专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06426403B1 TRAF family molecules, polynucleotides encoding them, and antibodies against them 失效
标题翻译： TRAF家族分子，编码它们的多核苷酸和针对它们的抗体
公开(公告)号：US06426403B1
公开(公告)日：2002-07-30
申请号：US09138277
申请日：1998-08-18
申请人： Motomi Nakata , Hiroyasu Nakano , Hideo Yagita , Ko Okumura
发明人： Motomi Nakata , Hiroyasu Nakano , Hideo Yagita , Ko Okumura
IPC分类号： C07K1452
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/715 , C07K14/7151
摘要： This invention relates to a TRAF family molecule, a polynucleotide encoding the molecules, an antibody against the molecules, and an antisense polynucleotide of the molecule. Employing an oligo-DNA primer capable of amplifying the most highly conserved region of a known TRAF family molecule, PCR was performed with the aid of cDNA derived from various cell strains and tissues as a template. Thus, the base sequence of the gene of an unknown TRAF family molecule and the amino acid sequence of the TRAF family molecule encoded by the gene were elucidated. An antibody against the molecule was also prepared. By utilizing the TRAF family molecules, genes thereof, and antibodies against the molecules, there are provided methods for elucidating the functions of the proteins and methods for elucidating the signal transduction system of the TNF-R family involving the molecules, as well as probes for research and diagosis, which suggest applications in therapeutic agents.
摘要翻译：本发明涉及TRAF家族分子，编码该分子的多核苷酸，针对该分子的抗体以及该分子的反义多核苷酸。使用能够扩增已知TRAF家族分子的最高度保守区域的寡DNA引物，借助于源自各种细胞株和组织的cDNA作为模板进行PCR。因此，阐明了未知TRAF家族分子的基因的碱基序列和由该基因编码的TRAF家族分子的氨基酸序列。还制备了抗分子的抗体。通过利用TRAF家族分子，其基因和针对分子的抗体，提供了阐明蛋白质功能的方法和阐明涉及分子的TNF-R家族的信号转导系统的方法，以及用于研究和诊断，这表明在治疗药物中的应用。

2. 发明授权

US5232832A Antibody reactive to hamster immunoglobulins and assay using same 失效
标题翻译：抗体对免疫球蛋白的反应和使用相同的测定
公开(公告)号：US5232832A
公开(公告)日：1993-08-03
申请号：US797957
申请日：1991-11-26
申请人： Motomi Nakata , Hiroshi Eto , Yukihito Hasunuma , Hideo Yagita , Ko Okumura
发明人： Motomi Nakata , Hiroshi Eto , Yukihito Hasunuma , Hideo Yagita , Ko Okumura
IPC分类号： G01N33/53 , C07K16/42 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/4283
摘要： A monoclonal antibody specifically reactive to hamster immunoglobulins, a hybridoma producing said monoclonal antibody, and an immunoassay utilizing said monoclonal antibody are provided. The monoclonal antibody is useful in an immunoassay as a secondary antibody to a hamster-derived primary antibody or antiserum raised against various antigens.

3. 发明授权

US06946255B1 Monoclonal antibody reacting specifically reacting with Fas ligand and production process thereof 失效
标题翻译：与Fas配体特异性反应的单克隆抗体及其制备方法
公开(公告)号：US06946255B1
公开(公告)日：2005-09-20
申请号：US08913555
申请日：1996-03-21
申请人： Nobuhiko Kayagaki , Hideo Yagita , Ko Okumura , Motomi Nakata
发明人： Nobuhiko Kayagaki , Hideo Yagita , Ko Okumura , Motomi Nakata
IPC分类号： A61K38/00 , C07K16/28 , C12P21/08 , G01N33/53 , C07K21/08
CPC分类号： C07K16/2875 , A61K38/00 , C07K2317/74 , Y10S435/81
摘要： The invention provides monoclonal antibodies, which specifically react with a Fas ligand, or active fragments thereof, a production process of the monoclonal antibodies, which specifically react with a Fas ligand, hybridomas separately producing a monoclonal antibody, which specifically reacts with a Fas ligand present on a cell surface, a method of detecting a Fas ligand in a solution, and a kit for use in detecting a Fas ligand, comprising plurality of monoclonal antibodies against Fas ligand in combination.
摘要翻译：本发明提供了与Fas配体或其活性片段特异性反应的单克隆抗体，其与Fas配体特异性反应的单克隆抗体的制备方法，分别产生单克隆抗体的杂交瘤，其与存在的Fas配体特异性反应在细胞表面上，检测溶液中的Fas配体的方法，以及用于检测Fas配体的试剂盒，其组合包含多个针对Fas配体的单克隆抗体。

