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1. 发明授权

US06490489B2 Implantable cardiac single pass coronary sinus lead for providing pacing and defibrillation and method of manufacture 有权
标题翻译：可植入心脏单程冠状动脉窦导管用于提供起搏和除颤及其制造方法
公开(公告)号：US06490489B2
公开(公告)日：2002-12-03
申请号：US09771505
申请日：2001-01-26
申请人： Gene A. Bornzin , Anne M. Pianca , Kevin L. Morgan , John R. Helland , Joseph J. Florio
发明人： Gene A. Bornzin , Anne M. Pianca , Kevin L. Morgan , John R. Helland , Joseph J. Florio
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： A single chronic implantable cardiac lead for use in the coronary sinus region of the heart provides both atrial and ventricular pacing and defibrillation therapy. The lead includes an elongated lead body having a distal end and a proximal end, a first electrode assembly including a ventricular pacing electrode and a ventricular defibrillation at the distal end, a second electrode assembly proximal to the first electrode assembly including at least one atrial pacing electrode and an atrial defibrillation electrode, and a further defibrillation electrode proximal to the second electrode assembly. The electrode assemblies and further defibrillation electrode are spaced apart so that when the lead is implanted within the coronary sinus region of the heart with the first electrode assembly adjacent the left ventricle, the second electrode assembly is adjacent the left atrium and the further defibrillation electrode is within the right atrium and/or the superior vena cava.
摘要翻译：用于心脏冠状静脉窦区域的单一慢性可植入心脏线可提供心房起搏和除颤治疗。引线包括具有远端和近端的细长引线主体，包括心室起搏电极和在远端处的心室除颤的第一电极组件，靠近第一电极组件的第二电极组件，包括至少一个心房起搏电极和心房除颤电极，以及靠近第二电极组件的另外的除颤电极。电极组件和另外的除颤电极间隔开，使得当铅被植入心脏的冠状窦区域内时，第一电极组件邻近左心室，第二电极组件邻近左心房，另外的除颤电极在右心房和/或上腔静脉内。

2. 发明授权

US07313444B2 Self-anchoring coronary sinus lead 有权
标题翻译：自固定冠状动脉窦导联
公开(公告)号：US07313444B2
公开(公告)日：2007-12-25
申请号：US10081457
申请日：2002-02-21
申请人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
发明人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： An implantable cardiac lead system suitable for placement in the coronary sinus region of the heart. The lead system comprises a lead having two or more non-helical bends in its distal portion. The two or more non-helical bends cooperate to prevent the lead from dislodgment or displacement inside the coronary sinus. The lead system may further comprise a stylet suitable for steering the lead into at least one of the coronary sinus vein, great cardiac vein, left marginal vein, left posterior ventricular vein, and small cardiac vein. The stylet is tapered in its distal portion to provide enhanced maneuverability and steerability inside the coronary sinus region. The lead system may also comprise an introducer which aids in introducing the lead into the heart.
摘要翻译：适用于放置在心脏冠状静脉窦区域的可植入心脏引导系统。引导系统包括在其远端部分中具有两个或多个非螺旋形弯曲部的引线。两个或更多个非螺旋形弯曲合作以防止铅在冠状窦内发生移位或移位。引导系统还可以包括适于将引线引导到冠状静脉窦静脉，大心静脉，左边缘静脉，左后脑室静脉和小心静脉中的至少一个的探针。探针在其远端部分逐渐变细，以在冠状窦区域内提供增强的机动性和可操纵性。引导系统还可以包括有助于将引入引入心脏的导引器。

3. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

4. 发明授权

US06937900B1 AC/DC multi-axis accelerometer for determining patient activity and body position 有权
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06937900B1
公开(公告)日：2005-08-30
申请号：US10205188
申请日：2002-07-24
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

5. 发明授权

US06456890B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456890B2
公开(公告)日：2002-09-24
申请号：US09797531
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N100
CPC分类号： A61N1/056
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multi-lumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多腔管沿着导丝线前进，直到达到所需的位置，导线从主体和多管腔管中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

6. 发明授权

US06456889B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456889B2
公开(公告)日：2002-09-24
申请号：US09797281
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N1100
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multilumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多根管沿引导线前进，直到达到所需的位置，导线从主体和多管腔中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

7. 发明授权

US06459937B1 Endocardial pacing lead with detachable tip electrode assembly 失效
标题翻译：心内膜起搏导联带有可拆卸的尖端电极组件
公开(公告)号：US06459937B1
公开(公告)日：2002-10-01
申请号：US09558484
申请日：2000-04-25
申请人： Kevin L. Morgan , Gene A. Bornzin , Anne M. Pianca
发明人： Kevin L. Morgan , Gene A. Bornzin , Anne M. Pianca
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61N2001/0578 , A61N2001/058
摘要： A body implantable lead assembly includes a lead body and a tip electrode assembly at the distal end of the lead body. The tip electrode assembly is detachably connected to the lead body by means of a threaded coupling actuatable by a stylet inserted through the lumen of the lead body. The lead body may therefore be removed leaving behind a chronically implanted tip electrode assembly. The invention has particular utility in the context of passive endocardial heart pacing leads whose tip electrode assemblies include tines which become entangled in the trabecular network of the heart, and are therefore difficult to remove.
摘要翻译：一种身体可植入引线组件包括在引线主体的远端处的引线主体和尖端电极组件。尖端电极组件通过螺纹连接件可拆卸地连接到引线主体，螺纹连接可以通过插入穿过引线主体的内腔的探针进行激活。因此引线体可以被移除留下长时间植入的尖端电极组件。本发明在被动心内膜心脏起搏引线的上下文中具有特别的用途，其尖端电极组件包括缠结在心脏小梁网中的尖齿，因此难以移除。

