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1. 发明申请

US20050167875A1 Stretched polytetrafluoroethylene moldings and process for production thereof 有权
标题翻译：拉伸聚四氟乙烯模制品及其生产方法
公开(公告)号：US20050167875A1
公开(公告)日：2005-08-04
申请号：US10513150
申请日：2003-05-01
申请人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata , Koichiro Natori
发明人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata , Koichiro Natori
IPC分类号： B29C47/00 , B29C47/54 , B29C55/00 , B29C55/22 , C08J9/00 , C08L27/18 , B29C67/00 , B28B11/08
CPC分类号： B29C47/54 , B29C47/0004 , B29C47/0014 , B29C47/0023 , B29C55/005 , B29C55/22 , B29K2027/18 , B29L2031/7534 , B29L2031/7542
摘要： Disclosed are expanded polytetrafluoroethylene products, such as porous polytetrafluoroethylene tubes, having high axial tear strength and a process for their production. Each expanded polytetrafluoroethylene product has a microstructure, which comprises fibrils and nodes interconnected with each other by the fibrils, and has an axial tear strength of not lower than 6,000 gf/mm as calculated in accordance with the following formula: L/[T×(V/100)] where L (gf) is an axial tear load, T (mm) is a wall thickness, and V (%) is a volume ratio of resin. The process for the production of the expanded polytetrafluoroethylene product includes a high-speed extrusion step.
摘要翻译：公开了具有高轴向撕裂强度的膨胀聚四氟乙烯产品，例如多孔聚四氟乙烯管，以及它们的生产方法。每个膨胀的聚四氟乙烯产品具有显微组织，其包括通过原纤维互相连接的原纤维和节点，并且具有不低于6,000gf / mm的轴向撕裂强度，根据下式计算：L / [Tx（V / 100）]其中L（gf）是轴向撕裂载荷，T（mm）是壁厚，V（％）是树脂的体积比。膨胀聚四氟乙烯制品的生产方法包括高速挤出步骤。

2. 发明授权

US07691299B2 Process for production of expanded polytetrafluoroetylene products 有权
标题翻译：生产膨胀聚四氟乙烯产品的方法
公开(公告)号：US07691299B2
公开(公告)日：2010-04-06
申请号：US10513150
申请日：2003-05-01
申请人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata , Koichiro Natori
发明人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata , Koichiro Natori
IPC分类号： B27J5/00 , D01D5/24 , A61F2/06
CPC分类号： B29C47/54 , B29C47/0004 , B29C47/0014 , B29C47/0023 , B29C55/005 , B29C55/22 , B29K2027/18 , B29L2031/7534 , B29L2031/7542
摘要： Disclosed are expanded polytetrafluoroethylene products, such as porous polytetrafluoroethylene tubes, having high axial tear strength and a process for their production. Each expanded polytetrafluoroethylene product has a microstructure, which comprises fibrils and nodes interconnected with each other by the fibrils, and has an axial tear strength of not lower than 6,000 gf/mm as calculated in accordance with the following formula: L/[T×(V/100)] where L (gf) is an axial tear load, T (mm) is a wall thickness, and V (%) is a volume ratio of resin. The process for the production of the expanded polytetrafluoroethylene product includes a high-speed extrusion step.
摘要翻译：公开了具有高轴向撕裂强度的膨胀聚四氟乙烯产品，例如多孔聚四氟乙烯管，以及它们的生产方法。每个膨胀的聚四氟乙烯产品具有显微组织，其包括通过原纤维相互连接的原纤维和节点，并且具有根据下式计算的不低于6,000gf / mm的轴向撕裂强度：L / [T×（ V / 100）]其中L（gf）是轴向撕裂载荷，T（mm）是壁厚，V（％）是树脂的体积比。膨胀聚四氟乙烯制品的生产方法包括高速挤出步骤。

