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1. 发明申请

US20100279299A1 Devices and Methods for Heating Biological Samples 审中-公开
标题翻译：用于加热生物样品的装置和方法
公开(公告)号：US20100279299A1
公开(公告)日：2010-11-04
申请号：US12753806
申请日：2010-04-02
申请人： George Maltezos , Adrian Fawcett , Matthew Johnston , Xing Yang , David Tracy
发明人： George Maltezos , Adrian Fawcett , Matthew Johnston , Xing Yang , David Tracy
IPC分类号： C12Q1/68 , C12M1/02 , C12M1/34 , C12P19/34
CPC分类号： B01L7/52 , B01L2200/14 , B01L2300/0636 , B01L2300/0829 , B01L2300/1822 , B01L2300/185 , G01N2021/6439 , G01N2035/00356 , G01N2035/00366
摘要： This invention provides a systems and methods for regulating temperature and heat transfer in applications in which it is desirable to maintain temperature uniformity such as thermal cycling applications. A heat block is used to rapidly transfer heat to or from a set of one or more reaction vessels.
摘要翻译：本发明提供一种在需要保持诸如热循环应用的温度均匀性的应用中调节温度和热传递的系统和方法。热块用于将热量快速传递到一组或多个反应容器的一个或多个反应容器。

2. 发明授权

US09068947B2 Optical system for multiple reactions 有权
标题翻译：光学系统多反应
公开(公告)号：US09068947B2
公开(公告)日：2015-06-30
申请号：US13132315
申请日：2009-12-03
申请人： Adrian Fawcett , David Tracy
发明人： Adrian Fawcett , David Tracy
IPC分类号： G01N21/03 , G02B5/04 , C12Q1/68 , G01N21/64 , B01L3/00
CPC分类号： G01N21/6452 , B01L3/50851 , C12Q1/686 , G01N21/0303 , G01N21/0332 , G01N2021/6417 , G01N2021/6463 , G02B5/04 , G02B5/045
摘要： The invention relates to optical systems and methods for measurement of samples in multiple sample vessels using an array of light sources where the light from the light sources is divided into multiple light beams, and each beam is directed to a sample vessel.
摘要翻译：本发明涉及用于使用光源阵列测量多个样品容器中的样品的光学系统和方法，其中来自光源的光被分成多个光束，并且每个光束被引导到样品容器。

3. 发明申请

US20110057117A1 OPTICAL SYSTEM FOR MULTIPLE REACTIONS 有权
标题翻译：多种反应的光学系统
公开(公告)号：US20110057117A1
公开(公告)日：2011-03-10
申请号：US12841725
申请日：2010-07-22
申请人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
发明人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
IPC分类号： G01J1/58 , F21S4/00 , F21V5/00 , F21V9/16
CPC分类号： G01N21/6486 , B01L7/52 , B01L2300/046 , B01L2300/0829 , B01L2300/1805 , G01N21/0332 , G01N21/6452 , G01N2021/0367 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2201/02 , G01N2201/062 , G01N2201/0626 , G01N2201/0627 , G01N2201/0636
摘要： Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.
摘要翻译：提供了多种反应的光学系统和相应的方法。光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

4. 发明申请

US20150226672A1 OPTICAL SYSTEM FOR MULTIPLE REACTIONS 审中-公开
标题翻译：多种反应的光学系统
公开(公告)号：US20150226672A1
公开(公告)日：2015-08-13
申请号：US14620998
申请日：2015-02-12
申请人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
发明人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
IPC分类号： G01N21/64 , B01L7/00 , G01N21/03
CPC分类号： G01N21/6486 , B01L7/52 , B01L2300/046 , B01L2300/0829 , B01L2300/1805 , G01N21/0332 , G01N21/6452 , G01N2021/0367 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2201/02 , G01N2201/062 , G01N2201/0626 , G01N2201/0627 , G01N2201/0636
摘要： Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.
摘要翻译：提供了多种反应的光学系统和相应的方法。光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

