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1. 发明申请

WO2012163738A1 MONITORING STENOSIS FORMATION IN AN ARTERIOVENOUS ACCESS 审中-公开
标题翻译：监测异常进入的STENOSIS形成
公开(公告)号：WO2012163738A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059522
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , MANDERSSON, Bengt , MUNGUIA MENA, Marco , VASQUEZ OBANDO, Pablo
发明人： OLDE, Bo , SOLEM, Kristian , MANDERSSON, Bengt , MUNGUIA MENA, Marco , VASQUEZ OBANDO, Pablo
IPC分类号： A61M1/36
CPC分类号： A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3658 , A61M2205/3375
摘要： A device (1) is arranged to monitor, in a sequence of time- separated sessions on a human subject, an arteriovenous (AV) access (4) which is configured to be connected in fluid communication with an extracorporeal fluid circuit (14). In each session, the device obtains a current signal from an acoustic sensor (2A, 2B) arranged on the human subject to detect acoustic emission created by a flow of blood through the AV access (4), and determines an acoustic envelope of the current signal. The device (1) also obtains shape-indicating data of a reference envelope which is representative of the acoustic emission at the anastomosis of the AV access (4), and processes the acoustic envelope as a function of the shape- indicating data to calculate a parameter value indicative of the status of the AV access (4), e.g. for detection of stenosis formation in the AV access (4).
摘要翻译：设备（1）被布置成以人类对象的时间分隔的会话序列来监视被配置为与体外流体回路（14）流体连通地连接的动静脉（AV）访问（4）。在每个会话中，设备从布置在人体上的声学传感器（2A，2B）获取电流信号，以检测通过AV存取（4）的血液流产生的声发射，并确定电流的声包络信号。设备（1）还获得代表AV接入（4）的吻合处的声发射的参考包络的形状指示数据，并且根据形状指示数据处理声包络以计算指示AV接入（4）的状态的参数值，例如用于检测AV接入中的狭窄形成（4）。

2. 发明申请

WO2011080189A1 MONITORING A PROPERTY OF THE CARDIOVASCULAR SYSTEM OF A SUBJECT 审中-公开
标题翻译：监测一个主体的心脏血管系统的属性
公开(公告)号：WO2011080189A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070551
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61B5/0215 , A61M1/36
CPC分类号： A61B5/0215 , A61B5/7203 , A61B5/725 , A61B5/7257 , A61B5/7264 , A61M1/3639 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3656 , A61M2205/3331 , A61M2230/06
摘要： A device (25) is configured to monitor a cardiovascular property of a subject. The device (25) obtains measurement data from a primary pressure wave sensor (4a-4c) arranged to detect pressure waves in an extracorporeal fluid circuit (20) in fluid communication with the cardiovascular system of the subject. The device has a signal processor (29) configured to generate a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject; determine beat classification data for each heart pulse in the monitoring signal; and calculate, based at least partly on the beat classification data, a parameter value indicative of the cardiovascular property. The beat classification data may distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats. The cardiovascular property may be an arterial status of the cardiovascular system, a degree of calcification in the cardiovascular system, a status of a blood vessel access used for connecting the extracorporeal fluid circuit (20) to the cardiovascular system, a heart rate variability, a heart rate, a heart rate turbulence, an ectopic beat count, or an origin of ectopic beats. The device (25) may be attached to or part of a dialysis machine.
摘要翻译：设备（25）被配置为监测受试者的心血管性质。装置（25）从主压力波传感器（4a-4c）获得测量数据，所述第一压力波传感器（4a-4c）布置成检测与受试者的心血管系统流体连通的体外流体回路（20）中的压力波。该装置具有信号处理器（29），其被配置为基于测量数据产生与时间相关的监测信号，使得监测信号包括心脏脉冲序列，其中每个心脏脉搏表示源自心跳的压力波主题; 确定监测信号中每个心脏脉搏的搏动分类数据; 并且至少部分地基于节拍分类数据计算指示心血管特性的参数值。节拍分类数据可以区分源自正常心跳的心脏脉搏和源自异位心跳的心脏脉冲。心血管性质可以是心血管系统的动脉状态，心血管系统中的钙化程度，用于将体外流体回路（20）连接到心血管系统的血管通路的状态，心率变异性，心率，心率湍流，异位搏动计数或异位搏动的来源。设备（25）可以附接到透析机或其一部分。

