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1. 发明申请

WO2006054903A2 METHOD OF CARDIAC IMAGING 审中-公开
标题翻译：心脏成像方法
公开(公告)号：WO2006054903A2
公开(公告)日：2006-05-26
申请号：PCT/NO2005000434
申请日：2005-11-18
申请人： GE HEALTHCARE AS , LERCHE MATHILDE , ZANDT RENE , GOLMAN KLAES , THANING MIKKEL , ARDENKJAER-LARSEN JAN-HENRIK , PETERSSON STEFAN
发明人： LERCHE MATHILDE , ZANDT RENE , GOLMAN KLAES , THANING MIKKEL , ARDENKJAER-LARSEN JAN-HENRIK , PETERSSON STEFAN
IPC分类号： A61K49/06
CPC分类号： G01R33/5601 , A61B5/055 , A61K49/06
摘要： The invention relates to a method of cardiac imaging using hyperpolarised 13 C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.
摘要翻译：本发明涉及使用超极化的13 C-丙酮酸作为MR成像剂的心脏成像方法，其可以测定心肌细胞的存活力。

2. 发明申请

WO0237132A8 METHODS AND DEVICES FOR DISSOLVING HYPERPOLARISED SOLID MATERIAL FOR NMR ANALYSES 审中-公开
标题翻译：核磁共振分析用于溶解固体高分子材料的方法和装置
公开(公告)号：WO0237132A8
公开(公告)日：2003-12-04
申请号：PCT/EP0112736
申请日：2001-11-02
申请人： AMERSHAM HEALTH AS , ARDENKJAER-LARSEN JAN HENRIK , AXELSSON OSKAR H E , GOLMAN KLAES KOPPEL , HANSSON GEORG , JOHANNESSON H , SERVIN ROLF , THANING MIKKEL , HANSSON LENNART
发明人： ARDENKJAER-LARSEN JAN HENRIK , AXELSSON OSKAR H E , GOLMAN KLAES KOPPEL , HANSSON GEORG , JOHANNESSON H , SERVIN ROLF , THANING MIKKEL , HANSSON LENNART
IPC分类号： G01N24/00 , A61B5/055 , G01N1/28 , G01N1/44 , G01N24/08 , G01R20060101 , G01R1/00 , G01R33/28 , G01R33/30 , G01R33/31 , G01R33/32 , G01R33/62 , G01V3/00 , A61K49/06
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译：本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。

3. 发明申请

WO2009027422A3 NOZZLE FOR A POLARIZER FOR DYNAMIC NUCLEAR SPIN POLARISATION (DNP) 审中-公开
标题翻译：用于动态核弹性极化极化的喷嘴（DNP）
公开(公告)号：WO2009027422A3
公开(公告)日：2009-09-03
申请号：PCT/EP2008061197
申请日：2008-08-27
申请人： GE HEALTHCARE LTD , ARDENKJAER-LARSEN JAN HENRIK , DIETRICH DAVID KEY , GRAM KARL ANDREAS , LEACH ANDREW M , MILLER PETER , TELFEYAN ERIC J , THANING MIKKEL , WHITT DAVID B
发明人： ARDENKJAER-LARSEN JAN HENRIK , DIETRICH DAVID KEY , GRAM KARL ANDREAS , LEACH ANDREW M , MILLER PETER , TELFEYAN ERIC J , THANING MIKKEL , WHITT DAVID B
IPC分类号： G01R33/30 , B01L99/00 , G01N1/10 , G01R33/62
CPC分类号： G01R33/307 , B01F1/0022 , B01L3/0293 , G01N1/38 , G01N2001/1025 , G01N2001/383 , G01R33/282 , G01R33/62
摘要： DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.
摘要翻译： DNP偏振器包括壳体，其容纳与由所述壳体支撑的喷嘴流体连通的管状流体导管的自由端，所述喷嘴包括输入端口，分配端口和锥形内表面或限定喷嘴流径的阶梯式内表面在所述输入端口和所述分配端口之间流体连通地延伸。

