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1. 发明授权

US07212853B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07212853B1
公开(公告)日：2007-05-01
申请号：US08952368
申请日：1996-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。

2. 发明授权

US07136698B2 Electrotransport agent delivery apparatus 有权
标题翻译：电子输送装置
公开(公告)号：US07136698B2
公开(公告)日：2006-11-14
申请号：US10778748
申请日：2004-02-12
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein the length of the applied current pulses is at least 5 msec and preferably at least 10 msec. Most preferably, the current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中所施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。最优选地，电流脉冲具有高于临界水平（I C）的幅度，在该临界水平下皮肤被转换成更高的电运送输送效率（E）状态。

3. 发明授权

US06718201B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US06718201B1
公开(公告)日：2004-04-06
申请号：US08952367
申请日：1997-11-17
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport device and method of operating same provides a pulsed DC current of specified frequency and duration which transforms the skin into a higher electrotransport delivery efficiency state.
摘要翻译：电输送装置及其操作方法提供指定频率和持续时间的脉冲直流电流，其将皮肤转变成更高的电输送输送效率状态。

4. 发明授权

US07572252B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07572252B1
公开(公告)日：2009-08-11
申请号：US08484934
申请日：1995-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
IPC分类号： A61M31/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0014 , A61K9/06 , A61K31/4468 , A61M2037/0007 , A61N1/30
摘要： A method of increasing the delivery efficiency of an agent through a body surface by electrotransport is disclosed wherein the electrotransport current is applied for durations at a higher current density values followed by durations of lower current density values wherein the higher current density applications transform the body surface to an enhanced, non-transitory agent delivery efficiency state.
摘要翻译：公开了一种通过电运输提高试剂通过身体表面的输送效率的方法，其中电传输电流以较高电流密度值施加持续时间，随后是较低电流密度值的持续时间，其中较高的电流密度应用转变体表面以增强，非临时代理分配效率状态。

5. 发明授权

US5983130A Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US5983130A
公开(公告)日：1999-11-09
申请号：US483069
申请日：1995-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device for delivering a therapeutic agent through a body surface, and a method for increasing agent delivery efficiency, is provided. The device includes a current controller which delivers a pulsating electrotransport current and peak current density I.sub.max, I.sub.max being greater than a critical current density level I.sub.c above which the body exhibits a non-transitory higher agent delivery efficiency. Methods for increasing electrotransport delivery efficiency (E) of an agent through a body surface by creation of a higher agent delivery efficiency state are also provided.
摘要翻译：提供了一种用于通过身体表面递送治疗剂的电转运剂递送装置和用于提高药剂输送效率的方法。该装置包括电流控制器，该电流控制器提供脉动电输送电流和峰值电流密度Imax，Imax大于临界电流密度水平Ic，在该临界电流密度水平以上，身体表现出非瞬时更高的药剂输送效率。还提供了通过创建更高的试剂递送效率状态来提高试剂通过身体表面的电传送递送效率（E）的方法。

6. 发明授权

US5464387A Transdermal delivery device 失效
标题翻译：透皮递送装置
公开(公告)号：US5464387A
公开(公告)日：1995-11-07
申请号：US330031
申请日：1994-10-27
申请人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory , Gary A. Lattin
发明人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory , Gary A. Lattin
IPC分类号： A61K9/00 , A61K9/70 , A61N1/30
CPC分类号： A61K9/7084 , A61K9/0009 , A61K9/7092 , A61N1/0448 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
摘要翻译：提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。最优选地，活性药物是被动药物的可离子化形式（即盐形式）。

7. 发明授权

US5232438A Membrane for electrotransport transdermal drug delivery 失效
标题翻译：用于电转运透皮药物递送的膜
公开(公告)号：US5232438A
公开(公告)日：1993-08-03
申请号：US898618
申请日：1992-06-15
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0444
摘要： A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
摘要翻译：一种膜，当没有电流流动时能够抑制剂量从递送系统释放，并且对电辅助剂递送提供最小的阻抗，对于并入电转运剂递送系统和用于体外测定中的测定剂释放速率是有用的。

8. 发明授权

US5203768A Transdermal delivery device 失效
标题翻译：超传送装置
公开(公告)号：US5203768A
公开(公告)日：1993-04-20
申请号：US735126
申请日：1991-07-24
申请人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
发明人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
IPC分类号： A61K9/00 , A61N1/30
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
摘要翻译：提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。最优选地，活性药物是被动药物的可离子化形式（即盐形式）。

9. 发明授权

US5320598A Iontophoretic delivery device and method of hydrating same 失效
公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

10. 发明授权

US5298017A Layered electrotransport drug delivery system 失效
标题翻译：分层电运输药物输送系统
公开(公告)号：US5298017A
公开(公告)日：1994-03-29
申请号：US998154
申请日：1992-12-29
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoretic agent delivery device, having a layered structure and peripheral insulation, wherein ion transport occurs through two opposing surfaces of said device. The device is especially suited to agent delivery through body surfaces exposed to body fluids. A method of delivering an agent through a body surface exposed to body fluids is also disclosed.
摘要翻译：一种具有分层结构和外围绝缘的离子电渗疗剂输送装置，其中通过所述装置的两个相对的表面进行离子转运。该装置特别适用于通过暴露于体液的身体表面的药剂递送。还公开了通过暴露于体液的身体表面递送药剂的方法。

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