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1. 发明申请

US20130150563A1 LIPID-CONJUGATED ANTIBODIES 审中-公开
标题翻译： LIPID-CONJUGATED抗体
公开(公告)号：US20130150563A1
公开(公告)日：2013-06-13
申请号：US13808982
申请日：2011-07-08
申请人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
发明人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
IPC分类号： C07K16/08
CPC分类号： C07K16/08 , A61K47/6851 , A61K51/1006 , A61K51/1027 , C07K16/1063 , C07K16/28 , C07K2317/77
摘要： The present invention relates to novel lipid-conjugated antibodies for use in the treatment or the prevention of diseases, including but not limited to cancer, metabolic diseases including but not limited to hyperglycemia and diabetes, obesity, hypertension, hypercholesterolemia, allergy, asthma, Alzheimer's disease, and infectious diseases including but not limited to diseases caused by viruses, bacteria and fungi.
摘要翻译：本发明涉及用于治疗或预防疾病（包括但不限于癌症），代谢疾病，包括但不限于高血糖症和糖尿病，肥胖症，高血压，高胆固醇血症，变态反应，哮喘，阿尔茨海默病疾病和传染病，包括但不限于病毒，细菌和真菌引起的疾病。

2. 发明申请

US20190338008A1 LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS 审中-公开
公开(公告)号：US20190338008A1
公开(公告)日：2019-11-07
申请号：US15759911
申请日：2016-10-21
申请人： Anandan PALANI , Ravi NARGUND , Paul E. CARRINGTON , Tomi SAWYER , Qiaolin DENG , Antonello PESSI , Elisabetta BIANCHI , Fe-derica ORYIETO , Merck Sharp & Dohme Corp.
发明人： Anandan Palani , Ravi Nargund , Paul E. Carrington , Tomi Sawyer , Qiaolin Deng , Antonello Pessi , Elisabetta Bianchi , Federica Orvieto
IPC分类号： C07K14/605 , A61P3/04 , A61K38/28
摘要： Long-acting co-agonists of the glucagon and GLP-1 receptors are described.

3. 发明申请

US20120165503A1 OXYNTOMODULIN ANALOGS 审中-公开
标题翻译：氧自由基模拟物
公开(公告)号：US20120165503A1
公开(公告)日：2012-06-28
申请号：US13202524
申请日：2009-12-18
申请人： Paul E. Carrington , George Eiermann , Donald Marsh , Joseph Metzger , Alessandro Pocai , Ranabir Sinha Roy , Bianchi Bianchi , Paolo Ingallinella , Antonello Pessi , Alessia Santoprete , Elena Capito , Richard Dimarchi , Brian Ward
发明人： Paul E. Carrington , George Eiermann , Donald Marsh , Joseph Metzger , Alessandro Pocai , Ranabir Sinha Roy , Bianchi Bianchi , Paolo Ingallinella , Antonello Pessi , Alessia Santoprete , Elena Capito , Richard Dimarchi , Brian Ward
IPC分类号： C07K14/605
CPC分类号： C07K14/575 , C07K14/605
摘要： Peptide analogs of oxyntomodulin (OXM, glucagon-37), which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to act as a dual GLP-1/glucagon receptor (GCGR) agonistm are described. The peptide analogs are useful for treatment of metabolic disorders such as diabetes and obesity.
摘要翻译：已经修饰为对二肽基肽酶IV（DPP-IV）的切割和失活具有抗性并且增加肽类似物的体内半衰期的胃泌酸调节蛋白（OXM，胰高血糖素-37）的肽类似物，作为双重GLP-1 /胰高血糖素受体（GCGR）激动剂。肽类似物可用于治疗代谢性疾病如糖尿病和肥胖症。

4. 发明申请

US20100075907A1 NEUROMEDIN U RECEPTOR AGONISTS AND USES THEREOF 审中-公开
标题翻译： NEUROMEDIN U受体激素及其用途
公开(公告)号：US20100075907A1
公开(公告)日：2010-03-25
申请号：US12623085
申请日：2009-11-20
申请人： Donald J. Marsh , Antonello Pessi , Maria A. Bednarek , Elisabetta Bianchi , Paolo Ingallinella , Andrea M. Peier
发明人： Donald J. Marsh , Antonello Pessi , Maria A. Bednarek , Elisabetta Bianchi , Paolo Ingallinella , Andrea M. Peier
IPC分类号： A61K38/16 , C07K14/00 , C07K7/06 , C07K7/08 , A61P9/00 , A61K38/08 , A61K38/10 , A61P3/00 , A61P35/00
CPC分类号： C07K14/575 , A61K38/00 , A61K47/543 , A61K47/554 , A61K47/60
摘要： Neuromedin U receptor agonists for use in the treatment of metabolic disorders such as obesity and diabetes are disclosed.
摘要翻译：公开了用于治疗代谢性疾病如肥胖症和糖尿病的神经介肽U受体激动剂。

