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1. 发明授权

US06770764B2 Trypsin substrate and diagnostic device, and method of using same 有权
标题翻译：胰蛋白酶底物和诊断装置及其使用方法
公开(公告)号：US06770764B2
公开(公告)日：2004-08-03
申请号：US09844816
申请日：2001-04-30
申请人： Paul F. Corey , Steven W. Felman , Gary E. Rehm , Michael J. Pugia
发明人： Paul F. Corey , Steven W. Felman , Gary E. Rehm , Michael J. Pugia
IPC分类号： C07D20736
CPC分类号： C07C279/36 , C07B2200/07 , C07D207/36 , C07D209/36 , C07D277/34 , C07D311/16 , C12Q1/37 , Y02P20/55
摘要： A compound of the formula (I) wherein R1 is a protecting group for N&agr;, R2 is a protecting group for NG, and R3 is aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O—C single bond, which liberates R3—OH; a diagnostic device comprising same; a method for preparing the diagnostic device; and a method of using the diagnostic device to detect levels of urinary trypsin inhibitor in a biological sample; and a diagnostic kit for detecting levels of urinary trypsin inhibitor in a biological sample.
摘要翻译：式（I）的化合物，其中R 1是Nalpha的保护基，R 2是NG的保护基，R 3是芳基，并且其中式（I）的化合物是胰蛋白酶底物使得胰蛋白酶切割OC单键，其释放R 3 -OH; 包括该诊断装置的诊断装置; 一种诊断装置的制备方法; 以及使用该诊断装置检测生物样品中尿胰蛋白酶抑制剂水平的方法; 以及用于检测生物样品中尿胰蛋白酶抑制剂水平的诊断试剂盒。

2. 发明授权

US07001737B2 Urinary trypsin inhibitor assay containing a chelating agent 失效
标题翻译：含有螯合剂的尿胰蛋白酶抑制剂测定
公开(公告)号：US07001737B2
公开(公告)日：2006-02-21
申请号：US09844815
申请日：2001-04-30
申请人： Gary E. Rehm , Michael J. Pugia , Paul F. Corey
发明人： Gary E. Rehm , Michael J. Pugia , Paul F. Corey
IPC分类号： G01N33/573 , G01N33/53
CPC分类号： C12Q1/37 , G01N2333/811 , G01N2333/976
摘要： Disclosed is an assay for determining the presence and concentration of trypsin inhibitor in urine samples. The assay reagents, which may be used either in the liquid or dry states, include trypsin, a trypsin substrate and a polycarboxylic chelating agent. The inclusion of the chelating agent in the assay has been found to reduce variation in the assay results.
摘要翻译：公开了用于测定尿液样品中胰蛋白酶抑制剂的存在和浓度的测定法。可以以液体或干燥状态使用的测定试剂包括胰蛋白酶，胰蛋白酶底物和多羧酸螯合剂。发现螯合剂在测定中的包含减少了测定结果的变化。

3. 发明授权

US06955921B2 Trypsin substrate and diagnostic device, and method of using same 有权
标题翻译：胰蛋白酶底物和诊断装置及其使用方法
公开(公告)号：US06955921B2
公开(公告)日：2005-10-18
申请号：US10287239
申请日：2002-11-04
申请人： Paul F. Corey , Steven W. Felman , Gary E. Rehm , Michael J. Pugia
发明人： Paul F. Corey , Steven W. Felman , Gary E. Rehm , Michael J. Pugia
IPC分类号： C07D207/36 , G01N21/64 , G01N33/48 , G01N33/573 , G01N33/68
CPC分类号： C07D207/36 , Y02P20/55
摘要： A compound of the formula (I) wherein R1 is a protecting group for Nα, R2 is a protecting group for NG, and R3 is aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O—C single bond, which liberates R3—OH; a diagnostic device comprising same; a method for preparing the diagnostic device; and a method of using the diagnostic device to detect levels of urinary trypsin inhibitor in a biological sample; and a diagnostic kit for detecting levels of urinary trypsin inhibitor in a biological sample.
摘要翻译：其中R 1为Nalpha，R 2的保护基的式（I）化合物是N，N的保护基，和 R 3是芳基，其中式（I）化合物是胰蛋白酶底物，使得胰蛋白酶切割释放R 3 -OH的OC单键; 包括该诊断装置的诊断装置; 一种诊断装置的制备方法; 以及使用该诊断装置检测生物样品中尿胰蛋白酶抑制剂水平的方法; 以及用于检测生物样品中尿胰蛋白酶抑制剂水平的诊断试剂盒。

