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    • 2. 发明申请
    • PORT OPENING OF HEAT EXCHANGER
    • 热交换器端口打开
    • WO2010069872A1
    • 2010-06-24
    • PCT/EP2009/066929
    • 2009-12-11
    • SWEP International ABANDERSSON, SvenHOBERG, SvanteDAHLBERG, Tomas
    • ANDERSSON, SvenHOBERG, SvanteDAHLBERG, Tomas
    • F28D9/00
    • F28D9/005F28F3/046F28F2225/00
    • A brazed heat exchanger (100,200) for exchanging heat between fluids comprises a number of heat exchanging plates (110,210) provided with a pressed pattern of ridges (120,220) and grooves (130,230). The heat exchanger plates (110,210) arc stacked onto one another such that flow channels (211,212) are formed between said plates (110,210), and the flow channels (211,212) are in selective communication with port openings (140,240). Port skirts (170,250,260) are arranged on the heat exchanging plates (110,210), said port skirts (170, 250, 260) at least partly surrounding the port openings (140,240), extending in a generally perpendicular direction as compared to a plane of the heat exchanger plates (110,210) and being arranged to overlap one another to form a pipe like configuration or a part thereof.
    • 用于在流体之间交换热量的钎焊热交换器(100,200)包括多个热交换板(110,210),所述热交换板设置有压制的脊(120,220)和凹槽(130,230)。 热交换器板(110,210)彼此堆叠,使得在所述板(110,210)之间形成流动通道(211,212),并且流动通道(211,212)与开口(140,240)选择性连通。 端口裙子(170,250,260)布置在热交换板(110,210)上,所述端口裙部(170,250,260)至少部分地围绕端口开口(140,240),大致垂直于与 热交换器板(110,210)并且被布置成彼此重叠以形成管状构造或其一部分。
    • 5. 发明申请
    • HETEROCYCLIC METHYL FREE RADICALS AS IMAGE ENHANCING AGENTS
    • 作为图像增强剂的杂环甲基自由基
    • WO1996039367A1
    • 1996-12-12
    • PCT/GB1995002151
    • 1995-09-08
    • NYCOMED IMAGING A/SCOCKBAIN, Julian, R., M.ANDERSSON, SvenRYDBECK, AnnaSERVIN, RolfWISTRAND, Lars-GoranRADNER, Finn
    • NYCOMED IMAGING A/SCOCKBAIN, Julian, R., M.
    • C07B61/02
    • A61K49/20C07B61/02C07D493/04C07D495/04C07D497/04C07D519/00C07F7/0814
    • The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula (1) or (2), wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O)n (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or an S(O)n group; R is a hydrogen atom or group of formula -M, -XM, -X-Ar where M is a water solubilising group, and Ar represents a 5-10 membered aromatic ring optionally substituted by a water solubilising group M; and each of the groups R , which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilising group M, or two groups R together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally wit the ring attachment carbon replaced by a silicon atom, and R where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilising group M. The novel radicals have good stability, long relaxation times and good relaxivity.
    • 本发明提供了在Overhauser MRI中有用的新型持久性自由基,其是作为至少一个芳基具有式(1)或(2)的基团的三芳基甲基,其中每个可以相同或不同的X是氧或硫原子或 基团CO或S(O)n(其中n为1至3),条件是至少一个基团X为硫原子或S(O)n基团; R 1是氢原子或式-M,-XM,-X-Ar 2的基团,其中M是水增溶基团,Ar 2表示5-10元芳环,其任选被 水增溶组M; 可以相同或不同的基团R 7中的每一个为氢原子或烃基或水溶性基团M,或两个基团R 7与它们所键合的原子一起 代表羰基或5至8元环亚烷基,单或二 - 氧杂环亚烷基,单或二 - 氮杂环烷叉基或单 - 或二 - 硫杂环亚烷基,任选地使环连接碳被硅原子取代,R 7表示 任选地被羟基,任选烷氧基化,任选羟基化的酰氧基或烷基或水增溶基团M取代。新基团具有良好的稳定性,长的弛豫时间和良好的弛豫性。