3. 发明申请

WO2011080185A1 APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
标题翻译：用于预测快速症状性血压降低的装置和方法
公开(公告)号：WO2011080185A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070546
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/021 , A61B5/024
CPC分类号： A61B5/4836 , A61B5/0205 , A61B5/021 , A61B5/02108 , A61B5/02416 , A61B5/053 , A61M1/30 , A61M1/36 , A61M2230/30
摘要： A monitoring arrangement 100 is configured to predict a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (p ps ) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (p ps ), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.
摘要翻译：监测装置100被配置为预测受试者的血压中的快速有症状的下降，例如，在治疗期间或在操作飞行器时。为此目的，相对于被检体（P）的周边体部（105）的脉冲形状参数（pps）通过适于检测血管中的光反应变化的脉搏血氧仪（110）重复记录。基于接收的脉冲形状参数（pps）中的每一个来计算相应的脉冲幅度测量，并且基于由此计算的脉冲幅度测量值来计算统计色散测量。调查统计色散测量是否满足参考测量的决策标准。如果发现满足判定标准，则产生输出信号（a）。

4. 发明申请

WO2009156174A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OR A FLUID CONNECTION 审中-公开
标题翻译：用于监测完整性或流体连接的方法和装置
公开(公告)号：WO2009156174A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/004640
申请日：2009-06-26
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.
摘要翻译：监视装置（25）基于来自压力传感器（4a-4c）的至少一个与时间有关的测量信号来监视第一和第二流体容纳系统（S1，S2）之间的流体连接（C）的完整性第一流体容纳系统（S1）。第一流体容纳系统（S1）包括第一脉冲发生器（3），第二流体容纳系统（S2）包括第二脉冲发生器（3'）。压力传感器（4a-4c）被布置成检测源自第一脉冲发生器（3）的第一脉冲和源自第二脉冲发生器（3'）的第二脉冲。流体连接（C）的完整性基于测量信号中第二个脉冲的存在来确定。可以通过在时域中分析测量信号和/或通过使用指示所述至少一个测量信号中的第二脉冲的定时的定时信息来检测第二脉冲。分析可以基于表示测量信号的时间窗内的信号值分布的参数值。例如，可以将参数值计算为信号值的统计色散测量值，或者可以由时间窗口内的信号值与第二脉冲的预测时间信号曲线的匹配产生。流体连接（C）可以建立在人体血液系统和体外血流回路之间，例如，用于体外血液治疗。

5. 发明申请

WO2009127683A1 METHOD AND DEVICES FOR MONITORING FLOW CIRCUITS 审中-公开
标题翻译：用于监测流量电路的方法和装置
公开(公告)号：WO2009127683A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054514
申请日：2009-04-16
申请人： GAMBRO LUNDIA AB , FURMANSKI, Martin , ROSLUND, Anders , OLDE, Bo , SOLEM, Kristian
发明人： FURMANSKI, Martin , ROSLUND, Anders , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61M5/168 , G01M3/00 , A61M205/15 , A61M230/06
CPC分类号： G01M3/2815 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M5/16859 , A61M2205/15 , A61M2205/18 , A61M2230/06
摘要： A device is provided for monitoring the integrity of a flow circuit in fluid communication with a receptacle. The flow circuit comprises a pumping device for transferring fluid through the flow circuit. The device operates according to a monitoring method in which a pressure signal is received (401) from a pressure sensor, the pressure signal being indicative of fluid pressure in the receptacle or the flow circuit. The pressure signal is then processed (406-407) for detection of a beating signal. The beating signal manifests itself as an amplitude modulation of the pressure signal and is formed by interference between pressure waves generated by a pulse generator associated with the receptacle and pressure waves generated by the pumping device. The integrity of the flow circuit is determined (408-409) based at least partly on the presence or absence of the beating signal. The device and the flow circuit may be part of an apparatus for extracorporeal blood treatment, and the method may be implemented as a computer program product.
摘要翻译：提供了一种用于监测与容器流体连通的流动回路的完整性的装置。流动回路包括用于通过流动回路传送流体的泵送装置。该装置根据从压力传感器接收压力信号（401）的监测方法进行操作，压力信号表示容器或流路中的流体压力。然后对压力信号进行处理（406-407）以检测跳动信号。跳动信号表现为压力信号的幅度调制，并且由与由插座相关联的脉冲发生器产生的压力波和由泵送装置产生的压力波之间的干扰形成。至少部分地基于跳动信号的存在或不存在来确定流动电路的完整性（408-409）。装置和流路可以是用于体外血液处理的装置的一部分，并且该方法可以被实现为计算机程序产品。