4. 发明授权

US06316264B1 Test strip for the assay of an analyte in a liquid sample 有权
标题翻译：用于液体样品中分析物测定的试纸
公开(公告)号：US06316264B1
公开(公告)日：2001-11-13
申请号：US09466637
申请日：1999-12-17
申请人： Paul F. Corey , Michael J. Pugia , Gary E. Rehm
发明人： Paul F. Corey , Michael J. Pugia , Gary E. Rehm
IPC分类号： G01N3122
CPC分类号： G01N33/521 , Y10T436/173076
摘要： An improved test strip for determining the presence or concentration of unknown or a constituent in a liquid test sample is disclosed. The test strip comprises a support strip and a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of interacting with the constituent of interest to produce a detectable or measurable response. The test strip further comprises an infrared dye, applied either to the support strip or incorporated into a test pad, which ensures proper alignment of the test strip in an apparatus having a detection system for the detectable or measurable response. The improved test strip reduces the number of erroneous assays for the constituent of interest.
摘要翻译：公开了一种改进的测试条，用于确定液体测试样品中未知物或成分的存在或浓度。测试条包括支撑带和测试垫，其中测试垫包括载体矩阵，其包含能够与感兴趣的成分相互作用以产生可检测或可测量的响应的试剂组合物。测试条进一步包括红外染料，施加到支撑条上或并入测试垫中，这确保测试条在具有用于可检测或可测量响应的检测系统的装置中的适当对准。改进的测试条减少了感兴趣的成分的错误测定的数量。

5. 发明申请

US20130041236A1 SAMPLE ANALYSIS SYSTEM AND METHOD OF USE 审中-公开
标题翻译：样本分析系统及其使用方法
公开(公告)号：US20130041236A1
公开(公告)日：2013-02-14
申请号：US13643633
申请日：2011-04-22
申请人： Michael J. Pugia , Gregory Paul Panebianco , Henry Lu
发明人： Michael J. Pugia , Gregory Paul Panebianco , Henry Lu
IPC分类号： A61B5/20 , G01N33/53 , G01N33/48 , B23P17/04
CPC分类号： A61B10/007 , A61B10/0045 , B01L3/5027 , B01L3/502707 , B01L3/508 , B01L2200/025 , B01L2200/027 , B01L2200/0621 , B01L2300/0654 , B01L2300/0816 , B01L2300/0832 , B01L2300/0851 , B01L2400/0406 , B01L2400/0457 , Y10T29/49826
摘要： A sample collection device having a sample container and microfluidic device having one or more microfluidic circuits, the system for analyzing biological samples. The microfluidic device has a sample inlet port, a microconduit in communication with the inlet port and with reaction chamber. The reaction chamber is connected to an air vent via another microconduit. Air may be vented from the microfluidic circuit via the air vent of the microfluidic circuit via an air vent in the sample container.
摘要翻译：具有样品容器和具有一个或多个微流体电路的微流体装置的样品收集装置，用于分析生物样品的系统。微流体装置具有样品入口，与入口连通的微型管道和反应室。反应室通过另一个微型管道连接到通风口。空气可以经由微流体回路的通气孔从微流体回路经由样品容器中的排气口排出。

