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1. 发明授权

US5254752A Preparation of 4-halobenzyl alcohols 失效
标题翻译：制备4-卤代苄醇
公开(公告)号：US5254752A
公开(公告)日：1993-10-19
申请号：US960774
申请日：1992-10-14
申请人： Franz Merger , Martin Brudermueller , Martin Schmidt-Radde
发明人： Franz Merger , Martin Brudermueller , Martin Schmidt-Radde
IPC分类号： C07C29/141 , C07C29/145 , C07C33/46 , C07C41/18 , C07C43/174 , C07C27/04
CPC分类号： C07C29/141 , C07C29/145 , C07C33/46
摘要： The invention provides a process for the preparation of a 4-halobenzyl alcohol of the formula ##STR1## where R.sup.1 is hydrogen, C.sub.1 - to C.sub.20 -alkyl, C.sub.2 - to C.sub.20 -alkoxyalkyl, C.sub.3 - to C.sub.20 -cycloalkyl, or C.sub.4 - to C.sub.30 -cycloalkylalkyl,R.sup.2 is C.sub.1 - to C.sub.20 -alkyl, C.sub.2 - to C.sub.20 -alkoxyalkyl, C.sub.3 - to C.sub.20 -cycloalkyl or C.sub.4 - to C.sub.30 -cycloalkylalkyl,X is halogen andm is 0 to 2,by reacting a haloaromatic carbonyl compound of the formula ##STR2## where R.sup.1, R.sup.2, X and m are as defined above, with hydrogen on a hydrogenation catalyst consisting essentially of copper oxide (I), copper oxide (II) and mixtures thereof in the presence of at least one primary, secondary or tertiary amine selected from the group consisting of acyclic, cyclic and heterocyclic aliphatic amines, in the presence or absence of an inert solvent, at from 50.degree. to 130.degree. C. and at from 10 to 200 bar.
摘要翻译：本发明提供制备式（I）的4-卤代苄醇的方法，其中R 1是氢，C 1 -C 20烷基，C 2 -C 20烷氧基烷基，C 3 -C 20环烷基或 C 4 -C 30 - 环烷基烷基，R 2是C 1〜C 20 - 烷基，C 2〜C 20 - 烷氧基烷基，C 3〜C 20 - 环烷基或C 4〜C 30 - 环烷基烷基，X是卤素，m是0〜2，其中R1，R2，X和m如上所定义的式（II）的卤代芳基羰基化合物与氢在基本上由氧化铜（I），氧化铜（II）和它们的混合物组成的氢化催化剂上在惰性溶剂存在或不存在下，在50-130℃和10-200℃下存在至少一种选自无环，环状和杂环脂族胺的伯，仲或叔胺酒吧。

2. 发明授权

US06201160B1 Preparation of alcohols 失效
标题翻译：醇的制备
公开(公告)号：US06201160B1
公开(公告)日：2001-03-13
申请号：US08737736
申请日：1996-11-19
申请人： Martin Brudermüller , Matthias Irgang , Martin Schmidt-Radde , Franz Merger , Tom Witzel , Detlef Kratz , Eckehard Danz , Arnold Wittwer , Michael Hesse , Manfred Sauerwald , Cristina Freire Erdbrügger
发明人： Martin Brudermüller , Matthias Irgang , Martin Schmidt-Radde , Franz Merger , Tom Witzel , Detlef Kratz , Eckehard Danz , Arnold Wittwer , Michael Hesse , Manfred Sauerwald , Cristina Freire Erdbrügger
IPC分类号： C07C2704
CPC分类号： C07C29/145 , B01J21/08 , B01J23/72 , B01J23/868 , C07C29/141 , C07C29/175 , C07C2601/08 , C07C2603/68 , C07C31/205 , C07C31/20 , C07C31/12 , C07C31/125 , C07C31/278 , C07C31/274
摘要： Alcohols are prepared by the catalytic hydrogenation of the corresponding carbonyl compounds at elevated temperatures and at superatmospheric pressure in the liquid phase by a process in which the catalyst used contains copper on an SiO2-containing carrier in the presence or absence of one or more of the elements magnesium, barium, zinc and chromium.
摘要翻译：醇通过在液相中在升高的温度和超大气压下的催化氢化制备，其中使用的催化剂在含有SiO 2的载体上含有铜，在存在或不存在一种或多种元素镁，钡，锌和铬。