5. 发明申请

US20070224212A1 Stable Peptide Mimetic of Hiv Gp41 Fusion Intermediate 有权
标题翻译：稳定肽模拟的HIF Gp41融合中间体
公开(公告)号：US20070224212A1
公开(公告)日：2007-09-27
申请号：US11628483
申请日：2005-05-27
申请人： Elisabetta Bianchi , Antonello Pessi , Romas Geleziunas , David Bramhill
发明人： Elisabetta Bianchi , Antonello Pessi , Romas Geleziunas , David Bramhill
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , G01N2333/16 , G01N2500/02
摘要： Methods of covalently-stabilizing alpha-helical, chimeric peptides constrained within a homotrimeric or heterotrimeric coiled-coil structure are disclosed. The coiled-coil structures made by the methods disclosed within this specification mimic all or a portion of the internal, trimeric coiled-coil motif contained within the fusogenic conformation of an enveloped virus membrane-fusion protein, particularly the internal coiled-coil domain of the HIV gp41 ectodomain. The HIV-derived, chimeric peptides disclosed comprise a non-HIV, soluble, trimeric form of a coiled-coil fused in helical phase to all or a portion of the N-helix of HIV gp41 and are covalently-stabilized in a homotrimeric or heterotrimeric coiled-coil structure through the formation of disulfide or chemoselective bonds between said peptides. The covalently-stabilized, HIV-derived, homotrimeric or heterotrimeric coiled-coil structures made by the methods disclosed herein represent a close mimetic of a HIV gp41 fusion intermediate and are potent inhibitors of HIV infectivity. These HIV-derived chimeric peptides may provide for therapeutic treatment against HIV infection by inhibiting the virus-host cell membrane fusion process.
摘要翻译：公开了限制在同三聚体或异三聚体卷曲螺旋结构内的共价稳定的α-螺旋嵌合肽的方法。通过本说明书中公开的方法制备的盘绕线圈结构模拟包含在包膜病毒膜 - 融合蛋白的融合构象内的内部三聚体卷曲螺旋基序的全部或一部分，特别是内部卷曲螺旋结构域 HIV gp41胞外域。所公开的HIV衍生的嵌合肽包含螺旋状螺旋状的非HIV，可溶性三聚体形式，其与HIV gp41的全部或部分N-螺旋融合，并且以同三聚或异三聚体共价稳定通过在所述肽之间形成二硫键或化学选择性键来进行卷曲螺旋结构。由本文公开的方法制备的共价稳定的HIV衍生的同源三聚体或异三聚体卷曲螺旋结构代表HIV gp41融合中间体的密切模拟物，并且是HIV感染性的有效抑制剂。这些HIV衍生的嵌合肽可以通过抑制病毒宿主细胞膜融合过程来提供针对HIV感染的治疗性治疗。

6. 发明授权

US5225530A Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of malarial affections 失效
标题翻译：用于制备抗疟疾疫苗的多肽和用于检测疟疾感染的诊断试剂盒
公开(公告)号：US5225530A
公开(公告)日：1993-07-06
申请号：US803483
申请日：1991-12-04
申请人： Adriano Bernardi , Fabio Bonelli , Antonello Pessi , Antonio S. Verdini
发明人： Adriano Bernardi , Fabio Bonelli , Antonello Pessi , Antonio S. Verdini
IPC分类号： A61K39/00 , C07K14/445
CPC分类号： C07K14/445 , A61K39/00
摘要： Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons, constituted by: a synthetic peptide, which repeates the region I of P. falciparum and by a variable number of repetitive tetrapeptide units of CS protein of P. falciparum linked to each other by an amidic bond between the tail proline of I region and the head asparagine of the first tetrapeptide.
摘要翻译：用于制备抗疟疾疫苗的多肽和用于在恶性疟原虫临床样品中检测抗细菌抗体的诊断试剂盒，其由以下组成：合成肽，其重复恶性疟原虫的区域I和可变数量的重复四肽单元通过I区的尾脯氨酸与第一四肽的头天冬酰胺之间的酰胺键彼此连接的恶性疟原虫的CS蛋白。

