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1. 发明申请

US20110071768A1 DEVICE FOR ESTIMATING SURVIVAL CELL COUNT, COMPUTER PROGRAM, AND RECORDING MEDIUM 有权
标题翻译：用于估计生存细胞计数，计算机程序和记录介质的设备
公开(公告)号：US20110071768A1
公开(公告)日：2011-03-24
申请号：US12995066
申请日：2009-05-29
申请人： Fumiaki Abe , Ayako Uchijima , Masamichi Muto , Ayako Horigome
发明人： Fumiaki Abe , Ayako Uchijima , Masamichi Muto , Ayako Horigome
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： C12Q1/06
摘要： By accurately estimating the survival cell count in a probiotic product, the time for developing the product can be shortened. In a device (1) for estimating survival cell count, a calculation unit (14) calculates an estimated result of the survival cell count nt (CFU/g) of a specific strain contained in a composition after storage, in accordance with the following equation (I). (I) Log10 nt=Log10 n0−t×EXP{(AT×T+BT)w+(CT×T+DT)}, provided that t stands for the storage period (days)× 1/30, nt stands for the survival cell count (CFU/g) of the strain contained in the composition after the storage period t (days), n0 stands for the viable cell count (CFU/g) of the strain contained in the composition at the initiation of storage, T stands for the storage temperature (° C.), w stands for the water activity value of the composition, AT and CT stand for experimentally determined coefficients specific to the strain, and BT and DT stand for experimentally determined constants specific to the strain.
摘要翻译：通过准确估计益生菌产品中的存活细胞计数，可以缩短开发产品的时间。在用于估计存活细胞计数的装置（1）中，计算单元（14）根据以下等式计算储存后的组合物中包含的特定菌株的存活细胞计数nt（CFU / g）的估计结果（一世）。（I）Log10 nt = Log10 n0-t×EXP {（AT×T + BT）w +（CT×T + DT）}，条件是t代表保存期（天）×1/30，nt表示储存期t（天）后组合物中所含的菌株的存活细胞计数（CFU / g），n0表示储存开始时组合物中包含的菌株的活菌数（CFU / g），T 代表储存温度（℃），w代表组合物的水活度值，AT和CT代表实验确定的菌株特异性系数，BT和DT代表对菌株特异性的实验测定常数。

2. 发明授权

US09014990B2 Device for estimating survival cell count, computer program, and recording medium 有权
标题翻译：用于估计存活细胞计数，计算机程序和记录介质的装置
公开(公告)号：US09014990B2
公开(公告)日：2015-04-21
申请号：US12995066
申请日：2009-05-29
申请人： Fumiaki Abe , Ayako Uchijima , Masamichi Muto , Ayako Horigome
发明人： Fumiaki Abe , Ayako Uchijima , Masamichi Muto , Ayako Horigome
IPC分类号： G01N31/00 , C12Q1/06
CPC分类号： C12Q1/06
摘要： By accurately estimating the survival cell count in a probiotic product, the time for developing the product can be shortened. In a device (1) for estimating survival cell count, a calculation unit (14) calculates an estimated result of the survival cell count nt (CFU/g) of a specific strain contained in a composition after storage, in accordance with the following equation (I). (I) Log10nt=Log10n0−t×EXP{(AT×T+BT)w+(CT×T+DT)}, provided that t stands for the storage period (days)× 1/30, nt stands for the survival cell count (CFU/g) of the strain contained in the composition after the storage period t (days), n0 stands for the viable cell count (CFU/g) of the strain contained in the composition at the initiation of storage, T stands for the storage temperature (° C.), w stands for the water activity value of the composition, AT and CT stand for experimentally determined coefficients specific to the strain, and BT and DT stand for experimentally determined constants specific to the strain.
摘要翻译：通过准确估计益生菌产品中的存活细胞计数，可以缩短开发产品的时间。在用于估计存活细胞计数的装置（1）中，计算单元（14）根据以下等式计算储存后的组合物中包含的特定菌株的存活细胞计数nt（CFU / g）的估计结果（一世）。（I）Log10nt = Log10n0-t×EXP {（AT×T + BT）w +（CT×T + DT）}，条件是t代表储存期（天）×1/30，nt表示存活细胞在储存期t（天）后，组合物中所含的菌株的计数（CFU / g），n0表示开始保存时组合物中包含的菌株的活菌数（CFU / g），T表示储存温度（℃），w代表组合物的水活度值，AT和CT代表实验确定的应变特性系数，BT和DT代表对应变特异的实验测定常数。

