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1. 发明授权

US5994083A Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable 失效
公开(公告)号：US5994083A
公开(公告)日：1999-11-30
申请号：US553257
申请日：1995-11-13
申请人： Franco Felici , Alessandra Luzzago , Paolo Monaci , Alfredo Nicosia , Riccardo Cortese
发明人： Franco Felici , Alessandra Luzzago , Paolo Monaci , Alfredo Nicosia , Riccardo Cortese
IPC分类号： G01N33/53 , A61K35/76 , A61K39/00 , C07K7/08 , C07K14/02 , C07K14/18 , C07K14/47 , C07K16/32 , C09K8/38 , C12N7/00 , C12N15/09 , C12N15/10 , C40B30/06 , C40B40/02 , G01N33/569 , G01N33/576 , G01N33/537 , G01N33/566
CPC分类号： C40B40/02 , C07K14/005 , C07K14/4713 , C07K16/32 , C12N15/1037 , A61K39/00 , C07K2319/40 , C07K2319/735 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist ofthe antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.

2. 发明授权

US06541210B1 Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable 失效
标题翻译：用于制备免疫原或诊断试剂的方法，以及由此获得的免疫原或诊断试剂
公开(公告)号：US06541210B1
公开(公告)日：2003-04-01
申请号：US09441992
申请日：1999-11-18
申请人： Franco Felici , Alessandra Luzzago , Paolo Monaci , Alfredo Nicosia , Riccardo Cortese
发明人： Franco Felici , Alessandra Luzzago , Paolo Monaci , Alfredo Nicosia , Riccardo Cortese
IPC分类号： G01N3353
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example, using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the disease, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 在使用遗传操作技术（例如，使用为本发明的目的而工程设计的质粒）的引入到编码噬菌体衣壳蛋白的基因中的随机序列寡核苷酸插入物表达的衣壳寡肽的表面上显示的噬菌体文库的构建遗传图谱如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用所选择的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于该疾病，包括典型的所谓自身免疫性疾病的免疫学疾病，具有已知或未知的病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

3. 发明申请

US20080286275A1 Antigen Binding Proteins Directed Against Scavenger Receptor B1 that Inhibit Hcv Replication 有权
标题翻译：针对抑制Hcv复制的清道夫受体B1的抗原结合蛋白
公开(公告)号：US20080286275A1
公开(公告)日：2008-11-20
申请号：US11631765
申请日：2005-07-01
申请人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12P21/00 , A61P31/12 , C12N5/00 , C07H21/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

4. 发明授权

US08142794B2 Hepatitis C virus vaccine 有权
标题翻译：丙型肝炎病毒疫苗
公开(公告)号：US08142794B2
公开(公告)日：2012-03-27
申请号：US12396747
申请日：2009-03-03
申请人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
发明人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
IPC分类号： C12N7/00 , C07H21/04
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2800/108 , C12N2810/6018 , C12N2830/003 , C12N2840/20 , C12N2840/203
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
摘要翻译：本发明的特征在于Ad6载体和编码含有非活性NS5B RNA依赖性RNA聚合酶区域的Met-NS3-NS4A-NS4B-NS5A-NS5B多肽的核酸。核酸特别可用作腺病毒或DNA质粒疫苗的组分，其提供用于产生针对HCV的HCV特异性细胞介导的免疫（CMI）应答的广泛范围的抗原。

5. 发明授权

US07598362B2 Hepatitis C virus vaccine 有权
标题翻译：丙型肝炎病毒疫苗
公开(公告)号：US07598362B2
公开(公告)日：2009-10-06
申请号：US10492178
申请日：2002-10-10
申请人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
发明人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
IPC分类号： C07H21/04 , C12N7/00
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2800/108 , C12N2810/6018 , C12N2830/003 , C12N2840/20 , C12N2840/203
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
摘要翻译：本发明的特征在于Ad6载体和编码含有非活性NS5B RNA依赖性RNA聚合酶区域的Met-NS3-NS4A-NS4B-NS5A-NS5B多肽的核酸。核酸特别可用作腺病毒或DNA质粒疫苗的组分，其提供用于产生针对HCV的HCV特异性细胞介导的免疫（CMI）应答的广泛范围的抗原。

