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1. 发明授权

US06937900B1 AC/DC multi-axis accelerometer for determining patient activity and body position 有权
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06937900B1
公开(公告)日：2005-08-30
申请号：US10205188
申请日：2002-07-24
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

2. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

3. 发明授权

US5810739A Methods and apparatus for classifying cardiac events with an implantable cardiac device 失效
标题翻译：用可植入心脏装置分类心脏事件的方法和装置
公开(公告)号：US5810739A
公开(公告)日：1998-09-22
申请号：US770767
申请日：1996-12-19
申请人： Gene A. Bornzin , Alan B. Vogel , Ali Enayat Zadeh , Jonathan A. Kleks , Raymond J. Wilson
发明人： Gene A. Bornzin , Alan B. Vogel , Ali Enayat Zadeh , Jonathan A. Kleks , Raymond J. Wilson
IPC分类号： A61N1/37 , A61N5/0452
CPC分类号： A61N1/3702
摘要： Methods and apparatus are provided for classifying cardiac events with an implantable cardiac device. Cardiac signals are stored in a buffer. When a significant cardiac event is confirmed, a corresponding segment of the stored cardiac signals is processed to generate a set of feature values. The set of feature values is compared to various sets of reference values. Each set of reference values preferably corresponds to a separate type of cardiac event, so that the cardiac device may classify the significant cardiac event by matching its set of feature values to a set of reference values. Feature values include the maximum positive and negative slew rates exhibited by the cardiac signal during the segment, the maximum positive and negative signal amplitudes, the times to reach the maximum positive and negative signal amplitudes, the area under the cardiac signal curve, the area under the cardiac signal curve above zero as compared to the area below zero, and the number of zero crossings made by the cardiac signal. Additional feature values are generated by simultaneously processing the cardiac signals measured along two different vector directions in the heart.
摘要翻译：提供了用可植入式心脏装置对心脏事件进行分类的方法和装置。心脏信号存储在缓冲区中。当确定重要的心脏事件时，处理存储的心脏信号的对应段以产生一组特征值。将特征值集合与各种参考值集进行比较。每组参考值优选对应于单独类型的心脏事件，使得心脏设备可以通过将其特征值集合与一组参考值相匹配来对重要心脏事件进行分类。特征值包括段内心脏信号显示的最大正负压摆率，最大正负信号幅度，达到最大正和负信号幅度的时间，心脏信号曲线下的面积，与零度以下的区域相比，零点以上的心脏信号曲线以及由心脏信号产生的过零点数。通过同时处理在心脏中沿着两个不同矢量方向测量的心脏信号来产生附加特征值。

4. 发明授权

US08269635B2 Method and apparatus for monitoring ingestion of medications using an implantable medical device 有权
公开(公告)号：US08269635B2
公开(公告)日：2012-09-18
申请号：US12705435
申请日：2010-02-12
申请人： Mark W. Kroll , Alan B. Vogel
发明人： Mark W. Kroll , Alan B. Vogel
IPC分类号： G08B23/00
CPC分类号： G06F19/3456 , A61B5/0031 , A61B5/076 , A61B5/1116 , A61B5/1123 , A61B5/4205 , A61B5/4833 , A61B5/4839 , A61B7/008 , A61B90/90 , A61B90/98 , A61B2562/0219 , A61N1/365 , G06F19/00 , Y10S128/903
摘要： An implantable medical device, such as a pacemaker or implantable cardioverter defibrillator (ICD), is configured to automatically detect ingestion of medications to verify that prescribed medications are taken in a timely manner and at the correct dosage. Briefly, individual pills are provided with miniature radio frequency identification (RFID) devices capable of transmitting RFID tag signals, which identify the medication contained within the pill and its dosage. The implanted device is equipped with an RFID transceiver for receiving tag signals from a pill as it is being ingested. The implanted system decodes the tag to identify the medication and its dosage, then accesses an onboard database to verify that the medication being ingested was in fact prescribed to the patient and to verify that the correct dosage was taken. Warning signals are generated if the wrong medication or the wrong dosage was taken. Therapy may also be automatically adjusted. Non-RF-based ID devices are also described, which instead transmit ID data via biphasic current pulses.