4. 发明授权

US6068841A Antibodies to Fas-L for treatment of hepatitis 失效
标题翻译： Fas-L抗体用于治疗肝炎
公开(公告)号：US6068841A
公开(公告)日：2000-05-30
申请号：US65059
申请日：1998-04-27
申请人： Ken-ichiro Seino , Nobuhiko Kayagaki , Hideo Yagita , Ko Okumura , Motomi Nakata
发明人： Ken-ichiro Seino , Nobuhiko Kayagaki , Hideo Yagita , Ko Okumura , Motomi Nakata
IPC分类号： A61K39/395 , A61K38/00 , A61P1/16 , A61P31/12 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12P21/08
CPC分类号： C07K16/2875 , A61K38/00
摘要： The invention provides therapeutic agents for hepatitis, comprising an antibody against a human Fas ligand, or an active fragment thereof as an active ingredient. The therapeutic agents for hepatitis according to the invention are particularly effective for the treatment of hepatitis caused by the death of hepatocytes due to apoptosis among many kinds of hepatitis.
摘要翻译： PCT No.PCT / JP96 / 03089 Sec。 371日期：1998年4月27日 102（e）日期1998年4月27日PCT 1996年10月24日PCT公布。公开号WO97 / 15326 日期：1997年5月1日本发明提供了包含针对人Fas配体的抗体或其活性片段作为活性成分的肝炎治疗剂。根据本发明的肝炎治疗剂对于治疗肝细胞死亡引起的肝炎特别有效，因为许多种肝炎引起的细胞凋亡。

5. 发明授权

US5855888A Drug for the treatment of rheumatoid arthritis 失效
标题翻译：用于治疗类风湿关节炎的药物
公开(公告)号：US5855888A
公开(公告)日：1999-01-05
申请号：US727406
申请日：1996-10-17
申请人： Tadashi Nishida , Sachiko Miyake , Hideo Yagita , Ko Okumura
发明人： Tadashi Nishida , Sachiko Miyake , Hideo Yagita , Ko Okumura
IPC分类号： A61K38/00 , C07K16/28 , C12P21/08 , A61K39/395
CPC分类号： C07K16/2845 , C07K16/2821 , C07K16/2839 , C07K16/2842 , C07K16/2875 , A61K38/00
摘要： A drug for the treatment of rheumatoid arthritis, which comprises as an active ingredient a monoclonal antibody which recognizes specifically extracellular region of human VLA-2. Preferable drug for the treatment of rheumatoid arthritis comprises as an active ingredient a monoclonal antibody which recognizes specifically extracellular region of human VLA-2, .alpha. chain. The above drug for the treatment of rheumatoid arthritis can suppress swelling due to arthritis in rheumatoid arthritis with low toxicity and hence is useful for the treatment of rheumatoid arthritis.
摘要翻译： PCT No.PCT / JP95 / 00527 Sec。 371日期1996年10月17日第 102（e）日期1996年10月17日PCT 1995年3月22日PCT公布。第WO95 / 28961号公报日期：1995年11月2日用于治疗类风湿性关节炎的药物，其包含识别人VLA-2特异性胞外区域的单克隆抗体作为活性成分。用于治疗类风湿性关节炎的优选药物包括作为活性成分，其识别人VLA-2，α链的特异性细胞外区域的单克隆抗体。用于治疗类风湿性关节炎的上述药物可以抑制由于类风湿性关节炎中的关节炎引起的低毒性的肿胀，因此可用于治疗类风湿性关节炎。

6. 发明授权

US08404233B2 Neutralizing monoclonal antibody against human DLL4 有权
标题翻译：针对人类DLL4的中和单克隆抗体
公开(公告)号：US08404233B2
公开(公告)日：2013-03-26
申请号：US12599804
申请日：2008-05-15
申请人： Makoto Sunamura , Hideo Yagita
发明人： Makoto Sunamura , Hideo Yagita
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12P21/00 , C12P21/08 , C12N5/00 , C12N15/00 , C12N15/09 , C12N15/13
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a binding protein capable of binding to delta-like ligand 4 (DLL4) as well as methods and uses thereof in therapy, diagnosis or imaging. Also provided are fusion proteins and protein conjugates, nucleic acid molecules encoding the binding proteins and methods of preparing binding proteins capable of binding to DLL4.
摘要翻译：本发明提供能够结合δ样配体4（DLL4）的结合蛋白以及其在治疗，诊断或成像中的方法和用途。还提供了融合蛋白和蛋白质缀合物，编码结合蛋白的核酸分子和制备能够结合DLL4的结合蛋白的方法。

7. 发明申请

US20100303812A1 NEUTRALIZING MONOCLONAL ANTIBODY AGAINST HUMAN DLL4 有权
标题翻译：中和人类DLL4的单克隆抗体
公开(公告)号：US20100303812A1
公开(公告)日：2010-12-02
申请号：US12599804
申请日：2008-05-15
申请人： Makoto Sunamura , Hideo Yagita
发明人： Makoto Sunamura , Hideo Yagita
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , A61K31/7088 , G01N33/53 , A61P35/00 , A61P37/06 , A61P15/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a binding protein capable of binding to DLL4 as well as methods and uses thereof in therapy, diagnosis or imaging. Also provided are fusion proteins and protein conjugates, nucleic acid molecules encoding the binding proteins and methods of preparing binding proteins capable of binding to DLL4.
摘要翻译：本发明提供能够结合DLL4的结合蛋白以及其在治疗，诊断或成像中的方法和用途。还提供了融合蛋白和蛋白质缀合物，编码结合蛋白的核酸分子和制备能够结合DLL4的结合蛋白的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式