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1. 发明授权

US07371229B2 Dual electrode advanced electrochemical delivery system 失效
标题翻译：双电极高级电化学输送系统
公开(公告)号：US07371229B2
公开(公告)日：2008-05-13
申请号：US10353769
申请日：2003-01-28
申请人： Felix Theeuwes , Jeremy Corwin Wright , Stahinja K. Zecevic
发明人： Felix Theeuwes , Jeremy Corwin Wright , Stahinja K. Zecevic
IPC分类号： A61K9/22
CPC分类号： H01M2/0202 , A61M2005/14513 , A61N1/30 , B01D61/427 , H01M10/425 , H01M10/484
摘要： The present invention is disclosed herein as an electrochemical cell having a cell housing with a first half cell and a second half cell, and an ion selective membrane between the cells. The electrochemical cell further has a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with both the first electrode and the second electrode. The electrodes of the cell are configured so that the electrochemical cell maintains a substantially constant salt concentration level throughout operation. The cell is preferably used in conjunction with an implantable fluid delivery apparatus. A method for using the device is additionally disclosed.
摘要翻译：本发明在此被公开为具有具有第一半电池和第二半电池的电池壳体的电化学电池以及电池之间的离子选择性膜。电化学电池还具有位于第一半单元内的第一电极，位于第二半单元内的第二电极，与第一电极和第二电极电连通的电解质。电池的电极被配置为使得电化学电池在整个操作中保持基本上恒定的盐浓度水平。细胞优选与可植入流体输送装置结合使用。另外公开了一种使用该装置的方法。

2. 发明授权

US07470267B2 Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method 失效
标题翻译：流体输送装置具有带有阴离子交换膜的电化学泵和相关方法
公开(公告)号：US07470267B2
公开(公告)日：2008-12-30
申请号：US10137661
申请日：2002-05-01
申请人： Ashok V. Joshi , Strahinja K. Zecevic , Sai Bhavaraju , Felix Theeuwes , Jeremy Corwin Wright
发明人： Ashok V. Joshi , Strahinja K. Zecevic , Sai Bhavaraju , Felix Theeuwes , Jeremy Corwin Wright
IPC分类号： A61K9/22
CPC分类号： A61M5/1452 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513
摘要： A fluid delivery device, comprising an electrochemical pump, wherein the pump is capable of transporting water; a pump product chamber, wherein the pump product chamber is capable of retaining water generated from the pump; a displaceable member positioned between the pump product chamber and a reservoir, wherein the displaceable member is controllably displaced upon generation of water from the electrochemical pump; a reservoir, wherein the reservoir is capable of containing a fluid which is delivered upon displacement of the displaceable member; and an housing for containing the pump, the pump product chamber, the displaceable member, and the reservoir.
摘要翻译：一种流体输送装置，包括电化学泵，其中所述泵能够输送水; 泵产品室，其中所述泵产品室能够保留从所述泵产生的水; 定位在所述泵产品室和储存器之间的可移位构件，其中所述可移位构件在从所述电化学泵产生水时可控地移位; 储存器，其中所述储存器能够容纳在所述可移位构件移位时被输送的流体; 以及用于容纳泵，泵产品室，可移动构件和储存器的壳体。

3. 发明授权

US06872292B2 Voltage modulation of advanced electrochemical delivery system 失效
标题翻译：先进的电化学传递系统的电压调制
公开(公告)号：US06872292B2
公开(公告)日：2005-03-29
申请号：US10353770
申请日：2003-01-28
申请人： Felix Theeuwes , Jeremy Corwin Wright
发明人： Felix Theeuwes , Jeremy Corwin Wright
IPC分类号： A61M5/142 , A61M5/145 , B01D61/42 , B01D61/44 , A61N1/30
CPC分类号： B01D61/427 , A61M5/14276 , A61M2005/14513
摘要： An electro-osmotic cell capable of substantially reducing zero-current transport is disclosed, wherein the cell includes a cell housing having a first half cell and a second half cell, with an ion selective membrane therebetween, a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with the first electrode and the second electrode, and a wiring apparatus electrically connecting the first electrode and the second electrode, wherein the wiring apparatus has one or more structures used for counteracting salt concentration increases within the electro-osmotic cell. Such a cell may be used within an electro-osmotic fluid delivery device, along with a fluid inlet, a piston member adjacent the electro osmotic cell, and a drug reservoir adjacent the piston member, wherein the drug reservoir includes a sealed compartment having an exit port. A method for using such a device is similarly disclosed.
摘要翻译：公开了能够显着减少零电流输送的电渗透电池，其中电池包括具有第一半电池和第二半电池的电池壳体，其间具有离子选择性膜，位于第一半电池内的第一电极位于所述第二半单元内的第二电极，与所述第一电极和所述第二电极电连通的电解质，以及电连接所述第一电极和所述第二电极的布线装置，其中所述布线装置具有用于在电渗透细胞内抵消盐浓度增加。这样的细胞可以与电渗透流体递送装置一起使用，以及流体入口，邻近电渗透细胞的活塞构件和邻近活塞构件的药物储存器，其中药物储存器包括密封隔室，其具有出口港口。类似地公开了使用这种装置的方法。