5. 发明授权

US08987685B2 Optical system for multiple reactions 有权
标题翻译：光学系统多反应
公开(公告)号：US08987685B2
公开(公告)日：2015-03-24
申请号：US12841725
申请日：2010-07-22
申请人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
发明人： Adrian Fawcett , David Tracy , Kevin Daley Simmons
IPC分类号： G01J1/58 , G01N21/64 , B01L7/00
CPC分类号： G01N21/6486 , B01L7/52 , B01L2300/046 , B01L2300/0829 , B01L2300/1805 , G01N21/0332 , G01N21/6452 , G01N2021/0367 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2201/02 , G01N2201/062 , G01N2201/0626 , G01N2201/0627 , G01N2201/0636
摘要： Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes (LEDs)) configured to output excitation energy along an excitation optical path. In addition, a detector configured to receive emission energy along a detection optical path in the same plane as the excitation optical path is also provided.
摘要翻译：提供了多种反应的光学系统和相应的方法。光学系统相对于热组件处于固定位置，并且包括被配置为沿着激发光路输出激发能量的至少一组激励源（例如，发光二极管（LED））。此外，还提供了被配置为沿着与激励光路相同的平面中的检测光路接收发射能量的检测器。

6. 发明申请

US20140198313A1 SCALABLE SPECTROSCOPIC DETECTION AND MEASUREMENT 有权
标题翻译：可扩展的光谱检测和测量
公开(公告)号：US20140198313A1
公开(公告)日：2014-07-17
申请号：US14008964
申请日：2012-03-27
申请人： David Tracy , Peter Lewis Stokes , Sepehr Kiani
发明人： David Tracy , Peter Lewis Stokes , Sepehr Kiani
IPC分类号： G01J3/42 , G01J3/44
CPC分类号： G01J3/42 , G01J3/0208 , G01J3/021 , G01J3/0216 , G01J3/0248 , G01J3/0291 , G01J3/06 , G01J3/08 , G01J3/10 , G01J3/14 , G01J3/18 , G01J3/2803 , G01J3/44 , G01J3/4406 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6456
摘要： The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.
摘要翻译：本发明一般涉及一种用于检测和测量来自样品的光的光谱特性的系统，方法和试剂盒，或同时进行多个样品中存在的每个样品的光的光谱特性的可伸缩检测和测量，其中系统包括：包括分散元件的光学系列; 和图像传感器。检测和测量的光可以包括从样品散射的光，通过样品内的化学过程作为化学发光发射，被样品选择性吸收，或者在激发后作为荧光从样品中发射。

7. 发明申请

US20070109542A1 Optical resonance analysis unit 审中-公开
标题翻译：光学谐振分析单元
公开(公告)号：US20070109542A1
公开(公告)日：2007-05-17
申请号：US10566303
申请日：2004-08-02
申请人： David Tracy , Jennifer Brockman , Keith Ferrara , Martin Shenker , Robert Kersten , Steven Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
发明人： David Tracy , Jennifer Brockman , Keith Ferrara , Martin Shenker , Robert Kersten , Steven Cohen , Gary Bodley , Patrick Tuxbury , Paul Hetherington , Enrico Picozza
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： An optical analysis unit especially suitable for performing grating coupled surface plasmon resonance (SPR) imaging features a pivoting light source capable of scanning through a range of angles of incident light projected onto a stationary target sensor, such as an SPR sensor. The reflected image from the illuminated sensor is detected, e.g., by a CCD camera and the image and angular scan data are processed, for example by a fitting algorithm, to provide real time analysis of reactions taking place on the surface of the sensor.
摘要翻译：特别适用于执行光栅耦合表面等离子体共振（SPR）成像的光学分析单元具有能够扫描投射到固定目标传感器（例如SPR传感器）上的入射光的角度范围的枢转光源。例如通过CCD照相机检测来自照明传感器的反射图像，并且例如通过拟合算法处理图像和角度扫描数据，以提供在传感器的表面上发生的反应的实时分析。

