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1. 发明申请

US20060097065A1 Methods for delivering volatile materials at different time periods 审中-公开
标题翻译：在不同时间段递送挥发性物质的方法
公开(公告)号：US20060097065A1
公开(公告)日：2006-05-11
申请号：US11103151
申请日：2005-04-11
申请人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell , Fernando Tollens , Jonathan Cetti
发明人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell , Fernando Tollens , Jonathan Cetti
IPC分类号： A61L9/04
CPC分类号： A01M1/2044 , A01M1/2055 , A61L9/04 , A61L9/127
摘要： A method for emitting or releasing volatile materials to the atmosphere is provided. More specifically, a method for delivering two or more volatile materials at different time periods using a non-aerosol, non-energized volatile material delivery system via an evaporative surface device, without a source of heat, gas, or electrical current, is also provided.
摘要翻译：提供了向挥发性物质释放或释放大气的方法。更具体地说，还提供了一种用于通过蒸发表面装置，在不产生热源，气体或电流的情况下使用非气溶胶，非能量挥发性材料输送系统在不同时间段递送两种或更多种挥发性材料的方法。

2. 发明申请

US20060097066A1 Systems and devices for delivering volatile materials 审中-公开
标题翻译：用于输送挥发性物质的系统和设备
公开(公告)号：US20060097066A1
公开(公告)日：2006-05-11
申请号：US11103372
申请日：2005-04-11
申请人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell , Fernando Tollens , Jonathan Cetti , Hirotaka Uchiyama
发明人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell , Fernando Tollens , Jonathan Cetti , Hirotaka Uchiyama
IPC分类号： A61L9/04
CPC分类号： A61L9/127 , A01M1/2044
摘要： A non-energized volatile material delivery system for emitting or releasing volatile materials to the atmosphere is provided. More specifically, delivery systems for delivering one or more volatile materials using a non-aerosol, non-energized volatile material delivery system via an evaporative surface device, without a source of heat, gas, or electrical current, are also provided.
摘要翻译：提供了一种用于将挥发性物质释放或释放到大气中的无能挥发性物质输送系统。更具体地，还提供了用于使用非气溶胶，非能量挥发性材料输送系统经由蒸发表面装置输送一种或多种挥发性材料而不产生热，气体或电流的输送系统。

3. 发明申请

US20050161522A1 Methods for delivering volatile materials 有权
标题翻译：交付挥发性物质的方法
公开(公告)号：US20050161522A1
公开(公告)日：2005-07-28
申请号：US11086080
申请日：2005-03-22
申请人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell
发明人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell
IPC分类号： A61L9/04 , B05B17/00 , B05D1/00
CPC分类号： A61L9/04 , A01M1/2044 , A01M1/2055 , A61L9/127
摘要： A method for emitting or releasing volatile materials to the atmosphere is provided. More specifically, a method for delivering one or more volatile materials using a non-aerosol, non-energized volatile material delivery system via an evaporative surface device, without a source of heat, gas, or electrical current, are also provided.
摘要翻译：提供了向挥发性物质释放或释放大气的方法。更具体地说，还提供了一种用于通过蒸发表面装置使用非气溶胶，非能量挥发性材料输送系统输送一种或多种挥发性材料的方法，而不产生热源，气体或电流。

4. 发明申请

US20060076429A1 Methods for delivering volatile materials 审中-公开
公开(公告)号：US20060076429A1
公开(公告)日：2006-04-13
申请号：US10963303
申请日：2004-10-12
申请人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell
发明人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell
IPC分类号： A61L9/04
CPC分类号： A61L9/127 , A61L9/04
摘要： A method for emitting or releasing volatile materials to the atmosphere is provided. More specifically, a method for delivering one or more volatile materials using a non-aerosol, non-energized volatile material delivery system via an evaporative surface device, without a source of heat, gas, or electrical current, are also provided.