3. 发明申请

US20090173439A1 COMPOSITE STRUCTURE AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：复合结构及其制造方法
公开(公告)号：US20090173439A1
公开(公告)日：2009-07-09
申请号：US12401219
申请日：2009-03-10
申请人： Fumihiro HAYASHI , Yasuhiro Okuda , Motomi Nakata
发明人： Fumihiro HAYASHI , Yasuhiro Okuda , Motomi Nakata
IPC分类号： B32B37/02
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/072 , A61F2002/075
摘要： A composite structure comprising two polytetrafluoroethylene porous layers and a framework structural member having a plurality of gaps or openings, the framework structural member being disposed between the two polytetrafluoroethylene porous layers, wherein the composite structure is structured such that the polytetrafluoroethylene porous layers are united together by being adhered with each other through the gaps or openings of the framework structural member and such that the respective polytetrafluoroethylene porous layers (A1) and (A2) are united with the framework structural member closely along the surfaces of the respective constituent elements of the framework structural member in such a manner as to wrap the respective elements. The method of manufacturing the composite structure is characterized in that it includes a step of applying pressure through a mass of fine particles.
摘要翻译：包括两个聚四氟乙烯多孔层的复合结构和具有多个间隙或开口的框架结构构件，所述框架结构构件设置在所述两个聚四氟乙烯多孔层之间，其中所述复合结构被构造成使得所述聚四氟乙烯多孔层通过通过框架结构构件的间隙或开口彼此粘合，并且使得相应的聚四氟乙烯多孔层（A1）和（A2）与框架结构构件紧密地沿着框架结构的各个构成元件的表面结合构件以包裹各个元件的方式。制造复合结构体的方法的特征在于，其包括通过大量微粒施加压力的步骤。

4. 发明授权

US08506750B2 Composite structure and process for producing the same 有权
标题翻译：复合结构及其制造方法
公开(公告)号：US08506750B2
公开(公告)日：2013-08-13
申请号：US12401219
申请日：2009-03-10
申请人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata
发明人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata
IPC分类号： B32B37/00
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/072 , A61F2002/075
摘要： A composite structure comprising two polytetrafluoroethylene porous layers and a framework structural member having a plurality of gaps or openings, the framework structural member being disposed between the two polytetrafluoroethylene porous layers, wherein the composite structure is structured such that the polytetrafluoroethylene porous layers are united together by being adhered with each other through the gaps or openings of the framework structural member and such that the respective polytetrafluoroethylene porous layers (A1) and (A2) are united with the framework structural member closely along the surfaces of the respective constituent elements of the framework structural member in such a manner as to wrap the respective elements. The method of manufacturing the composite structure is characterized in that it includes a step of applying pressure through a mass of fine particles.
摘要翻译：包括两个聚四氟乙烯多孔层的复合结构和具有多个间隙或开口的框架结构构件，所述框架结构构件设置在所述两个聚四氟乙烯多孔层之间，其中所述复合结构被构造成使得所述聚四氟乙烯多孔层通过通过框架结构构件的间隙或开口彼此粘合，并且使得相应的聚四氟乙烯多孔层（A1）和（A2）与框架结构构件紧密地沿着框架结构的各个构成元件的表面结合构件以包裹各个元件的方式。制造复合结构体的方法的特征在于，其包括通过大量微粒施加压力的步骤。

5. 发明申请

US20070173917A1 Composite structure and process for producing the same 审中-公开
标题翻译：复合结构及其制造方法
公开(公告)号：US20070173917A1
公开(公告)日：2007-07-26
申请号：US10590739
申请日：2004-02-27
申请人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata
发明人： Fumihiro Hayashi , Yasuhiro Okuda , Motomi Nakata
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/072 , A61F2002/075
摘要： A composite structure comprising two polytetrafluoroethylene porous layers and a framework structural member having a plurality of gaps or openings, the framework structural member being disposed between the two polytetrafluoroethylene porous layers, wherein the composite structure is structured such that the polytetrafluoroethylene porous layers are united together by being adhered with each other through the gaps or openings of the framework structural member and such that the respective polytetrafluoroethylene porous layers (A1) and (A2) are united with the framework structural member closely along the surfaces of the respective constituent elements of the framework structural member in such a manner as to wrap the respective elements. The method of manufacturing the composite structure is characterized in that it includes a step of applying pressure through a mass of fine particles.
摘要翻译：包括两个聚四氟乙烯多孔层的复合结构和具有多个间隙或开口的框架结构构件，所述框架结构构件设置在所述两个聚四氟乙烯多孔层之间，其中所述复合结构被构造成使得所述聚四氟乙烯多孔层通过通过框架结构构件的间隙或开口彼此粘合，并且使得相应的聚四氟乙烯多孔层（A 1）和（A 2）与框架结构构件紧密地沿着相应的构成元件的表面框架结构构件以包裹各个元件的方式。制造复合结构体的方法的特征在于，其包括通过大量微粒施加压力的步骤。

