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    • 4. 发明授权
    • Systems and methods for training a convolutional neural network that is robust to missing input information
    • US12026934B2
    • 2024-07-02
    • US17531720
    • 2021-11-20
    • Xue FengQuan ChenKanchan Ghimire
    • Xue FengQuan ChenKanchan Ghimire
    • G06V10/774G06N3/04G06V10/25G06V10/80G06V10/94
    • G06V10/774G06N3/04G06V10/25G06V10/80G06V10/95
    • The present disclosure relates to a method and apparatus for training a convolutional neural network (CNN) that is robust to missing input information. The method includes: receive a plurality of three-dimensional (3D) images per case obtained from a CT, an MRI, or a PET system or the combination thereof; receive accompanying metadata for each received 3D images, comprising pixel spacing, slice thickness, and matrix size; processing the received 3D images per case utilizing the received metadata of each 3D images to generate 4D images containing complimentary information from received imaging modalities, wherein the generated 4D images may miss a plurality of imaging modalities; further process the generated 4D images if the generated 4D images miss a plurality of imaging modalities, wherein the step comprises: fill the generated 4D images with a fixed value for all pixels of missed imaging modalities; build an adaptable deep learning framework using CNNs for image segmentation that utilizes the generated 4D images as input; train the CNNs with the generated 4D images to obtain segmentation labels for each region-of-interest (ROI) by emulating missing modality, wherein the step of emulating missing modality in training comprises: randomly decide whether or not to emulate; if decide to emulate, randomly select a plurality of input modalities to emulate as missing and fill the images with a fixed value for all pixels of the selected input modalities; and deploy the trained CNNs on 4D images generated from 3D images for each new testing case employing the steps of receiving and processing 3D images described above to obtain segmentation labels for each ROI, wherein the step of deployment comprises: accommodate missing modalities in generated 4D images by filling the images with the same fixed value used in training for missed modalities.
    • 6. 发明申请
    • SYSTEMS AND METHODS FOR REDUCED OFF-RESONANCE BLURRING IN SPIRAL IMAGING
    • 用于减少螺旋成像中的非共振辐射的系统和方法
    • US20140152304A1
    • 2014-06-05
    • US13868095
    • 2013-04-22
    • Samuel W. FieldenCraig H. MeyerXue Feng
    • Samuel W. FieldenCraig H. MeyerXue Feng
    • G01R33/565
    • G01R33/565G01R33/4824
    • Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.
    • 系统,减少获取的磁共振成像数据中的非共振模糊的方法。 该方法包括:通过沿着第一冗余螺旋进/出轨迹对k空间中的一个或多个位置执行第一采样,获取一个或多个螺旋输入/输出交错中的每一个的第一组螺旋插入数据,以及 通过沿着第二冗余螺旋进/出轨迹执行所述k空间中的所述一个或多个位置中的每个位置的第二采样来获取所述一个或多个螺旋输入/输出交错中的每一个的第二组螺旋插入数据, 其中所述第二冗余螺旋进/出轨迹对应于所述第一冗余螺旋进/出轨迹的时间反转轨迹。 该方法还可以包括将第一组螺旋插入数据和第二组螺旋插值数据与平均化操作组合,以减少伪影。
    • 8. 发明公开
    • SYSTEM AND METHOD FOR FAST MONTE CARLO DOSE CALCULATION USING A VIRTUAL SOURCE MODEL
    • US20230154586A1
    • 2023-05-18
    • US17528590
    • 2021-11-17
    • James CastleQuan ChenXue Feng
    • James CastleQuan ChenXue Feng
    • G16H20/10G16H50/50G16H30/40G16H15/00G06T7/00
    • G16H20/10G16H50/50G16H30/40G16H15/00G06T7/0012G06T2207/10081
    • The present disclosure relates to a method and apparatus for fast Monte Carlo (MC) dose calculation using a virtual source model (VSM). The method includes: receiving three-dimensional (3D) images obtained by a computed tomography (CT) system; receiving 3D planned dose images, 3D organ segmentation contour images, and radiotherapy plans generated by a treatment planning system (TPS); processing all 3D images to have the same spatial resolution and matrix size; processing 3D CT images to convert image intensity to density; processing the radiotherapy plans to generate instructions on how to simulate plan delivery; building VSM using inverse cumulative density function (CDF) tables for the simulation of radiotherapy plans, wherein the step of building VSM comprises: receiving output data files containing phase-space information for the radiation output of a specific medical linear accelerator treatment head; calculating the probability of particles' inplane and crossplane positions reverse transported from the phase-space surface back to the treatment head; calculating the Gaussian means and standard deviations of particles' positions at the treatment head and determining the criteria for particle source; calculating the probabilities for each particle source; calculating the probabilities for the medical linear accelerator treatment head to produce different particle species; binning the inplane position probability information of particles into a single histogram for each source and particle species; binning the crossplane position probability information of particles into histograms for each bin of the inplane position histogram for each source and particle species; binning the inplane direction cosine probability information of particles into histograms for each bin of the inplane position histogram for each source and particle species; binning the crossplane direction cosine probability information of particles into histograms for each bin of the crossplane position histogram for each source and particle species; binning the kinetic energy probability information of particles into radially binned histograms for each source and particle species; converting probability densities for inplane and crossplane positions, inplane and crossplane direction cosines, and kinetic energies histograms into cumulative probability densities for each source and particle species; and inverting cumulative probability densities and converting into probability binned inverse CDF tables; simulating and transporting external beams using VSM through virtual treatment machines to the 3D CT densities according to radiotherapy plans to produce 3D images of simulated patient dose; and post-processing 3D planned dose, organ segmentation contour, and simulated patient dose images to obtain a final report comparing planned versus simulated dose.