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1. 发明授权

US07001737B2 Urinary trypsin inhibitor assay containing a chelating agent 失效
标题翻译：含有螯合剂的尿胰蛋白酶抑制剂测定
公开(公告)号：US07001737B2
公开(公告)日：2006-02-21
申请号：US09844815
申请日：2001-04-30
申请人： Gary E. Rehm , Michael J. Pugia , Paul F. Corey
发明人： Gary E. Rehm , Michael J. Pugia , Paul F. Corey
IPC分类号： G01N33/573 , G01N33/53
CPC分类号： C12Q1/37 , G01N2333/811 , G01N2333/976
摘要： Disclosed is an assay for determining the presence and concentration of trypsin inhibitor in urine samples. The assay reagents, which may be used either in the liquid or dry states, include trypsin, a trypsin substrate and a polycarboxylic chelating agent. The inclusion of the chelating agent in the assay has been found to reduce variation in the assay results.
摘要翻译：公开了用于测定尿液样品中胰蛋白酶抑制剂的存在和浓度的测定法。可以以液体或干燥状态使用的测定试剂包括胰蛋白酶，胰蛋白酶底物和多羧酸螯合剂。发现螯合剂在测定中的包含减少了测定结果的变化。

2. 发明授权

US06955921B2 Trypsin substrate and diagnostic device, and method of using same 有权
标题翻译：胰蛋白酶底物和诊断装置及其使用方法
公开(公告)号：US06955921B2
公开(公告)日：2005-10-18
申请号：US10287239
申请日：2002-11-04
申请人： Paul F. Corey , Steven W. Felman , Gary E. Rehm , Michael J. Pugia
发明人： Paul F. Corey , Steven W. Felman , Gary E. Rehm , Michael J. Pugia
IPC分类号： C07D207/36 , G01N21/64 , G01N33/48 , G01N33/573 , G01N33/68
CPC分类号： C07D207/36 , Y02P20/55
摘要： A compound of the formula (I) wherein R1 is a protecting group for Nα, R2 is a protecting group for NG, and R3 is aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O—C single bond, which liberates R3—OH; a diagnostic device comprising same; a method for preparing the diagnostic device; and a method of using the diagnostic device to detect levels of urinary trypsin inhibitor in a biological sample; and a diagnostic kit for detecting levels of urinary trypsin inhibitor in a biological sample.
摘要翻译：其中R 1为Nalpha，R 2的保护基的式（I）化合物是N，N的保护基，和 R 3是芳基，其中式（I）化合物是胰蛋白酶底物，使得胰蛋白酶切割释放R 3 -OH的OC单键; 包括该诊断装置的诊断装置; 一种诊断装置的制备方法; 以及使用该诊断装置检测生物样品中尿胰蛋白酶抑制剂水平的方法; 以及用于检测生物样品中尿胰蛋白酶抑制剂水平的诊断试剂盒。

3. 发明授权

US06316264B1 Test strip for the assay of an analyte in a liquid sample 有权
标题翻译：用于液体样品中分析物测定的试纸
公开(公告)号：US06316264B1
公开(公告)日：2001-11-13
申请号：US09466637
申请日：1999-12-17
申请人： Paul F. Corey , Michael J. Pugia , Gary E. Rehm
发明人： Paul F. Corey , Michael J. Pugia , Gary E. Rehm
IPC分类号： G01N3122
CPC分类号： G01N33/521 , Y10T436/173076
摘要： An improved test strip for determining the presence or concentration of unknown or a constituent in a liquid test sample is disclosed. The test strip comprises a support strip and a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of interacting with the constituent of interest to produce a detectable or measurable response. The test strip further comprises an infrared dye, applied either to the support strip or incorporated into a test pad, which ensures proper alignment of the test strip in an apparatus having a detection system for the detectable or measurable response. The improved test strip reduces the number of erroneous assays for the constituent of interest.
摘要翻译：公开了一种改进的测试条，用于确定液体测试样品中未知物或成分的存在或浓度。测试条包括支撑带和测试垫，其中测试垫包括载体矩阵，其包含能够与感兴趣的成分相互作用以产生可检测或可测量的响应的试剂组合物。测试条进一步包括红外染料，施加到支撑条上或并入测试垫中，这确保测试条在具有用于可检测或可测量响应的检测系统的装置中的适当对准。改进的测试条减少了感兴趣的成分的错误测定的数量。

4. 发明授权

US5264589A Merocyanine protein error indicators 失效
标题翻译：梅花蛋白错误指标
公开(公告)号：US5264589A
公开(公告)日：1993-11-23
申请号：US710955
申请日：1991-06-06
申请人： Paul F. Corey
发明人： Paul F. Corey
IPC分类号： C07D209/12 , C07D263/56 , C07D277/64 , C07D293/12 , C09B23/14 , G01N31/00 , G01N31/22 , G01N33/52 , G01N33/68 , C07D209/02
CPC分类号： C09B23/145 , G01N33/523 , G01N33/6839 , Y10S436/81
摘要： The present invention provides a merocyanine protein error indicator compound. Merocyanine compounds are a new class of protein error indicators, providing an analytical tool useful in the detection of protein in a sample.