5. 发明授权

US06430440B1 Magnetoresistive-based position sensor for use in an implantable electrical device 失效
标题翻译：用于可植入电气设备的基于磁阻的位置传感器
公开(公告)号：US06430440B1
公开(公告)日：2002-08-06
申请号：US09457194
申请日：1999-12-08
申请人： Kenneth R. McNeil, II , Balakrishnan Shankar , Alan B. Vogel , Scott Gibson
发明人： Kenneth R. McNeil, II , Balakrishnan Shankar , Alan B. Vogel , Scott Gibson
IPC分类号： A61N118
CPC分类号： A61N1/36542 , A61B5/11
摘要： An implantable cardiac stimulation device including an activity/position sensor that incorporates a magnetoresistive sensor and a magnet that are positioned so as to move relative to each other in response to activity and the body position of the patient when the device is implanted in the body of the patient. In one embodiment, the sensor includes a magnetoresistive sensor that is made from giant magnetoresistive (GMR) materials. Preferably, a magnet is positioned on a flexible cantilevered beam so as to be positioned adjacent the magnetoresistive sensor. Movement of the patient results in relative movement of the magnet with respect to the magnetoresistive sensor and generates a signal having an AC component corresponding to a patient's activity and a DC component corresponding to the patient's body position. The signal can be used by the implantable cardiac stimulation device's processor for adjusting the delivery of therapeutic electrical stimulation such as by adjusting the pacing rate of pacing pulses being delivered to the patient's heart.
摘要翻译：一种植入式心脏刺激装置，包括活动/位置传感器，其包括磁阻传感器和磁体，所述活动/位置传感器被定位成响应于患者的活动和身体位置而相对于彼此移动，当该装置被植入体内时患者。在一个实施例中，传感器包括由巨磁阻（GMR）材料制成的磁阻传感器。优选地，磁体定位在柔性悬臂梁上，以便邻近磁阻传感器定位。患者的移动导致磁体相对于磁阻传感器的相对移动，并且产生具有对应于患者活动的AC分量的信号和对应于患者身体位置的DC分量。该信号可被可植入心脏刺激装置的处理器用于调节治疗性电刺激的递送，例如通过调节递送至患者心脏的起搏脉冲的起搏速率。

6. 发明授权

US08388670B1 Sensor/lead systems for use with implantable medical devices 有权
标题翻译：用于可植入医疗器械的传感器/引线系统
公开(公告)号：US08388670B1
公开(公告)日：2013-03-05
申请号：US11623663
申请日：2007-01-16
申请人： Yongning Zou , James B. Hamilton , Alan B. Vogel , Chris Sorensen , Ryan Albu
发明人： Yongning Zou , James B. Hamilton , Alan B. Vogel , Chris Sorensen , Ryan Albu
IPC分类号： A61F7/00
CPC分类号： A61B5/6869 , A61B5/01 , A61B5/029 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/7285 , A61B2562/0204 , A61B2562/0219 , A61B2562/0247 , A61N1/056 , A61N1/368 , A61N1/3704 , A61N1/3962
摘要： Techniques are provided for equipping sensing/pacing leads with physiological sensors without requiring additional conductors within the leads. In a bipolar lead example for use with a pacemaker, a sensor is connected between tip and ring conductors of the lead. The sensor is configured to be activated only in response to enhanced pacing pulse (EPPs) having magnitudes or durations greater than typical pacing pulses or in response to impedance detection pulses (IMPs). In a unipolar example, the sensor is connected to the tip conductor and includes an output terminal on the external housing of the lead for providing a return current path to the pacemaker. The sensor of the unipolar lead is likewise configured to respond only to EPPs or IMPs. In other examples, the sensors are configured to be fitted to the external housing of the lead and to derive power from the lead via electromagnetic induction. Still other examples include actuators rather than sensors.
摘要翻译：提供了技术，用于使传感/起搏线与生理传感器配套，而不需要引线内的额外导线。在与起搏器一起使用的双极引线示例中，传感器连接在引线的尖端和环形导体之间。传感器被配置为仅响应于具有大于典型起搏脉冲的大小或持续时间或响应于阻抗检测脉冲（IMPs）的增强的起搏脉冲（EPP）被激活。在单极示例中，传感器连接到尖端导体，并且在引线的外部壳体上包括输出端子，用于提供到起搏器的返回电流路径。单极引线的传感器同样配置为只响应EPP或IMP。在其他示例中，传感器被配置为安装到引线的外部壳体并且通过电磁感应从引线导出功率。还有其他示例包括致动器而不是传感器。