3. 发明申请

US20110112813A1 METHOD FOR ESTIMATING SURVIVAL CELL COUNT, AND METHOD FOR SETTING GUARANTEED CELL COUNT 有权
标题翻译：评估存活细胞计数的方法和设定保证细胞计数的方法
公开(公告)号：US20110112813A1
公开(公告)日：2011-05-12
申请号：US12995064
申请日：2009-05-29
申请人： Fumiaki Abe , Ayako Uchijima , Ayako Horigome
发明人： Fumiaki Abe , Ayako Uchijima , Ayako Horigome
IPC分类号： G06F17/11
CPC分类号： G06F19/00 , C12Q1/06
摘要： The present invention provides a method for estimating survival cell count, which is able to calculate an accurately estimated result of the survival cell count of a specific strain in a probiotic product with respect to its storage period, and to shorten the time for developing the product, and a method for setting a guaranteed cell count, which is able to readily calculate a guaranteed cell count of a specific strain in a probiotic product within its quality guarantee period. The method for estimating the survival cell count is characterized by estimating the survival cell count nt (CFU/g) of a specific strain contained in a composition after storage, in accordance with the following equation (I). (I) Log10 nt=Log10 n0−t×EXP{(AT×T+BT)w+(CT×T+DT)}, provided that t stands for the storage period (days)×1/30, nt stands for the survival cell count (CFU/g) of the strain contained in the composition after the storage period t (days), n0 stands for the viable cell count (CFU/g) of the strain contained in the composition at the initiation of storage, T stands for the storage temperature (° C.), w stands for the water activity value of the composition, AT and CT stand for experimentally determined coefficients specific to the strain, and BT and DT stand for experimentally determined constants specific to the strain.
摘要翻译：本发明提供一种用于估计存活细胞计数的方法，其能够计算益生菌产品相对于其储存期的特定菌株的存活细胞计数的准确估计结果，并缩短开发产品的时间以及用于设定保证细胞计数的方法，其能够容易地计算其质量保证期内益生菌产品中特定菌株的保证细胞计数。用于估计存活细胞计数的方法的特征在于根据以下等式（I）估计储存后组合物中包含的特定菌株的存活细胞计数nt（CFU / g）。（I）Log10 nt = Log10 n0-t×EXP {（AT×T + BT）w +（CT×T + DT）}，条件是t代表保存期（天）×1/30，nt表示储存期t（天）后组合物中所含的菌株的存活细胞计数（CFU / g），n0表示储存开始时组合物中包含的菌株的活菌数（CFU / g），T 代表储存温度（℃），w代表组合物的水活度值，AT和CT代表实验确定的菌株特异性系数，BT和DT代表对菌株特异性的实验测定常数。