5. 发明授权

US5183743A Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme substrates 失效
标题翻译：显色二苯并氮杂酮和二苯并噻吖啶酮酶底物
公开(公告)号：US5183743A
公开(公告)日：1993-02-02
申请号：US800112
申请日：1991-11-29
申请人： Paul F. Corey
发明人： Paul F. Corey
IPC分类号： C07D267/18 , C07D281/14 , C07F9/6527 , C07F9/6536 , C07H17/00 , C12Q1/34
CPC分类号： C12Q1/34 , C07D267/18 , C07D281/14 , C07F9/6527 , C07F9/6536 , C07H17/00 , C12Q2334/00 , G01N2333/924
摘要： Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e] [1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.
摘要翻译：包含具有酶切割基团的二苯并[b，e] [1,4]氧氮杂酮或二苯并[b，e] [1,4]噻吩酮核的显色酶底物化合物，例如糖，羧酸，氨基酸，肽，磷酸或硫酸。底物化合物通常在水性介质中高度可溶，仅稍微着色，并且在酶切割时产生显示出吸光度变化大的显色剂和低于7的pKa。这样的底物可用作测定酶的指示剂分析物和酶用于各种测定中的标记，包括免疫测定。

6. 发明授权

US4657855A Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample 失效
标题翻译：用于确定测试样品中白细胞，酯酶和蛋白酶的存在的组合物和测试装置
公开(公告)号：US4657855A
公开(公告)日：1987-04-14
申请号：US597338
申请日：1984-04-06
申请人： Paul F. Corey , A. Christopher Skjold , James H. Pendergrass , Lonnie Stover
发明人： Paul F. Corey , A. Christopher Skjold , James H. Pendergrass , Lonnie Stover
IPC分类号： C07D207/34 , C07D307/58 , C07D333/32 , C12Q1/37 , C12Q1/44 , G01N33/49 , G01N33/50 , C12Q1/38
CPC分类号： C12Q1/44 , C12Q1/37 , C12Q2334/70 , C12Q2337/00 , Y10S435/805
摘要： A composition for determining the presence of leukocytes, esterase or protease in a test sample. The composition comprises an ester having the structure ##STR1## in which: A is an N-blocked-amino acid residue or an N-blocked-peptide residue, X is O, S or NR', R is aryl, or lower alkyl, R* is H, or lower alkyl, and R' is H, lower alkyl or aryl; and a suitable buffer substance.
摘要翻译：用于确定测试样品中白细胞，酯酶或蛋白酶的存在的组合物。该组合物包含具有以下结构的酯：其中：A为N-封端 - 氨基酸残基或N-封闭肽残基，X为O，S或NR'，R为芳基或低级烷基， R *是H或低级烷基，R'是H，低级烷基或芳基; 和合适的缓冲物质。

7. 发明授权

US4543421A Conjugate addition of organocuprates generated from copper (I) cyanide and vinyl stannanes useful in prostaglandin analog synthesis 失效
标题翻译：从用于前列腺素类似物合成的氰化铜和乙烯基锡烷产生的有机碳酸盐的共轭加成
公开(公告)号：US4543421A
公开(公告)日：1985-09-24
申请号：US493709
申请日：1983-05-11
申请人： Paul F. Corey , Harold C. Kluender
发明人： Paul F. Corey , Harold C. Kluender
IPC分类号： C07C67/00 , C07C401/00 , C07C405/00 , C07F7/18 , C07F7/22 , C07C177/00
CPC分类号： C07F7/2212 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07F7/1852 , C07F7/1856
摘要： An improved method for the preparation of prostaglandin analogs which comprises preparation of two equivalents of an alkyl or alkenyl lithium reagent in an aprotic solvent mixture such as pentane or hexane and tetrahydrofuran, conversion of said reagent by addition of 1 equivalent of copper (I) cyanide to a copper reagent, conversion of said copper reagent to the blocked prostaglandin analog by the addition of a 2-alkylcyclopent-2-en-1-one reagent and quenching of the resultant reaction mixture with aprotic media or an active acylating agent and finally optionally deblocking the resultant product is disclosed. This method is an improvement over previous methods in that more modest temperatures and less hazardous and/or less complex reagents are used and in that for some analogs the method is shorter than previous methods.
摘要翻译：一种用于制备前列腺素类似物的改进方法，其包括在非质子溶剂混合物如戊烷或己烷和四氢呋喃中制备两当量的烷基或烯基锂试剂，所述试剂通过加入1当量的氰化铜（I）通过加入2-烷基环戊-2-烯-1-酮试剂将所述铜试剂转变成封闭的前列腺素类似物，并用非质子介质或活性酰化剂淬灭所得反应混合物，最后任选地公开了解结果产物。该方法是对以前的方法的改进，因为使用更温和的温度和更少的危险和/或较不复杂的试剂，并且对于一些类似物，该方法比先前的方法更短。