5. 发明申请

US20050211790A1 Systems and devices for delivering volatile materials 审中-公开
标题翻译：用于输送挥发性物质的系统和设备
公开(公告)号：US20050211790A1
公开(公告)日：2005-09-29
申请号：US11085921
申请日：2005-03-22
申请人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell
发明人： Frank Kvietok , Elizabeth Rohrbaugh , Michael Farrell
IPC分类号： A01M1/20 , A61L9/04 , A61L9/12
CPC分类号： A01M1/2044 , A61L9/127
摘要： A non-energized volatile material delivery system for emitting or releasing volatile materials to the atmosphere is provided. More specifically, delivery systems for delivering one or more volatile materials using a non-aerosol, non-energized volatile material delivery system via an evaporative surface device, without a source of heat, gas, or electrical current, are also provided.
摘要翻译：提供了一种用于将挥发性物质释放或释放到大气中的无能挥发性物质输送系统。更具体地，还提供了用于使用非气溶胶，非能量挥发性材料输送系统经由蒸发表面装置输送一种或多种挥发性材料而不产生热，气体或电流的输送系统。

6. 发明授权

US08481270B2 Method for chromogenic detection of two or more target molecules in a single sample 有权
标题翻译：一种样品中两种或更多种靶分子的显色检测方法
公开(公告)号：US08481270B2
公开(公告)日：2013-07-09
申请号：US13059274
申请日：2009-08-21
申请人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Thomas Grogan , Fabien Gaire , Mary Padilla , Christopher Bieniarz
发明人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Thomas Grogan , Fabien Gaire , Mary Padilla , Christopher Bieniarz
IPC分类号： C12Q1/68 , G01N33/58 , G01N33/53
CPC分类号： C12Q1/6841 , G01N33/53 , G01N33/581 , G01N33/583
摘要： The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.
摘要翻译：本发明提供了用于检测单个组织样品中两种或更多种靶分子的方法和试剂盒，例如用于单一组织样品中的基因和蛋白质双重检测。方法包括用特异性结合第一靶分子的第一结合部分处理组织样品。方法还包括在使组织样品与半抗原标记的结合部分接触或同时检测第二靶分子之前或同时使用含有可溶于富电子的芳族化合物的溶液处理组织样品。在一个实例中，第一靶分子是蛋白质，第二个是核酸序列，第一个靶分子通过免疫组织化学检测，第二个是原位杂交。所公开的方法由于半抗原标记的特异性结合部分与沉积在第一靶分子附近的不溶性富电子化合物的非特异性结合而减少背景。

7. 发明申请

US20110139155A1 METHODS AND APPARATUS FOR MONITORING THE CARDIOVASCULAR CONDITION OF PATIENTS WITH SLEEP DISORDERED BREATHING 有权
标题翻译：用于监测患有睡眠障碍性呼吸的患者的心脏血管病变的方法和装置
公开(公告)号：US20110139155A1
公开(公告)日：2011-06-16
申请号：US12982536
申请日：2010-12-30
申请人： Michael Farrell , Malcolm Hebblewhite , Deidre Stewart , Ann Tisthammer , Maya Vance , Robin Randolph
发明人： Michael Farrell , Malcolm Hebblewhite , Deidre Stewart , Ann Tisthammer , Maya Vance , Robin Randolph
IPC分类号： A61M16/00
CPC分类号： A61B5/7282 , A61B5/0205 , A61B5/4818 , A61B5/742 , A61B5/7475 , A61M16/0051 , A61M16/0066 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/085 , A61M16/0875 , A61M2016/0039 , A61M2205/3569 , A61M2205/3592 , A61M2230/04 , G06F19/00 , G06F19/3418
摘要： A method for relating to each other cardiovascular and sleep disordered breathing conditions of a patient. The patient's heart rate and/or detailed echocardiogram data is monitored and recorded continuously or periodically together with sleep disordered breathing information on similar time scales. Changes in the patient's heart rate associated with changes in sleep disordered breathing can then be observed. More specifically, positive airway pressure at therapeutic levels for treatment of sleep disordered breathing is applied while events associated with the treatment of the patient's sleep disordered breathing are detected and recorded. At the same time, information concerning the cardiovascular condition of the patient is stored and the stored information concerning the cardiovascular condition of the patient and the recorded events associated with the treatment of the patient's sleep disordered breathing are related to each other.
摘要翻译：一种与患者相关的心血管和睡眠无序呼吸状况的方法。患者的心率和/或详细的超声心动图数据与类似时间尺度上的睡眠紊乱呼吸信息一起被连续地或周期性地监测和记录。然后可以观察到与睡眠紊乱呼吸相关的患者心率变化。更具体地，应用治疗睡眠呼吸紊乱的治疗水平的气道正压，同时检测和记录与治疗患者睡眠无序呼吸相关的事件。同时，存储关于患者的心血管状况的信息，并且关于患者的心血管状况的存储信息以及与治疗患者睡眠无序呼吸相关联的记录事件彼此相关。