8. 发明授权

US07130686B1 Selection of preventative arrhythmia therapy based on patient specific histogram data 有权
标题翻译：基于患者特异性直方图数据选择预防性心律失常治疗
公开(公告)号：US07130686B1
公开(公告)日：2006-10-31
申请号：US10187501
申请日：2002-07-01
申请人： Paul A. Levine , Gene A. Bornzin , Anne M. Pianca
发明人： Paul A. Levine , Gene A. Bornzin , Anne M. Pianca
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/36514 , A61N1/36521 , A61N1/36557 , A61N1/395
摘要： Methods and systems for providing cardiac therapy are described. In some embodiments, methods and systems are configured to deliver atrial tachyarrhythmia therapy by confirming that a patient is asleep and thereafter administering the therapy. Sleep can be confirmed, in some embodiments, through the use of a histogram that can be calculated using one or more parameters that are monitored by an implantable stimulation device. Parameters can include both physiological and non-physiological parameters. In other embodiments, atrial tachyarrhythmia therapy is delivered by determining desirable times to administer such therapy. Other various systems and methods for administering cardiac therapy are described.
摘要翻译：描述了提供心脏治疗的方法和系统。在一些实施例中，方法和系统被配置为通过确认患者睡着并且之后施用治疗来递送心房快速性心律失常治疗。在一些实施例中，可以通过使用可以使用由可植入刺激装置监测的一个或多个参数来计算的直方图来确认睡眠。参数可以包括生理参数和非生理参数。在其它实施方案中，通过确定施用此类治疗的期望时间来递送心房快速性心律失常治疗。描述了用于施用心脏治疗的其它各种系统和方法。

9. 发明授权

US08688218B2 Lead connector for an implantable electric stimulation system and methods of making and using 失效
标题翻译：用于可植入电刺激系统的引线连接器及其制造和使用方法
公开(公告)号：US08688218B2
公开(公告)日：2014-04-01
申请号：US13281257
申请日：2011-10-25
申请人： Anne M. Pianca
发明人： Anne M. Pianca
IPC分类号： A61N1/372
CPC分类号： A61N1/05 , A61N1/3752
摘要： A lead-connection system includes a lead and a connector. The lead includes a distal end, a proximal end, a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductor wires electrically coupling each of the plurality of electrodes to a different one of the plurality of terminals. The connector defines a port for receiving the proximal end of the lead and a plurality of connector contacts. The number of connector contacts is greater than the number of terminals disposed on the proximal end of the lead. When the connector receives the proximal end of the lead, each of the terminals disposed on the proximal end of the lead makes electrical contact with at least one of the connector contacts of the connector and no two terminals make electrical contact with a same one of the connector contacts.
摘要翻译：引线连接系统包括引线和连接器。引线包括远端，近端，设置在远端的多个电极，设置在近端的多个端子，以及将多个电极中的每一个电连接到不同的电极的多个导体线多个终端。连接器限定用于接收引线的近端的端口和多个连接器触点。连接器触点的数量大于设置在引线的近端上的端子的数量。当连接器接收引线的近端时，设置在引线的近端的每个端子与连接器的至少一个连接器触点电接触，并且没有两个端子与相同的一个连接器触点

10. 发明授权

US08646172B2 Electrode array assembly and method of making same 有权
标题翻译：电极阵列组装及其制作方法
公开(公告)号：US08646172B2
公开(公告)日：2014-02-11
申请号：US13013599
申请日：2011-01-25
申请人： Janusz A. Kuzma , Anne M. Pianca
发明人： Janusz A. Kuzma , Anne M. Pianca
IPC分类号： H01R43/00 , A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553 , Y10T29/49117 , Y10T29/49204 , Y10T29/49208 , Y10T29/4922
摘要： A method of manufacturing a stimulation lead includes providing a lead body having an insulation section that defines a central lumen extending along the insulation section and conductor lumens extending along the insulation section and arranged around, and external to, the central lumen. The lead body also includes conductive contacts located along an axial end of the lead body and conductor wires with each conductor wire disposed within one of the conductor lumens and each of the conductor lumens having at least one of the conductor wires disposed therein. After providing the lead body, conductively at least one of the conductor wires to each of the conductive contacts; and placing non-conductive material into a portion of at least one of the conductor lumens of the lead body. A portion of the conductor lumens and at least a portion of the non-conductive material are disposed radially beneath the conductive contacts.
摘要翻译：制造刺激引线的方法包括提供引线本体，该引线本体具有绝缘部分，该绝缘部分限定沿着绝缘部分延伸的中心管腔和沿着绝缘部分延伸并且布置在中心管腔周围和外部的导体管腔。引线体还包括位于引线主体的轴向端部的导电触点和导体布线，导体布线设置在导体腔内的一个内，并且每个导体流明具有布置在其中的至少一个导线。在提供引线体之后，导电地将至少一根导线连接到每个导电触头; 以及将非导电材料放置在所述引线体的导体腔中的至少一个的一部分中。导体内腔的一部分和非导电材料的至少一部分径向设置在导电触头下方。

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