6. 发明申请

US20090233992A1 HEPATITIS C VIRUS VACCINE 有权
公开(公告)号：US20090233992A1
公开(公告)日：2009-09-17
申请号：US12396747
申请日：2009-03-03
申请人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloen
发明人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloen
IPC分类号： A61K31/7088
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2800/108 , C12N2810/6018 , C12N2830/003 , C12N2840/20 , C12N2840/203
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
摘要翻译：本发明的特征在于Ad6载体和编码含有非活性NS5B RNA依赖性RNA聚合酶区域的Met-NS3-NS4A-NS4B-NS5A-NS5B多肽的核酸。核酸特别可用作腺病毒或DNA质粒疫苗的组分，其提供用于产生针对HCV的HCV特异性细胞介导的免疫（CMI）应答的广泛范围的抗原。

7. 发明授权

US07928193B2 Antigen binding proteins directed against scavenger receptor B1 that inhibit HCV replication 有权
标题翻译：针对抑制HCV复制的清道夫受体B1的抗原结合蛋白
公开(公告)号：US07928193B2
公开(公告)日：2011-04-19
申请号：US11631765
申请日：2005-07-01
申请人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： C07K14/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

8. 发明授权

US06265169B1 Method based on the use of bacteriophages for the detection biological molecules in biological samples 有权
标题翻译：基于使用噬菌体检测生物样品中生物分子的方法
公开(公告)号：US06265169B1
公开(公告)日：2001-07-24
申请号：US09424302
申请日：2000-02-17
申请人： Riccardo Cortese , Paolo Monaci
发明人： Riccardo Cortese , Paolo Monaci
IPC分类号： C12Q168
CPC分类号： C12Q1/682 , C12Q1/6804 , C12Q1/70 , G01N33/566
摘要： The present invention refers to a method that allows the use of filamentous bacteriophages to detect the presence of molecules of interest in biological samples. It consists of a series of combined operations, which are drawn up and defined according to the characteristics of the phages employed. These have, exposed on the surfaces of the capsid, at least one molecule, generally but not exclusively of proteic nature, capable of binding at least one molecule of interest present in the biological sample. Detection of the presence of the molecule takes place, according to the method of the invention, using the association between the molecule exposed on the surfaces of the phage and the genome of the phage itself. The ability to form specific complexes typical of the molecule exposed on the capsid enables formation of phage-molecule of interest complexes, which can be detected by means of amplification of known sequences in the phage DNA. The method according to the invention is extremely sensitive and can be used in particular for diagnostic and prognostic purposes.
摘要翻译：本发明涉及允许使用丝状噬菌体来检测生物样品中感兴趣的分子的存在的方法。它由一系列联合作业组成，根据所采用的噬菌体的特点制定和定义。这些具有暴露在衣壳表面上的至少一种能够结合存在于生物样品中的至少一个目标分子的分子，通常但不仅限于蛋白质性质。使用暴露在噬菌体表面上的分子与噬菌体本身的基因组之间的关联，根据本发明的方法发生分子存在的检测。形成在衣壳上暴露的分子典型的特异性复合物的能力能够形成感兴趣的噬菌体分子复合物，其可以通过噬菌体DNA中已知序列的扩增来检测。根据本发明的方法是非常敏感的，并且可以特别用于诊断和预后目的。

9. 发明申请

US20130150563A1 LIPID-CONJUGATED ANTIBODIES 审中-公开
标题翻译： LIPID-CONJUGATED抗体
公开(公告)号：US20130150563A1
公开(公告)日：2013-06-13
申请号：US13808982
申请日：2011-07-08
申请人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
发明人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
IPC分类号： C07K16/08
CPC分类号： C07K16/08 , A61K47/6851 , A61K51/1006 , A61K51/1027 , C07K16/1063 , C07K16/28 , C07K2317/77
摘要： The present invention relates to novel lipid-conjugated antibodies for use in the treatment or the prevention of diseases, including but not limited to cancer, metabolic diseases including but not limited to hyperglycemia and diabetes, obesity, hypertension, hypercholesterolemia, allergy, asthma, Alzheimer's disease, and infectious diseases including but not limited to diseases caused by viruses, bacteria and fungi.
摘要翻译：本发明涉及用于治疗或预防疾病（包括但不限于癌症），代谢疾病，包括但不限于高血糖症和糖尿病，肥胖症，高血压，高胆固醇血症，变态反应，哮喘，阿尔茨海默病疾病和传染病，包括但不限于病毒，细菌和真菌引起的疾病。

10. 发明授权

US09718863B2 Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof 有权
公开(公告)号：US09718863B2
公开(公告)日：2017-08-01
申请号：US13147193
申请日：2010-02-06
申请人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
发明人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
IPC分类号： C07K14/005 , A61K39/12 , A61K39/235 , C12N7/00 , C12N15/861 , C12N15/86 , A61K39/00 , A61K48/00
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2710/16634 , C12N2740/16134 , C12N2770/24234
摘要： The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.

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