8. 发明申请

US20100184087A1 Haptens, hapten conjugates, compositions thereof and method for their preparation and use 有权
标题翻译：半抗原，半抗原共轭物，其组合物及其制备和使用方法
公开(公告)号：US20100184087A1
公开(公告)日：2010-07-22
申请号：US12660017
申请日：2010-02-17
申请人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
发明人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C07D495/04 , C12Q1/6804 , C12Q1/6841 , C12Q1/6886 , G01N33/532 , G01N33/533 , G01N33/58 , G01N33/582 , G01N33/583 , Y10S435/961 , Y10S530/807
摘要： A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.
摘要翻译：描述了用于执行多路诊断测定的方法，例如样品中两种或更多种不同靶标。一个实施方案包括使样品与特异性结合两个或更多个不同靶标的两个或多个特异性结合部分接触。两个或更多个特异性结合部分与不同的半抗原结合，至少一个半抗原是恶唑，吡唑，噻唑，除二硝基苯基以外的硝基芳基化合物，苯并呋咱，三萜烯，脲，硫脲，旋叶，香豆素，环链烷醇，杂二芳基，偶氮芳基或苯并二氮杂。将样品与两种或更多种可分别检测的不同的抗半抗原抗体接触。两种或更多种不同的抗半抗原抗体可以缀合到不同的可检测标记上。

9. 发明授权

US07642064B2 Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest 有权
标题翻译：酶催化的金属沉积用于增强感兴趣的分析物的检测
公开(公告)号：US07642064B2
公开(公告)日：2010-01-05
申请号：US11015646
申请日：2004-12-20
申请人： Christopher Bieniarz , Michael Farrell
发明人： Christopher Bieniarz , Michael Farrell
IPC分类号： C12Q1/42 , C12Q1/44 , C12Q1/54 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/551
CPC分类号： C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26 , G01N33/581
摘要： The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species and a soluble metal ion. The enzyme catalyzes the conversion of the inactive reductive species to an active reducing agent, which in turn reduces the metal ion to a metal atom thereby providing an enhanced means of detecting the analyte via metal deposition.
摘要翻译：本发明涉及通过免疫测定或通过杂交来检测目的分析物的增强方法，包括在氧化还原惰性还原物质和可溶性金属离子存在下将酶标记的缀合物分子与目的分析物结合。酶催化无活性还原物质转化为活性还原剂，其又将金属离子还原成金属原子，从而提供通过金属沉积检测分析物的增强方法。

10. 发明申请

US20070192680A1 Smart layer rendering 失效
标题翻译：智能层渲染
公开(公告)号：US20070192680A1
公开(公告)日：2007-08-16
申请号：US11356655
申请日：2006-02-16
申请人： Javier Morales , Michael Farrell
发明人： Javier Morales , Michael Farrell
IPC分类号： G06F17/00
CPC分类号： G06F17/2288
摘要： A document can contain multiple print layers. Different layers can be combined to produce different document versions. In this manner, a document can have an English version and a Spanish version sharing graphics layers but having different text layers. A document version specification can be used for producing a certain version of the document. Some documents, however, have many layers and desired layer combinations. A set of document version specifications can be used to ensure that all the desired versions are produced without any version being forgotten or any undesired version being produced. Dividing the layers amongst a set of layer groups helps in creating the specifications. A set of rules can be submitted to a rule module to automatically generate the desired specifications.
摘要翻译：文档可以包含多个打印图层。可以组合不同的层以产生不同的文档版本。以这种方式，文档可以具有共享图形层但具有不同文本层的英文版和西班牙文版本。文档版本规范可用于生成某个版本的文档。然而，一些文件具有许多层和期望的层组合。可以使用一组文档版本规范来确保所有期望的版本都被生成，而不会忘记任何版本被遗忘或任何不需要的版本。在一组图层组之间划分图层有助于创建规格。一组规则可以提交给规则模块，以自动生成所需的规范。

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