7. 发明授权

US07876228B2 Method and apparatus for monitoring ingestion of medications using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置监测摄取药物的方法和装置
公开(公告)号：US07876228B2
公开(公告)日：2011-01-25
申请号：US12174594
申请日：2008-07-16
申请人： Mark W. Kroll , Alan B. Vogel
发明人： Mark W. Kroll , Alan B. Vogel
IPC分类号： G08B23/00
CPC分类号： G06F19/3456 , A61B5/0031 , A61B5/076 , A61B5/1116 , A61B5/1123 , A61B5/4205 , A61B5/4833 , A61B5/4839 , A61B7/008 , A61B90/90 , A61B90/98 , A61B2562/0219 , A61N1/365 , G06F19/00 , Y10S128/903
摘要： An implantable medical device, such as a pacemaker or implantable cardioverter defibrillator (ICD), is configured to automatically detect ingestion of medications to verify that prescribed medications are taken in a timely manner and at the correct dosage. Briefly, individual pills are provided with miniature radio frequency identification (RFID) devices capable of transmitting RFID tag signals, which identify the medication contained within the pill and its dosage. The implanted device is equipped with an RFID transceiver for receiving tag signals from a pill as it is being ingested. The implanted system decodes the tag to identify the medication and its dosage, then accesses an onboard database to verify that the medication being ingested was in fact prescribed to the patient and to verify that the correct dosage was taken. Warning signals are generated if the wrong medication or the wrong dosage was taken. Therapy may also be automatically adjusted. Non-RF-based ID devices are also described, which instead transmit ID data via biphasic current pulses.
摘要翻译：诸如起搏器或植入式心律转复除颤器（ICD）的可植入医疗装置被配置为自动检测药物的摄取以验证是否及时以正确剂量服用规定的药物。简而言之，单独的药丸配备有能够发送RFID标签信号的微型射频识别（RFID）设备，其识别药物中所含的药物及其剂量。植入装置配备有RFID收发器，用于在被摄取时从药片接收标签信号。植入的系统解码标签以识别药物及其剂量，然后访问车载数据库以验证被摄取的药物实际上是对患者进行处方，并验证是否采取了正确的剂量。如果使用了错误的药物或错误的剂量，就会产生警告信号。治疗也可以自动调整。还描述了基于非RF的ID设备，其代替通过双相电流脉冲发送ID数据。

8. 发明授权

US07753855B1 Implantable cardiac device providing sudden cardiac death susceptibility indicator and method 有权
标题翻译：植入式心脏装置提供突发性心源性死亡易感性指标和方法
公开(公告)号：US07753855B1
公开(公告)日：2010-07-13
申请号：US11618293
申请日：2006-12-29
申请人： Alan B. Vogel , Chris Sorensen
发明人： Alan B. Vogel , Chris Sorensen
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7275 , A61N1/3621 , A61N1/3962 , G06F19/00
摘要： An implantable cardiac stimulation device determines sudden cardiac death susceptibility of a heart. The device comprises a first measuring circuit that measures intrinsic rest rate of the heart, a second measuring circuit that measures heart rate response of the heart and a third measuring circuit that measures heart rate recovery of the heart. The device further comprises a comparator that compares the measured intrinsic rest rate, the measured heart rate response, and the measured heart rate recovery to respective first, second, and third standards and a response circuit that provides a predetermined response when the comparisons of the measured intrinsic rest rate, the measured heart rate response, and the measured heart rate recovery to the respective standards indicate a susceptibility of sudden cardiac death.
摘要翻译：可植入心脏刺激装置确定心脏的心脏死亡易感性。该装置包括测量心脏固有静息速率的第一测量电路，测量心脏心率响应的第二测量电路和测量心脏心率恢复的第三测量电路。该装置还包括比较器，其将测量的固有休息率，测量的心率响应和测量的心率恢复与相应的第一，第二和第三标准进行比较，以及响应电路，当比较所测量的心率恢复时，固有的休息率，测量的心率反应和测量的心率恢复到相应的标准表明心脏猝死的敏感性。