3. 发明授权

US5304685A Preparation of 3-(hydroxyphenyl)propionaldehydes and their hydrogenation to 3-(hydroxyphenyl)propanols 失效
标题翻译： 3-（羟基苯基）丙醛的制备及其氢化为3-（羟基苯基）丙醇
公开(公告)号：US5304685A
公开(公告)日：1994-04-19
申请号：US037881
申请日：1993-03-26
申请人： Franz Merger , Martin Schmidt-Radde
发明人： Franz Merger , Martin Schmidt-Radde
IPC分类号： C07B61/00 , C07C37/00 , C07C39/11 , C07C45/68 , C07C45/71 , C07C47/27 , C07C45/00 , C07C29/14
CPC分类号： C07C39/11 , C07C45/71 , C07C47/27
摘要： A process for preparing 3-(hydroxyphenyl)propionaldehydes of the formula I ##STR1## and, where appropriate, for preparing 3-(hydroxyphenyl)propanols of the formula II ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen, C.sub.1 -C.sub.20 -alkyl, C.sub.3 -C.sub.20 -cycloalkyl, C.sub.4 -C.sub.20 -alkylcycloalkyl, C.sub.4 -C.sub.20 -cycloalkylalkyl or C.sub.5 -C.sub.20 -alkylcycloalkylalkyl,R.sup.3 and R.sup.4 are each aryl, C.sub.7 -C.sub.20 -aralkyl, heterocycloalkyl or C.sub.3 -C.sub.20 -heterocycloalkylalkyl, entailsa) reacting phenols of the formula III ##STR3## where R.sup.1 and R.sup.2 have the abovementioned meanings, with 3-hydroxypropionaldehydes of the formula IV ##STR4## where R.sup.3 and R.sup.4 have the abovementioned meanings, in the presence of a basic catalyst at from 90.degree. to 230.degree. C. and under from 0.01 to 50 bar and, where appropriate,b) treating the resulting 3-(hydroxyphenyl)propionaldehydes of the formula I ##STR5## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the abovementioned meanings, with hydrogen in the presence of a hydrogenation catalyst at from 0.degree. to 250.degree. C. and under from 0.1 to 300 bar.
摘要翻译：制备式I（I）的3-（羟基苯基）丙醛的方法，以及适当时制备式II的3-（羟基苯基）丙醇的方法，其中R 1，R 2，R 3和 R 4各自为氢，C 1 -C 20 - 烷基，C 3 -C 20 - 环烷基，C 4 -C 20 - 烷基环烷基，C 4 -C 20 - 环烷基烷基或C 5 -C 20 - 烷基环烷基烷基，R 3和R 4各自为芳基，C 7 -C 20 - 芳烷基，杂环烷基或 C 3 -C 20杂环烷基烷基需要a）使具有上述含义的式III化合物III（III）的酚与式IV的3-羟基丙醛反应，其中R 3和R 4具有在碱性催化剂存在下，在90〜230℃，0.01〜50巴下，适当时，b）处理得到的式（I）的3-（羟基苯基）丙醛 I）其中R 1，R 2，R 3和R 4具有上述含义，在氢化催化剂存在下，在0〜250℃下， 0.1至300巴。

4. 发明授权

US5380919A Preparation of neopentyl glycol hydroxypivalate 失效
标题翻译：新戊二醇羟基新戊酸酯的制备
公开(公告)号：US5380919A
公开(公告)日：1995-01-10
申请号：US32025
申请日：1993-03-16
申请人： Franz Merger , Martin Schmidt-Radde
发明人： Franz Merger , Martin Schmidt-Radde
IPC分类号： B01J23/04 , C07B61/00 , C07C67/44 , C07C69/675
CPC分类号： C07C67/44
摘要： A process for preparing neopentyl glycol hydroxypivalate by base-catalyzed disproportionation of hydroxypivalaldehyde, wherein the reaction is carried out in the presence of a readily water-soluble alkaline earth metal salt and of an alkali metal hydroxide.
摘要翻译：通过羟基新戊醛的碱催化歧化制备新戊二醇羟基新戊酸的方法，其中反应在容易水溶性的碱土金属盐和碱金属氢氧化物的存在下进行。

5. 发明授权

US5254757A Preparation of 2,2-bis-hydroxymethyl-butanediol-(1,4) 失效
标题翻译：制备2,2-双羟甲基丁二醇 - （1,4）
公开(公告)号：US5254757A
公开(公告)日：1993-10-19
申请号：US964865
申请日：1993-10-22
申请人： Franz Merger , Martin Schmidt-Radde
发明人： Franz Merger , Martin Schmidt-Radde
IPC分类号： C07B61/00 , C07C29/141 , C07C31/24 , C07C45/59 , C07C45/75 , C07C47/19 , C07C27/04 , C07C29/145 , C07C31/18
CPC分类号： C07C47/19 , C07C29/141 , C07C31/24 , C07C45/75
摘要： A process for the preparation of 2,2-bis-hydroxymethyl-butanediol-(1,4) of formula I ##STR1## wherein 4-hydroxybutyraldehyde of formula II ##STR2## and/or 2-hydroxytetrahydrofuran of formula III ##STR3## is/are condensed with formaldehyde in the presence of a basic catalyst and the resulting reaction mixture is then catalytically hydrogenated, and 2,2-bis-hydroxymethyl-butanediol-(1,4) is isolated from the hydrogenation product.
摘要翻译：制备式I的2,2-双羟甲基丁二醇 - （1,4）的方法（I）其中式II的4-羟基丁醛和/或2-羟基四氢呋喃式III（III）在碱性催化剂存在下与甲醛缩合，然后将所得反应混合物进行催化氢化，并将2,2-双羟甲基丁二醇 - （1,4）从氢化产物。