6. 发明授权

US06777540B1 Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand 有权
标题翻译：与Fas配体或其活性片段特异性反应的人源化免疫球蛋白和诱导Fas配体凋亡的区域
公开(公告)号：US06777540B1
公开(公告)日：2004-08-17
申请号：US09254180
申请日：1999-04-15
申请人： Ko Okumura , Motomi Nakata , Hirofumi Higuchi , Yoshitaka Ushio , Hiroaki Maeda , Yasuyuki Eda
发明人： Ko Okumura , Motomi Nakata , Hirofumi Higuchi , Yoshitaka Ushio , Hiroaki Maeda , Yasuyuki Eda
IPC分类号： C07K1600
CPC分类号： C07K16/2875 , C07K14/70575 , C07K2317/24 , C07K2317/34 , C07K2319/00
摘要： Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows creation of recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents.
摘要翻译：提供了与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段，证明了Fas配体上对Fas-Fas配体与Fas表达细胞相互作用诱导的细胞凋亡重要的位点。通过重组DNA技术从与Fas配体特异性反应的单克隆抗体的杂交瘤制备与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段。人源化免疫球蛋白可以抑制Fas配体和Fas之间的生理反应，如细胞凋亡。此外，鉴定在Fas配体上并负责细胞凋亡诱导的位点允许产生对位点内的氨基酸具有特异性反应性的重组蛋白质或肽，以便抑制细胞凋亡，并找到新的治疗剂或诊断剂。

7. 发明申请

US20080195328A1 Peptide or Protein Phosphorylation Analyzer, Phosphorylation Discrimination Program, and Recording Medium For the Program 审中-公开
标题翻译：肽或蛋白质磷酸化分析仪，磷酸化鉴别程序和程序记录介质
公开(公告)号：US20080195328A1
公开(公告)日：2008-08-14
申请号：US11572683
申请日：2005-07-11
申请人： Motomi Nakata , Kunio Awazu
发明人： Motomi Nakata , Kunio Awazu
IPC分类号： G06F19/00
CPC分类号： G01N21/35 , G01N21/3577
摘要： To provide an analyzer configured to enable to determine whether or not phosphoric acid is bound to a peptide or protein in a short time according to a simple procedure, and to provide a program for use in the analyzer, and a recording medium for storing the program.A spectrum of a peptide or protein in the infrared region is determined so as to specify the type of a phosphorylated amino acid in the peptide or protein based on a peak position in a region of 1,000 to 1,100 [cm−1] of the spectrum.
摘要翻译：提供一种分析器，其被配置为能够根据简单的过程在短时间内确定磷酸是否与肽或蛋白质结合，并且提供用于分析仪的程序和用于存储程序的记录介质。确定红外区域中的肽或蛋白质的光谱，以便基于在1,000至1,100 [cm -1]的区域中的峰位置来指定肽或蛋白质中的磷酸化氨基酸的类型， SUP>]。

8. 发明授权

US5232832A Antibody reactive to hamster immunoglobulins and assay using same 失效
标题翻译：抗体对免疫球蛋白的反应和使用相同的测定
公开(公告)号：US5232832A
公开(公告)日：1993-08-03
申请号：US797957
申请日：1991-11-26
申请人： Motomi Nakata , Hiroshi Eto , Yukihito Hasunuma , Hideo Yagita , Ko Okumura
发明人： Motomi Nakata , Hiroshi Eto , Yukihito Hasunuma , Hideo Yagita , Ko Okumura
IPC分类号： G01N33/53 , C07K16/42 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/4283
摘要： A monoclonal antibody specifically reactive to hamster immunoglobulins, a hybridoma producing said monoclonal antibody, and an immunoassay utilizing said monoclonal antibody are provided. The monoclonal antibody is useful in an immunoassay as a secondary antibody to a hamster-derived primary antibody or antiserum raised against various antigens.