8. 发明申请

US20060262313A1 Optical Resonance Analysis System 有权
标题翻译：光学共振分析系统
公开(公告)号：US20060262313A1
公开(公告)日：2006-11-23
申请号：US11460932
申请日：2006-07-28
申请人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
发明人： Dar Bahatt , Jerry Cahill , Koichi Nishikida , Enrico Picozza , Paul Saviano , David Tracy , Yongdong Wang
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).
摘要翻译：一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380）的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。分析系统还包括用于检测反射或透射照明的检测装置（90）。另一实施例包括变形成像装置（120）。

9. 发明授权

US6033880A Nucleic acid amplification reaction apparatus and method 失效
标题翻译：核酸扩增反应装置及方法
公开(公告)号：US6033880A
公开(公告)日：2000-03-07
申请号：US27989
申请日：1998-02-23
申请人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg , Richard W. Noreiks
发明人： Lawrence A. Haff , Enrico Picozza , Will Bloch , Robert Ragusa , Joseph DiCesare , David Tracy , Paul Saviano , Timothy M. Woudenberg , Richard W. Noreiks
IPC分类号： C12N15/09 , B01J19/00 , B01L7/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/00 , C12P19/34
CPC分类号： B01L7/525 , B01J19/0046 , B01L7/52 , B01L9/065 , B01J2219/00495 , B01J2219/00722 , B01L2300/1883 , C12Q1/686 , C40B40/06 , C40B60/14 , G01N2035/00237 , Y10T436/116664
摘要： Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.
摘要翻译：用于在至少一个毛细管中的反应混合物中进行核酸扩增反应和优选聚合酶链式反应（PCR）的装置和方法。公开了几个不同的实施例。一个实施例通过穿过两个恒温流体浴的毛细管回路循环样品。另一个实施例中，毛细管在两个热交换器之间交替布置，使得样品仅穿过管中一次。其他实施例保持热交换器平稳，并在它们之间平移样品。另外的实施例保持样品静止，并且自动地将热交换器平移或旋转通过毛细管内包含的样品，以进行扩增反应所需的热循环。

10. 发明授权

US5428558A Correction of spectra for stray radiation 失效
标题翻译：杂散辐射光谱校正
公开(公告)号：US5428558A
公开(公告)日：1995-06-27
申请号：US168800
申请日：1993-12-17
申请人： Jerry E. Cahill , Alan M. Ganz , Paul Saviano , David Tracy , Yongdong Wang
发明人： Jerry E. Cahill , Alan M. Ganz , Paul Saviano , David Tracy , Yongdong Wang
IPC分类号： G01J3/02 , G01J3/28 , G01N21/27 , G01D18/00
CPC分类号： G01J3/28 , G01J2003/2866
摘要： A method and apparatus are provided for correction of spectra for stray radiation in a spectrometric instrument, involving a sequence of steps as follows. Spectral patterns are obtained with the instrument initially for monochromatic radiation at a plurality of selected calibration wavelengths. By computer program, the peak profile at the calibration wavelength in each pattern is replaced with a substitute based on the remaining pattern. The resulting data are interpolated to effect values denoted "stray proportions" for the ordered wavelengths of the instrument. Spectral data at each ordered wavelength are obtained with the instrument for a sample, and multiplied in the computer program by stray proportions for corresponding wavelengths to effect further sets of values denoted "stray portions" that are identified to the ordered wavelengths. Each set is identified to one of the wavelength increments of the instrument across the spectral range. In each set, the stray portions for the ordered wavelengths are summed. The total for each wavelength increment is subtracted from the original sample data for the increment to effect spectral data corrected for stray.
摘要翻译：提供了一种用于校正光谱仪器中杂散辐射的光谱的方法和装置，涉及如下的一系列步骤。在多个选定的校准波长下，仪器最初用于单色辐射获得光谱图案。通过计算机程序，每个模式中校准波长处的峰值曲线被替换为基于剩余模式的替代。内插所得数据以对仪器的有序波长表示为“杂散比”的值。用样品的仪器获得每个有序波长的光谱数据，并在计算机程序中乘以相应波长的杂散比例，以实现被标识为有序波长的标记为“杂散部分”的另外一组值。每个组被识别为跨越光谱范围的仪器的波长增量之一。在每组中，将有序波长的杂散部分相加。从原始采样数据中减去每个波长增量的总和，以增加修正为杂散的光谱数据。

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