6. 发明授权

US5689010A Preparation of higher aldehydes 失效
标题翻译：制备较高级的醛
公开(公告)号：US5689010A
公开(公告)日：1997-11-18
申请号：US638592
申请日：1996-04-29
申请人： Rocco Paciello , Franz Merger , Michael Roper , Heinz-Josef Kneuper
发明人： Rocco Paciello , Franz Merger , Michael Roper , Heinz-Josef Kneuper
IPC分类号： B01J31/22 , C07B61/00 , C07C45/50 , C07C45/62 , C07C45/73 , C07C45/74 , C07C47/02 , C07C47/21 , C07C45/49
CPC分类号： C07C45/50 , C07C45/62 , C07C45/74
摘要： Aldehydes with a higher number of carbon atoms and high selection are prepared by reacting olefins, in particular from petrochemical refinery products, by a hydroformylation with aldol condensation using a mixed catalyst of rhodium-carbonyl-phosphines and Mannich catalyst.
摘要翻译：通过使用铑 - 羰基膦和Mannich催化剂的混合催化剂通过使醛醇缩合的加氢甲酰化反应，使烯烃，特别是石油化学品炼油产物反应，制备具有较高碳原子数和高选择性的醛。

7. 发明授权

US5416240A Preparation of poloxy-alkylene glycols 失效
标题翻译：烷氧基 - 亚烷基二醇的制备
公开(公告)号：US5416240A
公开(公告)日：1995-05-16
申请号：US24903
申请日：1993-03-02
申请人： Hans-Juergen Weyer , Rolf Fischer , Gerhard Jeschek , Franz Merger , Herbert Mueller
发明人： Hans-Juergen Weyer , Rolf Fischer , Gerhard Jeschek , Franz Merger , Herbert Mueller
IPC分类号： C08G65/02 , C08G65/08 , C08G65/16 , C08G65/20 , C07C41/01 , C07C41/02
CPC分类号： C08G65/20
摘要： Polyoxyalkylene glycols are prepared by a process in which tetrahydrofuran is polymerized with a total of not more than 95 mol %, based on the amount of tetrahydrofuran used, of one or more comonomers from the group consisting of the cyclic ethers and acetals in the absence of water and in the presence of a monohydric alcohol or of a monocarboxylic acid with the aid of an anhydrous heteropoly acid catalyst, and the polyoxyalkylene glycol is liberated from the resulting polyoxyalkylene glycol monoethers or polyoxyalkylene glycol monoesters by cleavage of the monoether or monoester bond.
摘要翻译：聚氧亚烷基二醇通过以下方法制备，其中四氢呋喃基于所用四氢呋喃的总量不超过95摩尔％，在不存在共聚单体的情况下聚合来自由环醚和缩醛组成的组中的一种或多种共聚单体水和一元醇或单羧酸存在下，借助于无水杂多酸催化剂，通过裂解单醚或单酯键，从所得聚氧亚烷基二醇单醚或聚氧亚烷基二醇单酯中释放出聚氧亚烷基二醇。

8. 发明授权

US5268499A Preparation of mixtures of 3-aminopropionitrile and ethylene cyanohydrin 失效
标题翻译：制备3-氨基丙腈和乙烯氰醇的混合物
公开(公告)号：US5268499A
公开(公告)日：1993-12-07
申请号：US47303
申请日：1993-04-19
申请人： Franz Merger , Martin Brudermueller , Wolfgang Harder , Juergen Hartig , Dieter Franz
发明人： Franz Merger , Martin Brudermueller , Wolfgang Harder , Juergen Hartig , Dieter Franz
IPC分类号： C07C253/30
CPC分类号： C07C253/30
摘要： A process for preparing mixtures of 3-aminopropionitrile of the formula IH.sub.2 N--CH.sub.2 --CH.sub.2 --CN (I)and ethylene cyanohydrin of the formula IIHO--CH.sub.2 --CH.sub.2 --CN (II)comprises reacting bis(2-cyanoethyl) ether of the formula IIINC--CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --CN (III)with ammonia at from 50 to 170.degree. C. and under from 1 to 500 bar thermally or in the presence of a heterogeneous catalyst.
摘要翻译：制备式I H 2 N-CH 2 -CH 2 -N（I）的3-氨基丙腈和式II HO-CH2-CH2-CN（Ⅱ）的乙烯氰醇的混合物的方法包括使双（2-氰乙基）醚式III NC-CH2-CH2-O-CH2-CH2-CN（III）与氨在50至170℃下和在1至500巴下加热或在多相催化剂存在下反应。

