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1. 发明授权

US5650170A Dosage form for delivering drug at a controlled rate to the intestine and to the colon 失效
标题翻译：以可控的速率将药物递送至肠道和结肠的剂型
公开(公告)号：US5650170A
公开(公告)日：1997-07-22
申请号：US696473
申请日：1991-05-06
申请人： Jeremy Corwin Wright , George V. Guittard
发明人： Jeremy Corwin Wright , George V. Guittard
IPC分类号： A61K9/00 , A61K9/22 , A61K9/28 , A61K9/24
CPC分类号： A61K9/0004
摘要： A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means for preventing the passage of fluid through the delay means.
摘要翻译：公开了用于将药物递送到肠和结肠的药物递送装置。该装置包括用于延迟药物在胃中的输送的外部装置和用于防止流体通过延迟装置的疏水装置。

2. 发明授权

US4092769A Fiber bundle encapsulating apparatus 失效
标题翻译：纤维束封装装置
公开(公告)号：US4092769A
公开(公告)日：1978-06-06
申请号：US676752
申请日：1976-04-14
申请人： Thomas David Dickson, Jr. , Jeremy Corwin Wright
发明人： Thomas David Dickson, Jr. , Jeremy Corwin Wright
IPC分类号： B23P11/02 , B23P19/02 , B29C70/54 , G02B6/44 , B23P19/04
CPC分类号： G02B6/4479 , B23P11/022 , B23P19/022 , B29C70/542 , G02B6/4485 , Y10T29/49838 , Y10T29/4987 , Y10T29/53652 , Y10T29/53657 , Y10T29/53696
摘要： An apparatus and process for longitudinally encapsulating a bundle of aligned fibers within an elastomeric tube of smaller diameter than the normal diameter of the bundle in which: the tube is confined within a tubular inner channel of an openable casing, the diameter of the casing being at least as large as the normal diameter of the bundle; the ends of the tube are slipped over nipples at each end of the channel; air is pressured into the tube via one of the nipples thereby expanding the tube outwardly against the channel wall; the bundle of fibers is drawn through one of the nipples into the expanded tube; and the tube is depressurized to permit it to contract radially about the bundle of fibers.
摘要翻译：一种用于将一束对齐的纤维纵向包封在比该束的正常直径小的直径的弹性体管内的装置和方法，其中：管被限制在可打开外壳的管状内部通道内，外壳的直径在至少与束的正常直径一样大; 管的端部在通道的每个端部处的乳头上滑动; 空气通过一个接头压入管中，从而使管向外扩张通过通道壁; 纤维束通过其中一个乳头被拉入膨胀管中; 并且将管减压以允许其围绕纤维束径向收缩。

3. 发明授权

US07470267B2 Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method 失效
标题翻译：流体输送装置具有带有阴离子交换膜的电化学泵和相关方法
公开(公告)号：US07470267B2
公开(公告)日：2008-12-30
申请号：US10137661
申请日：2002-05-01
申请人： Ashok V. Joshi , Strahinja K. Zecevic , Sai Bhavaraju , Felix Theeuwes , Jeremy Corwin Wright
发明人： Ashok V. Joshi , Strahinja K. Zecevic , Sai Bhavaraju , Felix Theeuwes , Jeremy Corwin Wright
IPC分类号： A61K9/22
CPC分类号： A61M5/1452 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513
摘要： A fluid delivery device, comprising an electrochemical pump, wherein the pump is capable of transporting water; a pump product chamber, wherein the pump product chamber is capable of retaining water generated from the pump; a displaceable member positioned between the pump product chamber and a reservoir, wherein the displaceable member is controllably displaced upon generation of water from the electrochemical pump; a reservoir, wherein the reservoir is capable of containing a fluid which is delivered upon displacement of the displaceable member; and an housing for containing the pump, the pump product chamber, the displaceable member, and the reservoir.
摘要翻译：一种流体输送装置，包括电化学泵，其中所述泵能够输送水; 泵产品室，其中所述泵产品室能够保留从所述泵产生的水; 定位在所述泵产品室和储存器之间的可移位构件，其中所述可移位构件在从所述电化学泵产生水时可控地移位; 储存器，其中所述储存器能够容纳在所述可移位构件移位时被输送的流体; 以及用于容纳泵，泵产品室，可移动构件和储存器的壳体。