4. 发明授权

US08700373B2 Method for estimating survival cell count, and method for setting guaranteed cell count 有权
标题翻译：估计存活细胞计数的方法，以及设定保证细胞计数的方法
公开(公告)号：US08700373B2
公开(公告)日：2014-04-15
申请号：US12995064
申请日：2009-05-29
申请人： Fumiaki Abe , Ayako Uchijima , Ayako Horigome
发明人： Fumiaki Abe , Ayako Uchijima , Ayako Horigome
IPC分类号： G06G7/58 , G06F19/00
CPC分类号： G06F19/00 , C12Q1/06
摘要： The present invention provides a method for estimating survival cell count, which is able to calculate an accurately estimated result of the survival cell count of a specific strain in a probiotic product with respect to its storage period, and to shorten the time for developing the product, and a method for setting a guaranteed cell count, which is able to readily calculate a guaranteed cell count of a specific strain in a probiotic product within its quality guarantee period. The method for estimating the survival cell count is characterized by estimating the survival cell count nt (CFU/g) of a specific strain contained in a composition after storage, in accordance with the following equation (I). (I) Log10 nt=Log10 n0−t×EXP{(AT×T+BT)w+(CT×T+DT)}, provided that t stands for the storage period (days)×1/30, nt stands for the survival cell count (CFU/g) of the strain contained in the composition after the storage period t (days), n0 stands for the viable cell count (CFU/g) of the strain contained in the composition at the initiation of storage, T stands for the storage temperature (° C.), w stands for the water activity value of the composition, AT and CT stand for experimentally determined coefficients specific to the strain, and BT and DT stand for experimentally determined constants specific to the strain.
摘要翻译：本发明提供一种用于估计存活细胞计数的方法，其能够计算益生菌产品相对于其储存期的特定菌株的存活细胞计数的准确估计结果，并缩短开发产品的时间以及用于设定保证细胞计数的方法，其能够容易地计算其质量保证期内益生菌产品中特定菌株的保证细胞计数。用于估计存活细胞计数的方法的特征在于根据以下等式（I）估计储存后组合物中包含的特定菌株的存活细胞计数nt（CFU / g）。（I）Log10 nt = Log10 n0-t×EXP {（AT×T + BT）w +（CT×T + DT）}，条件是t代表保存期（天）×1/30，nt表示储存期t（天）后组合物中所含菌株的存活细胞计数（CFU / g），n0表示储存开始时组合物中包含的菌株的活菌数（CFU / g），T 代表储存温度（℃），w代表组合物的水活度值，AT和CT代表实验确定的菌株特异性系数，BT和DT代表对菌株特异性的实验测定常数。

5. 发明授权

US08420128B2 Method of imparting heat resistance to lactoferrin 有权
标题翻译：赋予乳铁蛋白耐热性的方法
公开(公告)号：US08420128B2
公开(公告)日：2013-04-16
申请号：US12867979
申请日：2009-03-31
申请人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
发明人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
IPC分类号： A01N59/20 , A61K33/34
CPC分类号： A61K47/42 , A23L33/19 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/2063 , A61K9/4866 , A61K38/40 , A61K47/26
摘要： An agent for thermally stabilizing lactoferrin, which comprises a nucleic acid as an active ingredient, can be added to lactoferrin to impart thermal stability to lactoferrin. Thermally stabilized lactoferrin can be heat-sterilized at a pH value around a neutral pH value while keeping its activity.
摘要翻译：可以将含有核酸作为活性成分的用于热稳定的乳铁蛋白的试剂加入到乳铁蛋白中以赋予乳铁蛋白热稳定性。热稳定的乳铁蛋白可以在pH值约为中性pH值的同时保持其活性而被热灭菌。

6. 发明申请

US20100310673A1 SUBSTANCE AND COMPOSITION BOTH CAPABLE OF IMPARTING HEAT RESISTANCE 有权
标题翻译：具有耐腐蚀性的两种物质和组合物
公开(公告)号：US20100310673A1
公开(公告)日：2010-12-09
申请号：US12867979
申请日：2009-03-31
申请人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
发明人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
IPC分类号： A61K33/34 , C07H21/00 , A61K33/26 , A61K33/30 , A61K38/40 , C07K14/79 , A61P31/04 , A61P3/00 , A61P37/04 , A61P29/00 , A23L1/305
CPC分类号： A61K47/42 , A23L33/19 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/2063 , A61K9/4866 , A61K38/40 , A61K47/26
摘要： An agent for thermally stabilizing lactoferrin, which comprises a nucleic acid as an active ingredient, can be added to lactoferrin to impart thermal stability to lactoferrin. Thermally stabilized lactoferrin can be heat-sterilized at a pH value around a neutral pH value while keeping its activity.
摘要翻译：可以将含有核酸作为活性成分的用于热稳定的乳铁蛋白的试剂加入到乳铁蛋白中以赋予乳铁蛋白热稳定性。热稳定的乳铁蛋白可以在pH值约为中性pH值的同时保持其活性而被热灭菌。