6. 发明申请

WO2011080191A1 MONITORING BLOOD PRESSURE 审中-公开
标题翻译：监测血压
公开(公告)号：WO2011080191A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070557
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/021
CPC分类号： A61B5/021 , A61B5/02125 , A61B5/022 , A61M1/3639
摘要： A device (25) is configured to determine a blood pressure value of a subject, based on a combination of signals obtained from sensors (35, 40) associated at least with an extracorporeal blood flow circuit (20) that is connected in fluid communication with the vascular system of the subject. The combination of signals may be a first signal from a first pulse sensor (40) arranged to detect pressure waves in the extracorporeal blood flow circuit (20) and a second signal indicative of an activation of a pulse generator (30) associated with the patient. Alternatively the combination of signals may be a first signal from a first pulse sensor arranged to detect pressure waves in the vascular system and a second signal indicative of an activation of a pulse generator (3) associated with the extracorporeal blood flow circuit (20). The device comprises a signal processor which is configured to process the first and second signals to determine a time difference between a first time point associated with the first signal and a second time point associated with the second signal; and calculate the blood pressure value based on the time difference. The device (25) may be included in an apparatus (200) for blood treatment, such as a dialysis machine.
摘要翻译：设备（25）被配置为基于从至少与体外血流回路（20）相关联的传感器（35,40）获得的信号的组合来确定对象的血压值，所述体外流血回路（20）与受试者的血管系统。信号的组合可以是来自第一脉冲传感器（40）的第一信号，其布置成检测体外血流回路（20）中的压力波，以及指示与患者相关联的脉冲发生器（30）的激活的第二信号。或者，信号的组合可以是来自布置成检测血管系统中的压力波的第一脉冲传感器的第一信号和指示与体外血流回路（20）相关联的脉冲发生器（3）的激活的第二信号。所述设备包括信号处理器，其被配置为处理所述第一和第二信号以确定与所述第一信号相关联的第一时间点和与所述第二信号相关联的第二时间点之间的时间差; 并根据时差计算血压值。装置（25）可以包括在用于血液处理的装置（200）中，例如透析机。

7. 发明申请

WO2011080190A1 APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
标题翻译：用于预测快速症状性血压降低的装置和方法
公开(公告)号：WO2011080190A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070555
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/0215
CPC分类号： A61B5/0215 , A61M1/3639
摘要： A monitoring device (29) is included in a medical system to implement a method for prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment such as dialysis. To this aim, a pulse shape parameter (p PS ) with respect to a pulse generator of the subject is registered by means of a pressure sensor (4a, 4b, 4c) arranged in an extracorporeal blood flow circuit coupled to a cardiovascular system of the subject (P). The pressure sensor (4a, 4b, 4c) is adapted to detect pressure variations in blood vessels of the subject (P). It is investigated, during measurement period, whether or not one or more of the pulse shape parameters fulfil a decision criterion. An output signal (α) is generated if the decision criterion is found to be fulfilled, to indicate a predicted rapid symptomatic blood pressure decrease in the subject (P). The decision criterion may operate on pulse magnitude measures calculated for the received pulse shape parameters (p PS ), or statistical dispersion measures calculated based on the thus-calculated pulse magnitude measures.
摘要翻译：监测装置（29）包括在医疗系统中以实现用于预测受试者血压中快速症状下降的方法，例如，在透析等医疗过程中。为此，相对于被检体的脉冲发生器的脉冲形状参数（pPS）通过布置在与被检体的心血管系统耦合的体外血流回路中的压力传感器（4a，4b，4c）来记录（P）。压力传感器（4a，4b，4c）适于检测被检体（P）的血管中的压力变化。在测量期间，对脉冲形状参数中的一个或多个是否满足判定标准进行了研究。如果发现判定标准被满足，则产生输出信号（a），以指示对象（P）中预测的快速有症状的血压下降。决策标准可以对针对接收的脉冲形状参数（pPS）计算的脉冲幅度测量值进行操作，或者基于由此计算的脉冲幅度测量值计算的统计色散测量值。