9. 发明申请

US20110177407A1 ELECTROCHEMICAL REACTOR, METHOD FOR MANUFACTURING THE ELECTROCHEMICAL REACTOR, GAS DECOMPOSING ELEMENT, AMMONIA DECOMPOSING ELEMENT, AND POWER GENERATOR 审中-公开
标题翻译：电化学反应器，制造电化学反应器的方法，气体分解元件，氨分解元素和发电机
公开(公告)号：US20110177407A1
公开(公告)日：2011-07-21
申请号：US13120606
申请日：2009-09-17
申请人： Masatoshi Majima , Atsushi Fukunaga , Shinji Inazawa , Toshio Ueda , Motomi Nakata , Hiroki Mori , Masahiro Yamakawa
发明人： Masatoshi Majima , Atsushi Fukunaga , Shinji Inazawa , Toshio Ueda , Motomi Nakata , Hiroki Mori , Masahiro Yamakawa
IPC分类号： H01M8/06 , H01M8/00 , C25B9/00 , C25B9/06 , C25B9/08
CPC分类号： B01D53/326 , B01D53/56 , B01D53/58 , B01D53/72 , B01D2251/102 , B01D2257/7027 , B01D2257/708 , H01M4/8652 , H01M4/8657 , H01M4/9066 , H01M8/008 , H01M8/2404 , H01M8/243 , H01M8/2432 , H01M2008/1293 , Y02P70/56 , Y02W30/86
摘要： [Object] To provide an electrochemical reactor that is small in size but high in throughput capacity, does not generate NOx or carbon dioxide, can be operated at a low running cost, is easy to handle during assembling, and has a simple structure and high durability, a method for manufacturing the reactor, a gas decomposing element, an ammonia decomposing element, and a power generator.[Solution] An electrochemical reactor 10 includes a porous anode 2, a porous cathode 5 that is paired with the anode, and an ion conductive material 1 having an ion conductivity and being interposed between the anode and the cathode. The anode 2 includes surface-oxidized metal particle chains 21.
摘要翻译：本发明提供一种尺寸小但吞吐能力高的电化学反应器，不产生NOx或二氧化碳，可以低运行成本运行，组装时易于处理，结构简单高耐久性，制造反应器的方法，气体分解元件，氨分解元件和发电机。电解质反应器10包括多孔阳极2，与阳极配对的多孔阴极5和具有离子传导性且介于阳极和阴极之间的离子传导材料1。阳极2包括表面氧化金属粒子链21。

10. 发明授权

US06426403B1 TRAF family molecules, polynucleotides encoding them, and antibodies against them 失效
标题翻译： TRAF家族分子，编码它们的多核苷酸和针对它们的抗体
公开(公告)号：US06426403B1
公开(公告)日：2002-07-30
申请号：US09138277
申请日：1998-08-18
申请人： Motomi Nakata , Hiroyasu Nakano , Hideo Yagita , Ko Okumura
发明人： Motomi Nakata , Hiroyasu Nakano , Hideo Yagita , Ko Okumura
IPC分类号： C07K1452
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/715 , C07K14/7151
摘要： This invention relates to a TRAF family molecule, a polynucleotide encoding the molecules, an antibody against the molecules, and an antisense polynucleotide of the molecule. Employing an oligo-DNA primer capable of amplifying the most highly conserved region of a known TRAF family molecule, PCR was performed with the aid of cDNA derived from various cell strains and tissues as a template. Thus, the base sequence of the gene of an unknown TRAF family molecule and the amino acid sequence of the TRAF family molecule encoded by the gene were elucidated. An antibody against the molecule was also prepared. By utilizing the TRAF family molecules, genes thereof, and antibodies against the molecules, there are provided methods for elucidating the functions of the proteins and methods for elucidating the signal transduction system of the TNF-R family involving the molecules, as well as probes for research and diagosis, which suggest applications in therapeutic agents.
摘要翻译：本发明涉及TRAF家族分子，编码该分子的多核苷酸，针对该分子的抗体以及该分子的反义多核苷酸。使用能够扩增已知TRAF家族分子的最高度保守区域的寡DNA引物，借助于源自各种细胞株和组织的cDNA作为模板进行PCR。因此，阐明了未知TRAF家族分子的基因的碱基序列和由该基因编码的TRAF家族分子的氨基酸序列。还制备了抗分子的抗体。通过利用TRAF家族分子，其基因和针对分子的抗体，提供了阐明蛋白质功能的方法和阐明涉及分子的TNF-R家族的信号转导系统的方法，以及用于研究和诊断，这表明在治疗药物中的应用。

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