9. 发明授权

US07414534B1 Method and apparatus for monitoring ingestion of medications using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置监测摄取药物的方法和装置
公开(公告)号：US07414534B1
公开(公告)日：2008-08-19
申请号：US10985298
申请日：2004-11-09
申请人： Mark W. Kroll , Alan B. Vogel
发明人： Mark W. Kroll , Alan B. Vogel
IPC分类号： G08B23/00
CPC分类号： G06F19/3456 , A61B5/0031 , A61B5/076 , A61B5/1116 , A61B5/1123 , A61B5/4205 , A61B5/4833 , A61B5/4839 , A61B7/008 , A61B90/90 , A61B90/98 , A61B2562/0219 , A61N1/365 , G06F19/00 , Y10S128/903
摘要： An implantable medical device, such as a pacemaker or implantable cardioverter defibrillator (ICD), is configured to automatically detect ingestion of medications to verify that prescribed medications are taken in a timely manner and at the correct dosage. Briefly, individual pills are provided with miniature radio frequency identification (RFID) devices capable of transmitting RFID tag signals, which identify the medication contained within the pill and its dosage. The implanted device is equipped with an RFID transceiver for receiving tag signals from a pill as it is being ingested. The implanted system decodes the tag to identify the medication and its dosage, then accesses an onboard database to verify that the medication being ingested was in fact prescribed to the patient and to verify that the correct dosage was taken. Warning signals are generated if the wrong medication or the wrong dosage was taken. Therapy may also be automatically adjusted. Non-RF-based ID devices are also described, which instead transmit ID data via biphasic current pulses.
摘要翻译：诸如起搏器或植入式心律转复除颤器（ICD）的可植入医疗装置被配置为自动检测药物的摄取以验证是否及时以正确的剂量服用规定的药物。简而言之，单独的药丸配备有能够发送RFID标签信号的微型射频识别（RFID）设备，其识别药物中所含的药物及其剂量。植入装置配备有RFID收发器，用于在被摄取时从药片接收标签信号。植入系统解码标签以识别药物及其剂量，然后访问车载数据库以验证被摄取的药物实际上已经被给予患者并验证正确的剂量是否被采取。如果使用了错误的药物或错误的剂量，就会产生警告信号。治疗也可以自动调整。还描述了基于非RF的ID设备，其代替通过双相电流脉冲发送ID数据。

10. 发明授权

US5755741A Body position and activity sensor 失效
标题翻译：身体位置和活动传感器
公开(公告)号：US5755741A
公开(公告)日：1998-05-26
申请号：US678622
申请日：1996-07-10
申请人： Alan B. Vogel
发明人： Alan B. Vogel
IPC分类号： A61N1/365 , G01C9/06 , G01C9/18 , G01C9/20 , H01H29/20 , A61N1/362
CPC分类号： A61N1/36542 , G01C9/20 , H01H29/20 , G01C2009/068 , G01C2009/182
摘要： A sensor that is implantable within the body of a patient that provides an indication of movement and orientation of the patient. The sensor is comprised of a cylindrical enclosure having a central electrode positioned within the cavity formed by the enclosure that is co-axial with the axis of the cylinder. One or more peripheral electrodes are positioned within the cavity and extend in a direction parallel to the central electrode. An electrolytic fluid is positioned in the enclosure so that movement of the sensor results in variations in the amount of electrolytic solution between the central electrode and the one or more peripheral electrodes. An alternating current signal is applied to the central electrode and the one or more peripheral electrodes and the resulting voltage signal is measured between the central electrode and the one or more peripheral electrodes. The voltage signal will vary depending upon the amount of solution located between the central electrode and the peripheral electrodes thereby giving an indication of the orientation of the sensor. The leads for the electrodes preferably extend out of a single surface in a single direction to permit mounting on a planar mounting plate. Further, the peripheral electrodes are preferably configured so that each point on an inner surface of the peripheral electrodes is substantially the same distance from the central electrode to prevent localized corrosion or build-up of electrostatic plating.
摘要翻译：可植入患者体内的传感器，其提供患者的运动和取向的指示。该传感器包括圆柱形外壳，其中心电极位于与外壳形成的空腔内，该外壳与气缸的轴线同轴。一个或多个外围电极定位在空腔内并且在平行于中心电极的方向上延伸。电解液被定位在外壳中，使得传感器的运动导致中心电极和一个或多个外围电极之间的电解溶液的量的变化。将交流信号施加到中心电极和一个或多个外围电极，并且在中心电极和一个或多个外围电极之间测量所得到的电压信号。电压信号将根据位于中心电极和周边电极之间的溶液量而变化，从而给出传感器的取向的指示。电极的引线优选在单个方向上从单个表面延伸出来以允许安装在平面安装板上。此外，周边电极优选构造成使得周边电极的内表面上的每个点与中心电极的距离基本相同，以防止静电电镀的局部腐蚀或积聚。

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