4. 发明授权

US07371229B2 Dual electrode advanced electrochemical delivery system 失效
标题翻译：双电极高级电化学输送系统
公开(公告)号：US07371229B2
公开(公告)日：2008-05-13
申请号：US10353769
申请日：2003-01-28
申请人： Felix Theeuwes , Jeremy Corwin Wright , Stahinja K. Zecevic
发明人： Felix Theeuwes , Jeremy Corwin Wright , Stahinja K. Zecevic
IPC分类号： A61K9/22
CPC分类号： H01M2/0202 , A61M2005/14513 , A61N1/30 , B01D61/427 , H01M10/425 , H01M10/484
摘要： The present invention is disclosed herein as an electrochemical cell having a cell housing with a first half cell and a second half cell, and an ion selective membrane between the cells. The electrochemical cell further has a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with both the first electrode and the second electrode. The electrodes of the cell are configured so that the electrochemical cell maintains a substantially constant salt concentration level throughout operation. The cell is preferably used in conjunction with an implantable fluid delivery apparatus. A method for using the device is additionally disclosed.
摘要翻译：本发明在此被公开为具有具有第一半电池和第二半电池的电池壳体的电化学电池以及电池之间的离子选择性膜。电化学电池还具有位于第一半单元内的第一电极，位于第二半单元内的第二电极，与第一电极和第二电极电连通的电解质。电池的电极被配置为使得电化学电池在整个操作中保持基本上恒定的盐浓度水平。细胞优选与可植入流体输送装置结合使用。另外公开了一种使用该装置的方法。

5. 发明授权

US06872292B2 Voltage modulation of advanced electrochemical delivery system 失效
标题翻译：先进的电化学传递系统的电压调制
公开(公告)号：US06872292B2
公开(公告)日：2005-03-29
申请号：US10353770
申请日：2003-01-28
申请人： Felix Theeuwes , Jeremy Corwin Wright
发明人： Felix Theeuwes , Jeremy Corwin Wright
IPC分类号： A61M5/142 , A61M5/145 , B01D61/42 , B01D61/44 , A61N1/30
CPC分类号： B01D61/427 , A61M5/14276 , A61M2005/14513
摘要： An electro-osmotic cell capable of substantially reducing zero-current transport is disclosed, wherein the cell includes a cell housing having a first half cell and a second half cell, with an ion selective membrane therebetween, a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with the first electrode and the second electrode, and a wiring apparatus electrically connecting the first electrode and the second electrode, wherein the wiring apparatus has one or more structures used for counteracting salt concentration increases within the electro-osmotic cell. Such a cell may be used within an electro-osmotic fluid delivery device, along with a fluid inlet, a piston member adjacent the electro osmotic cell, and a drug reservoir adjacent the piston member, wherein the drug reservoir includes a sealed compartment having an exit port. A method for using such a device is similarly disclosed.
摘要翻译：公开了能够显着减少零电流输送的电渗透电池，其中电池包括具有第一半电池和第二半电池的电池壳体，其间具有离子选择性膜，位于第一半电池内的第一电极位于所述第二半单元内的第二电极，与所述第一电极和所述第二电极电连通的电解质，以及电连接所述第一电极和所述第二电极的布线装置，其中所述布线装置具有用于在电渗透细胞内抵消盐浓度增加。这样的细胞可以与电渗透流体递送装置一起使用，以及流体入口，邻近电渗透细胞的活塞构件和邻近活塞构件的药物储存器，其中药物储存器包括密封隔室，其具有出口港口。类似地公开了使用这种装置的方法。

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