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    • 7. 发明授权
    • Sample block apparatus and method of maintaining a microcard on a sample block
    • 样品块装置和在样品块上维持微卡的方法
    • US07452712B2
    • 2008-11-18
    • US10207263
    • 2002-07-30
    • Adrian Fawcett
    • Adrian Fawcett
    • C12M1/34C12M1/38
    • C12Q1/686B01L7/52B01L9/523B01L2200/025B01L2300/0609B01L2300/0816B01L2300/0864B01L2300/0887B01L2300/1805Y10S435/809
    • A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control system operatively connected with the sample block. The upper surface of the sample block may include a plurality of channels, the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that a retention force is imparted on the microcard to urge the microcard toward the sample block. Methods of maintaining a microcard on a sample block of a thermal cycling device are also provided.
    • 一种用于热循环包含在具有顶表面和底表面的微卡中的生物材料样品的热循环装置。 热循环装置可以包括具有被配置为接合微卡的底表面的上表面的样品块,真空装置和与样品块可操作地连接的温度控制系统。 样品块的上表面可以包括多个通道,通道限定样品块和可以定位在其上的微卡的底表面之间的空间。 真空装置可以与样品块流体连通,用于将气体从样品块中的通道限定的空间中排出。 真空装置可以被配置为基本上保持样品块和微卡之间的真空,使得在微卡上施加保持力以将微卡推向样品块。 还提供了在热循环装置的样品块上维持微卡的方法。
    • 9. 发明申请
    • Thermal cycler for PCR
    • US20070117200A1
    • 2007-05-24
    • US11654238
    • 2007-01-17
    • John AtwoodAdrian FawcettKeith FerraraPaul HetheringtonRichard NoreiksDouglas OlsenJohn WidomskiCharles Wittmer
    • John AtwoodAdrian FawcettKeith FerraraPaul HetheringtonRichard NoreiksDouglas OlsenJohn WidomskiCharles Wittmer
    • C12M1/34
    • B01L7/52B01L3/50853B01L2300/0829B01L2300/1822B01L2300/1827C12Q1/686F25B21/04F25B2321/021G01R27/205G05D23/1919H01L35/30Y10T137/1516
    • An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.