4. 发明申请

WO2006011810A2 METHOD OF TUMOUR IMAGING 审中-公开
标题翻译：肿瘤成像方法
公开(公告)号：WO2006011810A2
公开(公告)日：2006-02-02
申请号：PCT/NO2005000282
申请日：2005-07-28
申请人： AMERSHAM HEALTH AS , THANING MIKKEL , ZANDT RENE IN T
发明人： THANING MIKKEL , ZANDT RENE IN T
IPC分类号： A61K49/06 , A61B5/055 , G01R33/20
CPC分类号： G01R33/485 , A61K51/0406 , G01R33/5601
摘要： The invention relates to a method tumour imaging using hyperpolarised 13 C-pyruvate as MR imaging agent, the method allowing for the discrimination between tumour tissue and healthy tissue.
摘要翻译：本发明涉及使用超极化的13 C-丙酮酸作为MR成像剂的方法肿瘤成像方法，该方法允许区分肿瘤组织和健康组织。

5. 发明申请

WO2007064226A3 METHOD OF DYNAMIC NUCLEAR POLARISATION (DNP) USING A TRITYL RADICAL AND A PARAMAGNETIC METAL ION 审中-公开
标题翻译：动态核偏振方法（DNP）使用三角波和参比金属离子
公开(公告)号：WO2007064226A3
公开(公告)日：2007-10-18
申请号：PCT/NO2006000449
申请日：2006-12-01
申请人： GE HEALTHCARE AS , THANING MIKKEL , SERVIN ROLF
发明人： THANING MIKKEL , SERVIN ROLF
IPC分类号： A61K49/10 , A61K49/20
CPC分类号： A61K49/20 , A61K49/10 , A61K49/124
摘要： The invention relates to a method of dynamic nuclear polarisation (DNP) using a combination of a trityl radical and a paramagnetic metal ion as the polarising agent leading to enhanced levels of polarisation in the sample to be polarised and to compositions and polarising agents for use in the method.
摘要翻译：本发明涉及使用三苯甲基和顺磁金属离子的组合作为偏振剂的动态核极化（DNP）的方法，导致待极化的样品中的极化水平增加，以及用于方法。

6. 发明申请

WO2009008734A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009008734A3
公开(公告)日：2009-10-29
申请号：PCT/NO2008000255
申请日：2008-07-04
申请人： GE HEALTHCARE AS , THANING MIKKEL
发明人： THANING MIKKEL
IPC分类号： A61K49/04
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438 , A61K49/0452
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CHO) -X-N(R3)-R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式RN（CHO）-XN（R3）-R的两个连接的碘化苯基的化合物，其中X表示任选取代的亚烷基，R 3表示氢原子或酰基官能团， R表示进一步被亲水部分取代的三碘化苯基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

7. 发明申请

WO2007069909A3 METHOD TO PRODUCE HYPERPOLARISED CARBOXYLATES OF ORGANIC AMINES 审中-公开
标题翻译：生产高分子量有机氨基甲酸酯的方法
公开(公告)号：WO2007069909A3
公开(公告)日：2007-10-18
申请号：PCT/NO2006000481
申请日：2006-12-15
申请人： GE HEALTHCARE AS , THANING MIKKEL , GRAM KARL ANDREAS
发明人： THANING MIKKEL , GRAM KARL ANDREAS
IPC分类号： A61K49/10 , A61K49/20
CPC分类号： A61K49/20 , A61K49/06 , A61K49/10 , A61K49/106
摘要： The invention relates to a dynamic nuclear polarisation method for producing hyperpolarised carboxylates of organic amines and amino compounds and compositions for use in that method. The DNP agent preferably is a stable oxygen- based, sulphur-based or carbon-based trityl radical. Optionally a paramagnetic metal ion is present.
摘要翻译：本发明涉及用于生产有机胺和氨基化合物的超极化羧酸盐的动态核极化方法和用于该方法的组合物。 DNP剂优选为稳定的氧基，硫基或碳基三苯甲基基团。可选地存在顺磁金属离子。