7. 发明授权

US5210018A Immunoenzymatic method in homogeneous phase for the determination of anti-plasmodium falciparum-sporozoite antibodies in human blood 失效
标题翻译：用于确定人血液中抗体 - 抗体 - 球孢子虫抗体的均相中的免疫方法
公开(公告)号：US5210018A
公开(公告)日：1993-05-11
申请号：US341041
申请日：1989-04-20
申请人： Carlo A. Nuzzolo , Adriano Bernardi , Antonello Pessi , Antonio S. Verdini
发明人： Carlo A. Nuzzolo , Adriano Bernardi , Antonello Pessi , Antonio S. Verdini
IPC分类号： G01N33/539 , G01N33/569
CPC分类号： G01N33/56905 , G01N33/539 , Y10S435/947 , Y10S435/975
摘要： An immunoenzymatic method for the detection of anti-Plasmodium falciparum-sporozoite antibodies in a sample of human blood, which operates, in homogeneous phase, and under suitable conditions, with a synthetic polypeptidic antigen (P), a synthetic antigen-enzyme (P-E) conjugate, wherein said antigen is capable of specifically reacting with the anti-Plasmodium falciparum-sporozoite antibodies (Ab) possibly present in the sample, and an inert substance capable of quantitatively precipitating the antibody-synthetic antigen-enzyme complex (Ab-P-E).The method, due to its specificity, sensitivity, reproducibility and rapidity, is particularly useful in the epidemiological investigations into malaria and in the evaluation of the efficacy of an antimalarial vaccine.

8. 发明授权

US5116946A Synthetic, immunologically active peptides useful for the preparation of antimalarial vaccines 失效
标题翻译：用于制备抗疟疾疫苗的合成，免疫活性肽
公开(公告)号：US5116946A
公开(公告)日：1992-05-26
申请号：US358932
申请日：1989-05-30
申请人： Antonio S. Verdini , Antonello Pessi , Fabio Bonelli
发明人： Antonio S. Verdini , Antonello Pessi , Fabio Bonelli
IPC分类号： A61K39/00 , C07K14/445
CPC分类号： C07K14/445 , A61K39/00
摘要： Synthetic peptides constituted by at least two repeating, consecutive units of asparaginyl-proline (Asn-Pro).sub.n sequence, are described.The peptides are powerful immunogens, capable of inducing in laboratory animals the formation of a high concentration of antibodies capable of reacting both with the (Asn-Pro).sub.n peptides, and with the immunodominant epitope of the circumsporozoite protein of Plasmodium falciparum.The peptides, which can be obtained in a pure form by chemical synthesis, are particularly useful for preparing antimalarial vaccines and diagnostic kits for the determination of malaria in man.
摘要翻译：描述了由至少两个重复连续单位的天冬酰胺酰脯氨酸（Asn-Pro）n序列构成的合成肽。这些肽是强大的免疫原，能够在实验动物中诱导形成高浓度的能够与（Asn-Pro）n肽反应的抗体，并与恶性疟原虫的环子孢子蛋白的免疫优势表位反应。可以通过化学合成以纯形式获得的肽特别可用于制备用于测定人类疟疾的抗疟疾疫苗和诊断试剂盒。

9. 发明授权

US4716149A Partially modified, retro-inverso neurotensin analogs 失效
标题翻译：部分修饰，逆转型神经降压素类似物
公开(公告)号：US4716149A
公开(公告)日：1987-12-29
申请号：US808617
申请日：1985-12-13
申请人： Fabio Bonelli , Antonello Pessi , Antonio S. Verdini
发明人： Fabio Bonelli , Antonello Pessi , Antonio S. Verdini
IPC分类号： C07K1/113 , A61K38/00 , A61P9/08 , A61P9/12 , C07K5/06 , C07K7/02 , A61K37/02 , C07K7/08
CPC分类号： C07K7/02
摘要： Pharmacologically active, partially retro-inverso, neurotensin-like peptides lasting longer than the natural hormone, corresponding to the formula ##STR1## wherein R.sup.1 and R.sup.2 are straight or branched (C.sub.1 -C.sub.7) alkyl radicals.The new compounds are useful as vasodilating and hypotensive agents.
摘要翻译：对应于式GlpLeuTyrGluAsnLysProArgArg（I）的图像，其中R1和R2是直链或支链（C1-C7）烷基，其药理活性的，部分逆转的，神经降压素样肽比天然激素长。新化合物可用作血管扩张剂和降血糖药。

10. 发明授权

US08969294B2 Glucagon/GLP-1 receptor co-agonists 有权
标题翻译：胰高血糖素/ GLP-1受体共激动剂
公开(公告)号：US08969294B2
公开(公告)日：2015-03-03
申请号：US13567858
申请日：2012-08-06
申请人： Elisabetta Bianchi , Antonello Pessi , Jonathan Day , Richard Dimarchi , David Smiley
发明人： Elisabetta Bianchi , Antonello Pessi , Jonathan Day , Richard Dimarchi , David Smiley
IPC分类号： A61K38/26 , A61K38/12 , A61K38/00 , C07K14/605
CPC分类号： C07K14/605
摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
摘要翻译：公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。通过形成分子内桥或通过酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。通过聚乙二醇化，酰化，烷基化，羧基末端氨基酸的取代，C-末端截短或加入选自下组的羧基末端肽，可以进一步改善这些高效胰高血糖素类似物的溶解度和稳定性由SEQ ID NO：26（GPSSGAPPPS），SEQ ID NO：27（KRNRNNIA）和SEQ ID NO：28（KRNR）组成。

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