8. 发明授权

US5279790A Merocyanine and nitro or nitroso substituted polyhalogenated phenolsulfonephthaleins as protein indicators in biological samples 失效
标题翻译：作为生物样品中的蛋白质指示剂，甲花青和硝基或亚硝基取代的多卤代苯酚磺酞属
公开(公告)号：US5279790A
公开(公告)日：1994-01-18
申请号：US929801
申请日：1992-11-02
申请人： Paul F. Corey , Angela A. Michaels , Ronald G. Sommer
发明人： Paul F. Corey , Angela A. Michaels , Ronald G. Sommer
IPC分类号： C07C309/44 , C07D209/12 , C07D263/56 , C07D277/64 , C07D293/12 , C07D327/04 , G01N31/00 , G01N31/22 , G01N33/52 , G01N33/68 , G01N21/00
CPC分类号： C07D263/56 , C07D209/12 , C07D277/64 , C07D293/12 , C07D327/04 , G01N33/521 , G01N33/6839 , Y10S436/81
摘要： The present invention provides an analytical test strip for the detection of protein in a biological sample including a novel combination of protein error indicators. The invention includes, in combination, a partially halogenated phenolsulfonephthalein protein error indicator having nitro or nitroso substituent groups in the B and/or C rings and a merocyanine protein error indicator.
摘要翻译：本发明提供了用于检测生物样品中的蛋白质的分析测试条，其包括蛋白质错误指示剂的新组合。本发明组合包括在B和/或C环中具有硝基或亚硝基取代基的部分卤化的苯酚磺酞蛋白错误指示剂和部花青蛋白错误指示剂。

9. 发明授权

US4668822A Method for preparing (+)S-2--hydroxy-2-methyl-hexanoic acid 失效
标题翻译：制备（+）S-2-羟基-2-甲基 - 己酸的方法
公开(公告)号：US4668822A
公开(公告)日：1987-05-26
申请号：US894390
申请日：1986-08-11
申请人： Paul F. Corey
发明人： Paul F. Corey
IPC分类号： C07C51/00 , C07C51/09 , C07C405/00 , C07D207/16 , C07D498/04 , C07C59/01
CPC分类号： C07D207/16 , C07C405/00 , C07C51/00 , C07C51/09
摘要： A method for preparing an important stereo-specific intermediate in the synthesis of prostaglandin analogs is disclosed. Said intermediate is (+)S-2-hydroxy-2-methyl-hexanoic acid and is prepared via an asymmetric halolactonization reaction utilizing L-proline as the chiral agent.
摘要翻译：公开了一种在前列腺素类似物的合成中制备重要的立体特异性中间体的方法。所述中间体是（+）S-2-羟基-2-甲基 - 己酸，并通过使用L-脯氨酸作为手性试剂的不对称卤代糖化反应来制备。

10. 发明授权

US4645842A Pyrrole compounds for detecting the presence of hydrolytic analytes 失效
标题翻译：用于检测水解分析物存在的吡咯化合物
公开(公告)号：US4645842A
公开(公告)日：1987-02-24
申请号：US597336
申请日：1984-04-06
申请人： Paul F. Corey , Frederick E. Ward , Kin F. Yip , Meitak T. Yip
发明人： Paul F. Corey , Frederick E. Ward , Kin F. Yip , Meitak T. Yip
IPC分类号： C07D207/34 , C07D207/36 , C07D303/48 , C07D333/32 , C07D333/38 , C07D339/04 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/52
CPC分类号： C12Q1/37 , C07D207/36 , C07D303/48 , C07D333/32 , C07D339/04 , C12Q1/44
摘要： A novel compound useful in detecting leukocytes, esterase and protease in a test sample. The compound has the structure ##STR1## in which: A is an acid residue, R is lower alkyl, aryl, carboxyl, carboxyl ester, amido or cyano, R* is H or lower alkyl, and X is O, S, or NR', in which R' is H, lower alkyl or aryl.
摘要翻译：用于检测试样中白细胞，酯酶和蛋白酶的新型化合物。该化合物具有以下结构：其中：A为酸残基，R为低级烷基，芳基，羧基，羧基酯，酰氨基或氰基，R *为H或低级烷基，X为O，S或NR '，其中R'是H，低级烷基或芳基。

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