量小动物长骨密度的方法和装置
公开(公告)号：US07706501B2
公开(公告)日：2010-04-27
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/083 , G01B15/00
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

9. 发明申请

US20090273944A1 VARIABLE CONDENSER FOR DELIVERY OF ILLUMINATION INCLUDING RECURSIVELY NESTED CIRCLE-TO-LINE FIBER OPTIC CONVERTER CABLE 失效
标题翻译：用于交付照明的可变式冷凝器，包括可重复使用的圆形光纤转换器电缆
公开(公告)号：US20090273944A1
公开(公告)日：2009-11-05
申请号：US12431823
申请日：2009-04-29
申请人： Gilbert Feke
发明人： Gilbert Feke
IPC分类号： G02B6/00
CPC分类号： G02B6/04 , G02B6/0008 , G02B26/103
摘要： A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input.
摘要翻译：用于传输照明的可变电容器，包括递归嵌套的圆形到光纤形状转换电缆和可调焦输入透镜系统。在光纤电缆的输入端，各组光纤包括相对较小的环，其相对于公共中心递归地嵌套。在光纤电缆的输出处，各组光纤包括一对线段，其以线中点递归地嵌套，由此线段对的嵌套级别具有与嵌套级别的精确或近似对应关系环形输出可以被分成多条线，由此各组光纤分布在多条线之间。输入透镜系统具有单个可调节聚焦装置，以改变入射到光纤光缆圆输入端的照明点的半径。

10. 发明申请

US20090067582A1 IMAGING TARGET FOR TESTING QUALITY OF MULTIPLE-MAGNIFICATION FOCUS AND IMAGE CO-REGISTRATION 有权
标题翻译：用于测试多重放大焦点和图像共同注册质量的成像目标
公开(公告)号：US20090067582A1
公开(公告)日：2009-03-12
申请号：US12195452
申请日：2008-08-21
申请人： Gilbert Feke
发明人： Gilbert Feke
IPC分类号： G01D18/00
CPC分类号： A61B6/587 , A61B6/583 , H04N5/32
摘要： An imaging target, suited for use in multi-modal imaging systems, includes test patterns for testing quality of both focus and co-registration for multiple magnifications and multiple modalities of operation of a multimodal imaging system.
摘要翻译：适用于多模式成像系统的成像目标包括用于测试多重放大倍数和多模式成像系统的多种操作模式的聚焦和共同对准质量的测试模式。

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