6. 发明授权

US08304254B2 Piezo dispensing of a diagnostic liquid onto a reagent surface 失效
标题翻译：诊断液体在试剂表面上的压电分配
公开(公告)号：US08304254B2
公开(公告)日：2012-11-06
申请号：US12598150
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N1/38
CPC分类号： G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
摘要翻译：生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。在不分配生物流体的间隔期间，可以分配试剂和其它流体。或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。

7. 发明授权

US07858758B2 Monoclonal antibodies for detection of urinary trypsin inhibitors 有权
标题翻译：用于检测尿胰蛋白酶抑制剂的单克隆抗体
公开(公告)号：US07858758B2
公开(公告)日：2010-12-28
申请号：US12144909
申请日：2008-06-24
申请人： Michael J. Pugia , Linda Anderson-Mauser , Solomon H. Murphy , Ronald G. Sommer , Shannon Gleason
发明人： Michael J. Pugia , Linda Anderson-Mauser , Solomon H. Murphy , Ronald G. Sommer , Shannon Gleason
IPC分类号： C07K16/00
CPC分类号： G01N33/573 , C07K16/18 , G01N2333/8107 , G01N2333/811 , G01N2333/976
摘要： Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.
摘要翻译：某些单克隆抗体能检测出在人类中具有疾病特征的尿胰蛋白酶抑制剂（UTIs）。特别地，UTI包括本文定义的AMBK，Bikunin，Uristatin，Uristatin-1，Uristatin-2，还包括其片段和聚集体。

8. 发明申请

US20100255592A1 PIEZO DISPENSING OF A DIAGNOSTIC LIQUID ONTO A REAGENT SURFACE 失效
标题翻译：将诊断液体的PIEZO分配到试剂表面
公开(公告)号：US20100255592A1
公开(公告)日：2010-10-07
申请号：US12598150
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N33/72 , G01N33/68 , G01N33/66
CPC分类号： G01N35/1016 , G01N2035/1034 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Assays in which samples of biological fluids are dispensed onto reagent-containing porous substrates are improved in the accuracy and repeatability by dispensing the biological fluids in two or more fractions thereof, separated by intervals in which the biological fluid is not dispensed. Reagents and other fluids may be dispensed during the intervals when the biological fluid is not dispensed. Alternatively, reagents and other fluids may be dispensed in a similar manner onto substrates already containing biological fluids.
摘要翻译：生物流体样品分配到含有试剂的多孔基材上的测定通过将生物流体分配在两个或更多个部分中，通过分配生物流体不分配的间隔而提高了精度和重复性。在不分配生物流体的间隔期间，可以分配试剂和其它流体。或者，可以以类似的方式将试剂和其它流体分配到已经含有生物流体的基底上。

9. 发明申请

US20100172801A1 METHOD FOR UNIFORM APPLICATION OF FLUID INTO A REACTIVE REAGENT AREA 审中-公开
标题翻译：将流体均匀地应用于反应性试剂区域的方法
公开(公告)号：US20100172801A1
公开(公告)日：2010-07-08
申请号：US12688346
申请日：2010-01-15
申请人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
发明人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
IPC分类号： G01N30/00 , G01N33/487
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
摘要翻译：通过在含有干支持试剂的区域中提供结构特征来改进用微流体装置获得的分析结果，其结构特征以预定均匀的方式引导样品流过该区域并促进空气吹扫。

10. 发明申请

US20090143275A1 ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE 有权
标题翻译： ADIPONECTIN受体片段和使用方法
公开(公告)号：US20090143275A1
公开(公告)日：2009-06-04
申请号：US12169983
申请日：2008-07-09
申请人： Michael J. Pugia , Rui Ma
发明人： Michael J. Pugia , Rui Ma
IPC分类号： A61K38/02 , A61P3/10 , A61P35/00
CPC分类号： C07K14/72 , A61K38/00
摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与公开了TNF-α和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

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