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1. 发明申请

US20050019751A1 Screening for hepatitis c virus entry inhibitors 审中-公开
标题翻译：筛查丙型肝炎病毒进入抑制剂
公开(公告)号：US20050019751A1
公开(公告)日：2005-01-27
申请号：US10494555
申请日：2002-11-01
申请人： Riccardo Cortese , Elisa Scarselli , Alessandra Vitelli
发明人： Riccardo Cortese , Elisa Scarselli , Alessandra Vitelli
IPC分类号： A61K39/395 , A61K45/00 , A61P1/16 , A61P31/14 , C07H21/04 , C07K1/00 , C07K14/00 , C07K17/00 , C12N15/09 , C12Q1/02 , C12Q1/70 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/576
CPC分类号： G01N33/5767 , G01N2333/18 , G01N2500/02
摘要： The present invention features methods of screening for compounds that inhibit HCV binding to a cell, methods of inhibiting IICV entry into a cell, and methods of actively or prophylactically treating against an IICV infection. The different methods are based on the identification of the scavenger receptor class B type I as a target site for HCV E2 binding to a cell.
摘要翻译：本发明的特征在于筛选抑制HCV结合细胞的化合物的方法，抑制IICV进入细胞的方法，以及主动或预防性治疗IICV感染的方法。不同的方法基于识别作为HCV E2与细胞结合的靶位点的B型清道夫受体。

2. 发明申请

US20080286275A1 Antigen Binding Proteins Directed Against Scavenger Receptor B1 that Inhibit Hcv Replication 有权
标题翻译：针对抑制Hcv复制的清道夫受体B1的抗原结合蛋白
公开(公告)号：US20080286275A1
公开(公告)日：2008-11-20
申请号：US11631765
申请日：2005-07-01
申请人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12P21/00 , A61P31/12 , C12N5/00 , C07H21/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

3. 发明申请

US20070259959A1 Ppar Agonists for the Treatment of Hcv Infection 审中-公开
标题翻译： Ppar激素治疗Hcv感染
公开(公告)号：US20070259959A1
公开(公告)日：2007-11-08
申请号：US10579509
申请日：2004-11-17
申请人： Riccardo Cortese , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： A61K31/192 , A61P31/12
CPC分类号： A61K31/216
摘要： The present invention concerns the use of PPARα agonists in methods and compositions for the treatment or prevention of infection by hepatitis C virus (HCV) in mammals, especially humans.
摘要翻译：本发明涉及PPARα激动剂在用于治疗或预防哺乳动物，特别是人类中丙型肝炎病毒（HCV）感染的方法和组合物中的用途。

4. 发明申请

US20140141042A1 Expression Systems 审中-公开
标题翻译：表达系统
公开(公告)号：US20140141042A1
公开(公告)日：2014-05-22
申请号：US13976873
申请日：2011-12-30
申请人： Alessandra Vitelli , Alfredo Nicosia , Riccardo Cortese
发明人： Alessandra Vitelli , Alfredo Nicosia , Riccardo Cortese
IPC分类号： C12N15/85
CPC分类号： A61K39/145 , A61K39/12 , A61K39/155 , A61K2039/53 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2760/18522 , C12N2760/18534 , C12N2800/22 , C12N2840/20
摘要： The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a T cell response, and a second polynucleotide encoding at least one protein peptide or variant thereof, which induces an anti-pathogenic B cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture. The expression system, polynucleotides, proteins, cells, and pharmaceutical compositions are useful in the prophylaxis or treatment of infections. The invention further relates to nucleotide constructs which comprises, essentially consists or consists of a polynucleotide encoding a modified influenza hemagglutinin (HA).
摘要翻译：本发明涉及包含编码蛋白质的多核苷酸的表达系统，其中所述表达系统包含编码诱导T细胞应答的至少一种蛋白质，肽或变体的第一多核苷酸，以及编码至少一种蛋白质肽或变体的第二多核苷酸其诱导抗致病性B细胞应答。本发明还涉及由表达系统编码的蛋白质混合物和包含表达系统或蛋白质混合物的细胞和包含表达系统或蛋白质混合物的药物组合物。表达系统，多核苷酸，蛋白质，细胞和药物组合物可用于预防或治疗感染。本发明还涉及核苷酸构建体，其包含，基本上由编码经修饰的流感血凝素（HA）的多核苷酸组成或组成。

5. 发明授权

US07928193B2 Antigen binding proteins directed against scavenger receptor B1 that inhibit HCV replication 有权
标题翻译：针对抑制HCV复制的清道夫受体B1的抗原结合蛋白
公开(公告)号：US07928193B2
公开(公告)日：2011-04-19
申请号：US11631765
申请日：2005-07-01
申请人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： C07K14/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

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