8. 发明申请

WO0223209A3 MRI METHOD INVOLVING THE USE OF A HYPERPOLARIZED CONTRAST AGENT 审中-公开
标题翻译：涉及使用超高效对比剂的MRI方法
公开(公告)号：WO0223209A3
公开(公告)日：2002-08-22
申请号：PCT/GB0104085
申请日：2001-09-12
申请人： AMERSHAM HEALTH AS , PETERSSON STEFAN , LEUNBACH IB , MANSSON SVEN , AXELSSON OSKAR , THANING MIKKEL , ANDERSSON SVEN , MOY DAVID
发明人： PETERSSON STEFAN , LEUNBACH IB , MANSSON SVEN , AXELSSON OSKAR , THANING MIKKEL , ANDERSSON SVEN
IPC分类号： G01R33/28 , A61B5/055 , A61K20060101 , A61K49/00 , C07C31/27 , C07C43/13 , C07C59/01 , C07C69/08 , C07C235/06 , C07C309/08 , C07C309/17 , C07C311/04 , C07C313/04 , G01R33/561 , G01R33/567
CPC分类号： G01R33/5601 , G01R33/56308 , G01R33/5673
摘要： The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for fluid dynamic investigations of the vasculature, b) exposing said sample or part of the sample to radiation of a frequency selected to excite nuclear spin transitions in said non-zero nuclear spin nuclei, c) detecting MR signals from said sample using any suitable manipulation method including pulse sequences. The invention also provides novel compounds.
摘要翻译：本发明提供了一种样品的对比增强磁共振成像方法，所述方法包括：a）向所述样品施用包含非零核自旋核的超极化MR造影剂，用于脉管系统的流体动力学研究，b）将所述样本或部分样本，以选择以激发所述非零核自旋核中的核自旋跃迁的频率的辐射，c）使用包括脉冲序列的任何合适的操作方法来检测来自所述样本的MR信号。本发明还提供新的化合物。

9. 发明专利

NO339119B1 Metode for å skille mellom friskt vev og tumorvev 未知
公开(公告)号：NO339119B1
公开(公告)日：2016-11-04
申请号：NO20071092
申请日：2007-02-27
申请人： ZANDT RENE INT , GE HEALTHCARE AS
发明人： THANING MIKKEL
IPC分类号： A61B5/055 , A61K49/06 , G01R33/485 , G01R33/56

10. 发明专利

JP2012236832A Method for producing composition, composition and use of the same 有权
标题翻译：生产组合物，组合物及其用途的方法
公开(公告)号：JP2012236832A
公开(公告)日：2012-12-06
申请号：JP2012156109
申请日：2012-07-12
申请人： Ge Healthcare As , ジーイー・ヘルスケア・アクスイェ・セルスカプ
发明人： THANING MIKKEL , ARDENKJAER-LARSEN JAN HENRIK , WOLBER JAN , LERCHE MATHILDE , ZANDT RENE
IPC分类号： C07D519/00 , A61K49/00 , C07B59/00 , C07B60/00 , C07C51/41 , C07C59/19 , C07D495/04
CPC分类号： A61K49/1815 , A61K49/10 , C07D519/00 , G01N24/00
摘要： PROBLEM TO BE SOLVED: To provide an improved method for producing a liquid composition containing a hyperpolarizedC-pyruvate salt, capable of obtaining the hyperpolarizedC-pyruvate salt having a very high polarization level, and a composition especially suitable for MR tumor imaging in a living body.SOLUTION: This method for producing the liquid composition containing the hyperpolarizedC-pyruvate salt is provided by comprising (a) a process of forming the liquid composition containing a radical expressed by formula (I),C-pyruvic acid and/orC-pyruvate salt, and freezing the composition, (b) a process of increasing theC nuclear polarization in the pyruvic acid and/or pyruvate salt contained in the mixture by DNP, (c) a process of obtaining the liquid composition by adding buffer liquid and a base to the frozen composition and thawing to convert theC-pyruvic acid toC-pyruvate salt, or when in the (a), only theC-pyruvic acid is used, by adding buffer solution to the frozen composition and thawing to obtain the liquid composition, and (d) a process of properly removing the radical and/or its reaction product from the liquid composition.
摘要翻译：要解决的问题：为了提供一种改进的制备含有超极化 C>丙酮酸盐的液体组合物的方法，该方法能够获得超极化解决方案：制备含有超极化 C 13丙酮酸盐的液体组合物的方法通过包括（a）形成含有基团表达的基团的液体组合物的方法来提供通过式（I），C-丙酮酸盐和/或C-丙酮酸盐，并将组合物冷冻（ b）通过DNP增加混合物中所含的丙酮酸和/或丙酮酸盐中的核极化的方法，（c）通过以下步骤获得液体组合物的方法：向冷冻组合物中加入缓冲液和碱，并解冻以将β-丙酮酸转化为β-丙酮酸盐，或者（a）中，只有在冷冻组合物中加入缓冲溶液并解冻得到液体组合物，才使用[d] ）从液体组合物中适当地除去基团和/或其反应产物的方法灰。版权所有（C）2013，JPO＆INPIT

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