9. 发明授权

US5256813A 3-substituted 2-hydroxy-3-formylpropionic esters, the preparation thereof and the use thereof for preparing 3-substituted 3-formylacrylic esters 失效
标题翻译： 3-取代的2-羟基-3-甲酰基丙酸酯，其制备及其用于制备3-取代的3-甲酰基丙烯酸酯的用途
公开(公告)号：US5256813A
公开(公告)日：1993-10-26
申请号：US883342
申请日：1992-05-15
申请人： Franz Merger , Juergen Frank
发明人： Franz Merger , Juergen Frank
IPC分类号： C07C69/675 , C07C69/732
CPC分类号： C07C69/675
摘要： A 3-substituted 2-hydroxy-3-formylpropionic ester of the formula I ##STR1## where R.sup.1 is lower alkyl, and R.sup.2 is straight-chain or branched alkyl of 1 to 10 carbon atoms, is obtained by adding an alkanal of the fomrula II ##STR2## and an alkyl glyoxylate of the formula III ##STR3## simultaneously to a catalyst system composed of a salt or a mixture of a secondary amine and a carboxylic acid in such a way that the temperature does not exceed 90.degree. C., preferably 80.degree. C., or else adding one of the reactants of the formula II or III to a mixture of the catalyst system described above and the other reactant in such a way that the temperature does not exceed 90.degree. C. The 2-hydroxy-3-formylpropionic eater of the formula I can be converted by treatment with dehydrating agents, especially acetic anhydride, into good yields of the corresponding 3-substituted 3-formylacrylic ester.
摘要翻译：其中R1是低级烷基，R2是具有1-10个碳原子的直链或支链烷基的式Ⅰ的3-取代的2-羟基-3-甲酰基丙酸酯是通过将烷基的II型和式III（III）的烷基乙醛酸盐同时与由仲胺和羧酸的盐或混合物组成的催化剂体系，使得温度不超过90℃，优选80℃，或者将一种式II或III的反应物加入到上述催化剂体系和另一种反应物的混合物中，使得温度不超过90℃。式I的2-羟基-3-甲酰基丙酸酯可以通过用脱水剂，特别是乙酸酐处理转化成相应3-取代的3-甲酰基丙烯酸酯的良好产率。

10. 发明授权

US5202461A 3-substituted 2-hydroxy-3-formylpropionic esters, the preparation thereof and the use thereof for preparing 3-substituted 3-formylacrylic esters 失效
标题翻译： 3-取代的2-羟基-3-甲基丙烯酸酯，其制备方法及其用于制备3-取代的3-甲基丙烯酸酯的用途
公开(公告)号：US5202461A
公开(公告)日：1993-04-13
申请号：US593891
申请日：1990-10-05
申请人： Franz Merger , Juergen Frank
发明人： Franz Merger , Juergen Frank
IPC分类号： B01J31/02 , B01J31/04 , C07B61/00 , C07C67/343 , C07C67/44 , C07C69/67 , C07C69/675
CPC分类号： C07C69/675
摘要： A 3-substituted 2-hydroxy3-formylpropionic ester of the formula I ##STR1## where R.sup.1 is lower alkyl, and R.sup.2 is straight-chain or branched alkyl of 1 to 10 carbon atoms, is obtained by adding an alkanal of the formula II ##STR2## and an alkyl glyoxylate of the formula III ##STR3## simultaneously to a catalyst system composed of a salt or a mixture of a secondary amine and a carboxylic acid in such a way that the temperature does not exceed 90.degree. C., preferably 80.degree. C., or else adding one of the reactants of the formula II or III to a mixture of the catalyst system described above and the other reactant in such a way that the temperature does not exceed 90.degree. C. The 2-hydroxy-3-formylpropionic ester of the formula I can be converted by treatment with dehydrating agents, especially acetic anhydride, into good yields of the corresponding 3-substituted 3-formylacrylic ester.
摘要翻译：通过加入式I的3-取代的2-羟基-3-甲酰基丙酸酯，其中R 1是低级烷基，R 2是1-10个碳原子的直链或支链烷基，式II（II）和式III（III）的烷基乙醛酸盐同时加入由盐或仲胺和羧酸的混合物组成的催化剂体系，使得温度不超过90℃，优选80℃，或者将一种式II或III的反应物加入到上述催化剂体系和另一种反应物的混合物中，使得温度不超过90℃ 式I的2-羟基-3-甲酰基丙酸酯可以通过用脱水剂，特别是乙酸酐处理转化成相应3-取代的3-甲酰基丙烯酸酯的良好产率。

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