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1. 发明授权

US07675032B2 Matrix-free MALDI mass spectrometry 失效
标题翻译：无基质MALDI质谱
公开(公告)号：US07675032B2
公开(公告)日：2010-03-09
申请号：US11532466
申请日：2006-09-15
申请人： Günther Bonn , M. S. Muhammad Ahsan Hashir , Günther Stecher , Rania Bakry
发明人： Günther Bonn , M. S. Muhammad Ahsan Hashir , Günther Stecher , Rania Bakry
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0418
摘要： Particles and monoliths are used for providing an ionized analyte for mass analysis by photon desorption having a size in the range of 0.5-100 μm, wherein the particles or monoliths are modified with a chemical compound capable of absorbing photons having a wave-length of at least 300 nm. The particles and monoliths allow the use of MALDI-MS for the high throughput screening of molecules having a molecular weight lower than 700 μ without interfering signals or with only a limited number of background signals.
摘要翻译：颗粒和整料用于提供离子化分析物，用于通过具有0.5-100μm范围内的尺寸的光子解吸进行质量分析，其中颗粒或整料用能够吸收波长为at的光子的化合物修饰至少300nm。颗粒和整料允许使用MALDI-MS进行高通量筛选分子量低于700μμ的分子，无干扰信号或只有有限数量的背景信号。

2. 发明授权

US08753661B2 Biological surfaces 有权
标题翻译：生物表面
公开(公告)号：US08753661B2
公开(公告)日：2014-06-17
申请号：US11792613
申请日：2005-12-07
申请人： Doris Steinmüller-Nethl , Detlef Steinmüller , Frank Rudolf Kloss , Robert Gassner , Günther Bonn , Christian Wolfgang Huck , Muhammed Najam-Ul-Haq , Matthias Rainer , Günther Stecher
发明人： Doris Steinmüller-Nethl , Detlef Steinmüller , Frank Rudolf Kloss , Robert Gassner , Günther Bonn , Christian Wolfgang Huck , Muhammed Najam-Ul-Haq , Matthias Rainer , Günther Stecher
IPC分类号： A61F2/00 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08
CPC分类号： A61L27/303 , A61L27/54 , A61L29/103 , A61L29/16 , A61L31/084
摘要： A base body contains a substrate that is at least partially coated with a carbon-containing layer. The carbon-containing layer is at least partially functionalized with a molecule that is bound directly or via at least one linker or functional group to the carbon-containing layer. The base body, which has a functionalized carbon-containing surface, is capable of influencing biological processes during a corresponding functionalization.
摘要翻译：基体包含至少部分地涂覆有含碳层的基材。含碳层至少部分地被直接结合或通过至少一个与含碳层的接头或官能团结合的分子官能化。具有官能化含碳表面的基体能够在相应的官能化过程中影响生物过程。

3. 发明授权

US08053247B2 Method and device for preparing an analyte for analysis by mass spectrometry 有权
标题翻译：用于通过质谱法制备用于分析的分析物的方法和装置
公开(公告)号：US08053247B2
公开(公告)日：2011-11-08
申请号：US11973912
申请日：2007-10-10
申请人： Isabel Feuerstein , Günther Bonn , Douglas T. Gjerde , Christian Huck , Guenther Stecher
发明人： Isabel Feuerstein , Günther Bonn , Douglas T. Gjerde , Christian Huck , Guenther Stecher
IPC分类号： G01N1/00 , G01N1/18
CPC分类号： G01N35/028 , G01N1/34 , G01N2035/103 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： The invention provides methods and apparatus for automated sample preparation for MALDI-TOF MS using columns in combination with a liquid handling system. The samples are typically biological such as serum or urine. The columns typically include a bed of media positioned within a modified pipette tip. In some embodiments, the invention provides methods for storing the prepared samples.
摘要翻译：本发明提供用于使用与液体处理系统结合的柱的MALDI-TOF MS的自动化样品制备的方法和装置。样品通常是生物的，如血清或尿液。柱通常包括定位在改进的移液管尖端内的介质床。在一些实施方案中，本发明提供了储存所制备样品的方法。