8. 发明申请

WO2011080186A1 CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT 审中-公开
标题翻译：控制流体转移到和/或从主体的流体装置
公开(公告)号：WO2011080186A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070547
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
发明人： OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61M1/36
CPC分类号： A61M1/3656 , A61B5/02125 , A61B5/0215 , A61B5/02405 , A61B5/4836 , A61M1/30 , A61M1/3643 , A61M1/3644 , A61M1/3653 , A61M1/3659 , A61M2205/3331 , A61M2205/6018
摘要： A control system (23) is arranged to control the operation of an apparatus (200) for for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.
摘要翻译：控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。控制系统可操作以在预处理模式和血液处理模式之间切换。血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或病人与血液回路（20）之间的能量传递，。控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别，采取专门的行动。该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。控制系统可以包括在用于血液处理的装置（200）中，例如透析机。

9. 发明申请

WO2007141246A2 PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
标题翻译：快速症状性血压降低预测
公开(公告)号：WO2007141246A2
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055477
申请日：2007-06-04
申请人： GAMBRO LUNDIA AB , SÖRNMO, Leif , SOLEM, Kristian , OLDE, Bo
发明人： SÖRNMO, Leif , SOLEM, Kristian , OLDE, Bo
IPC分类号： A61B5/021 , A61B5/1455
CPC分类号： A61B5/14551 , A61B5/021 , A61B5/02116 , A61M1/3639 , A61M2205/18 , A61M2205/50 , A61M2230/30
摘要： The invention relates to prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfils a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.
摘要翻译：本发明涉及预测受试者血压中快速有症状的下降，例如，在治疗期间或在操作飞行器时。为此目的，通过适于检测血管中的光反应变化的脉搏血氧仪（110）来记录相对于被检体（P）的外周身体部分（105）的脉搏形状参数（Pps）。基于在一次接收的脉冲形状参数（Pps）来计算初始脉冲幅度测量。在第一次之后的测量周期期间，基于接收的脉冲形状参数（Pps）的数量来计算相应的脉冲幅度测量。对于测量周期中的每个脉冲幅度测量，进一步研究测量是否满足相对于初始脉冲幅度测量的判定标准。如果发现满足判定标准，则产生报警触发信号（a）。

10. 发明申请

WO2012175267A1 DETECTING BLOOD PATH DISRUPTION IN EXTRACORPOREAL BLOOD PROCESSING 审中-公开
标题翻译：检测血液中血液中的血液流失
公开(公告)号：WO2012175267A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/059521
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
发明人： HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/3331 , A61M2205/3351 , G01N19/00
摘要： A device (7) monitors a blood path from a blood vessel access (3) of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access (3). A pumping device (4) in the blood path is operable to pump blood through the blood path from the blood withdrawal device (2') to the blood return device (2"). The monitoring device (7) obtains pressure data from a pressure sensor (6a) arranged upstream of the pumping device (4) in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device (4), e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor (6a), where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus (80) and have propagated on a propagation path (P2) in a direction downstream of the pumping device (4) through the blood return device (2"), the blood vessel access (3) and the blood withdrawal device (2') to the pressure sensor (6a).
摘要翻译：装置（7）通过体外血液处理装置监测来自人体受试者的血管通路（3）的血液通路并返回到血管通路（3）。血液通道中的抽吸装置（4）可操作用于将血液从血液提取装置（2'）泵送到血液返回装置（2“），血液通过血液通道从监测装置（7）获得压力数据传感器（6a），其布置在血液路径中的泵送装置（4）的上游，并且处理用于检测泵送装置（4）下游的血液路径中断的压力数据，例如由VND（静脉针头移动）通过评估压力传感器（6a）处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备（80）中的一个或多个脉冲发生器，并且在在泵送装置（4）的下游方向通过血液返回装置（2“），血管通路（3）和血液提取装置（2'）到压力传感器（6a）的传播路径（P2）。

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