7. 发明申请

US20120177624A1 ORAL DISINFECTANT, AND FOOD ADDITIVE COMPRISING THE DISINFECTANT 审中-公开
标题翻译：口服消毒剂和包含消毒剂的食品添加剂
公开(公告)号：US20120177624A1
公开(公告)日：2012-07-12
申请号：US13427242
申请日：2012-03-22
申请人： Kouichirou Shin , Ayako Horigome , Koji Yamauchi
发明人： Kouichirou Shin , Ayako Horigome , Koji Yamauchi
IPC分类号： A61K38/54 , A61P11/00 , A61P1/02
CPC分类号： A61K38/44 , A23C9/1213 , A23C13/16 , A23L29/06 , A23L33/10 , A61K31/19 , A61K31/194 , A61K31/198 , A61K31/7004 , A61K38/443 , C12Y101/03004 , C12Y111/01007 , A61K2300/00
摘要： Disclosed is a disinfectant which is safe, has few adverse side-effects, can be ingested together with a food or beverage by adding the disinfectant to the food or beverage, shows a bactericidal effect in the oral cavity, and has no problem even when ingested on a daily basis over a long period. Also disclosed is a food additive comprising the disinfectant. Specifically, disclosed is an oral disinfectant for the disinfection of an oral bacterium, which comprises lactoperoxidase, glucose oxidase, glucose and a pH-adjusting component.
摘要翻译：公开了一种安全的消毒剂，具有很少的副作用，可以通过向食品或饮料中加入消毒剂与食物或饮料一起摄入，在口腔中显示杀菌作用，即使摄入也没有问题长期以来每天都有。还公开了包含消毒剂的食品添加剂。具体地，公开了用于消毒口腔细菌的口腔消毒剂，其包括乳过氧化物酶，葡萄糖氧化酶，葡萄糖和pH调节组分。

8. 发明申请

US20100028274A1 ORAL DISINFECTANT, AND FOOD ADDITIVE COMPRISING THE DISINFECTANT 审中-公开
标题翻译：口服消毒剂和包含消毒剂的食品添加剂
公开(公告)号：US20100028274A1
公开(公告)日：2010-02-04
申请号：US12519585
申请日：2007-06-28
申请人： Kouichirou Shin , Ayako Horigome , Koji Yamauchi
发明人： Kouichirou Shin , Ayako Horigome , Koji Yamauchi
IPC分类号： A61K8/365 , A61K8/66 , A61P1/02
CPC分类号： A61K38/44 , A23C9/1213 , A23C13/16 , A23L29/06 , A23L33/10 , A61K31/19 , A61K31/194 , A61K31/198 , A61K31/7004 , A61K38/443 , C12Y101/03004 , C12Y111/01007 , A61K2300/00
摘要： Disclosed is a disinfectant which is safe, has few adverse side-effects, can be ingested together with a food or beverage by adding the disinfectant to the food or beverage, shows a bactericidal effect in the oral cavity, and has no problem even when ingested on a daily basis over a long period. Also disclosed is a food additive comprising the disinfectant. Specifically, disclosed is an oral disinfectant for the disinfection of an oral bacterium, which comprises lactoperoxidase, glucose oxidase, glucose and a pH-adjusting component.
摘要翻译：公开了一种安全的消毒剂，具有很少的副作用，可以通过向食品或饮料中加入消毒剂与食物或饮料一起摄入，在口腔中显示杀菌作用，即使摄入也没有问题长期以来每天都有。还公开了包含消毒剂的食品添加剂。具体地，公开了用于消毒口腔细菌的口腔消毒剂，其包括乳过氧化物酶，葡萄糖氧化酶，葡萄糖和pH调节组分。

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