4. 发明申请

US20130028953A1 Transdermal Delivery Systems for Sufentanil 审中-公开
标题翻译：舒芬太尼透皮给药系统
公开(公告)号：US20130028953A1
公开(公告)日：2013-01-31
申请号：US13486711
申请日：2012-06-01
申请人： Su II Yum , Felix Theeuwes
发明人： Su II Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61P29/00 , A61K31/4535
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

5. 发明授权

US08246977B2 Transdermal delivery systems 有权
标题翻译：透皮递送系统
公开(公告)号：US08246977B2
公开(公告)日：2012-08-21
申请号：US11665813
申请日：2005-10-21
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

6. 发明申请

US20100016267A1 Pharmaceutical compositions for administraton to a sinus 审中-公开
标题翻译：用于给鼻窦的药物组合物
公开(公告)号：US20100016267A1
公开(公告)日：2010-01-21
申请号：US10592886
申请日：2005-03-15
申请人： Felix Theeuwes , Arthur J. Tipton
发明人： Felix Theeuwes , Arthur J. Tipton
IPC分类号： A61K31/58 , A61P27/00
CPC分类号： A61K9/0043
摘要： Pharmaceutical compositions for delivering a drug to a sinus in a subject are provided. The compositions are formed by the combination of a carrier material and a drug and are specially adapted for delivery to a sinus. The compositions have no fixed shape, and the carrier material serves to increase the viscosity or specific volume of the composition after introduction of the composition into the sinus. Also provided are methods for delivering a drug to a subject. The methods entail administering a pharmaceutical composition according to the present invention directly to a sinus. The drug is then released from the composition to the sinus. The pharmaceutical compositions can be administered to a sinus in liquid form, for example, as a suspension or solution using standard techniques. Also provided is the use of a carrier material in the manufacture of a drug delivery composition. The drug delivery composition is for delivering a drug to a sinus in a subject. The composition comprises the carrier material combined with the drug to be delivered, and has no fixed shape. After the composition is introduced into a sinus, the carrier material serves to increase the viscosity or specific volume of the composition.
摘要翻译：提供用于将药物递送至受试者的窦的药物组合物。组合物通过载体材料和药物的组合形成，并且特别适于递送至窦。组合物没有固定的形状，并且载体材料用于在将组合物引入窦内后增加组合物的粘度或比体积。还提供了将药物递送到受试者的方法。所述方法需要将根据本发明的药物组合物直接给予鼻窦。然后将药物从组合物释放到窦。药物组合物可以以液体形式施用于窦，例如使用标准技术作为悬浮液或溶液施用。还提供了载体材料在制备药物递送组合物中的用途。药物递送组合物用于将药物递送至受试者的窦。该组合物包含与待输送药物结合的载体材料，并且不具有固定形状。在将组合物引入窦中之后，载体材料用于增加组合物的粘度或比体积。

7. 发明申请

US20080260811A1 Transdermal delivery systems 有权
标题翻译：透皮递送系统
公开(公告)号：US20080260811A1
公开(公告)日：2008-10-23
申请号：US11888661
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K31/4436 , A61K9/70 , A61P43/00
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

8. 发明申请

US20080175890A1 Transdermal delivery systems 有权
公开(公告)号：US20080175890A1
公开(公告)日：2008-07-24
申请号：US11888650
申请日：2007-07-31
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K31/4535 , A61K9/70 , A61P31/00
CPC分类号： A61K31/4535 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

9. 发明申请

US20070167932A1 Local concentration management system 审中-公开
标题翻译：本地集中管理制度
公开(公告)号：US20070167932A1
公开(公告)日：2007-07-19
申请号：US11726517
申请日：2007-03-21
申请人： Felix Theeuwes , Su Yum
发明人： Felix Theeuwes , Su Yum
IPC分类号： A61K9/22
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译：本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。

10. 发明授权

US07212853B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07212853B1
公开(公告)日：2007-05-01
申请号：US08952368
申请日：1996-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。

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