4. 发明授权

US07244902B2 Method for classifying wine and coffee 有权
标题翻译：葡萄酒和咖啡分类方法
公开(公告)号：US07244902B2
公开(公告)日：2007-07-17
申请号：US10479064
申请日：2002-05-06
申请人： Michael A. Popp , Günther Bonn , Christian Huck , Wolfgang Guggenbichler
发明人： Michael A. Popp , Günther Bonn , Christian Huck , Wolfgang Guggenbichler
IPC分类号： B07C5/00
CPC分类号： G01N33/146 , G01N33/14 , G06K9/00 , Y10S250/91
摘要： A method for classifying beverages of natural origin, such as wine or coffee. Classification is carried out by means of NIR spectroscopy and corresponding numerical-mathematical conditioning of the spectral data of the individual beverage samples, wherein respective obtained spectra are then correlated with a predetermined beverage, class. By means of the method of the invention it is possible to classify wines by sort of wine, growing regions, grape, vine, vintage, kind of material or wood of the wine cask used, and varying degree of maturity of the wine, and by other chemical parameters. Coffee, for example, may be classified by coffee sort, country of origin, coffee growing region, roasting method and defined chemical parameters, e.g., caffeine content, or chlorogenic acid content.
摘要翻译：用于分类天然来源的饮料的方法，例如葡萄酒或咖啡。通过NIR光谱法和各个饮料样品的光谱数据的相应的数学 - 数学调节进行分类，其中相应的获得的光谱然后与预定饮料类相关。通过本发明的方法，可以通过葡萄酒，生长区域，葡萄，葡萄藤，葡萄酒，葡萄酒，所使用的酒桶的材料或木材，葡萄酒的成熟程度以及葡萄酒的成熟程度来分类葡萄酒。其他化学参数。例如，咖啡可以通过咖啡分类，原产地，咖啡生长区域，焙烧方法和确定的化学参数（例如咖啡因含量或绿原酸含量）进行分类。

5. 发明授权

US08586641B2 Monolithic organic copolymer 有权
标题翻译：单片有机共聚物
公开(公告)号：US08586641B2
公开(公告)日：2013-11-19
申请号：US11551181
申请日：2006-10-19
申请人： Lukas Trojer , Günther Bonn
发明人： Lukas Trojer , Günther Bonn
IPC分类号： C08F220/06 , C08F220/14 , C08F236/20 , C08F212/08 , C08J9/28 , B01D15/08
CPC分类号： C08J9/28 , B01J20/261 , B01J20/264 , B01J20/28042 , B01J20/285 , B01J2220/82 , C08J2201/0543 , C08J2201/0546 , C08J2325/08
摘要： The present invention relates to a monolithic organic copolymer prepared by copolymerization of at least one monomer of the group consisting of styrene, (C1-C3)alkylstyrene, (meth)acrylic acid and esters thereof with a crosslinker in the presence of a macroporogen and a microporogen, wherein a) the sum of said at least one monomer of the group and the crosslinker is 10-20%, preferably 10-15%, by volume of the reaction mixture, with the rest being essentially macroporogen and microporogen, and the degree of said copolymerization is at least 70%, preferably at least 90%, more preferably at least 99%, or b) the sum of said at least one monomer of the group and the crosslinker is 30-50%, preferably 35-45%, by volume of the reaction mixture, with the rest being essentially macroporogen and microporogen, and the degree of said copolymerization is in the range of 25-60%, preferably 35-50%. These copolymers can be used in high-performance liquid chromatography for the separation of biopolymers as well as small molecules.
摘要翻译：本发明涉及一种整体式有机共聚物，其通过在大孔原子存在下将苯乙烯，（C1-C3）烷基苯乙烯，（甲基）丙烯酸及其酯与至少一种单体与交联剂共聚而成，微生物，其中a）所述基团和交联剂的所述至少一种单体的总和为反应混合物的体积的10-20％，优选10-15％，其余基本上为大孔隙和微孔，以及程度的所述共聚物为至少70％，优选至少90％，更优选至少99％，或b）所述基团和交联剂的所述至少一种单体之和为30-50％，优选35-45％，反应混合物的体积，其余基本上是大孔原子和微孔，并且所述共聚的程度在25-60％，优选35-50％的范围内。这些共聚物可用于高效液相色谱分离生物聚合物以及小分子。

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